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Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?

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World Journal of Gastroenterology 2020年第38期26卷 5896-5910页

作者： Mohammadreza Abdollahi Neda Khalilian Ekrami morteza ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh Department of Epidemiology University of GroningenGroningen 9700 RBNetherlands Research Center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran Liver and Gastrointestinal Diseases Research Center Tabriz University of Medical SciencesTabriz ***Iran

BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with ***-line treatments are needed for patients who have refractory ***,high-quality data on the alternative management of AIH are *** To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were *** calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for *** pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for *** biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),***,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment *** Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement.

关键词： Autoimmune hepatitis Efficacy Grading of Recommendations Assessment,Development and Evaluation approach Systematic review Meta-analysis Second-line

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Effect of cognitive behavioral therapy on anxiety and depression of infertile women: A meta-analysis

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Asian pacific Journal of Reproduction 2019年第6期8卷 251-259页

作者： Hossein Mashhadi Abdolahi morteza ghojazadeh Salman Abdi Mahdieh Abbasalizad Farhangi Zeinab Nikniaz Leila Nikniaz Tabriz Health Services Management Research Center Tabriz University of Medical SciencesTabrizIran Research Center for Evidence-Based Medicine Tabriz University of Medical SciencesTabrizIran Clinical Psychiatry Research Center Tabriz University of Medical SciencesTabrizIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran Liver and Gastrointestinal Diseases Research Center Tabriz University of Medical SciencesTabrizIran

Objective:To investigate the effect of cognitive behavioral therapy on anxiety and depression in infertile ***:This study was performed in 2019 by searching Google Scholar,Scopus,PubMed/MEDLINE,Cochrane library,EMBASE,Proquest,ISI Web of Science,MagIran,SID and *** studies were selected by two reviewers and outcomes of interest were *** meta-analysis was performed using the random effect models.Ⅰ-square statistic test was used for heterogeneity *** of publication bias was also ***:Eleven studies were included in this ***-group differences(cognitive behavioral therapy and control groups)in risk ratio for infertile women's depression was d=-1.36;95%CI=-1.81,-0.90;P<*** infertile women's anxiety,between-group differences in risk ratio wasd=-0.83;95%CI=-1.18,-0.47;P<***:Cognitive behavioral therapy is effective in the reduction of depression and anxiety in patients with or withoutin vitro fertilization/intracytoplasmic sperm injection ***,the lack of high-quality studies makes it challenging to make a solid and precise ***-designed studies should be undertaken in the future to confirm these results.

关键词： Cognitive behavioral therapy Anxiety Depression Infertile women Meta-analysis

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Microsporidiosis in Iran:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 322-330页

作者： Roghayeh Ghoyounchi Ehsan Ahmadpour Adel Spotin Mahmoud Mahami-Oskouei Azim Rezamand Nayyereh Aminisani morteza ghojazadeh Reza Berahmat Tahereh Mikaeili-Galeh Pediatric Health Research Center Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical Sciences Immunology Research Center Tabriz University of Medical Sciences Department of Pediatrics Faculty of MedicineTabriz University of Medical Sciences Department of Statistics and Epidemiology Faculty of Health SciencesTabriz University of Medical Sciences Research Center of Evidence Based Medicine Tabriz University of Medical Sciences

Objective:To examine all evidences about Microspondia infection in vertebrate/invertebrate hosts and Iranian populations distributed in different regions of the ***:All published articles up to December 2015,including descriptive and cross-sectional studies related to the prevalence and genotyping of Microspondia infection in Iran,was considered in this systematic *** meta-analysis was done using the random-effects model and Stats Direct statistical *** 5.05 software and maximum likelihood algorithm with Kimura 2-parameter model were used for phylogenetic ***:Of the 1 152 investigated studies,33 eligible studies reported a prevalence of Microspondia infection in vertebrate and invertebrate *** to this systematic review,the overall prevalence rate of Microsporidia infection in immunocompromised patients in Iran was 8.18%.Furthermore,the overall prevalence rate of Microsporidia infection in immunocompromised patients with chronic diarrhoea,patients with non-diarrhoea,gastroenteritis,and patients with CD4(< 200 cells/μL) was 15.4%,4.1%,0.5%,and 12.9%*** highest prevalence rate of human and animal Microsporidia was estimated in Kerman(29%) and Khuzestan(26.5%).The overall prevalence rate of Microsporidia infection in honeybees using the random-effects model was 40%.Furthermore,the highest prevalence rate of nosemosis was described in East Azerbaijan(48.2%).The maximum number of Microsporidia isolates from immunocompromised patients and pigeons in Iran belonged to genotypes D(n=16;50%) and E(n=6;20.6%) of Enterocytozoon ***:This study may be the first systematic review and meta-analysis that provides a broad outlook on the prevalence of microsporidiosis in *** is necessary to investigate Microsporidia infection in vertebrate and invertebrate hosts and environmental resources in Iran.

关键词： Microsporidia Microsporidiosis Genotypes Iran Prevalence Epidemiology

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Jadwar(Delphinium denudatum Wall.):a medicinal plant

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Traditional Medicine Research 2020年第6期5卷 487-497页

作者： Roghayeh Baghervand Navid Mehrdad Karimi morteza ghojazadeh Seyed Mostafa Araj-Khodaei Alireza Bagherzadeh karimi Sanam Dolati Mehri Bansans Seyed Mohammad Bagher Fazljou Department of Persian Medicine School of Traditional MedicineTabriz University of Medical SciencesTabriz ***Iran Department of Iranian Traditional Medicine School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research Center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran Physical Medicine&Rehabilitation Research Center Aging Research InstituteTabriz University of Medical SciencesTabriz ***Iran Department of Divinities and Islamic Sciences Faculty of TheologyTabriz UniversityTabriz ***Iran

Delphinium denudatum *** one of the important medicinal herbs of traditional Persian medicine and is known as *** plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier *** medicinal uses of Delphinium denudatum *** back to over 1,000 years ***(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum *** a herbal *** the following centuries,the usages of Delphinium denudatum *** the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and *** to modern studies,the dried roots of Delphinium denudatum *** antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving *** from roots of Delphinium denudatum *** also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine *** denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory *** effective therapeutic influence of root extract of Delphinium denudatum *** several diseases needs to be confirmed through controlled clinical *** article reviews the different features of Delphinium denudatum *** focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.

关键词： Delphinium denudatum Wall. Jadwar root Traditional Persian medicine Neurologic and psychiatric effects Anticonvulsant effects

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Common Prothrombotic Gene Mutations in Cerebral Venous Sinus Thrombosis in North-West of Iran

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Neuroscience & Medicine 2017年第4期8卷 68-76页

作者： Elyar Sadeghi-Hokmabadi Ebrahim Sakhinia Mehdi Farhoudi Somayyeh Hasaneh morteza ghojazadeh Mohammad Amin Farzi Sasan Andalib Masoumeh Nemati Omid Abbaszadeh Reza Rikhtegar Reshad Mirnour Neurosciences Research Center Department of Neurology Imam-Reza Hospital School of Medicine Tabriz University of Medical Sciences Tabriz Iran Connective Tissue Research Center Department of Medical Genetics Faculty of Medicine and Tabriz Genetic Analysis Centre (TGAC) Tabriz University of Medical Sciences Tabriz Iran Liver and Gastrointestinal Disease Research Center Tabriz University of Medical Sciences Tabriz Iran Department of Neurosurgery Poursina Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran

Objective: Cerebral venous sinus thrombosis (CVST) is a life-threatening cerebrovascular disease which has high prevalence and mortality rate in Iran. Thrombophilia caused by gene mutation is a common cause of CVST. The present study aimed at assessing the prevalence of thrombophilic gene mutations in Iranian CVST patients and then comparing it with normal population. Materials and methods: In a case-control study, polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) and amplification-refractory mutation system (ARMS-PCR) were carried out to detect common thrombophilic mutations in 70 CVST patients. Next, it was compared with 82 sex- and age-matched healthy controls. Results: Factor-V-Leiden, Factor-V-Leiden HR2, Factor prothrombin II, MTHFR (667C/T) and MTHFR (1298A/C) prevalence were significantly high in cases of CVST as compared to the controls (P values: 0.012, 0.019, 0.007 and 0.036, respectively). However, there was no significant difference between the two groups in plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), beta-fibrinogen (FGB), Factor VIII, Factor XIII, and tissue plasminogen activator (tPA) mutations. Conclusion: The findings of the present study suggest that Factor V-Leiden, Factor-V-Leiden HR2, prothrombin II (G20210A), and MTHFR (667C/T & 1298A/C) mutations are more frequent in CVST. Detection of these mutations may help clinicians to decide on the duration of treatment and referral to genetic counseling for valuable prevention.

关键词： Gene Mutation Cerebral Venous Sinus Thrombosis Thrombophilia

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