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Pulmonary artery stent thrombosis and symptomatic pulmonary hypertension following COVID-19 infection in Alagille patient:A case report

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World Journal of Clinical Cases 2025年第9期13卷 24-29页

作者： Shimon Izhakian Miriam Korlansky Dror Rosengarten Elchanan Bruckheimer mordechai reuven kramer Pulmonary Institute Rabin Medical CenterPetach Tikva 49100Israel Cardiac Catheterization Laboratory Schneider Children's Medical CenterPetach Tikva 49100Israel

BACKGROUND Alagille syndrome is a multisystem disease that results in various vascular anomalies,commonly involving the cardiac and pulmonary *** the best of our knowledge,there is no literature regarding the cardiovascular outcomes of these patients in association with coronavirus disease 2019(COVID-19).CASE SUMMARY A 34-year-old woman with a history of Alagille syndrome who underwent successful atrial septal defect with partial anomalous pulmonary veins and patent ductus arteriosus repair,as well as left pulmonary artery catheterization and stenting in childhood due to pulmonary *** patient was without any respiratory symptoms and was a dancer prior to contracting *** weeks after her COVID-19 infection,she developed left pulmonary artery stent thrombosis and subsequent symptomatic pulmonary hypertension.A treatment strategy of anticoagulation alongside pharmacological agents for pulmonary hypertension for 3 months followed by balloon pulmonary artery angioplasty to reopen the stenosis was *** In the era of COVID-19,patients with pulmonary vascular malformations and endovascular stents are at an increased risk for chronic thromboembolic *** may benefit from prophylactic antiplatelet or anticoagulation *** thrombosis is a devastating phenomenon and should be treated urgently and aggressively with balloon pulmonary angioplasty,and/or a thrombolytic agent.

关键词： Alagille syndrome Pulmonary artery stent Stent thrombosis COVID-19 Chronic thromboembolic pulmonary hypertension Pulmonary hypertension Case report

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