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Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Nano-Micro Letters 2020年第2期12卷 102-136页

作者： morteza hasanzadeh kafshgari Wolfgang HGoldmann Department of Engineering Physics Polytechnique MontreálMontrealQC H3C3A7Canada Department of Physics Biophysics GroupUniversity of Erlangen-Nuremberg91052 ErlangenGermany

Titanium dioxide(TiO2)nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical ***2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement,thermal conversion,specific surface area,and surface *** review highlights certain important aspects of fabrication strategies,which are employed to generate multifunctional TiO2 nanostructures,while outlining post-fabrication techniques with an emphasis on their suitability for *** biodistribution,toxicity,biocompatibility,cellular adhesion,and endocytosis of these nanostructures,when exposed to biological microenvironments,are examined in regard to their geometry,size,and surface *** final section focuses on recent biomedical applications of TiO2 nanostructures,specifically evaluating therapeutic delivery,photodynamic and sonodynamic therapy,bioimaging,biosensing,tissue regeneration,as well as chronic wound healing.

关键词： TiO2 nanostructures Drug delivery systems Bioimaging Biosensing Tissue regeneration

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Oligonucleotide delivery by chitosan-functionalized porous silicon nanoparticles

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Nano Research 2015年第6期8卷 2033-2046页

作者： morteza hasanzadeh kafshgari Bahman Delalat Wing Yin Tong Frances J. Harding Martti Kaasalainen Jarno Salonen Nicolas H. Voelcker ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Mawson Institute University of South Australia GPO Box 247 Adelaide SA 500 1 Australia Department of Physics and Astronomy University of Turku FI-20014 Turku Finland

Porous silicon nanoparficles （pSiNPs） are a promising nanocarrier system for drug delivery owing to their biocompatibility, biodegradability, and non-inflammatory nature. Here, we investigate the fabrication and characterization of thermally hydrocarbonized pSiNPs （THCpSiNPs） and chitosan-coated THCpSiNPs for therapeutic oligonucleotide delivery. Chitosan coating after oligonucleotide loading significantly improves sustained oligonucleotide release and suppresses burst release effects. Moreover, cellular uptake, endocytosis, and cytotoxicity of oligonucleotide-loaded THCpSiNPs have been evaluated in vitro. Standard cell viability assays demonstrate that cells incubated with the NPs at a concentration of 0.1 mg/mL are 95% viable. In addition, chitosan coating significantly enhances the uptake of oligonucleotide-loaded THCpSiNPs across the cell membrane. Moreover, histopathological analysis of liver, kidney, spleen, and skin tissue collected from mice receiving NPs further demonstrates the biocompatible and non-inflammatory properties of the NPs as a gene delivery vehicle for intravenous and subcutaneous administration in vivo. Taken together, these results suggest that THCpSiNPs provide a versatile platform that could be used as efficient vehicles for the intracellular delivery of oligonucleotides for gene therapy.

关键词： nanoparticles porous silicon chitosan gene delivery

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