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In vitro anticancer activity of polysaccharide extracted from red alga Jania rubens against breast and colon cancer cell lines

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Asian Pacific Journal of Tropical Medicine 2018年第10期11卷 583-589页

作者： Saly Gheda mostaf. el-sheekh Alaa Abou-Zeid Botany Department Faculty of Science Tanta University

Objective: To evaluate the potential role of the polysaccharides of the marine algae as an anticancer agent in vitro against colon cancer cell line(CoCa2) and breast cancer(MCF7) cell lines and to measure lactate dehydrogenase enzyme(LDH) activity as biomarker of membrane integrity of the cells. Methods: The cells of breast cancer(MCF7) and colon cancer(CoCa2)were used to evaluate the potential anticancer role of the polysaccharides of marine algae. Antiproliferative activity against MCF7 and CoCa2 cell lines were evaluated in vitro by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide(MTT) assay. Results: The in vitro assay of the antioxidant activity of eight marine seaweed species showed that the red seaweed Jania rubens(J. rubens) had the highest DPPH(2,2 diphenyl-1-picrylhydrazyl) free radical scavenging activity. The extracted polysaccharides with concentrations 0.1–40.0 mg/mL from J. rubens were tested for its anticancer potentiality and cytotoxic effects against the cell lines of human breast(MCF7) and colon cancer(CoCa2) cell lines by MTT assay. The inhibitory concentration at 50 (IC_(50)) value the of J. rubens polysaccharide extract was 0.312 5 mg/mL for MCF7 and 20 mg/mL for CoCa2. LDH activity and annexin V concentration were higher in the treated MCF7 and CaCo2 cells than in the untreated ones. Quantitative polymerase chain reaction technique indicated that the polysaccharide treatments caused up-regulation of Bax, caspase 8 and P53 genes expression in CoCa2 cells, and up-regulation of caspase 3 and down-regulation of Bcl2 genes expression in MCF7 cells. Conclusions: The polysaccharides of the red marine alga J. rubens could be a potential candidate for the natural compounds as antioxidant and anticancer therapy.

关键词： Marine algae Antioxidant activity Cytotoxicity Apoptosis Lactate dehydrogenase Polymerase chain reaction

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Quality Assessment of Drinking Water in Tanta City, Egypt

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Journal of Environmental Science and Engineering(B) 2013年第5期2卷 257-275页

作者： Maha Abdelfattah Khalil Zenhom el-Said Salem Saly Farouk Gheda Moustafa Mohamed E1-sheekh Botany Department Faculty of Science Tanta University Tanta 31527 Egypt Geology Department Faculty of Science Tanta University Tanta 31527 Egypt

The physico-chemical and biological （algal and bacterial） quality of tap water in Tanta City were elucidated. Samples were collected during December 2011, covering all the water plants and the areal extension of the pipe line network in Tanta. Total dissolved solids content classifies water origin into surface water, shallow and deep groundwater. Fe, Mn and hardness in some samples of groundwater origin are obviously exceeding the WHO （World Health Organization） limit. Mostly, green algae are found （31 species）, followed by diatoms （19 species）, then blue-green algae （13 species）. CCA （Canonical Corresponding Analysis） indicates that green algae are strongly correlated with pH, NH4, alkalinity, Mn and Si; diatoms with EC （electric conductivity）, turbidity, Zn and Si and blue green algae with EC and alkalinity. 50% of samples of surface origin, 80% of samples of both deep and shallow groundwater origins crossed WHO and Egyptian guideline in their content of mean TCC （Total Coliform Count）. CCA estimates strong correlations of TCC with temperature, NH4 and PO4; E. coli with EC; heterotrophic bacteria with turbidity and NO3; Salmonella sp. with Si and SO4 and Pseudomonas aeruginosa with Mn. Finally, the water plants treatment may be not effective and pipes serve as a reservoir for pathogenic microorganisms.

关键词： Water pollution drinking water physicochemical characteristics algae bacteria.

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Microalgae-based wastewater treatment:Mechanisms,challenges,recent advances,and future prospects

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Environmental Science and Ecotechnology 2023年第1期13卷 5-22页

作者： Abdallah Abdelfattah Sameh Samir Ali Hassan Ramadan Eslam Ibrahim el-Aswar Reham eltawab Shih-Hsin Ho Tamer elsamahy Shengnan Li mostaf. M.el-sheekh Michael Schagerl Michael Kornaros Jianzhong Sun School of Environment and Safety Engineering Jiangsu UniversityZhenjiang212013PR China Department of Public Works Engineering Faculty of EngineeringTanta UniversityTanta31511Egypt Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang212013PR China Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Central Laboratories for Environmental Quality Monitoring(CLEQM) National Water Research Center(NWRC)El-Kanater13621QalyubiyahEgypt State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090PR China Department of Functional and Evolutionary Ecology University of ViennaDjerassiplatz 1A-1030 ViennaAustria Laboratory of Biochemical Engineering&Environmental Technology(LBEET) Department of Chemical EngineeringUniversity of Patras1 Karatheodori Str.University Campus26504PatrasGreece

The rapid expansion of both the global economy and the human population has led to a shortage of water resources suitable for direct human *** a result,water remediation will inexorably become the primary focus on a global *** can be grown in various types of wastewaters(WW).They have a high potential to remove contaminants from the effluents of industries and urban *** review focuses on recent advances on WW remediation through microalgae *** has already been paid to microalgae-based wastewater treatment(WWT)due to its low energy requirements,the strong ability of microalgae to thrive under diverse environmental conditions,and the potential to transform WW nutrients into high-value *** turned out that microalgae-based WWT is an economical and sustainable ***,different types of toxins are removed by microalgae through biosorption,bioaccumulation,and biodegradation *** are toxins from agricultural runoffs and textile and pharmaceutical industrial *** have the potential to mitigate carbon dioxide and make use of the micronutrients that are present in the *** review paper highlights the application of microalgae in WW remediation and the remediation of diverse types of pollutants commonly present in WW through different mechanisms,simultaneous resource recovery,and efficient microalgae-based co-culturing systems along with bottlenecks and prospects.

关键词： Bioremediation Wastewater treatment Environmental applications Microalgae Co-culturing

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