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高性能通用处理部件在航空电子系统中的应用

航空电子技术 1993年第4期24卷 29-36页

作者： Russell M s.hansen J C 蔚为美

现代作战飞机对数据处理能力提出了大量的要求。为了满足这种要求,机载系统结构日益需要有多种用途的高可靠、高性能的分布处理节点。这些处理节点采用超高速集成电路/超大规模集成电路(VHsIC/VLsI)器件和表面安装工艺进行高度集成化和... 详细信息

现代作战飞机对数据处理能力提出了大量的要求。为了满足这种要求,机载系统结构日益需要有多种用途的高可靠、高性能的分布处理节点。这些处理节点采用超高速集成电路/超大规模集成电路(VHsIC/VLsI)器件和表面安装工艺进行高度集成化和模块化设计。本文所述的Unisys/AT&T通用处理部件(GPPE)模块就是这种处理节点的具体实现,它可广泛应用于航空电子系统。 GPPE采用下一代简化指令系统计算机(RIsC)微处理机技术,MIPs计算机系统公司的32位指令系统结构(IsA),工作频率为33MHz。该模块采用商用IsA和开放型系统结构,单宽度sEM-E军用模块的功能齐全极为经济有效。它还能让用户买到所需的开发工具。 GPPE还有多层数据安全机制和保护分类数据的多种特点。GPPE所用的6MB sRAM和512KB的EEPROM符合大型RIsC寻址空间和实时操作系统的要求。网络总线(N总线)底板接口为分布处理环境中的模块间通信提供低开销的报文传送协议和宽带的通路。GPPE能够支持联合综合航空电子系统工作组(JIAWG)二级维护概念。模块上的维护控制器通过双测试与维护总线(TM总)端口支持模块状态信息的操作报告。单个联合测试功能组(JIAG)接口支持基地测试和若干机内自测试方法都综合在模块上,有很高的故障复盖率和测试可信度。 GPPE适用于要求性能?

关键词：通用处理部件航空电子设备

Modification by Polychlorinated Biphenyls(PCBs)of Cadmium Induced Lesions in the Planarian Model,Dugesia dorotocephala

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Biomedical and Environmental sciences 1993年第4期6卷 367-384页

作者： LARRYG.hansen WAHEEDAM.TEHsEEN DAVIDJ.sCHAEFFER GEORGEL.FOLEY Department DepartmentDepartmentDepartment of Veterinary Biosciences of Veterinary Biosciences of Veterinary Pathobiology University of IUinois2001 S.Lincoln AveUrbanaIL 61801USA

The appearance of abnormal growths on the planarian, Dugesia dorotocephala, in response to cadmium with and without pre-exposure to L-buthionine-R, s-sulfoximine (BsO) and concurrent exposure to the polychlorinated biphenyls (PCBs) Aroclor 1254, PCB 28, PCB 110 or PCB 126 is described. Pigmented rose thorn (PRT) lesions were non-invasive and appeared in response to PCBs. Post-head (PH) lesions developed in up to 100% of the animals within 6-20 days post-dosing, progressed rather rapidly and were highly invasive. Round tail tip (RTT) lesions appeared in lower frequencies within 10-30 days, but progressed extremely rapidly resulting in tail loss within 48 h. We have referred to these types of lesions as 'tumors', but they are not necessarily characteristic of vertebrate neoplasms.PCBs interacted with cadmium in a complex way, in some cases increasing total lesions and decreasing time-to-lesion and in other cases having the opposite effects. A three-factor (PCB, PCB dose, Cd dose) nested analysis of variance model was used to determine lesion rates in order to compare PCB potencies as potentiators or antagonists. The Aroclor mixture was always the least potent co-toxicant but appeared to be the most potent antagonist; the coplanar PCB 126 was the most potent co-toxicant. The complex response surfaces and the lack of stoichiometry in dose-response relationships indicate that multiple mechanisms are responsible for PH and RTT lesions in planarians. These results emphasize the complexity of PCB toxicities and suggest further studies to validate the planarian model as a screen for combinations or environmental mixtures which may have altered biological potency in other species.

关键词： PCBs)of Cadmium Induced Lesions in the Planarian Model,Dugesia dorotocephala Modification by Polychlorinated Biphenyls

高强度间歇性运动干预2型糖尿病患者糖代谢及肠道菌群的变化

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中国组织工程研究 2025年第2期29卷 286-293页

作者：余杭林田浩冬文世媛黄丽刘昊为李汉森王培松彭莉西南大学体育学院重庆市400700 云南省第一人民医院昆明理工大学附属医院重症医学科云南省昆明市650000 深圳市坪山区外国语文源学校广东省深圳市518000

背景:运动对肠道菌群和糖代谢具有调节作用,但高强度间歇性运动对2型糖尿病患者肠道菌群和糖代谢的影响尚不明确。目的:探究高强度间歇性运动对2型糖尿病患者糖代谢及肠道菌群的影响。方法:招募11例2型糖尿病患者,脱落2例,最终有9例进... 详细信息

背景:运动对肠道菌群和糖代谢具有调节作用,但高强度间歇性运动对2型糖尿病患者肠道菌群和糖代谢的影响尚不明确。目的:探究高强度间歇性运动对2型糖尿病患者糖代谢及肠道菌群的影响。方法:招募11例2型糖尿病患者,脱落2例,最终有9例进入试验。对患者进行为期6周、每周3次的高强度间歇性运动干预,干预前后收集受试者的空腹血液和粪便样本,对血液样本进行糖代谢指标检测,对粪便样本进行肠道菌群检测,比较干预前后2型糖尿病患者糖代谢指标和肠道菌群指标的变化。结果与结论:①患者经6周的高强度间歇性运动干预后,血液指标中的空腹血糖和糖化血清蛋白水平显著降低(Pshannon指数)、丰富度(Chao指数)和覆盖度(Coverage指数)无显著变化;③Venn图显示,患者肠道菌群中的拟杆菌门、放线菌门、变形菌门和梭杆菌门的相对丰度增加,厚壁菌门的相对丰度降低,显著降低的是厚壁菌门中的扭链瘤胃球菌与活泼瘤胃球菌,这两种菌属均与糖代谢相关性指标异常以及其他疾病的发展呈正相关;④结果显示,高强度间歇性运动干预对2型糖尿病患者糖代谢相关指标具有改善作用,患者肠道中的有益菌群丰度增加,有害菌群丰度减少,增强了患者肠道菌群的稳定性。

关键词：高强度间歇性运动 2型糖尿病肠道菌群糖代谢干预

Detection and Persistence of Clinical <i>Escherichia coli</i>in Drinking Water Evaluated by a Rapid Enzyme Assay and qPCR

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Advances in Microbiology 2012年第3期2卷 252-262页

作者： Annette s. Bukh Nina E. hansen Peter Roslev Department of Biotechnology Chemistry and Environmental Engineering Aalborg University Aalborg Denmark

The aims of this study were to evaluate two methods, qPCR and a chemiluminescent assay (ColiLight II), for rapid detection of E. coli in water, and to examine the survival and persistence of clinical E. coli in drinking water and biofilm using qPCR and ColiLight II. qPCR and ColiLight II were compared with a cultivation-based method (MPN), and survival and persistence of four clinical E. coli strains in water and biofilms on stainless steel (ss) and polyethylene (PE) surfaces were studied in a flow-through reactor with non-disinfected drinking water using ColiLight II, qPCR, ATP bioluminescence, and MPN. ColiLight II and qPCR correlated well with MPN. In drinking water, some clinical E. coli strains showed prolonged survival in drinking water flow-through systems, and persisted 3 - 3.4 times longer than the theoretical washout due to incorporation into biofilms. strain specific attributes can significantly affect detection and persistence of E. coli in drinking water matrices.

关键词： Biofilm Clinical E. coli Chemiluminescent Assay Lab-scale Drinking Water Reactor system Drinking Water qPCR

MicroRNA-126 and epidermal growth factor-like domain 7 predict recurrence in patients with colon cancer treated with neoadjuvant chemotherapy

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Cancer Drug Resistance 2019年第3期2卷 885-896页

作者： Torben Frøstrup hansen Anting Liu Carlsen Julia Tanas Tanassi Ole Larsen Flemming Brandt sørensen Lars Henrik Jensen Anders Jakobsen Danish Colorectal Cancer Center south Vejle HospitalInstitute of Regional Health ResearchUniversity of Southern DenmarkVejle 7100Denmark Department of Autoimmunology and Biomarkers Statens Serum InstitutCopenhagen 2300Denmark Department of Congenital Disorders Statens Serum InstitutCopenhagen 2300Denmark Department of Oncology Herlev HospitalHerlev 2730Denmark University Institute of Pathology Aarhus University Hospitaland department of Clinical MedicineUniversity of AarhusAarhus 8200Denmark

Aim:Neoadjuvant chemotherapy may represent a shift in the treatment of locally advanced colon *** angiogenic couple has-microRNA-126(miRNA-126)and epidermal growth factor-like domain 7(EGFL7)are transcribed from the same gene and regulates all aspects of angiogenesis and may influence the ability of tumor cells to *** aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant ***:This study included 71 patients from a phase II study all planned for three cycles of capecitabine and oxaliplatin before *** was sampled at baseline and right before and after the *** miRNA-126 was analysed by RT-qPCR and a quantitative immunoassay was used for the analyses of ***:The rates of 5-year disease-free survival(DFs)and overall survival(Os)were 80%and 85%,*** level of circulating miRNA-126 before the operation predicts recurrence,P=*** patients with values below and above the median the recurrence rate was 31%and 4%,*** results applied to EGFL7.A combined estimate identified a subgroup of patients(25 of 71)with no recurrence and a 5-year DFs and Os rate of 100%,***:MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy.

关键词： Chemotherapy colon cancer epidermal growth factor-like domain 7 microRNA-126

Food Crises and Market Mechanisms

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Journal of Environmental science and Engineering(B) 2014年第1期3卷 30-48页

作者： Henning Otte hansen Department of Food and Resource Economics University of Copenhagen Frederiksberg C 1958 Denmark

since the 1950s, there have been several food crises with severe humanitarian, economic, political and market-related consequences. In the last decade, food crises occurred during 2007-2008 and again in 2010-2011. In the paper, the main explanations for the food crises are discussed with a focus on the 2007-2008 food crisis, and the main causes are divided into temporary/random and structural/long term and are listed. Although there are a large number of factors, the size of reserves, speculation and bioenergy seem to be significant causes of the rapidly increasing food prices which were a major cause of the food crisis. The consequences of the food crisis in 2007-2008 in particular are discussed, and some major lessons learnt are listed. Also, the present market situation is assessed, the conclusion of which is that there does not seem to be an immediate risk of another food crisis occurring in the short term. However, international cereal reserves are still vulnerable and lower compared to the level in the 1990s.

关键词： Food crises food prices reserves lessons consequences.

The Reappearance of an Ancient Rhetorical Dilemma in Modem Western Democracies

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国际修辞学研究

国际修辞学研究 2015年 57-64页

作者： Helena Moelgaard hansen University of Copenhagen Denmark and New York University

In this academic essay I will discuss the prevailing,yet ancient,rhetorical dilemma:Whether rhetoric is a matter of persuasion rather than a question of ethics in modern Western *** the fact that this rhetorical debate dates back to the time of Isocrates in Ancient Greece,my recent experience as a speechwriter at the national parliament of Denmark has demonstrated that rhetoric is perceived very differently in politics compared to *** prompted me to readdress rhetoric’s perpetual dilemma to discuss rhetoric’s role and value as an academic discipline in modern Western *** experience led me to the preliminary conclusion that academic rhetorical studies perhaps insist too much on rhetoric’s inherent ethics,yet I will argue that rhetoric’s normative function is essential to the concept of democracy,at all times.

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Label-free superior contrast with c-band ultra-violet extinction microscopy

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Light(science & Applications) 2023年第3期12卷 435-445页

作者： Florian ströhl Deanna L.Wolfson Ida s.Opstad Daniel H.hansen Hong Mao Balpreet s.Ahluwalia Department of Physics and Technology UiT The Arctic University of NorwayTromsøNorway Department of Clinical science Intervention and TechnologyKarolinska InstituteStockholmSweden

In 1934,Frits Zernike demonstrated that it is possible to exploit the sample’s refractive index to obtain superior contrast images of biological *** refractive index contrast of a cell surrounded by media yields a change in the phase and intensity of the transmitted light *** change can be due to either scattering or absorption caused by the *** cells are transparent at visible wavelengths,which means the imaginary component of their complex refractive index,also known as extinction coefficient k,is close to ***,we explore the use of c-band ultra-violet(UVC)light for high-contrast high-resolution label-free microscopy,as k is naturally substantially higher in the UVC than at visible *** differential phase contrast illumination and associated processing,we achieve a 7-to 300-fold improvement in contrast compared to visible-wavelength and UVA differential interference contrast microscopy or holotomography,and quantify the extinction coefficient distribution within liver sinusoidal endothelial *** a resolution down to 215 nm,we are,for the first time in a far-field label-free method,able to image individual fenestrations within their sieve plates which normally requires electron or fluorescence superresolution *** illumination also matches the excitation peak of intrinsically fluorescent proteins and amino acids and thus allows us to utilize autofluorescence as an independent imaging modality on the same setup.

关键词： wave. extinction violet

The Global Fur Industry： Trends, Globalization and specialization

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Journal of Agricultural science and Technology(A) 2014年第7期4卷 543-551页

作者： Henning Otte hansen Department of Food and Resource Economics University of Copenhagen Frederiksberg C 1958 Denmark

The fur industry and the entire fur cluster are in many ways an interesting and instructive example from which many lessons can be learned. Up to now, the international fur industry has not been thoroughly described or analyzed. A major reason is the rather limited availability of national and international statistics about the fur sector. This article analyzes the production and international trade in fur based on information from official statistics, trade associations, companies, scientific papers and reports, interviews with experts, etc.. Markets and market conditions play a very important role with regards to the fur sector, and the price of fur is volatile in the short and long run. A new world trade pattern and international specialization have emerged in recent years. The comparative advantages of the fur sector change along the fur value chain, while China＇s position on the global fur market has changed significantly.

关键词： Fur industry mink production fur garment international trade fur cluster.