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Plasmodium vivax subtelomeric transmembrane protein 1(PvSTP1), a homolog of P. falciparum SURFIN, is highly polymorphic

Plasmodium vivax subtelomeric transmembrane protein 1(PvSTP1...

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第八届全国免疫学学术大会

作者： Xiaotong Zhu morakot kaewthamasorn Kazuhide Yahata Ya-Ming Cao Osamu Kaneko Department of Immunology China Medical University Department of Protozoology Institute of Tropical Medicine (NEKKEN) Nagasaki University

Background and Objective:Plamodium vivax subtelomeric transmembrane protein 1(PvSTP1) is a predicted type I transmembrane protein, which shares homology with the P.falciparum SURFIN proteins that are located on the surface of infected erythrocytes.The structure of SURFIN–PvSTP1 family members incorporate features of several erythrocyte surface parasite-encoded proteins from human, rodent, and monkey malaria parasites;such as Pf EMP-1, pir, and SICAvar.Parasite proteins that are located on the surface of erythrocytes are often highly polymorphic in nature, possibly reflecting the action of positive diversifying selection driven by host immune factors.Methods:We analyzed the level of polymorphism in an 1182 bp nucleotide(nt) region encoding the predicted extracellular domain of PvSTP1 using 70 sequences originating from 52 P.vivax Chinese field isolates.Results:We found that the extracellular domain of PvSTP1 is highly polymorphic;a total of 307 polymorphic sites were observed with an average nucleotide diversity of 0.0999.Based on the predicted protein structure, we divided the sequenced region into two parts:a Cysteine-rich domain(nt 67 – 597) and a variable domain(nt 598 – 1248).Both domains were highly polymorphic with nucleotide diversities of 0.0995 and 0.1010, respectively.A significant excess of nonsynonymous substitutions over synonymous substitutions was detected in the variable domain.Tajima’s D test and Fu & Li’s D* and F* tests all detected the signature of positive selection on extracellular region.Conclusion:Thus, the extracellular region of PvSTP1 appears to have evolved under positive diversifying selection, possibly mediated by host immune pressure.

关键词： Plasmodium vivax Diversity polymorphism selection

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