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材料科学与工程（中英文版） 2011年第1期5卷 26-31页

作者： mostafa fawzy eissa Physics Department Faculty of Science Beni-suef University Beni-Suef 62511 Egypt

The Effect of （x-Radiation Dose on CR-39 Polymer Track Detectors Using Positron Annihilation Lifetime and UV-Spectroscopy

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材料科学与工程（中英文版） 2010年第11期4卷 48-52页

作者： mostafa fawzy eissa Esmat Mohamed Hassan Emad A. Badawi Physics Department Faculty of Science Beni-Suef University Beni-Suef 62511 Egypt Physics Department Faculty of Science Aswan South rally University Aswan 81528 Egypt Physics Department Faculty of Science EI-Minia University EI-Minia 61519 Egypt

Occurrence and ecotoxicological risk assessment of pesticides in sediments of the Rosetta branch,Nile River, Egypt

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Journal of Environmental Sciences 2022年第8期34卷 21-31页

作者： fawzy eissa Mahmoud Al-Sisi Khaled Ghanem Environment and Bio-agriculture Department Faculty of AgricultureAl-Azhar UniversityNasr CityCairo 11884Egypt Central Laboratory of Residue Analysis of Pesticides and Heavy Metals in Food(QCAP) Agricultural Research CenterDokkiGiza 12311Egypt

This study aimed to(1) monitor the occurrence and spatiotemporal variations of 100 pesticides in sediments collected monthly from July 2018 to June 2019 from sampling sites in El-Rahawy, Sabal, and Tala, along the Rosetta branch of the Nile River, Egypt, and(2) perform an ecological risk assessment for aquatic organisms upon exposure to the detected sediment pesticides based on the risk quotient(RQ) method. Out of the 100 pesticides monitored, 16 pesticides belonging to seven chemical families were detected, and 55% of the sediment samples were contaminated with one or more pesticide residues. The mean concentration(mg/kg dry weight(dw)) and detection frequency(%) of the four most frequently detected pesticides in the sediment samples were as follows: chlorpyrifos(0.18 mg/kg dw and 34%), p,p-DDE(0.018 mg/kg dw and 30%), cypermethrin(0.03 mg/kg dw and 14%), and deltamethrin(0.026 mg/kg dw and 13%). The spatial distribution exhibited that El-Rahawy had the highest pesticide load(2.86 mg/kg dw) among the studied sites, whereas the temporal variations revealed that the highest total pesticide concentrations were detected in winter season(1.73 mg/kg dw). Meanwhile, 12 pesticides showed high RQs(>1), posing a potential ecological risk to aquatic species that live and feed on such sediments.

关键词： Pesticide residues Sediments Spatiotemporal variations Risk quotient

Study of parameters affecting infection risk from contaminated injectable products using multiple spot contamination model: a case study of insulin vials

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Journal of Chinese Pharmaceutical Sciences 2016年第11期25卷 832-837页

作者： mostafa Essam eissa Hikma Pharma for Pharmaceutical Industry 2nd Industrial Zone

Infections of patients from consumption of contaminated pharmaceutical products constituted major health risk problems. Medicinal products are liable to microbial intrusion during in-use application. The current study focused on repeated contamination with constant level of microbiological burden by two bacteria viz. Staphylococcus aureus and Pseudomonas aeruginosa were used as dose-response models for infection through two different routes of administration. Nine different forms of insulin vials were subjected to this type of simulation study at constant assumed level of contaminations, preservative efficacy test(PET) and dose potency. Multi-spot contamination imitation study showed that initial fast rise in contamination, followed shortly by longer but steeper slope which finally turned into higher rate of contamination during the few last doses of the unit dosage forms, where the volume of the product became increasingly and progressively very small. When the probability of infection curves was constructed, both S. aureus and P. aeruginosa showed same pattern, with notably higher risk from septicemia route of the latter rather than subcutaneous route of the former. The present simulation study showed that continuous use of the same contaminated syringe progressively increased the risk of infection, especially at final few doses(between 3th and 10 th last doses depending on the dosage form sizes in the vials and the administration volumes) of the product. Small volume parenterals(SVP) are especially products at higher risk than the larger volume ones.

关键词： Insulin vials Staphylococcus aureus Pseudomonas aeruginosa Multi-spot contamination PET Simulation study

Inverse Gas Chromatography Used to Study Lubricating Oil Oxidation Mechanism via Changes in Kovats and Flory-Huggins Retention Parameters

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色谱 2006年第3期24卷 284-289页

作者： mostafa Nagy E eissa Elham A Egyptian Petroleum Research Institute CairoEgypt

Inverse gas chromatographic technique(IGC) was attempted as a new approach to follow the chem-ical changes that occur during lubricating base oil *** groups of the oxidized base oils were pre-pared at different oxygen flow rates,periods and temperatures according to *** corrected reten-tion volumes(VR) were calculated for a series of selected test solutes possessing different functional groups onthe oxidized base oils used as stationary *** retention index(I),Flory-Huggins interaction parame-ter(κ1∞,2),and partial molar free energy of solution(ΔGL∞),were calculated for the given test solutes *** relationships between theIvalues and the oxidation variables were plotted and *** results were confirmed by potentiometric *** study reveals that the magnitudes of variationofI,κ1∞,2orΔG∞Lretention parameters depend on the oxidation degree of the base *** differences be-tween theIvalues permit discrimination between the different oxidation *** words: inverse gas chromatography(IGC);oxidation;lubricating base oil;Kovats retention

关键词： test IGC KOH ASTM rate

Mid-term results of sub-trochanteric valgus osteotomy for symptomatic late stages Legg-Calvé-Perthes disease

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World Journal of Orthopedics 2023年第5期14卷 328-339页

作者： Khaled M Emara Ramy Ahmed Diab Ahmed K Emara Mohamed eissa mostafa Gemeah Shady Abdelghaffar Mahmoud Department of Orthopedic Surgery Ain Shams UniversityCairo 11591Egypt Department of Orthopedic Surgery Cleveland Clinic FoundationClevelandOH 9500United States Health Care Innovation Program Arizona State UniversityTempeAZ 85287United States

BACKGROUND The treatment of late stages of Legg-Calvé-Perthes disease(LCPD)is *** the concept of femoral head containment is a well-established technique of treatment,its use remains debatable in the late stages of the disease,as it does not improve symptoms in terms of limb length discrepancy and *** To assess the results of subtrochanteric valgus osteotomy in symptomatic patients with late-stage Perthes *** From 2000 to 2007,36 symptomatic patients with late stage of Perthes disease were surgically treated with subtrochanteric valgus osteotomy and followed-up for 8 to 11 years using the IOWA score and range of motion(ROM)*** Mose classification was also assessed at the last follow-up to reflect possible *** patients were 8 years old or older at the time of surgery,in the post-fragmentation stage,and complaining of pain,limited ROM,Trendelenburg gait,and/or abductor *** The preoperative IOWA score(average:53.3)markedly improved at the 1-year post follow-up period(average:85.41)and then slightly improved at the last follow-up(average:89.4)(P value<0.05).ROM improved,with internal rotation increased on average by 22°(from 10°preoperatively to 32°postoperatively)and abduction increased on average by 15.9°(from 25°preoperatively to 41°postoperatively).The mean Mose deviation of femoral heads was 4.1 mm at the end of the follow-up *** tests used were the paired t-test and Pearson correlation test,where the level of significance was a P value less than *** Subtrochanteric valgus osteotomy can be a good option for symptomatic relief in patients with late-stage of LCPD.

关键词： Legg-Calvé-Perthes disease Femoral head avascular necrosis Valgus osteotomy Deformity correction Post fragmentation stage Late stage Perthes

Mathematical Evaluation Changes in Rheological and Mechanical Properties of Pears during Storage under Variable Conditions

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Journal of Food Science and Engineering 2012年第10期2卷 564-575页

作者： Ayman H. Amer eissa Abdul Rahman O. Alghannam mostafa M. Azam Department of Agriculture Systems Engineering College of Agricultural and Food Sciences King Faisal University P.O. Box 420Al-Hassa 31982 Saudi Arabia Agriculture Engineering Department Faculty of Agriculture Minoufiya University Shibin El-Kom Egypt

In order to better design, fabricate and control pear handling machine, we should take into account mechanical and rheological properties of pear fruits as related to handling process. The changes in rheological properties of pears stored at 5, 15, 25 ℃ and variable （fluctuating） temperature for 12 days were evaluated in terms of elasticity and viscosity parameters using creep tests. The elasticity and viscosity parameters in creep tests in general decreased with increase in storage time both under constant and variable storage conditions. For the variable storage condition, a bulk mean temperature calculated to account for a series combination of storage time and temperature to which the pears subjected. The changes in rheological properties due to variable storage temperature were described as a function of storage time. The result indicated that except the viscosity parameter of the Maxwell component of the four-element model, it was possible to describe the changes in rheological properties as a function of storage time, which are better physical parameters to estimate the quality of pears.

关键词： Modeling rheological and mechanical properties pears storage Burger's model creep test.

Intensive care unit readmission in adult Egyptian patients undergoing living donor liver transplant:A single-centre retrospective cohort study

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World Journal of Hepatology 2022年第6期14卷 1150-1161页

作者： Manar Salah Iman fawzy Montasser Hanaa A El Gendy Alaa A Korraa Gamal M Elewa Hany Dabbous Hossam R Mahfouz mostafa Abdelrahman Mohammed Hisham Goda Mohamed Mohamed Bahaa El-Din Mahmoud El-Meteini Heba A Labib Department of Tropical Medicine Ain Shams Center for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of Anaesthesia and Critical Care Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of General Surgery and Liver Transplantation Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt

BACKGROUND Patients who undergo living donor liver transplantation(LDLT)may suffer complications that require intensive care unit(ICU)*** To identify the incidence,causes,and outcomes of ICU readmission after *** A retrospective cohort study was conducted on patients who underwent *** collected data included patient demographics,preoperative characteristics,intraoperative details;postoperative stay,complications,causes of ICU readmission,and *** were divided into two groups according to ICU readmission after hospital *** factors for ICU readmission were identified in univariate and multivariate *** The present study included 299 ***-one(10.4%)patients were readmitted to the ICU after *** who were readmitted to the ICU were older in age(53.0±5.1 vs 49.4±8.8,P=0.001)and had a significantly higher percentage of women(29%vs 13.4%,P=0.032),diabetics(41.9%vs 24.6%,P=0.039),hypertensives(22.6%vs 6.3%,P=0.006),and renal(6.5%vs 0%,P=0.010)patients as well as a significantly longer initial ICU stay(6 vs 4 d,respectively,P<0.001).Logistic regression analysis revealed that significant independent risk factors for ICU readmission included recipient age(OR=1.048,95%CI=1.005-1.094,P=0.030)and length of initial hospital stay(OR=0.836,95%CI=0.789-0.885,P<0.001).CONCLUSION The identification of high-risk patients(older age and shorter initial hospital stay)before ICU discharge may help provide optimal care and tailor follow-up to reduce the rate of ICU readmission.

关键词： Intensive care units Liver transplantation Patient readmission Risk factors

Does maintenance of Bevacizumab after treatment failure have a role in metastatic colon cancer?

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The Chinese-German Journal of Clinical Oncology 2009年第1期8卷 24-32页

作者： Khaled M. Galal Khaled Zaghlol Ehab Esmat fawzy Saleh Mansour Mahmoud Abdul Salam Ehab mostafa Mohamed Radiotherapy and Oncology Center (NEMROCK) Cairo University Oncology Center Saudi German Hospital Department of Internal Medicine Tanta University King Abdul Aziz University Hospital Department of Radiotherapy & Clinical Oncology Mansoura University King Faisal Specialized Hospital Department of Radiotherapy & Clinical Oncology Ain Shams University

Objective： To study the timing of Bevacizumab （BVC） in the overall treatment strategy of advanced metastatic colorectal cancer - early use （first-line） or later use. Methods： 41 patients with progressive metastatic colorectal carcinoma were included. Patients were randomized to receive chemotherapy with or without BVC. Primary end point was objective response. Secondary end points were median survival, time to tumor progression, and toxicity. Results： Partial response with second-line BVC group constituted 25% and 18.8% in patients with first-line chemotherapy and BVC-based regimen respectively, compared to 11.8% and 5.9% with second-line chemotherapy. Median time to progression was 3.1 vs. 2.3 months for cases with first-line chemotherapy and BVC-based regimens respectively. Median survival was 8.2 vs. 4 months in both groups respectively （P = 0.019）. Conclusion： Second-line chemotherapy combined BVC had higher disease control rate （partial response and stable disease）, median time to progression and median survival in BVC-naive patients compared to patients with first-line BVC-based therapy. BVC should be maintained in the second- and third-line settings, as cases with BVC discontinuation had significantly lower median time to disease progression and median survival. Selection of patients for use of BVC was recommended with taking into consideration the cost-benefit value and that the discontinuation of BVC would increase tumor progression.

关键词： second-line therapy Bevacizumab (BVC) metastatic colorectal carcinoma

Effect of fibrinolytic therapy on ST-elevation myocardial infarction clinical outcomes during the COVID-19 pandemic:A systematic review and meta-analysis

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World Journal of Cardiology 2023年第6期15卷 309-323页

作者： Anwar Khedr Hussam Al Hennawi Muhammed Khuzzaim Khan mostafa Elbanna Abbas B Jama Ekaterina Proskuriakova Hisham Mushtaq Mikael Mir Sydney Boike Ibtisam Rauf Aalaa eissa Meritxell Urtecho Thoyaja Koritala Nitesh Jain Lokesh Goyal Salim Surani Syed A Khan Department of Internal Medicine BronxCare Health SystemBronxNY 10457United States Department of Internal Medicine Jefferson Abington HospitalAbingtonPA 19001United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200Pakistan Department of Internal Medicine Rochester Regional HealthRochesterNY 14621United States Department of Critical Care Mayo Clinic Health SystemMankatoMN 56001United States Department of Internal Medicine Mount Sinai HospitalChicagoIL 60608United States Department of Internal Medicine St.Vincent's Medical CenterBridgeportCT 06606United States Department of Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine St.George's UniversitySchool of MedicineSt George SW170REGrenada Department of Medicine KFS UniversityKFS 33511Egypt Department of Medicine Robert D and Patricia E.Kern Center of Health Care DeliveryMayo ClinicRochesterMN 55905United States Department of Hospital Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Hospital Medicine Christus Sphon Hospital-shorelineCorpus ChristoTX 78404United States Department of Pulmonary Critical Care&Sleep MedicineTexas A&M UniversityCollege StationTX 77843United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States

BACKGROUND ST-elevation myocardial infarction(STEMI)is the result of transmural ischemia of the myocardium and is associated with a high mortality *** percutaneous coronary intervention(PPCI)is the recommended first-line treatment strategy for patients with *** timely delivery of PPCI became extremely challenging for STEMI patients during the coronavirus disease 2019(COVID-19)pandemic,leading to a projected steep rise in *** delays were overcome by the shift from first-line therapy and the development of modern fibrinolytic-based *** is unclear whether fibrinolytic-based reperfusion therapy is effective in improving STEMI *** To determine the incidence of fibrinolytic therapy during the COVID-19 pandemic and its effects on STEMI clinical *** PubMed,Google Scholar,Scopus,Web of Science,and Cochrane Central Register of Controlled Trials were queried from January 2020 up to February 2022 to identify studies investigating the effect of fibrinolytic therapy on the prognostic outcome of STEMI patients during the *** outcomes were the incidence of fibrinolysis and the risk of all-cause *** were meta-analyzed using the random effects model to derive odds ratios(OR)and 95%confidence *** assessment was carried out using the Newcastle-Ottawa *** Fourteen studies including 50136 STEMI patients(n=15142 in the pandemic arm;n=34994 in the pre-pandemic arm)were *** mean age was 61 years;79%were male,27%had type 2 diabetes,and 47%were *** with the pre-pandemic period,there was a significantly increased overall incidence of fibrinolysis during the pandemic period[OR:1.80(1.18 to 2.75);I2=78%;P=0.00;GRADE:Very low].The incidence of fibrinolysis was not associated with the risk of all-cause mortality in any *** countries with a low-and middle-income status reported a higher incidence of fibrinolysis[OR:5.16(2.18 to 12.22);I2=81%;P=0.00;GRADE:Very lo

关键词： ST-elevation myocardial infarction Myocardial infarction Thrombolytic therapy Fibrinolysis COVID-19 Pandemics