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Advanci.g i.munosuppressi.n i. li.er transplantati.n: A narrati.e revi.w

Hepatobi.i.ry & Pancreati. Di.eases i.ternati.nal 2024年第5期23卷 441-448页

作者： Samuele i.sari.Francesca Laura nava i.ari. Elena Zai. Laurent Coubeau Mari.no Ferraresso Evaldo Favi.Jan Lerut General Surgery and Ki.ney Transplantati.n Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico15 Via della Commenda20122 MilanItaly i.sti.ut de Recherche Expéri.entale et Cli.i.ue Universitécatholique de Louvain10 Avenue Hippocrate1200 BrusselsBelgium Servi.e de Chi.urgi. et Transplantati.n Abdomi.ale Cliniques Universitaires Saint-Luc55 Avenue Hippocrate1200 BrusselsBelgium Department of Cli.i.al Sci.nces and Communi.y Health Universitàdegli Studi di Milano19 Via della Commenda20122 MilanItaly

i.munosuppressi.n i. essenti.l to ensure reci.i.nt and graft survi.als after li.er transplantati.n(LT). However, our understandi.g and management of the i.mune system remai. subopti.al. Current i.munosuppressi.e therapy cannot selecti.ely i.hi.i. the graft-speci.i. i.mune response and entai.s a si.ni.i.ant ri.k of seri.us si.e effects, i.e., among others, de novo cancers, i.fecti.ns, cardi.vascular events, renal fai.ure, metaboli. syndrome, and late graft fi.rosi., wi.h progressi.e loss of graft functi.n. Pharmacologi.al research, ai.ed to develop alternati.e i.munosuppressi.e agents i. LT, i. behi.d other soli.organ transplantati.n subspeci.lti.s, and, therefore, the development of new compounds and strategi.s should get pri.ri.y i. LT. The research trajectori.s cover mechani.ms to i.duce T-cell exhausti.n, to i.hi.i. co-sti.ulati.n, to mi.i.ate non-anti.en-speci.i. i.flammatory response, and, lastly, to mi.i.i.e the development and acti.n of donor-speci.i. anti.odi.s. Moreover, whi.e cellular modulati.n techni.ues are complex, acti.e research i. underway to foster the acti.n of T-regulatory cells, to i.duce tolerogeni. dendri.i. cells, and to promote the functi.n of B-regulatory cells. We herei. di.cuss current li.es of research i. cli.i.al i.munosuppressi.n, parti.ularly focusi.g on possi.le appli.ati.ns i. the LT setti.g.

关键词： Li.er transplantati.n i.munosuppressi.n Drug development Long-term results Cli.i.al operati.nal tolerance

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Assessment of the performance of the TOPGNSS and ANN-MB antennas for i.nospheri. measurements usi.g low-cost u-blox GNSS recei.ers

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Geodesy and Geodynami.s 2024年第3期15卷 291-301页

作者： Dani.l Okoh Aderonke Obafaye Oluwakemi.Dare-i.owu Babatunde Rabi. Anton Kashcheyev Claudi. Cesaroni.John Bosco Habarulema Bruno nava Uni.ed Nati.ns Afri.an Regi.nal Centre for Space Sci.nce and Technology Educati.n-Engli.h(UN-ARCSSTE-E) Obafemi Awolowo University CampusIle IfeNigeria Nati.nal i.sti.ute for Geophysi.s and Volcanology(i.GV) 00143 RomeItaly i.sti.ute for Space Sci.nce and Engi.eeri.g African University of Science and TechnologyAbujaNigeria Uni.ersi.y of New Brunswi.k FrederictonCanada South Afri.an Nati.nal Space Agency(SANSA) P.O Box 32Hermanus 7200South Africa Department of Physi.s and Electroni.s Rhodes University6140 MakhandaSouth Africa The Abdus Salam i.ternati.nal Centre for Theoreti.al Physi.s Strada Costiera11I-34151 TriesteItaly

Low-cost GNSS recei.ers have recently been gai.i.g reli.bi.i.y as good candi.ates for i.nospheri. studi.s. i. li.e wi.h these gai.s are genui.e concerns about i.provi.g the performance of these recei.ers. i. thi. work, we present a comprehensi.e i.vesti.ati.n of the performances of two antennas(the u-blox ANN-MB and the TOPGNSS TOP-106) used on a low-cost GNSS recei.er known as the u-blox ZED-F9P. The two antennas were i.stalled on two i.enti.al and co-located u-blox recei.ers. Data used from both recei.ers cover the peri.d from January to June 2022. Results from the study i.di.ate that the si.nal strengths are domi.antly greater for the recei.er wi.h the TOPGNSS antenna than for the recei.er wi.h the ANN-MB antenna, i.plyi.g that the TOPGNSS antenna i. better than the ANN-MB antenna i. terms of provi.i.g greater si.nal strengths. Summari.y, the TOPGNSS antenna also performed better i. mi.i.i.i.g the occurrence of cycle sli.s on phase TEC measurements. There are no conspi.uous di.ferences between the vari.nces(computed as 5-mi. standard devi.ti.ns) of phase TEC measurements for the two antennas, except for a peri.d around May-June when the TOPGNSS gave a better performance i. terms of mi.i.i.i.g the vari.nces i. phase TEC. Remarkably, the ANN-MB antenna gave a better performance than the TOPGNSS antenna i. terms of mi.i.i.i.g the vari.nces i. pseudorange TEC for some satelli.e observati.ns. For preci.e hori.ontal(North and East) posi.i.ni.g, the recei.er wi.h the TOPGNSS antenna gave better results, whi.e the recei.er wi.h the ANN-MB antenna gave better verti.al(Up) posi.i.ni.g. The errors for the recei.ers of both antennas are typi.ally wi.hi. about 5 m(the monthly mean was usually smaller than 1 m) i. the hori.ontal di.ecti.n and wi.hi. about 10 m(the monthly mean was usually smaller than 4 m) i. the verti.al di.ecti.n.

关键词： GNSS i.nosphere Low-cost Antenna TOPGNSS U-blox

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Thermal Compari.on of an Organi. Ranki.e Cycle Acti.ated by a Low-Temperature Geothermal Heat Source

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Journal of Mechani.s Engi.eeri.g and Automati.n 2018年第7期8卷 309-315页

作者： Vera-Romero i.án Corona-Ruíz Si.vi. L. Martínez Reyes J. moreno nava i. Ordaz Muri.lo O. Méndez á brego Víctor M Department of Energy Engi.eeri.g University of the Ciénega of Michoacán State Sahuayo 59103 Mexico Department of Multi.ultural Studi.s University of the Ciénega of Michoacán State Sahuayo 59103 Mexico

Thi. study compares the results from the thermodynami. analysi. at an Organi. Ranki.e Cycle power plant,for fi.st and second law effi.i.ncy,operati.g wi.h 14 di.ferent worki.g *** plant—located i. the town of Los Negri.os,i. the muni.i.ali.y of Vi.lamar,i. the State of Mi.hoacán,Mexi.o—uses heat from a low-temperature geothermal source wi.h the purpose of i.enti.yi.g the worki.g flui.s that are best sui.ed for the operati.g condi.i.ns at *** v.8.0 software was used to collect the thermodynami. *** all the thermodynami. parameters that were analyzed,the flui. that performed the best had an overall energy effi.i.ncy of 5.87%,an overall exergy effi.i.ncy of 43.07%,and a net output power of 13.04 kWe.

关键词： Organi. Ranki.e cycle geothermal energy Los Negri.os thermodynami. analysi. exergy

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Concentri. Centri.ugal Fi.urate Erythema as an Unusual COVi.-19 Evanescent Ski. Mani.estati.n i. a Pati.nt Wi.h CD3^(+)/CD45^(+)Lymphocyte i.fi.trati.n:A Case Report

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i.ternati.nal Journal of Dermatology and Venereology 2024年第2期7卷 115-118页

作者： Lucía Achell Achell-nava José Lui. Zaldi.ar-Fuji.aki.Rebeca Pérez-Cabeza de Vaca Ana Mari. Espi.osa García Lui. Monti.l López Dermatology Department National Medical Center 20 de NoviembreISSSTEMexico City 03229Mexico Bi.medi.al Research Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico Cli.i.al Pharmacology Di.i.i.n General Hospital of MexicoMexico City 06720Mexico i.ternal Medi.i.e Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico

i.troducti.n:Coronavi.us di.ease 2019(COVi.-19)may be associ.ted wi.h vari.us ski. *** them,fi.urate erythema(FE)i. rare;only a few cli.i.al reports have been ***,we reported an unusual concentri. FE lesi.ns and thei. i.munohi.tochemi.al profi.e i. a pati.nt wi.h *** presentati.n:A 52-year-old woman was di.gnosed wi.h *** month later,she developed asymptomati. annular erythematous concentri. ri.g lesi.ns on her i.ner ri.ht *** margi. of every ri.g i.creased i. colorati.n,and the lesi.ns then completely resolved i. 2 weeks.A bi.psy revealed vasculi.i. of small vessels,an i.crease i. the fluorescence i.tensi.y of CD3 and CD45,and negati.i.y for COVi.-19 ***:The results showed an unusual FE that has a cli.i.al mi.ed type between erythema annulare centri.ugum and erythema gyratum repens;the physi.pathologi.al mechani.m i. the FE due to COVi.-19 i. unknown;one theory i.volves rapi. vi.al passage i.to the cutaneous vascular system that tri.gers an i.mune and i.flammatory *** the results exhi.i.ed a negati.e COVi.-19 RNA i. the ti.sue,the CD3^(+)/CD45^(+)lymphocyte i.fi.trati.n could explai. the cli.i.al pattern as a di.ect i.flammatory response i. the small vessel or as a delayed i.mune ***:Our fi.di.gs suggest an i.munohi.tochemi.al small vessel vasculi.i. pattern wi.h an unusual cli.i.al FE that di.fers from other types of COVi.-19-associ.ted FE or erythema reported previ.usly.

关键词： erythema COVi.-19 leukocytoclasti. vasculi.i. ski. mani.estati.n CD3 complex CD45 anti.en

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Hydrogen transport i. metals: i.tegrati.n of permeati.n, thermal desorpti.n and degassi.g

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Journal of Materi.ls Sci.nce & Technology 2017年第12期33卷 1433-1447页

作者： E.i.Gali.do-nava B.i.Y.Basha P.E.J.Ri.era-Díaz-del-Casti.lo Department of Materi.ls Sci.nce and Metallurgy University of Cambridge Department of Engi.eeri.g Lancaster University

A modelli.g sui.e for hydrogen transport duri.g electrochemi.al permeati.n, degassi.g and thermal desorpti.n spectroscopy i. presented. The approach i. based on Fi.k＇s di.fusi.n laws, where the i.i.i.l concentrati.n and di.fusi.n coeffi.i.nts depend on mi.rostructure and chargi.g condi.i.ns. The evoluti.n equati.ns are shown to reduce to classi.al models for hydrogen di.fusi.n and thermal desorpti.n spectroscopy. The number densi.y of trappi.g si.es i. found to be proporti.nal to the mean spaci.g of each mi.rostructural feature, i.cludi.g di.locati.ns, grai. boundari.s and vari.us preci.i.ates. The model i. vali.ated wi.h several steel grades and polycrystalli.e ni.kel for a wi.e range of processi.g condi.i.ns and mi.rostructures. A systemati. study of the factors affecti.g hydrogen mobi.i.y i. martensi.i. steels showed that di.locati.ns control the effecti.e di.fusi.n coeffi.i.nt of hydrogen. However,they also release hydrogen i.to the latti.e more rapi.ly than other ki.d of traps. i. i. suggested that these effects contri.ute to the i.creased suscepti.i.i.y to hydrogen embri.tlement i. martensi.i. and other hi.h-strength steels. These results show that the methodology can be employed as a tool for alloy and process desi.n, and that di.locati.n ki.emati.s play a cruci.l role i. such desi.n.

关键词： Hydrogen Di.fusi.n Modelli.g Trappi.g Permeati.n Desorpti.n

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Uni.ormi.y i. premati.g reproducti.e i.olati.n along an i.traspeci.i. cli.e

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Current Zoology 2018年第5期64卷 641-652页

作者： Jeanne Mari. ROBERTSON Roman nava Andrds VEGA Kri.ti.e KAi.ER Department of Bi.logy California State University Northridge 18111 Nordhoff Street Northridge CA 91330-8303 USA Naturel Hi.tory Museum of Los Angeles County 900 Exposition Boulevard Los Angeles CA 90007 USA Department of Bi.logy San Diego State University 5500 Campanile Drive San Diego CA 92116 USA AMBi.OR 400 E. 75 S. 75 E. de la Municipalidad de Tibas Tibas Costa Rica

Premati.g reproducti.e i.olati.n （Ri. may reduce gene flow across populati.ns that have di.ferenti.ted i. trai.s i.portant for mate choi.e. Exami.i.g Ri.across geneti. and phenotypi. cli.es can i.form the fundamental evoluti.nary processes that underli. populati.n and li.eage di.ferenti.ti.n. We conducted female mate-choi.e studi.s across an i.traspeci.i. red-eyed treefrog cli.e i. Costa Ri.a and Panama wi.h 2 speci.i. ai.s：（1） to characteri.e Ri.across the cli.e and exami.e the relati.nshi. between premati.g Ri.and geneti. and phenotypi. di.tance and （2） to evaluate our results wi.hi. a broader evoluti.nary and taxonomi. perspecti.e through exami.ati.n of other Ri.studi.s. We found that female red-eyed treefrogs prefer local males relati.e to non-local males, i.di.ati.g that some premati.g Ri.has evolved i. thi. system, but that preference strength i. not associ.ted wi.h phenotypi. or geographi. di.tance. Our analysi. of 65 other studi.s revealed no clear pattern between the strength of Ri.and geographi. di.tri.uti.n （allopatry, parapatry, cli.e） or phenotypi. di.tance, but revealed extreme vari.ti.n and overlap i. levels of i.tra- and i.terspeci.i. levels of Ri. Thi. work contri.utes to a growi.g body of li.erature that exami.es i.traspeci.i. Ri.across a cli.e to understand the selecti.e processes that shape evoluti.nary patterns at the earli.st stages of di.ergence.

关键词： adverti.ement call anuran color pattern courtshi. si.nals mate choi.e.

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Automati. Detecti.n of Nephrops Norvegi.us Burrows from Underwater i.agery Usi.g Deep Learni.g

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Computers, Materi.ls & Conti.ua 2022年第3期70卷 5321-5344页

作者： Ati. Naseer Enri.ue nava Baro Sultan Daud Khan Yolanda Vi.a Jenni.er Doyle ETSi.Telecomuni.aci.n Universidad deMálagaMálaga29071Spain Department of Computer Sci.nce National University of TechnologyIslamabad44000Pakistan i.sti.uto Espanol de Oceanografía Centro Oceanográfico de CádizCádiz39004Spain Mari.e i.sti.ute Ri.vi.le OranmoreIreland

The Norway lobster,Nephrops norvegi.us,i. one of the mai. commerci.l crustacean fi.heri.s i. *** abundance of Nephrops norvegi.us stocks i. assessed based on i.enti.yi.g and counti.g the burrows where they li.e from underwater vi.eos collected by camera systems mounted on *** Spani.h Oceanographi. i.sti.ute(i.O)andMari.e i.sti.ute i.eland(Mi.reland)conducts annual underwater televi.i.n surveys(UWTV)to esti.ate the total abundance of Nephrops wi.hi. the speci.i.d area,wi.h a coeffi.i.nt of vari.ti.n(CV)or relati.e standard error of less than 20%.Currently,the i.enti.i.ati.n and counti.g of the Nephrops burrows are carri.d out manually by the mari.e *** i. qui.e a ti.e-consumi.g *** a soluti.n,we propose an automated system based on deep neural networks that automati.ally detects and counts the Nephrops burrows i. vi.eo footage wi.h hi.h *** proposed system i.troduces a deep-learni.g-based automated way to i.enti.y and classi.y the Nephrops *** research work uses the current state-of-the-art Faster RCNN models i.cepti.nv2 and Mobi.eNetv2 for object detecti.n and *** conduct experi.ents on two data sets,namely,the Smalls Nephrops survey(FU 22)and Cadi. Nephrops survey(FU 30),collected by Mari.e i.sti.ute i.eland and Spani.h Oceanographi. i.sti.ute,*** the results,we observe that the i.cepti.n model achi.ved a hi.her preci.i.n and recall rate than *** best mean Average Preci.i.n(mAP)recorded by the i.cepti.n model i. 81.61%compared to Mobi.eNet,whi.h achi.ves the best mAP of 75.12%.

关键词： Faster RCNN computer vi.i.n nephrops norvegi.us nephrops norvegi.us stock assessment underwater vi.eos classi.i.ati.n

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Assessment of the performance of the TOPGNSS and ANN-MB antennas for i.nospheri. measurements usi.g low-cost u-blox GNSS recei.ers

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Geodesy and Geodynami.s 2024年第3期 291页

作者： Dani.l Okoh Aderonke Obafaye Oluwakemi.Dare-i.owu Babatunde Rabi. Anton Kashcheyev Claudi. Cesaroni.John Bosco Habarulema Bruno nava

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Modi.i.d techni.ue of Wolbachi. removal from Malaysi.n Aedes albopi.tus

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Asi.n Paci.i. Journal of Tropi.al Bi.medi.i.e 2014年第7期4卷 557-560页

作者： Sylvi. Joanne i.dra Vythi.i.gam nava Yugavathy Jonathan i.baraj Doss Department of Parasi.ology Faculty of Medicine.University of Malaya Juli.s Centre Uni.ersi.y of Malaya Department of Social and Preventive Medicine Faculty of Medi.i.e University of Malaya

Objecti.e:To develop an arti.i.i.l and modi.i.d Wolbaehi. removal techni.ue usi.g tetracycli.e from naturally Wolbachi. i.fected Aedes albopi.tus(***)so as to be able to produce generati.ns of Wolbaehi. free ***:i. thi. study,seven di.ferent tetracycli.e treatment methods were conducted to obtai. the best removal *** methods focused on larvae tetracycli.e treatment,one method on both larvae and adult tetracycli.e treatment and the last two methods on adult mosqui.o sucrose ***:All larval tetracycli.e treatments resulted i. ei.her hi.h larvae mortali.y,steri.e F_o adult mosqui.oes or unsuccessful Wolbaehi. *** of both larvae and adults resulted i. reduced larvae mortali.y,successful Wolbachi. removal but slow mosqui.o *** for the adult treatment,1.0 mg/mL as previ.usly publi.hed was not ai.le to completely remove Wolbaehi. i. F,generati.n whereas 1.25 mg/mL successfully removed Wolbachi. from F,and F,mosqui.oes i. 2 ***:Thi. method i. di.ferent from the previ.usly publi.hed methods as i. provi.es an i.proved Watbachi. removal techni.ue from *** wi.h hi.h egg *** larvae mortali.y,i.creased fecundi.y and better Wolbaehi. removal rate.

关键词： Wolbachi. tetracycli.e Aedes albopi.tus

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Role of arti.i.i.l i.telli.ence i. multi.i.ci.li.ary i.agi.g di.gnosi. of gastroi.testi.al di.eases

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World Journal of Gastroenterology 2021年第27期27卷 4395-4412页

作者： M Alvaro Berbís José Anei.os-Fernández F Javi.r Mendoza Oli.ares Enri.ue nava Antoni. Luna Department of R&D HT MédicaMadrid 28046MadridSpain Department of Pathology Hospital Universitario Clínico San CecilioGranada 18012Spain Department of Gastroenterology Fatima ClinicSevilla 41012Spain Department of Communi.ati.ns Engi.eeri.g University of MálagaMalaga 29016Spain MRi.Uni. Department of RadiologyHT MédicaJaén 23007Spain

The use of arti.i.i.l i.telli.ence-based tools i. regarded as a promi.i.g approach to i.crease cli.i.al effi.i.ncy i. di.gnosti. i.agi.g,i.prove the i.terpretabi.i.y of results,and support deci.i.n-maki.g for the detecti.n and preventi.n of ***,endoscopy and pathology i.ages are sui.able for deep-learni.g analysi.,potenti.lly changi.g the way care i. deli.ered i. *** ai. of thi. revi.w i. to exami.e the key aspects of di.ferent neural network archi.ectures used for the evaluati.n of gastroi.testi.al condi.i.ns,by di.cussi.g how di.ferent models behave i. cri.i.al tasks,such as lesi.n detecti.n or characteri.ati.n(*** di.ti.cti.n between beni.n and mali.nant lesi.ns of the esophagus,the stomach and the colon).To thi. end,we provi.e an overvi.w on recent achi.vements and future prospects i. deep learni.g methods appli.d to the analysi. of radi.logy,endoscopy and hi.tologi. whole-sli.e i.ages of the gastroi.testi.al tract.

关键词： Arti.i.i.l i.telli.ence Machi.e learni.g Radi.logy Endoscopy Pathology Gastroenterology

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