检索结果-南通市图书馆

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4^(+)T cells

引用

Cellular & Molecular Immunology 2023年第7期20卷 777-793页

作者： Yuwei Hao bahar Miraghazadeh Rochna Chand Ainsley R.Davies Chelisa Cardinez Kristy Kwong morgan b.downes Rebecca A.Sweet Pablo F.Cañete Lloyd J.D’Orsogna David A.Fulcher Sharon Choo Desmond Yip Geoffrey Peters Sonia Yip Matthew J.Witney Maxim Nekrasov Zhi-Ping Feng David C.Tscharke Carola G.Vinuesa Matthew C.Cook Centre for Personalised Immunology John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Translational Research Unit The Canberra HospitalCanberraACTAustralia Division of Immunology and Infectious Diseases John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Department of Immunology Fiona Stanley HospitalPerthWAAustralia Department of Immunology The Royal Children’s HospitalMelbourneVICAustralia Department of Medical Oncology The Canberra HospitalCanberraACTAustralia ANU Medical School The Australian National UniversityCanberraACTAustralia NHMRC Clinical Trials Unit The University of SydneySydneyNSWAustralia The ACRF biomolecular Resource Facility John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia ANU bioinformatics Consultancy John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Francis Crick Institute 1 Midland RdLondon NW11ATUK Cambridge Institute of Therapeutic Immunology and Infectious Disease University of CambridgeCambridgeUnited Kingdom.

As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency(PAD),analysis of affected patients could yield insights into T-cell differentiation and explain how environmental exposures modify clinical phenotypes conferred by single-gene ***57 marks dysfunctional T cells that have differentiated after antigenic ***,while circulating CD57^(+)CD4^(+)T cells are normally rare,we found that they are increased in patients with PAD and markedly increased with CTLA4 haploinsufficiency or *** performed single-cell RNA-seq analysis of matched CD57^(+)CD4^(+)T cells from blood and tonsil *** CD57^(+)CD4^(+)T cells(CD4cyt)exhibited a cytotoxic transcriptome similar to that of CD8^(+)effector cells,could kill b cells,and inhibited b-cell ***4 restrained the formation of *** CD57 also marked an abundant subset of follicular helper T cells,which is consistent with their antigen-driven differentiation,this subset had a preexhaustion transcriptomic signature marked by TCF7,TOX,and ID3 expression and constitutive expression of CTLA4 and did not become cytotoxic even after CTLA4 ***,CD57^(+)CD4^(+)T-cell cytotoxicity and exhaustion phenotypes are compartmentalised between blood and germinal ***4 is a key modifier of CD4^(+)T-cell cytotoxicity,and the pathological CD4cyt phenotype is accentuated by infection.

关键词： CTLA4 Immunodeficiency Cell exhaustion Terminal differentiation Cytotoxic CD4^(+)T cells CD57

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact on Soil Organic C and Total Soil N from Cool- and Warm-Season Legumes Used in a Green Manure-Forage Cropping System

引用

Agricultural Sciences 2024年第3期15卷 333-357页

作者： Clark b. Neely Francis M. Rouquette Jr. Cristine L.S. morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legumes are important components of livestock production systems in East Texas and the southeastern US. Forage legumes contribute nitrogen (N) to cropping systems through biological N fixation, and their seasonal biomass production can be managed to complement forage grasses. Our research objectives were to evaluate both warm- and cool-season annual forage legumes as green manure for biomass, N content, ability to enhance soil organic carbon (SOC) and soil N, and impact on post season forage grass crops. Nine warm-season forage legumes (WSL) were spring planted and incorporated as green manure in the fall. Forage rye (Secale cereale L.) was planted following the incorporation of WSL treatments. Eight cool-season forage legumes (CSL) were fall planted in previously fallow plots and incorporated as green manure in late spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was planted over all treatments in early summer after forage rye harvest and incorporation of CSL treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N concentration. Soil cores were taken from each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm, and soil C and N were measured using combustion analysis. Nylon mesh bags containing plant samples were buried at 15 cm and used to evaluate decomposition rate of above ground legume biomass, including change in C and N concentrations. Mungbean (Vigna radiata L. [Wilczek]) had the highest shoot biomass yield (6.24 t DM ha-1) and contributed the most total N (167 kg∙ha-1) and total C (3043 kg∙ha-1) of the WSL tested. Decomposition rate of WSL biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum L. spp. sativum), arrow leaf clover (Trifolium vesiculosum Savi.), and crimson clover (Trifolium incarnatum L.) were the most productive CSL in this trial. Austrian winter pea

关键词： Annual Legumes Soil N Soil Organic C Green Manure Deer browse Forage Cropping Systems

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Legume Green Manure and Intercropping for High biomass Sorghum Production

引用

Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark b. Neely Francis M. Rouquette Jr. Cristine L. S. morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (L.) Pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). Main plots were split into crimson clover green manure (CLGM) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CPGM), cowpea-sorghum intercrop (CPSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The CLGM increased (P sorghum biomass yield (16.5 t DM∙ha−1) 28% in year three but had no effect in the first two years. The CPSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CPGM increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-biomass Sorghum Legumes Green Manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells

引用

Signal Transduction and Targeted Therapy 2023年第10期8卷 4428-4430页

作者： Hildegard buning Michael morgan Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover30625Germany REbIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover30625Germany Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA02115USA

A recent study published in Cell by the Millay lab reports on an elegant strategy to expand the repertoire of lentiviral(LV)vectors from being the main delivery tool for ex vivo gene therapy to an in vivo applicable viral vector that specifically transduces skeletal muscle.1 This very significant advance may result in novel therapeutics for patients suffering from various skeletal muscle diseases.

关键词： skeletal directed muscle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design concerns of room and pillar retreat panels

引用

International Journal of Mining Science and Technology 2017年第1期27卷 29-35页

作者： Klemetti Ted M. Sears morgan M. Tulu Ihsan b. Mining Engineer Ground Control branch NIOSH Office of Mine Safety and Health ResearchPittsburghPAUSA

Why do some room and pillar retreat panels encounter abnormal conditions? What factors deserve the most consideration during the planning and execution phases of mining and what can be done to mitigate those abnormal conditions when they are encountered? To help answer these questions, and to determine some of the relevant factors influencing the conditions of room and pillar(R & P) retreat mining entries, four consecutive R & P retreat panels were evaluated. This evaluation was intended to reinforce the influence of topographic changes, depth of cover, multiple-seam interactions, geological conditions, and mining geometry. This paper details observations were made in four consecutive R & P retreat panels and the data were collected from an instrumentation site during retreat mining. The primary focus was on the differences observed among the four panels and within the panels themselves. The instrumentation study was initially planned to evaluate the interactions between primary and secondary support, but produced rather interesting results relating to the loading encountered under the current mining conditions. In addition to the observation and instrumentation, numerical modeling was performed to evaluate the stress conditions. both the La Model 3.0 and Rocscience Phase 2 programs were used to evaluate these four panels. The results of both models indicated a drastic reduction in the vertical stresses experienced in these panels due to the full extraction mining in overlying seams when compared to the full overburden load. both models showed a higher level of stress associated with the outside entries of the panels. These results agree quite well with the observations and instrumentation studies performed at the mine. These efforts provided two overarching conclusions concerning R & P retreat mine planning and execution. The first was that there are four areas that should not be overlooked during R & P retreat mining: topographic relief, multiple-seam stress relie

关键词：面板支柱设计仪器仪表相互作用开采条件地形变化地质条件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-starch polysaccharide-degrading enzymes may improve performance when included in wheat- but not maize-based diets fed to broiler chickens under subclinical necrotic enteritis challenge

引用

Animal Nutrition 2022年第3期10卷 54-67页

作者： Eunjoo Kim Amy F.Moss Natalie K.morgan Kosar Gharib-Naseri Peter Ader Mingan Choct School of Environmental and Rural Science University of New EnglandArmidaleNSW 2351Australia bASF SE 68623LampertheimGermany

The present study investigated whether supplementing fibre-degrading enzymes can ameliorate the severity of subclinical necrotic enteritis(NE)in broiler chickens offered wheat-or maize-based diets.A total of 1,544 mixed-sex broiler chickens were assigned to 16 experimental treatments as a 2×2×4 factorial arrangement of *** factors were the following:NE challenge,yes or no;diet type,wheat-or maize-based;and enzyme supplementation,control(no enzyme),family 10 xylanase(XYN10),family 11 xylanase(XYN11)or b-mannanase(MAN).Each treatment was replicated 6 times,with 16 birds per replicate pen.A three-way challenge×diet type×enzyme interaction occurred for body weight at 21 d of age(P=0.025)and overall feed conversion ratio(P=0.001).In the non-challenged birds fed the wheat-based diet,supplementing MAN increased d 21 body weight compared to the *** challenged birds fed the maize-based diet,supplemental XYN11 impeded body weight and overall FCR compared to the *** offered the maize-based diet presented heavier relative gizzard weights at both 16 and 21 d of age(Pbility(P=0.046)compared to those fed the wheatbased *** supplementation reduced ileal and jejunal digesta viscosity at 16 d of age only in birds fed the wheat-based diet(Pbirds fed the maizebased diet,and MAN reduced it in birds fed the wheat-based diet at 21 d of age(P=0.030).Supplementing XYN11 improved ileal soluble non-starch polysaccharides(NSP)digestibility in birds fed the wheat-based diet compared to non-supplemented birds(Pbirds fed the wheat-based diet displayed a higher abundance of bifidobacterium,Lactobacillus and Enterobacteriaceae and butyric acid in the caeca at 16 d of age compared to birds fed the maize-based diet(Pbated the negative impact of NE on growth performance in birds fed the maizebased *** wheat-based diets with

关键词： broiler chicken Carbohydrase Mannanase Necrotic enteritis Prebiotic oligosaccharides Xylanase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ileal profile of non-starch polysaccharides and oligosaccharides in response to exogenous enzymes in broiler chickens offered wheat-or maize-based diets under subclinical necrotic enteritis challenge

引用

Animal Nutrition 2022年第3期10卷 207-215页

The present study evaluated the impacts of fibre-degrading enzymes on the profiles of non-starch polysaccharides(NSP)and oligosaccharides(OS)in the ileum of broiler chickens offered wheat-or maize-based diets under subclinical necrotic enteritis(NE)challenge.A 224 factorial arrangement of treatments was *** were the following:NE challenge,no or yes;diet type,wheat-or maizebased;and supplemental enzymes,control(no enzyme),family 10 xylanase(XYN10),family 11 xylanase(XYN11)or b-mannanase(MAN).birds in the challenged group were inoculated with Eimeria on d 9 and Clostridium perfringens on d 14 and 15.A 3-way interaction(P=0.047)occurred on overall(d 0 to 16)weight *** NE was present,all the supplemental enzymes increased weight gain in birds fed the wheat-based diet;whereas in those fed the maize-based diet supplemental XYN10 and XYN11 decreased weight *** NE was absent,birds fed the wheat-based diet supplemented with XYN10 or MAN presented increased weight gain compared to non-supplemented birds,but no improvements with enzyme addition were observed in birds fed the maize-based diet.A 3-way interaction(P=0.002)was observed on insoluble NSP level in the *** NE was absent,all the supplemental enzymes reduced the ileal level of insoluble NSP,regardless of diet *** the challenged birds,supplementing XYN10 and MAN reduced insoluble NSP level in the ileum,but only in birds fed the wheat-based *** soluble NSP level was reduced by supplemental XYN11 and MAN,but only in birds fed the wheatbased diet,resulting in a 2-way diet typeenzyme interaction(Pbinose(P=0.030)level was highest in birds offered the wheat-based diet supplemented with ***,supplementation of NSP-degrading enzymes to the wheat-based diet enhanced bird performance regardless of NE challenge,with XYN11 significantly increasing oligosaccharide ***,enzyme addition did not improve growth performance in birds fed maize-based diet

关键词： broiler chicken Non-starch polysaccharide Subclinical necrotic enteritis Oligosaccharide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease

引用

Acta Pharmaceutica Sinica b 2022年第10期12卷 3924-3933页

作者： bo Qin Gregory b.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri M.L.morgan Wenchao Niu Lina Zhao Alan Armstrong David J.Mann Sheng Cui NHC Key Laboratory of Systems biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of Life Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional *** of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small *** we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding ***,we re-purpose these hits towards the main protease(Mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active *** hit fragments covalently link to the catalytic cysteine of Mpro to inhibit its *** demonstrate that targeting the active site cysteine of Mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Covalent fragments Allosteric inhibition EV71

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

OPTICAL IMAGING AND SPECTROSCOPY OF SUPERFICIAL TISSUE

引用

Journal of Innovative Optical Health Sciences 2008年第1期1卷 85-93页

作者： S.P.morgan I.M.STOCKFORD J.A.CROWE b.R.HAYES-GILL School of Electrical and Electronic Engineering University of Nottingham University Park Nottingham NG72RDUK

An overview of three techniques developed by our group for imaging superficial tissue is ***,a novel polarized light capillaroscope has been developed for imaging the *** capillaroscope has been used to make in vivo measurements of sickle cell disorder sufferers with aim of monitoring the polymerization of sickled red blood ***,hyperspectral imaging for measuring oxygen saturation is *** accuracy of such measurements is affected by the non-linear relationship between scattering and absorption and it is demonstrated that polarization techniques can be used to make the relationship more linear,thus improving ***,the use of smart CMOS optical sensors for laser Doppler blood flowmetry is described.A 32×32 pixel imaging array with on-chip processing is described and the potential for full field laser Doppler blood flow imaging is demonstrated through measurement on blood flow of tissue before and after occlusion.

关键词： capillaroscopy laser Doppler hyperspectral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

未来阻燃剂的设计(英文)

引用

中国材料进展 2013年第3期32卷 129-136,171页

作者： Alexander b morgan 代顿大学研究所俄亥俄州代顿45460

阻燃剂已经存在数千年了,但最近200年才发展出一些新化学结构的阻燃剂。目前使用的阻燃剂主要包括7种类型,它们是卤素基、磷基、膨胀体系、矿物填料、氮基、无机物基、高分子纳米复合体系等。现在,阻燃剂的使用仅仅专注于提供消防,也没... 详细信息

阻燃剂已经存在数千年了,但最近200年才发展出一些新化学结构的阻燃剂。目前使用的阻燃剂主要包括7种类型,它们是卤素基、磷基、膨胀体系、矿物填料、氮基、无机物基、高分子纳米复合体系等。现在,阻燃剂的使用仅仅专注于提供消防,也没有考虑如何延长它们的使用寿命,没有考虑如何处理阻燃剂使用结束后的后处理问题。随着将来对环境保护新要求的提升,以及新型起火原因的出现,现有的几类阻燃剂显然是不够的,必须努力开发新型阻燃剂,例如硅基阻燃剂、过度金属催化作用阻燃剂等。讨论了未来阻燃剂的设计必须考虑的环境保护和新的起火原因等问题,以及与未来新型阻燃剂有关的潜在化学问题。最后提出了在新型阻燃剂研究过程中,减少环境污染、保持防火安全的原则。

关键词：阻燃剂阻燃设计汽车塑料复合材料环境保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：