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Safety of the Aqueous Extract of the Leaves of Senna alata (L.) Roxb. (Leguminosae-Caesalpinioideae), a Plant Used in Benin to Treat Infections

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Journal of Biosciences and Medicines 2022年第12期10卷 86-95页

作者： Maximin Senou rené Dehou Félicienne Agbogba Pascal Tchogou Yollande Abissi Alban Houngbeme Gutemberg Kpossou Eugénie Anago Eugène Attakpa Laboratoire de Biologie Expérimentale et Clinique (LaBEC) Ecole Nationale Supérieure des Biosciences et Biotechnologie Appliquées Université Nationale des Sciences Technologies Ingénierie et Mathématiques d’Abomey Benin Laboratoire de Biologie Appliquée (LARBA) Ecole Polytechnique d’Abomey-Calavi (EPAC) Université d’Abomey-Calavi (UAC) Abomey-Calavi Benin Laboratoire National de Pharmacognosie/Centre Béninois de la Recherche Scientifique et Technique (CBRST) Porto-Novo Benin Laboratoire de l’Hô pital de Zone Saint jean de Dieu de Boko Parakou Benin Laboratoire de Physiopathologie Moléculaire et Toxicologie Faculté des Sciences et Techniques (FAST) Université d’Abomey-Calavi (UAC) Abomey-Calavi Benin

Description of the Subject: Senna alata (L.) was a plant in the Benin pharmacopoeia used to treat skin infections. Objectives: The aim of our work was to test its harmlessness in vivo. Method: Wistar rats received by gavage a single dose of 2000 mg/kg of Senna alata leaves aqueous extract for the Acute Oral Toxicity (AOT) test. For the sub-Chronic Oral Toxicity (SCT) test, rats force-fed the extract at a daily dose of 300 mg/Kg of body weight for 28 days. The weight of the rats was taken and the blood samples were collected on Day 0, then respectively day 14 for the AOT and Day 28 for the SCT. The renal balance was carried out by dosage of the creatinine, the liver balance by the transaminases AST and ALT and the blood balance by the hemogram. The liver, kidneys and spleen were removed for histological analysis. The results were analyzed using the Student test, with the significance level set at 5%. Results: The weight of the rats did not change significantly in the acute or subchronic oral toxicity tests suggesting an absence of physical disturbance in the rats. Serum creatinine did not vary significantly, suggesting preservation of renal function. That was the same for ASAT and ALAT transaminases, indicating an absence of hepatic cytolysis. In hematology, the hemoglobin level and the number of blood platelets did not vary significantly, suggesting that the extract did not create anemia and did not influence blood coagulation. Hepatic, renal and splenic parenchyma showed no atypia. Conclusion: The aqueous extract of Senna alata (L.) leaves did not reveal any acute or subchronic toxicity and offered prospects for its use in the treatment of infections.

关键词： Senna alata Oral Toxicity Liver Kidneys and Spleen

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从建构主义学习理论谈建筑学专业学习

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山西建筑 2020年第5期46卷 179-181页

作者：任书斌烟台大学建筑学院

从建构主义学习理论,尤其是皮亚杰的图式、同化、顺应和平衡概念出发,详细论述了建筑学学习过程中的一些特点,并提出了建筑学教学过程中应该注意的问题。

关键词：建构主义建筑学图式平衡

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新疆家犬体内存在细粒棘球绦虫G1(羊)株和G6(骆驼)株的分子证据(英文)

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中国寄生虫病防治杂志 2005年第5期18卷 333-335页

作者：张亚楼 jean-Mathieu BART 温浩马旭东苗玉清林仁勇王星卢晓梅新疆包虫病基础医学重点实验室新疆乌鲁木齐830054

目的收集家犬体内的细粒棘球绦虫成虫以建立新疆棘球蚴病的分子流行病学资料。方法对家犬体内成虫细胞色素c氧化酶Ⅰ基因序列进行测定以确定其亚株型。结果所有感染犬体内成虫的基因型为G1型。特别是1条家犬体内发现存在细粒棘球绦虫G1(... 详细信息

目的收集家犬体内的细粒棘球绦虫成虫以建立新疆棘球蚴病的分子流行病学资料。方法对家犬体内成虫细胞色素c氧化酶Ⅰ基因序列进行测定以确定其亚株型。结果所有感染犬体内成虫的基因型为G1型。特别是1条家犬体内发现存在细粒棘球绦虫G1(羊)株和G6(骆驼)株混合感染的情况。结论在新疆阻断羊犬和羊骆驼循环圈是预防棘球蚴病的重要措施。作为终末宿主的家犬与人类的感染密切相关,对感染犬的管理应该加强。

关键词：细粒棘球绦虫细胞色素c氧化酶Ⅰ基因棘球蚴病

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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain jean-François Ramée jean-Luc Raoul jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO rené Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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羟基固醇类的抗癌活性研究 1.7-羟基胆固醇水溶性衍生物体内抗癌活性试验

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沈阳药科大学学报 1986年第1期 8-13页

作者：容士宏 Bergmann Christian 刘鹏 Beck jean-Paul Ourisson Guy 沈阳药学院 Institut Centre de Neurochimie C.N.R.S. 5 rue Blaise-Pascal 67084 Strasbourg France Institur Centre de Neurochimie C.N.R.S. 5 rue Blaise-Pascal 67084 Strasbourg France 化学制药教研室 de Physiologie 12 rue rené-Descartes Université Louis-Pasteur 67000 Strasbourg France de Physiologie 12 rue rené-Descartes Université Louis-Pasteur 67000 Strasbourg France

本文是作者于1983年9月在法国斯特拉斯堡路易巴斯德大学通过的博士论文中的一部分。作者合成了7β-及7α-羟基胆固醇的水溶性衍生物,它们在动物体内试验有很明显的抗癌作用.

关键词：羟基固醇类抗癌活性 7β-羟基胆固醇双琥珀酸单酯钠 7α-羟基胆固醇双琥珀酸单酯钠

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中国中山吉宝盛世湾

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世界建筑导报 2019年第1期34卷 116-123页

作者： Gordana Jakimovska Joerg Lonkwitz Adriana Rodriguez Ossio Alexander Schramm Alice Yi-Ting Chiu Iris Pastor Caroline Filice Smith jean Chaussavoine Jun Wang Irina Bogdan Leo Xinyu Li Gilles Greis Alexander Meyers Sam Jia Jun ren Tamim Salah EI Negm Evan Jon Shieh Rafael Carbonero Vicario Tom Roe

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由To... 详细信息

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由TomRoe制作。吉宝湾码头吉宝湾新码头位于中国广东省中山市,座落于西江沿岸。该项目总体规划面积达50,000平方米,包括一个直通西江的码头、一座游艇俱乐部、高端住宅别墅以及海关大楼、桥梁、道路和周边外堤等配套基础设施。吉宝湾码头是中国境内首个,也是唯一个外国移民所有的私营港口。

关键词：中国境内中山市游艇俱乐部工作室海关大楼基础设施码头亚洲

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冠脉支架置入术与冠脉搭桥术治疗严重冠心病的对比研究——SYNTAX研究

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循证医学 2009年第6期9卷 339-344页

作者：柴仁杰张斌广东省人民医院广东省心血管病研究所心内科广东省医学科学院广州510080

1文献来源Serruys PW, morice MC, Kappetein AP, et *** coronary intervention versus coronaryartery bypass grafting for severe coronary artery disease [J]. N Engl J Med, 2009,360 （10）：961 - 972.

关键词：冠状动脉疾病经皮冠状动脉介入治疗冠状动脉旁路移植术

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Case report of a rare giant left anterior descending coronary artery aneurysm

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中华胸部外科电子杂志 2021年第3期8卷 160-163页

作者： Bleri Celmeta Antoine Mugniot Thomas Sénage jean-Christian Roussel Antonio Miceli Cardiothoracic Center Istituto Clinico“Sant’Ambrogio”MilanItaly Thoracic and Cardiovascular Surgery Department University Hospital CenterHôpital Guillaume et RenéLaënnecNantesFrance

Giant coronary artery aneurysm(CAA)is a rare condition,reportedly seen in 0.02-0.2%of patients undergoing coronary *** in most cases,patients may present with angina pectoris,myocardial infarction,cardiac tamponade or sudden *** that the natural history of the CAA is still not predictable,the optimal treatment remains still *** this case report,we present a male patient with a sudden non-exertional dyspnea and angina in a context of obesity,multiple large and medium vessels aneurysms and chronic kidney disease(CKD).A contrast CT detected a giant left anterior descending artery(LAD)CAA measuring 73 mm×47 mm,apparently compressing the circumflex(CX)and the pulmonary artery(PA).After undergoing a full(etiologic and aneurysm extension)panel of exams,the patient underwent a surgical exclusion of the giant CAA and a coronary artery bypass grafting(CABG)by using the left thoracic mammary artery(LITA).The hospitalization was uneventful,and the patient left the hospital completely *** conclusion,even in cases of giant coronary aneurysms,the treatment is surgical by excluding the aneurismatic sac and performing a surgical revascularization.

关键词： Giant coronary artery aneurysm angina dyspnea coronary artery bypass grafting(CABG) case report

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