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A study on the Explainability of Thyroid Cancer Prediction:sHAP Values and Association-Rule Based Feature Integration Framework

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Computers, Materials & Continua 2024年第5期79卷 3111-3138页

作者： sujithra sankar s.sathyalakshmi Department of Computer Applications Hindustan Institute of Technology and ScienceChennaiTamil NaduIndia Department of Computer Engineering Hindustan Institute of Technology and ScienceChennaiTamil NaduIndia

In the era of advanced machine learning techniques,the development of accurate predictive models for complex medical conditions,such as thyroid cancer,has shown remarkable *** predictivemodels for thyroid cancer enhance early detection,improve resource allocation,and reduce ***,the widespread adoption of these models in clinical practice demands predictive performance along with interpretability and *** paper proposes a novel association-rule based feature-integratedmachine learning model which shows better classification and prediction accuracy than present *** study also focuses on the application of sHapley Additive exPlanations(sHAP)values as a powerful tool for explaining thyroid cancer prediction *** the proposed method,the association-rule based feature integration framework identifies frequently occurring attribute combinations in the *** original dataset is used in trainingmachine learning models,and further used in generating sHAP values *** the next phase,the dataset is integrated with the dominant feature sets identified through association-rule based *** new integrated dataset is used in re-training the machine learning *** new sHAP values generated from these models help in validating the contributions of feature sets in predicting *** conventional machine learning models lack interpretability,which can hinder their integration into clinical decision-making *** this study,the sHAP values are introduced along with association-rule based feature integration as a comprehensive framework for understanding the contributions of feature sets inmodelling the *** study discusses the importance of reliable predictive models for early diagnosis of thyroid cancer,and a validation framework of *** proposed model shows an accuracy of 93.48%.Performance metrics such as precision,recall,F1-score,and the area un

关键词： Explainable AI machine learning clinical decision support systems thyroid cancer association-rule based framework sHAP values classification and prediction

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Correlation Composition Awareness Model with Pair Collaborative Localization for IoT Authentication and Localization

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Computers, Materials & Continua 2024年第4期79卷 943-961页

作者： Kranthi Alluri s.Gopikrishnan school of Computer science and Engineering VIT-AP UniversityAmaravathiAndhra Pradesh522241India

secure authentication and accurate localization among Internet of Things(IoT)sensors are pivotal for the functionality and integrity of IoT *** authentication and localization are intricate and symbiotic,impacting both the security and operational functionality of IoT ***,accurate localization and lightweight authentication on resource-constrained IoT devices pose several *** overcome these challenges,recent approaches have used encryption techniques with well-known key ***,these methods are inefficient due to the increasing number of data breaches in their localization *** proposed research efficiently integrates authentication and localization processes in such a way that they complement each other without compromising on security or *** proposed framework aims to detect active attacks within IoT networks,precisely localize malicious IoT devices participating in these attacks,and establish dynamic implicit authentication *** integrated framework proposes a Correlation Composition Awareness(CCA)model,which explores innovative approaches to device correlations,enhancing the accuracy of attack detection and ***,this framework introduces the Pair Collaborative Localization(PCL)technique,facilitating precise identification of the exact locations of malicious IoT *** address device authentication,a Behavior and Performance Measurement(BPM)scheme is developed,ensuring that only trusted devices gain access to the *** work has been evaluated across various environments and compared against existing *** results prove that the proposed methodology attains 96%attack detection accuracy,84%localization accuracy,and 98%device authentication accuracy.

关键词： sensor localization IoT authentication network security data accuracy precise location access control security framework

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Environmental factors in the development and progression of late-onset Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 253-270页

作者： moses N. Wainaina Zhichun Chen Chunjiu Zhong Department of Neurology Zhongshan Hospital state Key Laboratory of Medical Neurobiology Fudan University Pwani University Institutes of Brain science Fudan University

Late-onset Alzheimer＇s disease （LOAD） is an age-related neurodegenerative disorder characterized by gradual loss of synapses and neurons, but its pathogenesis remains to be clarified. Neurons live in an environment constituted by neurons themselves and glial cells. In this review, we propose that the neuronal degeneration in the AD brain is partially caused by diverse environmental factors. We first discuss various environmental stresses and the corresponding responses at different levels. Then we propose some mechanisms underlying the specific pathological changes, in particular, hypothalamic-pituitary adrenal axis dysfunction at the systemic level; cerebrovascular dysfunction, metal toxicity, glial activation, and Aβ toxicity at the intercellular level; and kinase-phosphatase imbalance and epigenetic modification at the intracellular level. Finally, we discuss the possibility of developing new strategies for the prevention and treatment of LOAD from the perspective of environmental stress. We conclude that environmental factors play a significant role in the development of LOAD through multiple pathological mechanisms.

关键词： Alzheimer's disease environmental factors corticotrophin-releasing factor cerebrovascular metatoxicity glia astrocyte microglia AI3 kinase phosphatase tau hyperphosphorylation epigenetic modificationDNA methylation histone acetylation

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Evaluation of red soil-bentonite mixtures for compacted clay liners

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 697-710页

作者： A.s.Devapriya T.Thyagaraj Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India

Compacted clay liners are an integral part of the waste landfills,which are provided to contain the leachate within the landfills and protect the surrounding ***,locally available natural soils are used for the construction of compacted clay liners if they satisfy the design ***,not all soils in their natural state satisfy all the design criteria for the liner ***,there is a definite need to modify the locally available natural soils by blending with bentonite to meet the required design criteria for the *** view of this,the present study evaluates the suitability of an Indian red soil enhanced with bentonite as a liner *** achieve this,a series of experiments were carried out using locally available red soil and ***,the suitability of the red soil was evaluated as a liner *** experimental results showed that the red soil met all the selection criteria stipulated by the Environmental Protection Agencies(EPAs)for the liners except the hydraulic conductivity ***,the red soil was mixed with bentonite contents of 10%,20%and 30%,and the red soil-bentonite mixtures were evaluated for their suitability for liners in their compacted ***,as the liners in the arid and semi-arid regions are subjected to moisture variations due to seasonal moisture fluctuations and other factors,the red soil-bentonite mixtures were subjected to wetdry cycles,and their suitability was evaluated after wet-dry *** experimental results revealed that all the red soil-bentonite mixtures met the stipulated EPA criteria for the liners in the as-compacted ***,the red soil-bentonite mixtures with 20%and 30%bentonite contents only satisfied the hydraulic conductivity requirement even after wet-dry *** experimental findings were supplemented with the microstructural insights captured through digital camera images,scanning electron microscopy(sEM),and mercury intrusion porosimetry(M

关键词： Compacted clay lines Hydraulic conductivity Wet-dry cycles Microstructure

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Big data challenge for monitoring quality in higher education institutions using business intelligence dashboards

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Journal of Electronic science and Technology 2024年第1期22卷 25-41页

作者： Ali sorour Anthony s.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

As big data becomes an apparent challenge to handle when building a business intelligence(BI)system,there is a motivation to handle this challenging issue in higher education institutions(HEIs).Monitoring quality in HEIs encompasses handling huge amounts of data coming from different *** paper reviews big data and analyses the cases from the literature regarding quality assurance(QA)in *** also outlines a framework that can address the big data challenge in HEIs to handle QA monitoring using BI dashboards and a prototype dashboard is presented in this *** dashboard was developed using a utilisation tool to monitor QA in HEIs to provide visual representations of big *** prototype dashboard enables stakeholders to monitor compliance with QA standards while addressing the big data challenge associated with the substantial volume of data managed by HEIs’QA *** paper also outlines how the developed system integrates big data from social media into the monitoring dashboard.

关键词： Big data Business intelligence(BI) Dashboards Higher education(HE) Quality assurance(QA) social media

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Bile acid metabolism and signaling in health and disease:molecular mechanisms and therapeutic targets

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signal Transduction and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： Joshua s.Fleishman sunil Kumar Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile acids,once considered mere dietary surfactants,now emerge as critical modulators of macronutrient(lipid,carbohydrate,protein)metabolism and the systemic pro-inflammatory/anti-inflammatory *** acid metabolism and signaling pathways play a crucial role in protecting against,or if aberrant,inducing cardiometabolic,inflammatory,and neoplastic conditions,strongly influencing health and *** curative treatment exists for any bile acid influenced disease,while the most promising and well-developed bile acid therapeutic was recently rejected by the ***,we provide a bottom-up approach on bile acids,mechanistically explaining their biochemistry,physiology,and pharmacology at canonical and non-canonical *** this mechanistic model of bile acids,we explain how abnormal bile acid physiology drives disease pathogenesis,emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic *** provide an in-depth summary on pre-existing bile acid receptor modulators,explain their shortcomings,and propose solutions for how they may be ***,we rationalize novel targets for further translational drug discovery and provide future *** than dismissing bile acid therapeutics due to recent setbacks,we believe that there is immense clinical potential and a high likelihood for the future success of bile acid therapeutics.

关键词： metabolism rejected shortcomings

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Evaluation of a software positioning tool to support sMEs in adoption of big data analytics

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Journal of Electronic science and Technology 2024年第1期22卷 13-24页

作者： Matthew Willetts Anthony s.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by large companies to achieve measurable benefits including increased profitability,customer demand forecasting,cheaper development of products,and improved stock *** and medium sized enterprises(sMEs)are the backbone of the global economy,comprising of 90%of businesses ***,only 10%sMEs have adopted big data analytics despite the competitive advantage they could *** research has analysed the barriers to adoption and a strategic framework has been developed to help sMEs adopt big data *** framework was converted into a scoring tool which has been applied to multiple case studies of sMEs in the *** paper documents the process of evaluating the framework based on the structured feedback from a focus group composed of experienced *** results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring tool based on the proposed *** research demonstrates that this positioning tool is beneficial for sMEs to achieve competitive advantages by increasing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation small and medium sized enterprises (sMEs) strategic framework

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A study on the Transmission Dynamics of the Omicron Variant of COVID-19 Using Nonlinear Mathematical Models

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Computer Modeling in Engineering & sciences 2024年第6期139卷 2265-2287页

作者： s.Dickson s.Padmasekaran Pushpendra Kumar Kottakkaran sooppy Nisar Hamidreza Marasi Department of Mathematics Periyar UniversitySalemTamilnadu636011India Faculty of Engineering and Natural sciences Istanbul Okan UniversityIstanbulTurkey Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Applied Mathematics Faculty of MathematicsStatistics and Computer ScienceUniversity of TabrizTabrizIran

This research examines the transmission dynamics of the Omicron variant of COVID-19 using sEIQIcRVW and sQIRV models,considering the delay in converting susceptible individuals into infected *** significant delays eventually resulted in the pandemic’s *** ensure the safety of the host population,this concept integrates quarantine and the COVID-19 *** investigate the stability of the proposed *** fundamental reproduction number influences stability *** to our findings,asymptomatic cases considerably impact the prevalence of Omicron infection in the *** real data of the Omicron variant from Chennai,Tamil Nadu,India,is used to validate the outputs.

关键词： Omicron local stability reproduction number steady states global stability

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Physics of porous materials under extreme laser-generated conditions

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Matter and Radiation at Extremes 2024年第3期9卷 1-3页

作者： V.T.Tikhonchuk s.Weber Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous materials offer unique possibilities for the production of plasmas with controlled density profiles for experiments on laser–matter *** are of growing relevance to many applications,such as inertial confinement fusion,fundamental research,and secondary *** the processes of transformation of a porous solid into a plasma is of fundamental interest and is needed for producing materials with desired properties.

关键词： interaction. properties. porous

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Transjugular intrahepatic portosystemic shunt for recompensating decompensated cirrhosis?

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World Journal of Gastroenterology 2024年第20期30卷 2621-2623页

作者： Dimitrios s Karagiannakis Academic Department of Gastroenterology and Hepatology Medical School of National and Kapodistrian University of AthensGeneral Hospital of Athens“Laiko”Athens 11527Greece

Transjugular intrahepatic portosystemic shunt(TIPs)is a medical procedure that has been used to manage variceal bleeding and ascites in patients with *** can prevent further decompensation and improve the survival of high-risk decompensated *** research indicates that TIPs could increase the possibility of recompensation of decompensated cirrhosis when it is combined with adequate suppression of the causative factor of liver ***,the results of the studies have been based on retrospective analysis,and further validation is required by conducting randomized controlled *** this context,we highlight the limitations of the current studies and emphasize the issues that must be addressed before TIPs can be recommended as a potential recompensating tool.

关键词： Decompensated cirrhosis Liver recompensation Baveno VII Transjugular intrahepatic portosystemic shunt

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