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In Frail Elderly Patients, Low-Dose Gemcitabine over 6-hour Infusion Is Equally Effective and Less Toxic Than the Standard Gemcitabine Protocol for Advanced Pancreatic Adenocarcinoma: A Randomized Phase II Trial

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Journal of Cancer Therapy 2020年第3期11卷 124-141页

作者： Salah Mabrouk Khallaf Elsayed mostafa Ali Ahmed MMaklad Mohamed Medhat Samir Anwar Tawfik Amin Muhammad Abbas El-masry Mona MSayed Dalia Osama Medical Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt Clinical Oncology and Nuclear Medicine Department Sohag UniversitySohagEgypt Surgical Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt Division of gastroenterology-Department of internal medicine Assiut UniversityAssiutEgypt Radiation Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt

Background:?Treatment of frail elderly patients with pancreatic cancer is still a major problem due to intolerance to standard chemotherapy doses. Aim:?This study aims to compare the low-dose gemcitabine over 6 hours (LD6h) to the standard gemcitabine protocol in terms of clinical benefit, survival, and safety in the frail elderly patients with advanced pancreatic adenocarcinoma. Methods:?Patients enrolled in this trial were randomly assigned by in a 1:1 fashion via closed envelope method to either receive gemcitabine of 1000 mg/m2?over 30-minute infusion on days 1, 8, and 15 of every 4-week cycle (standard protocol arm) or gemcitabine as a weekly low-dose (250 mg/m2) over 6-hour infusion (LD6h arm). Results:?We enrolled eighty-two eligible frail elderly patients with advanced pancreatic cancer. The patients were randomly assigned to receive either standard gemcitabine protocol (40 patients) or low-dose (250 mg/m2) gemcitabine over 6-hour infusion, given weekly (42 patients). There was no significant difference between the standard group and low-dose group as regard of the overall response rate (p = 0.654), the disease control rate (DCR) (p = 0.845), the median progression-free survival (PFS) (p = 0.908) and the overall survival (OS) (p = 0.331). The low-dose regimen had a significantly lower incidence of adverse effects grades 3 or 4 when compared to the standard regimen: (p = 0.024 for fatigue, p = 0.027 for hypotension, p = 0.012 for each anemia as well as thrombocytopenia, and p = 0.006 for neutropenia). Conclusion:?Low-dose gemcitabine over 6-hour infusion is equally effective and less toxic when compared to standard gemcitabine protocol in frail elderly patients with advanced pancreatic adenocarcinoma. So, we recommend the low-dose gemcitabine for frail elderly patients with advanced pancreatic cancer.

关键词： Continuous Infusion Elderly Frail Low Dose Gemcitabine Pancreatic Cancer

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Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases

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World Journal of Gastroenterology 2017年第38期23卷 7025-7036页

作者： ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab gastroenterology surgical center mansoura university

AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary *** This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the *** Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%.

关键词： Pancreaticoduodenectomy Pancreaticogastrostomy Pancreaticojejunostomy Postoperative pancreatic fistula Periampullary tumor

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Effect of Local Wound Infiltration with Ketamine versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines, a Randomized Clinical Trial

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Open Journal of Anesthesiology 2022年第8期12卷 261-277页

作者： Fatma A. El Sherif Moaaz Tohamy Mohamed A. M. mostafa Suzanne de la Adlan Sahar Abdel-Baky Mohamed Samar Mansour Mahmoud M. Mohammed Ahmad M. Abd El-Rahman Anethesia ICU and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt Anesthesia ICU and Pain Management National Cancer Institute Cairo University Cairo Egypt Clinical Pathology South Egypt Cancer Institute Assiut University Assiut Egypt Surgical Oncology South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Ketamine or dexmedetomidine as an adjuvant to bupivacaine in local wound infiltration attenuated postoperative stress response, especially with ketamine in patients undergoing total abdominal hysterectomy. Objectives: Compare effect of local wound infiltration with ketamine or dexmedetomidine added to bupivacaine to bupivacaine alone on inflammatory cytokine response after total abdominal hysterectomy. Methods: Sixty female patients with endometrial carcinoma underwent total abdominal hysterectomy and scheduled to receive local wound infiltration before wound closure either with one of three;40 ml of 0.25% bupivacaine alone (C Group) or with the addition of 2 mg/kg ketamine (K Group) or 2 μg/kg dexmedetomidine (D Group). After extubation, they were followed up for postoperative interleukin 6 (IL6), IL1β, IL10, and TNF-α levels were assessed at baseline, pre-infiltration, 6, and 24 h by blood samples obtained from each patient, hemodynamic variables, analgesic profile and side effects. Results: Inflammatory cytokines response was attenuated in K and D groups, evidenced by decreased mean pro-inflammatory cytokines IL6, TNF-α, and increased anti-inflammatory IL10 at 6 and 24 h postoperatively compared to pre-infiltration levels (p ≤ 0.01) with preservation of IL1β at its preoperative level (p > 0.05). Attenuation was more in K and D groups than in the C group and was highest in the K group with decreased 1st request, total morphine consumption without serious side effect. Conclusion: Local wound infiltration with ketamine or dexmedetomidine added to bupivacaine has a good postoperative analgesic profile and attenuated cytokines inflammatory response more than bupivacaine alone after total abdominal hysterectomy, with highest attenuation in ketamine group.

关键词： Ketamine Dexmedetomidine Local Infiltration Cytokines hysterectomy

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SChISTOSOMIASIS AND CARCINOGEN METABOLIZING ENZYMES.

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癌变．畸变．突变 1991年第S1期3卷 133-133页

作者： M.h.mostafa S.A.Sheweita A.F.Badawi A.h.El-Koweidv P.J.0'Conner Institute of Graduate studies and Research Alexandria UniversityAlexandriaEgypt&Paterson Institute for Cancer ResearchManchesterUKInstitute of Graduate studies and ResearchAlexandria UniversityAlexandriaEgypt&Paterson Institute for Cancer ResearchManchesterUKInstitute of Graduate studies and ResearchAlexandria UniversityAlexandriaEgypt&Paterson Institute for Cancer ResearchManchesterUKInstitute of Graduate studies and ResearchAlexandria UniversityAlexandriaEgypt&Paterson Institute for Cancer ResearchManchesterUKInstitute of Graduate studies and ResearchAlexandria UniversityAlexandriaEgypt&Paterson Institute for Cancer ResearchManchesterUK

Schistosomiasis ranks as one of the most important health prob-lems in developing countries with an estimated 200 millioninfected people in 72 different *** Egypt,bilharzialinfection is the most frequently found endem... 详细信息

关键词： ranks endemic parasitic Egypt representing bladder hydrocarbon cancel declined 田融

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Educational Program for Pregnant Women Regarding Obstetrics Dangerous Signs in Rural Areas

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Open Journal of Obstetrics and Gynecology 2021年第5期11卷 529-552页

作者： Mai Ahmed Gobran Marwa Tharwat Abdel Fatah Mohamed S. h. Ramadan Ghada A. Amer M. Mahmoud Rabeh Rofida M. Elshafei Almandouh hussein Bosilah hala hassan Saied Khalil Sharbat Thabet hassanine Manal Mansour mostafa Mohamed Sobhy Bakry Safaa A. Ibrahim Eman Ramadan Abd El Fattah Abeer M. Abdelbary Pathology Faculty of Medicine Zagazig University Zagazig Egypt Anatomy Faculty of Medicine Zagazig University Zagazig Egypt Obstetrics & Gynecology Faculty of Medicine Zagazig University Zagazig Egypt Zoology (Physiology) Department Faculty of Science Zagazig University Zagazig Egypt Stem Sharqiai Zagazig Egypt Nursing Faculty of Medicine Fayoum University Fayoum Egypt Obstetrics & Gynecology Faculty of Medicine Fayoum University Fayoum Egypt

Background: Complications linked to postpartum & pregnancy are one of the major causes of female death. In order to understand the causes of complications and encourage women to take sufficient action in order to receive emergency treatment, a critical step should therefore be taken to minimize complications related to pregnancy, in order to ensure the safety of both women and newborns. Aim of the work: Evaluate the effectiveness of the education programs for pregnant women on obstetric danger signs in rural areas and help minimize the incidence of pregnancy loss and comorbidities. Methods: A quasi-experimental design on 70 women from a population of through 372 women in six-month in antenatal clinics recruited from the previously mentioned settings with pre- and post-test was conducted at antenatal clinics (M.C.h centers) affiliated to the available geographical health zones in EL-fayoum rural area including: Al-sheikh hassan at sanorse. We collected the data of women characteristics by a self-administered interview q

关键词： Obstetric Danger Signs Knowledge Practice Obstetric Complications

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Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

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Classes and phyla of the kingdom Fungi

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Fungal Diversity 2024年第1期1卷 1-165页

作者： Nalin N.Wijayawardene Kevin D.hyde Kirill V.Mikhailov Gabor Peter Andre Aptroot Carmen L.A.Pires‑Zottarelli Bruno T.Goto Yuri S.Tokarev Danny haelewaters Samantha C.Karunarathna Paul M.Kirk Andre L.C.M.de A.Santiago Ramesh K.Saxena Nathan Schoutteten Madhara K.Wimalasena Vladimir V.Aleoshin Abdullah M.S.Al‑hatmi Kahandawa G.S.U.Ariyawansa Amanda R.Assuncao Thushara C.Bamunuarachchige hans‑Otto Baral D.Jayarama Bhat Janusz Błaszkowski Teun Boekhout Nattawut Boonyuen Michael Brysch‑herzberg Bin Cao Jonathan Cazabonne Xue‑Mei Chen Claudia Coleine Dong‑Qin Dai heide‑Marie Daniel Suzana B.G.da Silva Francisco Adriano de Souza Somayeh Dolatabadi Manish K.Dubey Arun K.Dutta Aseni Ediriweera Eleonora Egidi mostafa S.Elshahed Xinlei Fan Juliana R.B.Felix Mahesh C.A.Galappaththi Marizeth Groenewald Li‑Su han Bo huang Vedprakash G.hurdeal Anastasia N.Ignatieva Gustavo h.Jeronimo Ana L.de Jesus Serhii Kondratyuk Jaturong Kumla Martin Kukwa Qirui Li Juliana L.R.Lima Xiao‑Yong Liu Wenhua Lu h.Thorsten Lumbsch hugo Madrid Franco Magurno Guy Marson Eric h.C.McKenzie Audrius Menkis Armin Mešić Elaine C.R.Nascimento Elena S.Nassonova Yong Nie Naasson V.L.Oliveira Emilia A.Ossowska Julia Pawłowska Ursula Peintner Igor R.Pozdnyakov Bhagya M.Premarathne A.K.hasith Priyashantha C.Alisha Quandt Mariana B.Queiroz Kunhiraman C.Rajeshkumar Mubashar Raza Niranjan Roy Milan C.Samarakoon Alessandra A.Santos Lidiane A.Santos Felix Schumm Laura Selbmann Faruk Selcuk D.Rabern Simmons Anastasia V.Simakova Maudy Th.Smith Onden Paraparath Sruthi Nakarin Suwannarach Kazuaki Tanaka Saowaluck Tibpromma Elias O.Tomas Merve Ulukapı Nicolas Van Vooren Dhanushka N.Wanasinghe Evi Weber Qianzhen Wu Er Fu Yang Ryuichi Yoshioka Noha h.Youssef Annemarie Zandijk Gui‑Qing Zhang Jin‑Yong Zhang heng Zhao RuiLin Zhao Oleg A.Zverkov Marco Thines Sergey A.Karpov Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Tropical Microbiology Research Foundation 96/N/10Meemanagoda RoadPannipitiya 10230Sri Lanka Department of Bioprocess Technology Faculty of TechnologyRajarata UniversityMihintaleSri Lanka Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiangRai 57100Thailand Innovative Institutefor Plant health Zhongkai University of Agriculture and EngineeringGuangzhou 510225People’s Republic of China CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunmingYunnanChina Belozersky Institute of Physicochemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Build.40Moscow 119991Russian Federation Kharkevich Institute for Information Transmission Problems Russian Academy of SciencesMoscow 127051Russian Federation National Collection of Agricultural and Industrial Microorganisms Institute of Food Science and TechnologyHungarian University of Agriculture and Life SciencesSomlóiút 14‑161118 BudapestHungary Instituto de Biociências Universidade Federal de Mato Grosso do SulAvenida Costa e Silvas/n Bairro UniversitárioCampo GrandeMS CEP 79070‑900Brazil Instituto de Pesquisas Ambientais Secretaria do Meio AmbienteInfraestrutura e LogísticaAv.Miguel Stéfano 3687São PauloSP CEP 04301‑902Brazil Departamento de Botânica e Zoologia Universidade Federal do Rio Grande do NorteCampus UniversitárioNatalRN 59078-900Brazil All-Russian Institute of Plant Protection Sh.Podbelskogo 3PushkinSt.Petersburg 196608Russia Research Group Mycology Department of BiologyGhent University9000 GhentBelgium Faculty of Science University of South Bohemia37005ČeskéBudějoviceCzech Republic Department of Ecology and Evolutionary Biology University of Colora

Fungi are one of the most diverse groups of organisms with an estimated number of species in the range of 2–3 *** higher-level ranking of fungi has been discussed in the framework of molecular phylogenetics since hibbett et al.,and the definition and the higher ranks(e.g.,phyla)of the‘true fungi’have been revised in several subsequent *** accumulation of novel genomic data and the advancements in phylogenetics now facilitate a robust and precise foundation for the higher-level classification within the *** study provides an updated classification of the kingdom Fungi,drawing upon a comprehensive phylogenomic analysis of holomycota,with which we outline well-supported nodes of the fungal tree and explore more contentious *** accept 19 phyla of Fungi,***,Ascomycota,Basidiobolomycota,Basidiomycota,Blastocladiomycota,Calcarisporiellomycota,Chytridiomycota,Entomophthoromycota,Entorrhizomycota,Glomeromycota,Kickxellomycota,Monoblepharomycota,Mortierellomycota,Mucoromycota,Neocallimastigomycota,Olpidiomycota,Rozellomycota,Sanchytriomycota,and *** the phylogenies,Caulochytriomycota resides in Chytridiomycota;thus,the former is regarded as a synonym of the latter,while Caulochytriomycetes is viewed as a class in *** provide a description of each phylum followed by its classes.A new subphylum,Sanchytriomycotina Karpov is introduced as the only subphylum in *** subclass Pneumocystomycetidae Kirk et *** Pneumocystomycetes,Ascomycota is invalid and thus *** of fossil fungi in phyla and classes are also discussed,providing examples.

关键词： Caulochytriomycota Phylogenomic analyses Pneumocystomycetidae Sanchytriomycotina

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