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Laser generation of iron-doped silver nanotruffles with magnetic and plasmonic properties

Nano Research 2015年第12期8卷 4007-4023页

作者： Vincenzo Amendola Stefano Scaramuzza Stefano Agnoli Gaetano Granozzi moreno meneghetti Giulio Campo Valentina Bonanni Francesco Pineider Claudio Sangregorio Paolo Ghigna Stefano Polizzi Piero Riello Stefania Fiameni Luca Nodari Department of Chemical Sciences Universita di Padova Padova 1-35131 Italy Department of Chemistry University of Florence & INSTM Florence 1-50019 Italy ICCOM-CNR Sesto Fiorentino Florence 1-50019 Italy Department of Chemistry Universitta di Pavia Pavia 1-27100 Italy Department of Molecular Sciences and Nanosystems Universita Ca' Foscari Venezia and INSTM UdR Venezia Venezia-Mestre 1-30172 Italy CNR - IENI Padova 1-35127 Italy

A frontier topic in nanotechnology is the realization of multifunctional nanoparticles （NPs） via the appropriate combination of different elements of the periodic table. The coexistence of Fe and Ag in the same nanostructure, for instance, is interesting for nanophotonics, nanomedicine, and catalysis. However, alloying of Fe and Ag is inhibited for thermodynamic reasons. Here, we describe the synthesis of Fe-doped Ag NPs via laser ablation in liquid solution, bypassing thermodynamics constraints. These NPs have an innovative structure consisting of a scaffold of face-centered cubic metal Ag alternating with disordered Ag-Fe alloy domains, all arranged in a truffle-like morphology. The Fe-Ag NPs exhibit the plasmonic properties of Ag and the magnetic response of Fe-containing phases, and the surface of the Fe-Ag NPs can be functionalized in one step with thiolated molecules. Taking advantage of the multiple properties of Fe-Ag NPs, the magnetophoretic amplification of plasmonic properties is demonstrated with proof-of-concept surface-enhanced Raman scattering and photothermal heating experiments. The synthetic approach is of general applicability and virtually permits the preparation of a large variety of multi-element NPs in one step.

关键词： silver nanotruffles iron nanoparticles laser ablation laser ablation synthesis in solution(LASiS) nanoalloys

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Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： Pedro moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Individual and demographic responses of a marsh bird assemblage to habitat loss and subsequent restoration

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Avian Research 2020年第1期11卷 25-33页

作者： Ruben moreno-Opo Monticola Ornithological Group Faculty of BiologyUniversity Autonoma of MadridMadrid 28049Spain Deputy Directorate on Biodiversity Ministry for the Ecological TransitionMadrid 28071Spain

Background: The alteration and loss of habitats are two of the main threats that biodiversity conservation is cur?rently facing up to. The present study describes the effects of a perturbation and restoration in a reedbed habitat on a bird assemblage. We studied the bird community of a wetland of central Spain between 1995 and 2009, during which time an anthropic perturbation altered the original structure of the habitat;subsequently, as a result of restoration works, the habitat returned to its original ***: We evaluated the effects on six population and physical parameters of the birds at three different phases of their life cycles(breeding, wintering and post?breeding migration seasons) before, during and after the habitat alteration. GLM was used to analyze the influence of three independent variables(year, perturbation phase and temperature).Results: The relative abundance and the species richness values decreased when habitat was altered, but then recovered as a result of the regeneration works. This pattern was the clearest amongst specialist species. Breeding success also declined during the perturbation phase and then increased;likewise, the sex ratio changed given that the proportion of male birds increased when habitat was altered. These results are discussed in relation to changes on availability of resources in altered habitats, to the adaptive mechanisms in the exploitation of ecological requirements and to the selection of optimum and sub?optimum habitats by generalist and specialist ***: Ecosystem restoration can favour the recovery of population indexes of specialist passerines, although it depends on the efficiency of the type of restoration activity performed and on the complexity of the habitat.

关键词： Habitat loss Land-use planning Marsh Restoration Ringing station Reedbed

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Aerosol transmission of human pathogens:From miasmata to modern viral pandemics and their preservation potential in the Anthropocene record

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Geoscience Frontiers 2022年第6期13卷 210-223页

作者： Teresa moreno Wes Gibbons Institute of Environmental Assessment and Water Research IDAEA-CSIC08034 BarcelonaSpain Bimón Press Sitges08870 BarcelonaSpain

Ongoing uncertainty over the relative importance of aerosol transmission of COVID-19 is in part rooted in the history of medical science and our understanding of how epidemic diseases can spread through human populations. Ancient Greek medical theory held that such illnesses are transmitted by airborne pathogenic emanations containing particulate matter(“miasmata”). Notable Roman and medieval scholars such as Varro, Ibn al-Khatib and Fracastoro developed these ideas, combining them with early germ theory and the concept of contagion. A widely held but vaguely defined belief in toxic miasmatic mists as a dominant causative agent in disease propagation was overtaken by the science of 19th century microbiology and epidemiology, especially in the study of cholera, which was proven to be mainly transmitted by contaminated water. Airborne disease transmission came to be viewed as burdened by a dubious historical reputation and difficult to demonstrate convincingly. A breakthrough came with the classic mid-20th century work of Wells, Riley and Mills who proved how expiratory aerosols(their “droplet nuclei”)could transport still-infectious tuberculosis bacteria through ventilation systems. The topic of aerosol transmission of pathogenic respiratory diseases assumed a new dimension with the mid-late 20th century “Great Acceleration” of an increasingly hypermobile human population repeatedly infected by different strains of zoonotic viruses, and has taken centre stage this century in response to outbreaks of new respiratory infections that include coronaviruses. From a geoscience perspective, the consequences of pandemic-status diseases such as COVID-19, produced by viral pathogens utilising aerosols to infect a human population currently approaching 8 billion, are far-reaching and unprecedented. The obvious and sudden impacts on for example waste plastic production, water and air quality and atmospheric chemistry are accelerating human awareness of current environmental chal

关键词： COVID-19 History of epidemics Aerosol disease transmission Coronavirus Anthropocene record

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Extreme climatic events in relation to global change and their impact on life histories

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Current Zoology 2011年第3期57卷 375-389页

作者： Juan moreno Anders Pape Moller Departamento de Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC C/Jod Gutierrez Abascal 2 E-28006 Madrid Spain Laboratoire d'Ecologie Systematique et Evolution CNRS UMR 8079 Universite Paris-Sud Bfttiment 362 F-91405 Orsay Cedex Franc

Extreme weather conditions occur at an increasing rate as evidenced by higher frequency of hurricanes and more extreme precipitation and temperature anomalies. Such extreme environmental conditions will have important implications for all living organisms through greater frequency of reproductive failure and reduced adult survival. We review examples of reproductive failure and reduced survival related to extreme weather conditions. Phenotypic plasticity may not be sufficient to allow adaptation to extreme weather for many animals. Theory predicts reduced reproductive effort as a response to increased stochasticity. We predict that patterns of natural selection will change towards truncation selection as environmental conditions become more extreme. Such changes in patterns of selection may facilitate adaptation to extreme events. However, effects of selection on reproductive effort are difficult to detect. We present a number of predictions for the effects of extreme weather conditions in need of empirical tests. Finally, we suggest a number of empirical reviews that could improve our ability to judge the effects of extreme environmental conditions on life history [Current Zoology 57 （3）： 375-389, 2011].

关键词： Bet hedging Climate change Extreme weather Reproductive failure Truncation selection

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An Approach to Design MIMO FO Controllers for Unstable Nonlinear Plants

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IEEE/CAA Journal of Automatica Sinica 2016年第3期3卷 338-344页

作者： Arturo Rojas-moreno IEEE Department of Electrical Engineering Universidad de Ingenieriay Tecnologia (www.utec.edu.pe)

This paper develops an approach to control unstable nonlinear multi-inputs multi-output(MIMO) square plants using MIMO fractional order(FO) controllers. The controller design uses the linear time invariant(LTI) state space representation of the nonlinear model of the plant and the diagonal closedloop transfer matrix(TM) function to ensure decoupling between inputs. Each element of the obtained MIMO controller could be either a transfer function(TF) or a gain. A TF is associated in turn with its corresponding FO TF. For example, a D(Derivative) TF is related to a FO TF of the form Dδ, δ =[0, 1]. Two applications were performed to validate the developed approach via experimentation: control of the angular positions of a manipulator, and control of the car and arm positions of a translational manipulator.

关键词： Fractional calculus modeling of nonlinear sys-tem control of manipulator multivariable decoupling multivari-able nonlinear system

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Combining X-ray microtomography with computer simulation for analysis of granular and porous materials

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Particuology 2010年第2期8卷 81-99页

作者： Roberto moreno-Atanasio Richard A. Williams Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

The use of X-ray microtomographic （XMT） methods in analysing particulate systems has expanded rapidly in recent years with the availability of affordable desk-top apparatus. This review presents a summary of the major applications in which computer simulations are explicitly coupled with XMT in the area of granular and porous materials. We envisage two main ways of establishing the coupling between both techniques, based on the transference or exchange of information by using physical or geometrical parameters （i.e. a parametric link through fitting to a process model） or through the direct use of3D XMT digital images （i.e. comparing image pixels and features directly）. Examples of coupled applications are shown for the study of transport properties of rocks, particle packing, mechanical loading and sintering. Often, the link between XMT and computer simulations is based on visual comparisons and we conclude that the use of quantitative parameters such as the number of interparticle contacts, force networks or granule shape to link both techniques is still underrepresented in the literature. Strategies to provide a more robust and quantitative approach to optimise the information obtained from such tomography analyses are proposed. 2010 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

关键词： X-ray microtomographyGranular flowComputer modellingLattice Boltzmann methodDiscrete element method

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Biomimetic Control of Mechanical Systems Equipped with Musculotendon Actuators

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Journal of Bionic Engineering 2011年第1期8卷 56-68页

作者： Javicr moreno-Valenzuel Adriana Salinas-Avila Instituto Politecnico Naoional-CITEDl Av. del Parque 1310 Mesa de Otay Tianjuana B.C. 22510 Mexico

This paper addresses the problem of modelling, control, and simulation of a mechanical system actuated by an agonist-antagonist musculotendon subsystem. Contraction dynamics is given by case 1 of Zajac＇s model. Saturated semi positive proportional-derivative-type controllers with switching as neural excitation inputs are proposed. Stability theory of switched system and SOSTOOLS, which is a sum of squares optimization toolbox of Matlab, are used to determine the stability of the obtained closed-loop system. To corroborate the obtained theoretical results numerical simulations are carried out. As additional contribution, the discussed ideas are applied to the biomimetic control of a DC motor, i.e., the position control is addressed assuming the presence of musculotendon actuators. Real-experiments corroborate the expected results.

关键词： biomimetie control musculotendon dynamics neural excitation saturation switched systems

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