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Evolutionary model of brain tumor circulating cells: Cellular galaxy

World Journal of Clinical Oncology 2021年第1期12卷 13-30页

作者： Parvin Mehdipour Firoozeh Javan morteza faghih jouibari Mehdi Khaleghi Masoud Mehrazin Department of Medical Genetics Tehran University of Medical SciencesSchool of MedicineTehran ***TehranIran Department of Neurosurgery Shariati University HospitalTehran ***TehranIran Shariati Hospital Tehran University of Medical SciencesTehran ***TehranIran Tehran University of Medical Science Tehran ***TehranIran

BACKGROUND Although circulating tumor cells(CTCs)have been the focus of consideration for a decade,a categorized cell-based diagnostic strategy is *** personalized management and complementary/analytical-strategy of data require an alphabetic ***,we aimed to determine the behavior of CTCs in tumor and blood in order to provide the hypothetical-based agenda in the brain *** the protein expression(PE)using a single cell-based method would clarify the heterogeneity and diversity in tumor and blood,which are key events in the evolution in brain *** fact,heterogeneity,diversity,and evolution are required for cancer initiation and *** To explore CTCs in brain tumors and blood cells and to assay intensity of PE through personalized *** The focal population included 14 patients with meningioma,and four patients with metastatic brain tumors(T).PE was assayed by immunofluorescence in tumors cells and CTCs in 18 patients with brain *** test was applied between the T cells and CTCs in tumor tissue and in vascular system.T/CTC ratio-based classification of PE in macrophage chemoattractant chemokine ligand 2(CCL2),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),CD133,cyclin E,neurofilament marker,cytokeratin 19,and leukocyte common antigen(CD45)were *** Total analyzed cells ranged between 10794-92283 for tumor cells and between 117-2870 for *** of histopathologic and status of an ataxiatelangiectasia mutated polymorphism(D1853N)in 18 patients affected with brain tumors were also *** course of evolution and metastatic event relied on the elevated protein expression in CTCs,which could be considered as a prognostic *** protein expression of the migrated cells into the blood stream and the tumor was indicative of the occurrence of ***,the harmonic co-expression between CCL2/EGF and CCL2/VEGF could facilitate the tumor

关键词： Circulating tumor cells Brain tumor Protein expression Personalized Somatic/circulating tumor cell evolution Metastasis

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