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World Journal of Gastroenterology 2024年第17期30卷 2308-2310页

作者： Veronika Papp Pál Miheller Department of Surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

Gastric cystica profunda(GcP)is an uncommon but underestimated gastric lesion.Its precancerous potential determines its significance.In addition to previous mucosa injury due to operations,biopsy or polypectomy,chronic active and atrophic gastritis may also lead to the development of GcPs.By carefully examining the stomach and taking biopsy samples from the susceptible regions,the stage of atrophy can be determined.chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GcPs formation.GcPs frequently occur close to early gastric cancers(EGcs)or EGc can arise from the cystic glands.Endoscopic resection is an effective and minimally invasive treat-ment in GcP.

关键词： Gastric cystica profunda chronic active gastritis Atrophic gastritis Operative link for Gastritis Assessment staging Early gastric cancer Endoscopic resection

Mulberry Biomass-Derived Nanomedicines Mitigate colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu cheng Xu Wei Sun Erhu Zhao Min Wang Rui l.Reis Subhas c.Kundu Xiaoxiao Shi Bo Xiao State Key laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China chongqing Key laboratory of Soft-Matter Material chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal IcVS/3B’s-PT Government Associate laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(Uc)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MlNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MlNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MlNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

Time trends and outcomes of gastrostomy placement in a Swedish national cohort over two decades

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World Journal of Gastroenterology 2024年第10期30卷 1358-1367页

作者： Martin löfling Skogar Magnus Sundbom Department of Surgical Sciences Uppsala UniversityUppsala 75185Sweden

BAcKGROUND Percutaneous endoscopic gastrostomy(PEG)and laparoscopically inserted gastrostomy have become the gold standard for adult patients and children,respectively,requiring long-term enteral nutrition support.Procedure-related mortality is a rare event,often reported to be zero in smaller studies.National data on 30-d mortality and long-term survival rates after gastrostomy placement are scarce in the literature.AIM To study the use of gastrostomies in Sweden from 1998-2019 and to analyze procedure-related mortality and short-term(long-term survival.METHODS In this retrospective,population-based cohort study,individuals that had received a gastrostomy between 1998-2019 in Sweden were included.Individuals were identified in the Swedish National Patient Register,and survival analysis was possible by cross-referencing the Swedish Death Register.The cohort was divided into three age groups:children(0-18 years);adults(19-64 years);and elderly(≥65 years).Kaplan-Meier with log-rank test and cox regression were used for survival analysis.RESUlTS In total 48682 individuals(52%males,average age 60.9±25.3 years)were identified.The cohort consisted of 12.0%children,29.5%adults,and 58.5%elderly.An increased use of gastrostomies was observed during the study period,from 13.7/100000 to 22.3/100000 individuals(Pled(about 800 to 1800/year),with a corresponding decrease in open gastrostomy(about 700 to 340/year).laparoscopic gastrostomy increased more than ten-fold(about 20 to 240/year).Overall,PEG,open gastrostomy,and laparoscopic gastrostomy constituted 70.0%(n=34060),23.3%(n=11336),and 4.9%(n=2404),respectively.Procedure-related mortality was 0.1%(n=44)overall(PEG:0.05%,open:0.24%,laparoscopic:0.04%).The overall 30-d mortality rate was 10.0%(PEG:9.8%,open:12.4%,laparoscopic:1.7%)and decreased from 11.6%in 1998-2009 vs 8.5%in 2010-2019(Pl rates for children,adults,and elderly were 93.7%,67.5%,and 42.1%and 79.9%,39.2%,and 6.8%,respectively.Th

关键词： Gastrostomy Percutaneous endoscopic gastrostomy Dysphagia Enteral nutrition long-term Survival complication

Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

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cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong lamao Meichao Gu Xuanxuan Jin Ying liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine c.l Wong Wensheng Wei Biomedical Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate metabolites.In our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale cRISPR screening of cancer cells.We found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T cells.The coordinated function of these BTN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX complex.Additionally,an enzyme called QPcTl was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer cells.Through our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T cells.Moreover,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

Determination of the standardized ileal digestible calcium requirement of Ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： carrie l.Walk Raffaella Aureli Pauline Jenn DSM Nutritional Products Research center for Animal Nutrition and Health DSM Nutritional Products

An experiment was conducted to determine the standardized ileal digestible (SID) calcium requirement of fast-growing broilers from hatch to d 14 post-hatch.Ross 308 (n=360) male broilers were obtained on day of hatch and allocated to 1 of 5 treatments in battery cages.There were 6 birds per cage and 12 pens per treatment.Four treatments were formulated to contain 0.60%,0.46%,0.32% or 0.18% SID ca.The final treatment was formulated using total ca to meet or exceed all nutrient requirements,including 0.90% total ca and 0.49% non-phytate P (nPP),using the same ingredients.This treatment was the reference diet for comparison and validation of the SID ca diets.Birds and feed were weighed at placement and on d 14.Tibias and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d 14.Data were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression models.Increasing the SID ca content in the diet from 0.18% to 0.60% improved (quadratic,Plity corrected feed conversion ratio (mFcR).The estimated SID ca requirement to optimize gain or m FcR was between 0.39% and 0.52%.Tibia ash percent and weight increased (quadratic,Pca content in the diet increased and the estimated SID ca requirement was between 0.32% and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID ca compared with birds fed the reference diet.In conclusion,the SID ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534% and 0.398% when quadratic,straight-broken line,or quadratic-broken line regressions were used.These results agree with previously published data evaluating the SID ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirements Retention Tibia ash

Quantum vortices get stretched

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Frontiers of physics 2024年第3期19卷 225-227页

作者： Emanuel A.l.Henn São carlos Institute of Physics University of São Paulo-PO Box 36913560-970São CarlosBrazil

Since its discovery, superfluidity [1,2] remains one of the most remarkable phenomena in quantum physics. The onset of the quantum regime in liquid helium is visually striking, when the fluid flows without dissipation or detaches from a rotating bucket, remaining still upon soft rotations. The same phenomenon is present in the context of ultracold bosonic quantum gases where, most of the time, superfluidity walks hand-in-hand with the transition to Bose−Einstein condensation [3].

关键词： quantum rotating rotation

Research of surface-enhanced Raman scattering on Ag@PMBA@c@Au hybrid nanoparticles

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Optoelectronics letters 2024年第2期20卷 65-69页

作者： TAN Enzhong lÜ Suye liberal Study college Beijing Institute of Petrochemical TechnologyBeijing 102617China

Monodispersed, biocompatible, and readily-functionalized hybrid reporter-embedded core-shell nanopartilces(NPs) have been prepared in a simple route. This composite offers a potential platform for immunochemical detection using surface-enhanced Raman scattering(SERS) due to their high sensitivity, good stability and biocompatiblity. This also provides a new platform for insight into SERS enhancement mechanism.

关键词： mechanism. readily SERS

comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek J.Dittrich M.Knapek F.lukáˇc D.Koutný J.Jaroš R.Král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SlM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SlM material and unmeasurably low porosity in the SPS material.The main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion resistance.Both materials showed comparable strength of∼110 MPa in tension and compression and relatively good deformability of∼9%and∼21%for the SlM and SPS materials,respectively.The corrosion resistance of the SPS material in 0.1 M Nacl solution was superior to the SlM one and comparable to the conventional extruded material.The digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SlM material.On the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength corrosion resistance

Special Properties of Morita contexts

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Algebra colloquium 2024年第2期31卷 309-322页

作者： Kamal Paykan l.A.Bokut Department of Mathematics Tafresh UniversityTafreshIran 不详

In this paper we continue the study of various ring theoretic properties of Morita contexts.Necessary and sufficient conditions are obtained for a general Morita context or a trivial Morita context or a formal triangular matrix ring to satisfy a certain ring property which is among being Kasch,completely primary,quasi-duo,2-primal,NI,semiprimitive,projective-free,etc.We also characterize when a general Morita context is weakly principally quasi-Baer or strongly right mininjective.

关键词： Morita context formal triangular matrix ring Kasch quasi-duo Köthe's conjecture weakly principally quasi-Baer

Effects of High-Definition Transcranial Direct current Stimulation on Excitability of Spinal Motoneurons under Ankle Dorsi-Plantarflexion Fatigue Task

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