检索结果-南通市图书馆

Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi Murad Sarah-Lilly Hassan Youssef Haikel mossaad megahed Matthias Hannig Mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment

引用

World Journal of Experimental Medicine 2015年第4期5卷 206-217页

作者： Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell mossaad megahed Clinic of Operative Dentistry Periodontology and Preventive DentistryUniversity Hospital Saarland University Cancer Institute University of Mississippi Medical Center Department of Pathology University of Mississippi Medical Center Institut National de la Santé et de la Recherché Medical U1121 University of Strasbourg Department of Operative Dentistry and Endodontics Dental Faculty University of Strasbourg Department of Dermatology University of Mississippi Medical Center Clinic of Dermatology University Hospital of Aachen

Melanoma is the most aggressive form of skin *** intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment.

关键词： Melanoma Endoplasmic reticulum Apoptosis Autophagy Signaling pathways Chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

GMLP-IDS: A Novel Deep Learning-Based Intrusion Detection System for Smart Agriculture

引用

Computers, Materials & Continua 2023年第10期77卷 379-402页

作者： Abdelwahed Berguiga Ahlem Harchay Ayman Massaoudi mossaad Ben Ayed Hafedh Belmabrouk Department of Computer Science College of Science and Arts in GurayatJouf UniversitySakakahSaudi Arabia Olive Research Center Jouf UniversitySakakahSaudi Arabia Department of Electronic Industrial ENISoSousse UniversitySousseTunisia Department of Physics College of Science at ZulfiMajmaah UniversityMajmaahSaudi Arabia

Smart Agriculture,also known as Agricultural 5.0,is expected to be an integral part of our human lives to reduce the cost of agricultural inputs,increasing productivity and improving the quality of the final ***,the safety and ongoing maintenance of Smart Agriculture from cyber-attacks are vitally *** provide more comprehensive protection against potential cyber-attacks,this paper proposes a new deep learning-based intrusion detection system for securing Smart *** proposed Intrusion Detection System IDS,namely GMLPIDS,combines the feedforward neural network Multilayer Perceptron(MLP)and the Gaussian Mixture Model(GMM)that can better protect the Smart Agriculture ***-IDS is evaluated with the CIC-DDoS2019 dataset,which contains various Distributed Denial-of-Service(DDoS)*** paper first uses the Pearson’s correlation coefficient approach to determine the correlation between the CIC-DDoS2019 dataset characteristics and their corresponding class ***,the CIC-DDoS2019 dataset is divided randomly into two parts,i.e.,training and testing.75%of the data is used for training,and 25%is employed for *** performance of the newly proposed IDS has been compared to the traditional MLP model in terms of accuracy rating,loss rating,recall,and F1 *** are handled on both binary and multi-class classification *** results revealed that the proposed GMLP-IDS system achieved more than 99.99%detection accuracy and a loss of 0.02%compared to traditional ***,evaluation performance demonstrates that the proposed approach covers a more comprehensive range of security properties for Smart Agriculture and can be a promising solution for detecting unknown DDoS attacks.

关键词： Drones DDoS attacks Internet of Things deep learning multilayer perceptron gaussian mixture model Industry 5.0 Agricultural 5.0

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of different severity scores in correlating hemoglobin levels with the severity of hepatic decompensation: An observational study

引用

World Journal of Hepatology 2025年第1期17卷 55-63页

作者： Himayat Ullah Sarwat Huma Ghulam Yasin Muhammad Ashraf Nafisa Tahir Qazi Tahir Uddin Hossam Shabana Mostafa A R Hussein Abdulrahman Shalaby Mohammad mossaad Alsayyad Ashraf Said Ali Farahat Hani Ismail Hamed Hazem Sayed Ahmed Ayoub Mohammed S Imam Essam Elmahdi Department of Medicine College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Health Professions Education Health Services AcademyIslamabad 44000Pakistan Department of Orthopedics College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Department of Medicine NUST School of Health SciencesIslamabad 44000Pakistan Department of Surgery College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Faculty of Medicine Al-Azhar UniversityCairo 11865Egypt Faculty of Medicine for Boys Al-Azhar UniversityNew Damietta 34517Egypt Faculty of Medicine Mansoura UniversityMansoura 35511Egypt

BACKGROUND Chronic liver disease is a growing global health problem,leading to hepatic decompensation characterized by an array of clinical and biochemical *** scoring systems have been introduced in assessing the severity of hepatic decompensation with the most frequent ones are Child-Pugh score,model of end-stage liver disease(MELD)score,and MELD-Na *** is frequently observed in cirrhotic patients and is linked to worsened clinical *** studies have explored anemia in liver disease,few have investigated the correlation of hemoglobin level with the severity of hepatic *** To determine the relationship between hemoglobin levels and the severity of decompensated liver disease and comparing the strength of this correlation using the Child-Pugh,MELD,and MELD-Na *** This cross-sectional study was conducted at a tertiary care hospital with 652 decompensated liver disease patients enrolled in the *** was collected on demographics,clinical history,and laboratory findings,including hemoglobin levels,bilirubin,albumin,prothrombin time(international normalized ratio),sodium,and *** Child-Pugh,MELD,and MELD-Na scores were *** analysis was performed using Statistical Package for the Social Sciences version 26,and correlations between hemoglobin levels and severity scores were assessed using Spearman's correlation *** The study included 405 males(62.1%)and 247 females(37.9%)with an average age of 58.8 *** inverse correlations were found between hemoglobin levels and Child-Pugh,MELD,and MELD-Na scores(P<0.01),with the MELD scoring system being the strongest correlator among ***-way analysis of variance revealed significant differences in hemoglobin levels across the severity groups of each scoring system(P=0.001).Tukey's post hoc analysis confirmed significant internal differences among each severity *** Understanding the correlati

关键词： Hepatic decompensation Hemoglobin level Chronic liver disease Child Turcotte Pugh score Model of end-stage liver disease score Model of end-stage liver disease-Na score

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Post-endoscopic procedure satisfaction scores: Can we improve?

引用

World Journal of Gastrointestinal Endoscopy 2018年第1期10卷 23-29页

作者： Ankita Munjal Joshua M Steinberg Afnan mossaad Samuel J Kallus Mark C Mattar Nadim G Haddad Department of Internal Medicine Georgetown University Hospital Department of Gastroenterology MedStar Georgetown University Hospital Department of Internal Medicine MedStar Washington Hospital Center

AIM To organize post-procedure satisfaction data into a useful reference and analyze patient-centered parameters to find trends that influence patient *** A robust database of two cohorts of outpatients that underwent an endoscopic procedure at Georgetown University Hospital at two separate three-month intervals ranging from November 2012 to January 2013 and November 2015 to January 2016 was compiled. Time of year was identical to control for weather/seasonal issues that may have contributed to the patient experience. The variables recorded included age, sex, body mass index(BMI), type of procedure, indication for procedure, time of the procedure, length of the procedure, type of prep used, endoscopist, satisfactory score, and comments/reasons for score. For continuous variables, differences in averages were tested by two sample t-test, Wilcoxon rank sum test, and ANOVA as appropriate. For categorical variables, differences in proportions between two groups were tested by χ~2 test. Correlation test and linear regression analyses were conducted to examine relationships between length of procedure and continuous predictors. A P value < 0.05 used to indicate statistically significant *** The primary outcome of this study was to assess if telephone outreach after an endoscopic intervention was a satisfactory method of obtaining post-procedure satisfaction scores from patients at a tertiary care center. With the addition of post-procedure calls, instilled in January 2014, the response rate was 40.5%(508/1256 patients) from a prior completion rate of 3.4%(31/918) with the mail out survey initially. There was a statistically significant improved response rate pre and post intervention with P < 0001. The secondary outcome of this study was to assess if we could use predictive analytics to identify independent predictors of procedure length, such as gender, age, type of procedure, time of procedure, or BMI. The combined pre and post interven

关键词： Survey Quality improvement Patient satisfaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：