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Nano Research 2019年第4期12卷 759-766页

作者： Almudena Benitez Alvaro Caballero j.lian morales j.sef Hassoun Enrique Rodriguez-Castellon j.sus Canales-Vazquez Dpto. Quimica Inorganica e Ingenieria Qutmica Instituto de Quimica Fina y Nanoquimica Universidad de Cordoba 14071 Cordoba Spain Departm ent of Chemical and Pharmaceutical Sciences University of Ferrara Via Fossato di Mortara 17 44121 Ferrara Italy Dpto. de Quimica Inorganica Cristalografia y Mineralogia Facultad de Ciencias Universidad de Malaga 29071 Malaga Spain Instituto de Energias Renovables Universidad de Castilla-La Mancha Paseo de La Investigacion 1 Albacete 02071 Spain

Graphe ne nano sheets are a promising scaffold to accommodate S for achievi ng high performa nee Li/S battery. Nano sheet activation is used as a viable strategy to induce a micropore system and further improve the battery performance. Accordingly, chemical activation methods dominate despite the need of multiple stages, which slow down the process in addition to making them tiresome. Here, a three-dimensional (3D) N-doped graphene specimen was physically activated with CO2, a clean and single step process, and used for the preparation of a sulfur composite (A-3DNG/S). The A-3DNG/S composite exhibited outstanding electrochemical properties such as an excellent rate capability (1,000 mAh·g^-1 at 2C), high reversible capacity and cycling stability (average capacity ~ 800 mAh·g^-1 at 1C after 200 cycles), values which exceed those measured in chemically activated graphene. Therefore, these results support the use of physical activation as a simple and efficient alternative to improve the performance of carbons as an S host for high-performance Li-S batteries.

关键词： physical activation 3D-graphene solvothermal microwave synthesis Li-S battery

On a Shallow Water Model for the Simulation of Turbidity Currents

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Communications in Computational Physics 2009年第9期6卷 848-882页

作者： T.morales de Luna M.j.Castro Dıaz C.Pares Madronal E.D.Fernandez Nieto Analisis Matematico Facultad de Ciencias–Univ.MalagaCampus de Teatinoss/n29071-MalagaSpain Dpto.Matematica Aplicada I ETS Arquitectura–Univ.SevillaAvda.Reina Mercedes N.241012-SevillaSpain

We present a model for hyperpycnal plumes or turbidity currents that takes into account the interaction between the turbidity current and the bottom,considering deposition and erosion effects as well as solid transport of particles at the bed load due to the *** entrainment from the ambient water in which the turbidity current plunges is also *** of ambient water is neglected and the rigid lid assumption is *** model is obtained as a depth-average system of equations under the shallow water hypothesis describing the balance of fluid mass,sediment mass and mean *** character of the system is analyzed and numerical simulations are carried out using finite volume schemes and path-conservative Roe schemes.

关键词： Turbidity currents hyperbolic systems finite volume methods path-conservative schemes numerical modeling

Simultaneous pars plana vitrectomy,panretinal photocoagulation,cryotherapy,and Ahmed valve implantation for neovascular glaucoma

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International j.urnal of Ophthalmology(English edition) 2021年第9期14卷 1396-1401页

作者： Carolina Bernal-morales Marina Dotti-Boada Alvaro Olate-Perez Manuel j.Navarro-Angulo Laura Pelegrín Marc Figueras-Roca Institut Clínic d’Oftalmologia(ICOF) Hospital ClínicBarcelona 08028Spain August Pi i Sunyer Biomedical Research Institute(IDIBAPS) Barcelona 08028Spain

AIM:To describe and evaluate the efficacy of Ahmed glaucoma valve implantation(AGV)combined with pars plana vitrectomy(PPV)in a single surgical act for the treatment of advanced neovascular glaucoma(NVG).METHODS:Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV,AGV,and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period(2005-2018).Preoperative,intraoperative and postoperative data at day 1 and months 1,3,6,21,and 24 were systematically *** of surgical success was stablished at IOP between 6 and 21 mm Hg with or without topical ***:Main indications for surgery were NVG secondary to proliferative diabetic retinopathy(39.2%)and central retinal vein occlusion(37.3%).Mean(±SD)preoperative IOP was 42.0±11.2 mm Hg decreasing to 15.5±7.1 mm Hg at 12 mo and 15.8±9.1 mm Hg at 24 mo of follow *** incidence of success of IOP control was 76.0%at first postoperative month,reaching 88.3%at 6 *** of successful IOP control at long term was 74.4%at 12 mo and 71.4%at 24 *** evisceration for unsuccessful NVG management was required in 1 case(2.0%).CONCLUSION:Combination of AGV implantation and PPV in a single act may be a suitable option for severe forms of NVG in a case-by-case basis for effective IOP control and a complete panretinal photocoagulation.

关键词： neovascular glaucoma Ahmed valve pars plana vitrectomy panretinal photocoagulation cryotherapy

Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

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World j.urnal of Gastrointestinal Oncology 2021年第12期13卷 1997-2012页

作者： Armando Roj.s Cristian Lindner Iván Schneider Ileana Gonzàlez Hernan Araya Erik morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel morales Biomedical Research Lab. Medicine FacultyCatholic University of MauleTalca 34600000Chile Department of Clinical Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de Anatomía Patologica Hospital Regional de TalcaTalca 34600000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive *** is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM ***,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to *** the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC.

关键词： Diabetes mellitus Gastric cancer Tumor microenvironment Hyperglycemia Chronic inflammation

Time-frequency multiresolution of fault-generated transient signals in transmission lines using a morphological filter

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Protection and Control of Modern Power Systems 2023年第2期8卷 85-98页

作者： j.an Carlos Quispe j.hn morales Eduardo Orduna Carlo Liebermann Michael Bruhns Peter Schegner Universidad Nacional de San j.an-CONICET San JuanArgentina Universidad Tecnológica del Perú LimaPerú Technical University of Dresden DresdenGermany

The ongoing transformation of electrical power systems highlights the weaknesses of the protection schemes of traditional devices because they are designed and configured according to traditional characteristics of the ***,this work proposes a new methodology to study the fault-generated high frequency transient signals in transmission lines through multiresolution *** high frequency components are determined by a new digital filtering technique based on mathematical morphology theory and a spectral energy ***,wide spectra of signals in the time–frequency domain are *** performance of this method is verified on an electrical power system modeled in ATP-Draw,where simulation and test signals are developed for different locations,fault resistances,inception angles,high frequency noises,sampling frequencies,types of faults,and shapes of the structuring *** results show the characteristics of the fault such as the traveling wave frequency,location,and starting time.

关键词： Digital filter High frequency Mathematical morphology Time–frequency Traveling waves

Assays for predicting and monitoring responses to lung cancer immunotherapy

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Cancer Biology & Medicine 2015年第2期12卷 87-95页

作者： Cristina Teixidó Niki Karachaliou Maria González-Cao Daniela morales-Espinosa Rafael Rosell Pangaea Biotech Quirón Dexeus University Hospital Rosell Oncology Institute Quirón Dexeus University Hospital Cancer Biology and Precision Medicine Program Catalan Institute of OncologyHospital Germans Trias i Pujol

Immunotherapy has become a key strategy for cancer treatment, and two immune checkpoints, namely, programmed cell death 1 （PD-1） and its ligand （PD-L1）, have recently emerged as important targets. The interaction blockade of PD-1 and PD-L1 demonstrated promising activity and antitumor efficacy in early phase clinical trials for advanced solid tumors such as non-small cell lung cancer （NSCLC）. Many cell types in multiple tissues express PD-L1 as well as several tumor types, thereby suggesting that the ligand may play important roles in inhibiting immune responses throughout the body. Therefore, PD-L1 is a critical immunomodulating component within the lung microenvironment, but the correlation between PD-L1 expression and prognosis is controversial. More evidence is required to support the use of PD-L1 as a potential predictive biomarker. Clinical trials have measured PD-L1 in tumor tissues by immunohistochemistry （IHC） with different antibodies, but the assessment of PD-L1 is not yet standardized. Some commercial antibodies lack specificity and their reproducibility has not been fully evaluated. Further studies are required to clarify the optimal IHC assay as well as to predict and monitor the immune responses of the PD-I/PD-L1 pathway.

关键词： Immunotherapy lung cancer programmed cell death 1(PD-1) PD-1 ligand (PD-L1) antibody

Clinical evidence of human pathogens implicated in Alzheimer’s disease pathology and the therapeutic efficacy of antimicrobials:an overview

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Translational Neurodegeneration 2023年第1期12卷 374-390页

作者： Celso S.G.Catumbela Vij.yasree V.Giridharan Tatiana Barichello Rodrigo morales Department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTX 77030USA Translational Psychiatry Program Faillace Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTX 77054USA Graduate Program in Health Sciences University of Southern Santa Catarina(UNESC)CriciúmaSC 88806-000Brazil Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’Higgins8370993 SantiagoChile

A wealth of pre-clinical reports and data derived from human subj.cts and brain autopsies suggest that microbial infections are relevant to Alzheimer’s disease(AD).This has inspired the hypothesis that microbial infections increase the risk or even trigger the onset of *** models have been developed to explain the increase in pathogenic microbes in AD *** this hypothesis is well accepted in the field,it is not yet clear whether microbial neuroinvasion is a cause of AD or a consequence of the pathological changes experienced by the demented *** the same line,the gut microbiome has also been proposed as a modulator of *** this review,we focus on human-based evidence demonstrating the elevated abundance of microbes and microbe-derived molecules in AD hosts as well as their interactions with AD ***,the direct-purpose and potential off-target effects underpinning the efficacy of anti-microbial treatments in AD are also addressed.

关键词： Alzheimer’s disease Amyloid-β Pathogens Infections

Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases:A dangerous liaison?

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World j.urnal of Gastroenterology 2021年第19期27卷 2270-2280页

作者： Armando Roj.s Ivan Schneider Cristian Lindner Ileana Gonzalez Miguel Angel morales Medicine Faculty Catholic University of MauleTalca 3634000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling evidence supports the crucial role of the receptor for advanced glycation end-products(RAGE)axis activation in many clinical *** the beginning of the coronavirus disease 2019 pandemic,there is an increasing concern about the risk and handling of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in inflammatory gastrointestinal disorders,such as inflammatory bowel diseases(IBD).However,clinical data raised during pandemic suggests that IBD patients do not have an increased risk of contracting SARS-CoV-2 infection or develop a more severe course of *** the present review,we intend to highlight how two potentially important contributors to the inflammatory response to SARS-CoV-2 infection in IBD patients,the RAGE axis activation as well as the cross-talk with the renin-angiotensin system,are dampened by the high expression of soluble forms of both RAGE and the angiotensin-converting enzyme(ACE)*** soluble form of RAGE functions as a decoy for its ligands,and soluble ACE2 seems to be an additionally attenuating contributor to RAGE axis activation,particularly by avoiding the transactivation of the RAGE axis that can be produced by the virus-mediated imbalance of the ACE/angiotensin II/angiotensin II receptor type 1 pathway.

关键词： COVID-19 Inflammatory bowel diseases Advanced glycation Angiotensinconverting enzyme 2 Alarmins Receptor for advanced glycation end-products Receptor for advanced glycation end-products axis Inflammation

Potential of RP-UHPLC-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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j.urnal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： María del Mar Contreras Aránzazu morales-Soto Antonio Segura-Carretero j.vier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation < 5%). The detection and quantification limits were 0.07 μg/mL and 0.36 μg/mL, ***, the use of high-resolution MS enabled us to ensure the specificity, check impurities and better sensitivity. Therefore, this methodology promises to be suitable not only for the routine analysis of sofosbuvir in pharmaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir

Anterior myocardial pseudoinfarction in a patient with diabetic ketoacidosis

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j.urnal of Geriatric Cardiology 2018年第3期15卷 238-240页

作者： j.se Ruiz-morales Catarina Canha Farah Al-Saffar Saif Ibrahim Internal medicine department University of Florida Jacksonville FL USA Cardiology Department Mayo Clinic Scottsdale AZ USA Cardiology Department University of Florida Jacksonville FL USA

Diabetic ketoacidosis remains one of the most serious complications of diabetes mellitus. Among its precipitating factors is myocardial ischemia, responsible for 1% of the cases of diabetic *** Diabetic ketoacidosis both with and without hyperkalemia has been reported to mimic a myocardial infarction pattem on ECG with ST segment elevation, described as pseudoinfarction pattern. Thus, it is important to raise awareness among physicians, as subj.cting patients to invasive medical management can be avoided. We present a case of a 47-year-old female with diabetic ketoacidosis and hyperkalemia with initial ECG findings of ST segment elevation, but an urgent left heart catheterization revealed non-obstructive coronary disease.

关键词： Anterior STEMI DKA Heart attack Pseudoinfarction STEMI