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Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats

Animal Models and Experimental Medicine 2023年第2期6卷 168-177页

作者： Oluwafikemi Temitayo Iji Temitayo Olabisi Ajibade Oluwaseun Olanrewaju Esan Omolola Victoria Awoyomi Ademola Adetokunbo Oyagbemi moses olusola adetona Temidayo Olutayo Omobowale Momoh Audu Yakubu Oluwafemi Omoniyi Oguntibeju Evaristus Nwulia Federal College of Animal Health and Production Technology Moor PlantationIbadanNigeria Department of Veterinary Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria Department of Veterinary Medicine Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria Department of Anatomy Faculty of Basic Medical SciencesUniversity of IbadanIbadanNigeria Department of Environmental and Interdisciplinary Sciences College of ScienceEngineering&TechnologyCOPHSTexas Southern UniversityHoustonTexasUSA Department of Biomedical Sciences Faculty of Health and Wellness SciencesCape Peninsula University of TechnologyBellvilleSouth Africa Department of Psychiatry and Behavioral Sciences Howard University HospitalCollege of MedicineHoward UniversityWashingtonDistrict of ColumbiaUSA

Background:The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride(CoCl_(2)).This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoCl_(2)***:Forty-two(42)male rats were grouped as Control;(CoCl_(2);300 ppm);CoCl_(2)+Glycine(50 mg/kg);CoCl_(2)+Glycine(100 mg/kg);Glycine(50 mg/kg);and Glycine(100 mg/kg).The markers of hepatic and renal damage,oxidative stress,the antioxidant defense system,histopathology,and immunohistochemical localization of neutrophil gelatinase associated lipocalin(NGAL)and renal podocin were ***:Glycine significantly reduced the markers of oxidative stress(malondialdehyde content and H_(2)O_(2) generation),liver function tests(ALT,AST,and ALP),markers of renal function(creatinine and BUN),and decreased the expression of neutrophil gelatinase-associated lipocalin(NGAL)and podocin compared with rats exposed to CoCl_(2)toxicity without glycine *** lesions including patchy tubular epithelial necrosis,tubular epithelial degeneration and periglomerular inflammation in renal tissues,and severe portal hepatocellular necrosis,inflammation,and duct hyperplasia were observed in hepatic tissues of rats exposed to CoCl_(2)toxicity,but were mild to absent in glycine-treated ***:The results of this study clearly demonstrate protective effects of glycine against CoCl_(2)-induced tissue injuries and derangement of physiological activities of the hepatic and renal systems in *** protective effects are mediated via augmentation of total antioxidant capacity and upregulation of NGAL and podocin expression.

关键词： cobalt chloride hepatotoxicity nephrotoxicity oxidative stress podocin

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