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Immunohistochemica. Loca.iza.ion of a.pergillus a.d p53 in Huma. Lung Tissues

a.erica. Journa. of Molecula. Biology 2015年第4期5卷 117-123页

作者： Moha.na. G. a.-Sa.hir mosleh a. alkhatatbeh a.ed J. a.kha.ib Depa.tment of Biologica. Sciences Ohio University Zanesville Zanesville Ohio USA Depa.tment of Biologica. Sciences Jordan University of Science and Technology Irbid Jordan Depa.tment of Toxicology a.d Forensic Sciences Jordan University of Science and Technology Irbid Jordan

a.pergilli a.e fila.entous fungi which ca. ca.se opportunistic infections in a.quired Immunodeficiency Syndrome (a.DS) pa.ients. a.pergilli ca. be found in huma. tissues either in the form of spores or hypha.. p53 is a.tumor suppressor gene loca.ed in the short a.m of chromosome 17. It is a.potent tra.scriptiona. regula.or of genes which a.e involved in ma.y cellula. a.tivities including cell cycle a.rest, a.optosis a.d a.giogenesis. a.loss of tumor suppressor function of p53 is the most common event lea.ing to the development of huma. ca.cers. The ra.e by which p53 ha. a.homology between different species ha. been reported from huma. to other vertebra.es, it ha. been reported tha. it is a.a.la.le within Drosophila.mela.oga.ter a.d C. elega.s [1] [2]. The a.m of this study is to check if p53 is loca.ized within a.pergilli or not using immunohistochemica. techniques a.d study the rela.ionship between a.pergilli infection a.d p53 in huma. lung tissues. 45 different sa.ples of lung tissues, dia.nosed a. being none tumor, were ta.en ra.domly during the yea. of 2003-2004 from the a.topsy ca.es submitted to the forensic medicine center in Irbid, Jorda.. The sa.ple group consisted of 12 fema.es a.d 33 ma.es. La.eled Strepta.idin Biotin (LSa.) method a.d Ma.h-4 method were used to determine the a.pergilli infection a.d p53. The results show tha. the a.pergillus is presented in a.l used sa.ples (100% of the infection) in the form of spores or hypha. a.d a.l infected sa.ples ha.e muta.t p53 molecules (p53 wa. loca.ed in a.pergillus spores a.d hypha.). a.cording to this study, it is sa.e to posit tha. the muta.t p53 molecules ma. be used by a.pergillus for its multiplica.ion. Seemingly it is a.biologica. beha.ior of a.pergillus to produce p53. The fa.e of the p53 is questioned, is it going to intera.t with the huma. cells initia.ing ca.cer? Further experimenta. investiga.ions a.e required to determine such pa.hwa.. In conclusion, this study shows tha. a.pergillus is a.producin

关键词： a.pergilius p53 Immunohistochemica. Lung Tissues

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a.new design of pa.ity-preserving reversible multipliers ba.ed on multiple-control toffoli synthesis ta.geting emerging qua.tum circuits

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Frontiers of Computer Science 2024年第6期18卷 186908-186908页

作者： NOORa.La.Za.EH Mojta.a.mosleh Moha.ma. Da.Ta.Ka.a.ika Depa.tment of Computer Engineering Dezful Bra.ch Isla.ic a.a. University Germa. Resea.ch Centre for a.tificia. Intelligence (DFKI) Institute of Computer Science University of Bremen

With the recent demonstra.ion of qua.tum computers, interests in the field of reversible logic synthesis a.d optimiza.ion ha.e ta.en a.different turn. a. every qua.tum opera.ion is inherently reversible, there is a. immense motiva.ion for exploring reversible circuit design a.d optimiza.ion. When it comes to fa.lts in circuits, the pa.ity-preserving fea.ure dona.es to the detection of perma.ent a.d tempora.y fa.lts. In the context of reversible circuits, the pa.ity-preserving property ensures tha. the input a.d output pa.ities a.e equa.. In this pa.er we suggest six pa.ity-preserving reversible blocks (ZFa.SL) with improved qua.tum cost. The reversible blocks a.e synthesized using a. existing synthesis method tha. genera.es a.netlist of multiple-control Toffoli (MCT) ga.es. Va.ious optimiza.ion rules a.e a.plied a. the reversible circuit level, followed by tra.sforma.ion into a.netlist of elementa.y qua.tum ga.es from the NCV libra.y. The designs of full-a.der a.d unsigned a.d signed multipliers a.e proposed using the functiona. blocks tha. possess pa.ity-preserving properties. The proposed designs a.e compa.ed with sta.e-of-the-a.t methods a.d found to be better in terms of cost of rea.iza.ion. a.era.e sa.ings of 25.04%, 20.89%, 21.17%, a.d 51.03%, a.d 18.59%, 13.82%, 13.82%, a.d 27.65% respectively, a.e observed for 4-bit unsigned a.d 5-bit signed multipliers in terms of qua.tum cost, ga.ba.e output, consta.t input, a.d ga.e count a. compa.ed to recent works.

关键词： reversible circuits pa.ity-preserving NCV libra.y multiple-control Toffoli ga.es qua.tum circuits qua.tum cost

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Prediction of mode I fra.ture toughness of rock using linea. multiple regression a.d gene expression progra.ming

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2022年第5期14卷 1421-1432页

作者： Bija. a.ra.ia.ia. mosleh Eftekha.i Depa.tment of Mining Engineering Science and Research BranchIslamic Azad UniversityTehranIran Depa.tment of Mining Engineering Faculty of EngineeringTarbiat Modares UniversityTehranIran

Prediction of mode I fra.ture toughness(KIC) of rock is of significa.t importa.ce in rock engineering a.a.yses. In this study, linea. multiple regression(LMR) a.d gene expression progra.ming(GEP)methods were used to provide a.relia.le rela.ionship to determine mode I fra.ture toughness of rock. The presented model wa. developed ba.ed on 60 da.a.ets ta.en from the previous litera.ure. To predict fra.ture pa.a.eters, three mecha.ica. pa.a.eters of rock ma.s including unia.ia. compressive strength(UCS), Bra.ilia. tensile strength(BTS), a.d ela.tic modulus(E) ha.e been selected a. the input pa.a.eters. a.cluster of da.a.wa. collected a.d divided into two ra.dom groups of tra.ning a.d testing ***, different sta.istica. linea. a.d a.tificia. intelligence ba.ed nonlinea. a.a.yses were conducted on the tra.ning da.a.to provide a.relia.le prediction model of KIC. These two predictive methods were then eva.ua.ed ba.ed on the testing da.a. To eva.ua.e the efficiency of the proposed models for predicting the mode I fra.ture toughness of rock, va.ious sta.istica. indices including coefficient of determina.ion(R2),root mea. squa.e error(RMSE), a.d mea. a.solute error(Ma.) were utilized herein. In the ca.e of testing da.a.ets, the va.ues of R2, RMSE, a.d Ma. for the GEP model were 0.87, 0.188, a.d 0.156,respectively, while they were 0.74, 0.473, a.d 0.223, respectively, for the LMR model. The results indica.ed tha. the selected GEP model delivered superior performa.ce with a.higher R2va.ue a.d lower errors.

关键词： Mode I fra.ture Toughness Critica. stress intensity fa.tor Linea. multiple regression(LMR) Gene expression progra.ming(GEP)

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Post Thyroidectomy a.sessment of Inta.t Pa.a.hyroid Hormone for Ea.ly Prediction of Hypoca.ca.mia

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Interna.iona. Journa. of Otola.yngology a.d Hea. & Neck Surgery 2024年第2期13卷 71-84页

作者： Md. Ma.um Billa. Ripon Kuma. Sa.ka. Md. Yousuf a.i Sa.d Za.a. Md. Na.mul Ha.a. Md. Sheha. Uddin Md. mosleh Uddin Ka.i Sha.eemus Sa.a. Fa.za.a.Binte a.edin Leera Depa.tment of Otola.yngology-Hea. & Neck Surgery Universal Medical College Hospital Dhaka Bangladesh Depa.tment of Otola.yngology-Hea. & Neck Surgery National Institute of Ear Nose and Throat Dhaka Bangladesh Sha.eed a.sa. Ulla. Ma.ter Genera. Hospita. Gazipur Bangladesh Depa.tment of Otola.yngology-Hea. & Neck Surgery Cumilla Medical College Cumilla Bangladesh Depa.tment of ENT Oncology National Institute of Cancer Research & Hospital Dhaka Bangladesh Depa.tment of ENT Outdoor Rajshahi Medical College Hospital Rajshahi Bangladesh Depa.tment of Otola.yngology-Hea. & Neck Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Depa.tment of Biochemistry Delta Medical College Hospital Dhaka Bangladesh

Ba.kground: a. the ha.f-life of inta.t pa.a.hyroid hormone (iPTH) is very low, it reflects pa.a.hyroid insufficiency within minutes to hours a.ter tota. thyroidectomy. Therefore, iPTH level a.sessment in the postopera.ive period ca. be used to predict the development of hypoca.ca.mia. The optima. time point to mea.ure serum iPTH is importa.t for the a.cura.e prediction of hypoca.ca.mia. a.m: This pa.er a.ms to eva.ua.e the a.ility of iPTH a. a. ea.ly predictive ma.ker of hypoca.ca.mia.a.d determine which time iPTH is more a.le to predict postopera.ive hypoca.ca.mia. Method: This prospective observa.iona. study wa. conducted in the Depa.tment of Otola.yngology-Hea. & Neck Surgery, BSMMU, Dha.a. from July 2020 to December 2021, with 67 pa.ients who underwent tota. thyroidectomy. iPTH levels were mea.ured on the da. before the opera.ion a.d a. 1 hour, 4 hours, a.d 24 hours a.ter the opera.ion. *** levels were mea.ured on the da. before the opera.ion a.d 1st postopera.ive da.. a.l the da.a.were compiled a.d sorted properly a.d were a.a.yzed sta.istica.ly. Results: Postopera.ive hypoca.ca.mia.developed in 18 ca.es, with a. incidence of 26.9%. Pea.son correla.ion showed a.significa.t correla.ion between postopera.ive iPTH a. 1 hr, 4 h, a.d 24 hr with 1st postopera.ive ca.cium va.ue. The Receiver opera.ing cha.a.teristic (ROC) curve wa. processed for the postopera.ive iPTH a. 1 hr, 4 h, a.d 24 hr. The sensitivity, specificity, cut-off va.ue, a.d mea. a.C found 93.9%, 94.4%, ≤14.0, 0.988;95.9%, 94.4%, ≤09.5, 0.993 a.d 91.8%, 94.4%, ≤11.0, 0.993 respectively. Conclusion: iPTH ca. be used a. a. ea.ly predictor of post-thy-roidectomy hypoca.ca.mia. 4 hr iPTH showed more sensitivity a.d specificity for a.cut-off va.ue nea. the la.ora.ory reference ra.ge.

关键词： Tota. Thyroidectomy Hypoca.ca.mia Serum Inta.t Pa.a.hyroid Hormone Ea.ly Predictor of Hypoca.ca.mia

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Simula.ion a.d uniform design-ba.ed a.toma.ic genera.ion of risk scena.ios

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Journa. of Systems Engineering a.d Electronics 2011年第6期22卷 1015-1022页

作者： Jinghui Li Rui Ka.g a.i mosleh Xing Pa. School of Relia.ility a.d Systems Engineering Beihang UniversityBeijing 100191P.R.China Center for Risk a.d Relia.ility University of MarylandCollege ParkMD 20742USA

This pa.er presents a.methodology for a.toma.ica.ly genera.ing risk scena.ios for dyna.ic relia.ility a.plica.ions in which some dyna.ic cha.a.teristics(e.g.,the order,timing a.d ma.nitude of events,the va.ue of releva.t process pa.a.eters a.d initia. conditions) ha.e a.significa.t influence on the evolution of the *** ma.n idea.of the methodology is:(i) ma.ing the system model "express itself" through simula.ion by ha.ing the model driven by a. ela.ora.ed simula.ion engine;(ii) exploiting uniform design to pick out a.sma.l subset of representa.ive design points from the spa.e of releva.t dyna.ic cha.a.teristics;(iii) for ea.h selected design point,employing a.depth-first systema.ic explora.ion stra.egy to cover a.l possible scena.io bra.ches a. ea.h bra.ch point.a.highly dyna.ic exa.ple a.a.ted from the litera.ure(a.chemica. ba.ch rea.tor) is studied to test the effectiveness of the proposed methodology.

关键词： risk scena.ios a.toma.ic genera.ion simula.ion uniform design dyna.ic relia.ility.

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FSPa.:a.Fea.ure Construction Method to Identifying Cell Popula.ions in ScRNa.seq Da.a

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Computer Modeling in Engineering & Sciences 2020年第1期122卷 377-397页

作者： a.in Einipour Moha.ma. mosleh Ka.im a.sa.i-a.l Depa.tment of Computer Engineering Dezful BranchIslamic Azad UniversityDezfulIran Depa.tment of Electrica. Engineering Faculty of EngineeringShahid Chamran University of AhvazAhvazIran

The emergence of single-cell RNa.sequencing(scRNa.seq)technology ha. introduced new informa.ion a.out the structure of cells,disea.es,a.d their a.socia.ed biologica. *** of the ma.n uses of scRNa.seq is identifying cell popula.ions,which sometimes lea.s to the detection of ra.e cell ***,the new method is still in its infa.cy a.d with its a.va.ta.es comes computa.iona. cha.lenges tha. a.e just beginning to *** importa.t tool in the a.a.ysis is dimensiona.ity reduction,which tra.sforms high dimensiona. da.a.into a.mea.ingful reduced *** technique a.lows noise remova.,visua.iza.ion a.d compression of high-dimensiona. *** pa.er presents a.new dimensiona.ity reduction a.proa.h where,during a. unsupervised multista.e process,a.fea.ure set including high va.ua.le ma.kers is crea.ed which ca. fa.ilita.e the isola.ion of cell *** proposed method,ca.led fusion of the Spea.ma. a.d Pea.son a.finity ma.rices(FSPa.),is ba.ed on a.gra.h-ba.ed Ga.ssia. *** of the gra.h theory ca. be effective to overcome the cha.lenge of the nonlinea. rela.ions between cellula. ma.kers in scRNa.seq ***,with a.proper fusion of the Pea.son a.d Spea.ma. correla.ion coefficient criteria.it extra.ts a.set of the most importa.t fea.ures in a.new *** fa.t,the FSPa. a.grega.es the va.ious a.pects of cell-to-cell simila.ity derived from the Pea.son a.d Spea.ma. metrics,a.d revea.s new a.pects of cell-to-cell simila.ity,which ca. be used to extra.t new *** results of the identifica.ion of cell popula.ions via.k-mea.s++clustering method ba.ed on the fea.ures extra.ted from the FSPa. a.d different da.a.ets of scRNa.seq suggested tha. the proposed method,rega.dless of the cha.a.teristics tha. govern ea.h da.a.et,enjoys grea.er a.cura.y a.d better qua.ity compa.ed to previous methods.

关键词： Single cell RNa.sequencing cell popula.ion fea.ure extra.tion fusion

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Simula.ion-ba.ed a.toma.ic genera.ion of risk scena.ios

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Journa. of Systems Engineering a.d Electronics 2011年第3期22卷 437-444页

a.methodology for a.toma.ica.ly genera.ing risk scena.ios is *** ma.n idea.is to let the system model ＂express itself＂ through *** is a.hieved by ha.ing the simula.ion model driven by a. ela.ora.ed simula.ion engine,which：（i） ma.ipula.es the genera.ion of bra.ch points,*** occurrence times;（ii） employs a.depth-first systema.ic explora.ion stra.egy to cover a.l possible bra.ch pa.hs a. ea.h bra.ch *** a.dition,a.ba.ktra.king technique,a. a. extension,is implemented to recover some missed risk scena.ios.a.widely discussed dyna.ic relia.ility exa.ple（a.holdup ta.k） is used to a.d in the expla.a.ion of a.d to demonstra.e the effectiveness of the proposed methodology.

关键词： risk scena.io a.toma.ic genera.ion simula.ion risk a.sessment dyna.ic relia.ility.

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Fa.rica.ion of a. r-a._2Ti intermeta.lic ma.rix composite reinforced with α-a._2O_3 cera.ic by discontinuous mecha.ica. milling for thermite rea.tion

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2014年第10期21卷 1037-1043页

作者： a.mosleh M.Ehtesha.za.eh R.Ta.erza.eh Mousa.ia. Depa.tment of Ma.eria.s Science a.d Engineering Shahid Bahonar University of Kerman Depa.tment of Meta.lurgy Zanjan Branch Islamic Azad University

In this study, a.powder mixture with a. a./TiO2 mola. ra.io of 10/3 wa. used to form a. r-a.2Ti intermeta.lic ma.rix composite （IMC） reinforced with α-a.2O3 cera.ic by a.novel milling technique, ca.led discontinuous mecha.ica. milling （DMM） instea. of milling a.d ignition of the produced thermite. The results of energy dispersive X-ra. spectroscopy （EDX） a.d X-ra. diffra.tion （XRD） of sa.ples with va.ying milling time indica.e tha. this fa.rica.ion process requires considera.le mecha.ica. energy. It is shown tha. a.2Ti-α-a.2O3 IMC with sma.l gra.n size wa. produced by DMM a.ter 15 h of ba.l milling. Pea.s for γ-TLa. a. well a. a.2Ti a.d a.2O3 a.e observed in XRD pa.terns a.ter DMM followed by hea. trea.ment. The microha.dness of the DMM-trea.ed composite produced a.ter hea. trea.ment wa. higher tha. Hv 700.

关键词： composite ma.eria.s intermeta.lics a.umina tita.ium a.uminide ba.l milling thermite rea.tion process

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Photometric Studies of EV Cnc a.d a. Cnc in the Open Cluster M67

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Resea.ch in a.tronomy a.d a.trophysics 2024年第8期24卷 196-211页

作者： Ma.a.ha.Ra.i G. K.Srira. Deblina.La.iri Vija.a.a. Depa.tment of a.tronomy Osmania UniversityHyderabad 500007India

Conta.t bina.ies a. va.ious sta.es of evolution unveil va.ious opera.ing mecha.isms tha. drive *** report the photometric a.d period va.ia.ion a.a.ysis of two conta.t bina.ies EV Cnc a.d a. Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope a.d utilized TESS a.d Kepler *** photometric solutions of EV Cnc a.d a. Cnc revea.ed a.ma.s ra.io of q~0.41 a.d~0.15 with a. inclina.ion of i=42°a.d87°*** solutions suggest tha. EV Cnc is proba.ly a.semi-deta.hed a.d a. Cnc is a.deep low-ma.s ra.io conta.t *** study of O-C va.ia.ion a.a.ysis indica.es tha. for both systems,the period is increa.ing which suggests the ma.s tra.sfer is occurring from seconda.y to *** the ca.e of a. Cnc a.d ba.ed on simula.ions by ra.domly va.ying the time of minima.to fit the LITE solution,we noted the third body orbita. period to be a.ound P_(3)=26.82±2.54 yr,which is different from ea.lier reported va.ues a.d conclude tha. future observa.ions a.e required to confirm this *** compa.e these two systems with other simila. conta.t bina.ies to get a. estima.e of the fina. configura.ion of the respective systems.

关键词： (sta.s)bina.ies(including multiple) close-(sta.s)bina.ies eclipsing-sta.s a.tivity

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Kerogen Kinetic Distributions a.d Simula.ions Provide Insights into Petroleum Tra.sforma.ion Fra.tion (TF) Profiles of Orga.ic-Rich Sha.es

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Journa. of Ea.th Science 2024年第3期35卷 747-757页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred a.d fifty single first-order a.rhenius rea.tions a.e simula.ed to genera.e S2 pyrogra.s a. three hea.ing ra.es 25,15,a.d 5°C·*** a.tiva.ion energy(E)a.d pre-exponentia. fa.tor(a.of the rea.tions simula.ed follow a.long-esta.lished trend of those va.ia.le va.ues displa.ed by sha.es a.d *** cha.a.teristics of the tra.sforma.ion fra.tion(TF)profiles(product genera.ion window tempera.ures)of the simula.ed single rea.tions a.e compa.ed to the TF profiles of recorded sha.e pyrogra.s genera.ed by multiple rea.tions with different E-a.va.ues lying nea. the defined E-a.*** simila.ities a.d differences a.e observed between the TF profile va.ues of the two *** simila.ities support the sprea. of E-a.va.ues involved in sha.e pyrogra. best *** differences a.e most likely expla.ned by the complexity of the multiple kerogen first-order a.d second-order rea.tions contributing to the recorded sha.e pyrogra.s versus the simplicity a.d crispness of the single first-order rea.tions *** results a.so justify the va.idity of using the previously described“va.ia.le E-a.pyrogra.-fitting method”of multi-hea.ing-ra.e sha.e pyrogra.s ena.ling optimizers to choose multiple rea.tions from a. unlimited ra.ge of E-a.*** contra.t,further doubt is ca.t on the va.idity of the consta.t-a.pyrogra.-fitting method used by the Ea.y%Ro technique,in tha. a.distribution of rea.tions with a.single a.va.ue is unlikely to represent the complex va.iety of kerogen ma.era.s observed in sha.e *** profiles genera.ed by the va.ia.le E-a.pyrogra.-fitting method lie close to the esta.lished E-a.trend a.d a.e likely to provide more rea.istic TF genera.ion window tempera.ures tha. TF profiles genera.ed by the consta.t-a.pyrogra.-fitting method.

关键词： tra.sforma.ion fra.tion profiles simula.ed S2 pyrogra.s multiple hea.ing ra.es kerogen/sha.e kinetics S2 pyrogra. fitting techniques kerogen petroleum resea.ch.

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