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Circulating tumor cells and their role in prostate cancer

Asian Journal of Andrology 2019年第1期21卷 24-31页

作者： moritz maas Miriam Hegemann Steffen Rausch Jens Bedke Arnulf Stenzl Tilman Todenhofer Department of Urology University Hospital TuebingenHoppe-Seyler-Strabe 3Tuebingen 72076Germany.

Circulating tumor cells (CTC)have become an important biomarker in patients with advanced prostate *** count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer,a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been ***,the focus of research is shifting from CTC enumeration towards molecular characterization of CTC leading to the discovery of markers predicting treatment *** role of androgen receptor splice variants expressed by CTC as markers of resistance to abiraterone and enzalutamide has been assessed by various *** identification of CTC markers predicting treatment response represents a key step to guide the selection of treatment (e.g.,abiraterone/enzalutamide vs taxanes), particularly in patients with *** an alternative to CTC,the analysis of circulating tumor DNA has been shown to enable a noninvasive disease characterization having high potential to promote precision oncology.

关键词： AR-V7 biomarker cell-free DNA cfDNA circulating tumor cells ctDNA liquid biopsy prostate cancer

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Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

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Asian Journal of Andrology 2019年第1期21卷 12-18页

作者： Miriam Hegemann moritz maas Steffen Rausch Simon Walz lens Bedke Arnulf Stenzl Tilman Todenhofer Department of Urology University Hospital TuebingenTuebingen 72076Germany.

Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer,in the last decade,the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of complications caused by bone metastases in patients with castration-resistant prostate *** drugs have raised awareness of the importance of skeletal-related events which in the meantime represent an important end point also in trials using agents not specifically designed for bone ***-generation antihormona]drugs such as enzalutamide or abiraterone have been shown to have a positive impact on the incidence of skeletal complications and therefore provide an important tool in the armamentarium used for treating bone *** such as radium-223 dichloride([^223Ra])have been demonstrated not only to reduce skeletal-related events and bone-related pain,but also to prolong overall survival,thereby being the first bone-targeting agent showing a survival *** previous studies have not provided an obvious benefit of bone-targeted lesions in castration-sensitive disease,the use of these agents is not *** oligometastatic prostate cancer,the role of local treatment of metastases using stereotactic radiation or radiosurgery is a matter of intense debates and may play an increasing role in the future.

关键词： bone metastases bone-targeting agents denosumab hormonal therapy prostate cancer radium-223 dichloride zoledronic acid

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