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Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

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Neural Regeneration Research 2018年第11期13卷 1883-1884页

作者： Andrea E.Toth morten s.nielsen Department of Biomedicine Faculty of Health Aarhus University

The blood-brain barrier(BBB)and drug delivery:In our modern societies,the prevalence of nervous system disorders is increasing in relation to the aging *** overcome this problem,several interesting pharmacons and biom... 详细信息

关键词： Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten s.Hansen Kaja Madsen Maria Price Kent søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and systems Research(IMsR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(ssTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating ssTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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Deciphering the controlling factors for phase transitions in zeolitic imidazolate frameworks

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National science Review 2024年第4期11卷 151-163页

作者： Tao Du shanwu Li sudheer Ganisetti Mathieu Bauchy Yuanzheng Yue morten M.smedskjaer Department of Chemistry and Bioscience Aalborg University Department of Mechanical Engineering-Engineering Mechanics Michigan Technological University Physics of Amo Rphous and Inorganic solids Laboratory(PARIslab) Department of Civil and Environmental EngineeringUniversity of CaliforniaLos Angeles

Zeolitic imidazolate frameworks（ZIFs） feature complex phase transitions, including polymorphism,melting, vitrification, and polyamorphism. Experimentally probing their structural evolution during transitions involving amorphous phases is a significant challenge, especially at the medium-range length scale. To overcome this challenge, here we first train a deep learning-based force field to identify the structural characteristics of both crystalline and non-crystalline ZIF phases. This allows us to reproduce the structural evolution trend during the melting of crystals and formation of ZIF glasses at various length scales with an accuracy comparable to that of ab initio molecular dynamics, yet at a much lower computational cost. Based on this approach, we propose a new structural descriptor, namely, the ring orientation index, to capture the propensity for crystallization of ZIF-4(Zn（Im）2, Im = C3H3N2-) glasses, as well as for the formation of ZIF-zni(Zn（Im）2) out of the high-density amorphous phase. This crystal formation process is a result of the reorientation of imidazole rings by sacrificing the order of the structure around the zinc-centered tetrahedra. The outcomes of this work are useful for studying phase transitions in other metal-organic frameworks（MOFs） and may thus guide the development of MOF glasses.

关键词： metal-organic frameworks phase transitions melting glass formation transferable deep learning force field ring orientation

Prevalence of Charles Bonnet syndrome in low vision:a systematic review and meta-analysis

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Annals of Eye science 2022年第2期7卷 80-92页

作者： Yousif subhi Mads Assenholt nielsen Daniel Andrew Richard scott Lars morten Holm Amardeep singh Department of Ophthalmology RigshospitaletGlostrupDenmark Department of Clinical Research University of Southern DenmarkOdenseDenmark Faculty of Health and Medical sciences University of CopenhagenKøbenhavnDenmark Department of Ophthalmology Waikato District Health BoardHamiltonNew Zealand

Background:Charles Bonnet syndrome(CBs)is characterized by vivid lifelike visual hallucinations and is typically seen in individuals with visual *** this systematic review,we summarize current knowledge on the prevalence of CBs in patients with low ***:We searched 11 literature databases on 21 April 2021 for studies on the prevalence of CBs in low vision *** protocol was registered in the PROsPERO database(***42021255021).Eligible studies were defined as those on a population of low vision patients wherein the prevalence of CBs was evaluated(without any further restriction on the method for diagnosis of CBs).No restriction was enforced on study design,but we expected observational cross-sectional studies due to the nature of our research *** authors independently extracted data and evaluated risk of bias of individual studies using the Agency for Healthcare Research and Quality checklist for cross-sectional *** underwent qualitative review in the text and quantitatively in a prevalence meta-analysis using the random-effects *** analysis was made to evaluate the robustness of the summary ***:We identified 11 studies,which summarized data on 4,521 individuals with visual *** of CBs was based on screening questions or interviews,which in positive cases often was explored in more detail with follow-up questions or *** studies either had normal mental state as a participant eligibility criterion or as a part of the diagnosis of *** pooled prevalence of CBs in low vision patients aged≥40 years was 19.7%(95%CI:13.8%to 26.4%).The sensitivity analysis showed certain robustness in the summary prevalence estimate wherein prevalence estimates ranged from 16.9%to 22.5%.Conclusions:CBs is a prevalent condition in patients with low vision at a rate of approximately one in five *** that an estimated 239 million individuals have moderate visual im

关键词： Charles Bonnet syndrome(CBs) visual hallucinations low vision

Two-dimensional ferroelectrics from high throughput computational screening

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npj Computational Materials 2023年第1期9卷 1901-1911页

作者： Mads Kruse Urko Petralanda morten N.Gjerding Karsten W.Jacobsen Kristian s.Thygesen Thomas Olsen CAMD Department of PhysicsTechnical University of DenmarkDK-2800 Kongens LyngbyDenmark

We report a high throughput computational search for two-dimensional ferroelectric *** starting point is 252 pyroelectric materials from the computational 2D materials database(C2DB)and from these we identify 63 *** particular we find 49 materials with in-plane polarization,8 materials with out-of-plane polarization and 6 materials with coupled in-plane and out-of-plane *** of the known 2D ferroelectrics are recovered by the screening and the far majority of the predicted ferroelectrics are known as bulk van der Waals bonded compounds,which makes them accessible by direct *** roughly 25%of the materials we find a metastable state in the non-polar structure,which may imply a first order transition to the polar ***,we list the magnetic pyroelectrics extracted from the C2DB and focus on the case of VAgP2se6,which exhibits a three-state switchable polarization vector that is strongly coupled to the magnetic excitation spectrum.

关键词： materials polarization plane

Bullying among people with visual impairment: Prevalence, associated factors and relationship to self-efficacy and life satisfaction

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World Journal of Psychiatry 2018年第1期8卷 43-50页

作者： Audun Brunes morten B nielsen Trond Heir section for Trauma Catastrophes and Migration-Adults Norwegian Centre for Violence and Traumatic Stress Studies Department of Work Psychology and Physiology National Institute of Occupational Health Institute of Clinical Medicine Faculty of MedicineUniversity of Oslo

AIM To examine associated factors of bullying and to determine associations between bullying and psychosocial outcomes among individuals with visual impairments(Ⅵ). METHODs We conducted an age-stratified cross-sectional survey of adults with Ⅵ who were recruited from the Norwegian Association of the Blind and Partially sighted. Data were collected through structural telephone interviews in the period between February and May, 2017. Linear regression models were used to examine factors related to bullying and associations of bullying with self-efficacy and life *** A total of 736 individuals were interviewed. The lifetime and 6-mo prevalence of bullying was 41.7% and8.2%, respectively. The majority of bullied participants reported Ⅵ-specific bullying(65.1%). Victimization of bullying was associated with young age, early onsetage of Ⅵ, and having other impairments. Participants who reported bullying had lower levels of self-efficacy[Adjusted relative risk(ARR): 0.40, 95% confidence interval(CI): 0.19-0.85] and life satisfaction(ARR: 0.68,95%CI: 0.51-0.91).CONCLUsION Bullying is highly prevalent among individuals withⅥ. Our findings suggest that interventions to reduce bullying may be beneficial for improving the well-being and life quality of people with Ⅵ.

关键词： Blindness Bullying Life satisfaction Risk factors self-efficacy Victim Visual impairment

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

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World Journal of Gastroenterology 2017年第33期23卷 6137-6146页

作者： morten L Halling Jens Kjeldsen Torben Knudsen Jan nielsen Lars Koch Hansen Department of Gast-roenterology and Hepatology Hospital of Southwest Jutland Department of Medical Gastroenterology s Odense University Hospital Center for Clinical Epidemiology Odense Uni-versity Hospital

AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODs In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration system(CRs) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P s were estimated using Fisher's exact *** There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P s were all significantly more frequent in the IBD group. sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P sclerosing cholangitis(PsC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P s,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P soriatic arthritis and episcleritis. Restricted to women with UC(P stritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P s sarcoidosis. CONCLUsION Immune mediated diseases were si

关键词： Immune mediated diseases Ulcerative colitis Risk Prevalence Registry Chronic inflammatory diseases Autoimmune diseases Inflammatory bowel disease Crohn’s disease extraintestinal manifestations

Predicting solid state material platforms for quantum technologies

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npj Computational Materials 2022年第1期8卷 1983-1997页

作者： Oliver Lerstøl Hebnes Marianne Etzelmüller Bathen Øyvind sigmundson schøyen sebastian GWinther-Larsen Lasse Vines morten Hjorth-Jensen sopra steria Information Technology and ServicesN-4020StavangerNorway Department of Physics and Center for Computing in science Education University of OsloN-0316OsloNorway Advanced Power semiconductor Laboratory ETH Zürich8092ZürichSwitzerland Menon Economics N-0369OsloNorway Department of Physics and Center for Materials science and Nanotechnology University of OsloN-0316OsloNorway Department of Physics and Astronomy and Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI48824USA

semiconductor materials provide a compelling platform for quantum technologies(QT).However,identifying promising material hosts among the plethora of candidates is a major ***,we have developed a framework for the automated discovery of semiconductor platforms for QT using material informatics and machine learning *** approaches were implemented to label data for training the supervised machine learning(ML)algorithms logistic regression,decision trees,random forests and gradient *** find that an empirical approach relying exclusively on findings from the literature yields a clear separation between predicted suitable and unsuitable *** contrast to expectations from the literature focusing on band gap and ionic character as important properties for QT compatibility,the ML methods highlight features related to symmetry and crystal structure,including bond length,orientation and radial distribution,as influential when predicting a material as suitable for QT.

关键词： quantum symmetry separation

Vortex lattices in type-II superconductors studied by small-angle neutron scattering

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Frontiers of physics 2011年第4期6卷 398-409页

作者： morten Ring Eskildsen Department of Physics University of Notre Dame Notre Dame IN 46556 USA

Here we review recent small-angle scattering studies of the vortex lattice in a range of type-II superconductors carried out by our group. Emphasis is placed on providing examples of the kind of information which can be obtained by such measurements, focusing in particular on studies of the vortex lattice structure and form factor in LuNi2B2C, TmNi2B2C, CeCoIn5 and Ba（Fe0.93Co0.07）2As2.

关键词： superconductivity vortex lattice small-angle neutron scattering borocarbides pnic-tides CeCoIn5