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Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats

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the Journal of Biomedical Research 2023年第2期37卷 100-114页

作者： Solomon E.Owumi Uche O.Arunsi moses t.otunla Imisioluwa O.Oluwasuji Cancer Research and Molecular Biology Laboratories Department of BiochemistryFaculty of Basic Medical SciencesUniversity of IbadanIbadanOyo State 200004Nigeria Department of Cancer Immunology and Biotechnology School of MedicineUniversity of NottinghamNottingham NG72RDUK

Lead(Pb) and furan are toxic agents, and persistent exposure may impair human and animal reproductive function. We therefore explored the effects of Pb and furan on male rat hypothalamic-pituitary-gonadal reproductive status, oxidative stress, inflammation, and genomic integrity. We found that co-exposure to Pb and furan reduced the activities of testicular function enzymes, endogenous antioxidant levels, total sulfhydryl group,and glutathione. Sperm abnormality, biomarkers of oxidative stress, inflammation, and p53 expression were increased in a dose-dependent manner by treatment with furan and Pb. typical rat gonad histoarchitecture features were also damaged. Conclusively, co-exposure to Pb and furan induced male reproductive function derangement by decreasing the antioxidant defences in rats, increasing abnormalities in spermatozoa morphology, and reducing reproductive hormone in circulation. these pathophysiological alterations, if persistent, might provide a permissive environment for potentiating reproductive dysfunction and infertility.

关键词： infertility furan lead acetate oxidative stress DNA damage inflammation

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Evaluation of Fresh and Hardened Properties of Self-Compacting Concrete

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Open Journal of Civil Engineering 2015年第1期5卷 1-7页

作者： Oladipupo S. Olafusi Adekunle P. Adewuyi Abiodun I. otunla Adewale O. Babalola Department of Civil Engineering College of Engineering Federal University of Agriculture Abeokuta Nigeria

this paper compared the rheological properties and compressive strengths of self-compacting concrete (SCC) and conventional cement concrete. the flowability and segregation resistance of freshly mixed concrete specimens were examined by the V-funnel apparatus, while the characteristics of passing ability were investigated with the L-box apparatus. Cylindrical concrete specimens of 100 mm diameter × 200 mm length were investigated for compressive strength. the rheological properties of SCC are incomparable with those of the conventional concrete due to their diverse testing methods and characteristics of individual flow. the compressive strength results of hardened concrete showed that SCC gained strength slowly compared to the conventional cement concrete due to the presence of admixtures and its 28 days strength was lower than conventional cement concrete, but SCC eventually had potentials of higher strength beyond 90 days. Finally, the effect of water-cement ratio on the plastic properties of self-compacting concrete was quite negligible compared to conventional concrete.

关键词： Concrete Self-Compacting Concrete V-Funnel L-Box Density Compressive Strength

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