检索结果-南通市图书馆

Ascovirus and its Evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国病毒学 2007年第2期22卷 137-147页

作者： Xiao-Wen Cheng Xiu-Feng Wan Jianli Xue Richard C. moore Department of Microbiology Department of Botany Miami University Oxford Ohio 45056 USA

Ascoviruses, iridoviruses, asfarviruses and poxviruses are all cytoplasmic DNA viruses. The evolutionary origins of cytoplasmic DNA viruses have never been fully addressed. Morphological, genetic and molecular data were used to test if all four cytoplasmic virus families (Ascoviridae, Iridoviridae, Asfarviridae, and Poxvirirdae) evolved from nuclear replicating baculoviruses and how the four virus groups are related. Molecular phylogenetic analyses using DNA polymerase predicted that cytoplasmic DNA viruses might have evolved from nuclear replicating baculoviruses, and that poxviruses and asfarviruses share a common ancestor with iridoviruses. These three cytoplasmic viruses again shared a common ancestor with ascoviruses. Morphological and genetic data predicted the same evolutionary trend as molecular data predicted. A genome sequence comparison showed that ascoviruses have more baculovirus protein homologues than do iridoviruses, which suggested that ascoviruses have evolved from baculoviruses and iridoviruses evolved from ascoviruses. Poxviruses showed genetic and morphological similarity to other cytoplamic viruses, such as ascoviruses, suggesting it has undergone reticulate evolution via hybridization, recombination and lateral gene transfer with other viruses. Within the ascovirus family, we tested if molecular phylogenetic analyses agree with biological inference; that is, ascovirus had an evolutionary trend of increasing genome size, expanding host range and widening tissue tropism for these viruses. Both molecular and biological data predicted this evolutionary trend. The phylogenetic relationship among the four species of ascovirus was predicted to be that TnAV-2 and HvAV-3 shared a common ancestor with SfAV-1 and the three virus species again shared a common ancestor with DpAV-4.

关键词：细胞病毒分子种系系统识别技术

Integrity monitoring of fixed ambiguity Precise Point Positioning(PPP)solutions

在线全文

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2013年第3期16卷 141-148页

作者： Altti JOKINEN Shaojun FENG Wolfgang SCHUSTER Washington OCHIENG Chris HIDE Terry moore Chris HILL Department of Civil and Environmental Engineering Imperial College London Centre for Transport StudiesLondon SW72AZUK Nottingham Geospatial Institute(NGI) University of NottinghamNottingham NG72TUUK

Traditional positioning methods,such as conventional Real Time Kinematic(cRTK)rely upon local reference networks to enable users to achieve high-accuracy *** need for such relatively dense networks has significant cost *** Point Positioning(PPP)on the other hand is a positioning method capable of centimeter-level positioning without the need for such local networks,hence providing significant cost benefits especially in remote *** paper presents the state-of-the-art PPP method using both GPS and GLONASS measurements to estimate the float position solution before attempting to resolve GPS integer *** monitoring is carried out using the Imperial College Carrier-phase Receiver Autonomous Integrity Monitoring method.A new method to detect and exclude GPS base-satellite failures is developed.A base-satellite is a satellite whose measurements are differenced from other satellite’s measurements when using between-satellite-differenced measurements to estimate *** failure detection and exclusion methods are tested using static GNSS data recorded by International GNSS Service stations both in static and dynamic processing *** results show that failure detection can be achieved in all cases tested and failure exclusion can be achieved for static *** the kinematic processing cases,failure exclusion is more difficult because the higher noise in the measurement residuals increases the difficulty to distinguish between failures associated with the base-satellite and other satellites.

关键词： Precise Point Positioning(PPP) integrity ambiguity resolution failure exclusion

Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2017年第9期9卷 341-353页

作者： Brendan M Finnerty Katherine D Gray Maureen D moore Rasa Zarnegar Thomas J FaheyⅢ Department of Surgery New York Presbyterian HospitalWeill Cornell MedicineNew YorkNY 10065United States

Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets.

关键词： Epigenetics Carcinoid Neuroendocrine MicroRNA Methylation Histone modifications Chromatin remodeling LncRNA

Effect of glaucoma on identification of bottle cap color in ophthalmic medications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第1期12卷 169-171页

作者： Jonathan Paul Jon David Hammer Roozbeh Akhtari Brede Skillings Daniel B.moore Department of Ophthalmology University of Kentucky Northwell Health Department of Ophthalmology Krieger Eye Institute

A prospective, nonrandomized, observational trial of 60 glaucoma patients to correlate visual acuity and visual field with ability to distinguish bottle cap color of commonly used ophthalmic medications was conducted. A total of 103 eyes from 60 patients(30 women) were evaluated. The mean logMAR acuity was 0.34±0.54(approximately 20/45 Snellen acuity), average Humphrey Visual Field(HVF) mean deviation was-8.58±8.69 dB, mean Ishihara plates(out of 14) were 11.78±4.15, and bottle cap color score(out of 10) was 8.56±2.51. Multiple linear regression analysis revealed an independent correlation of visual acuity(P=0.0137) and Ishihara score(P0.05). Glaucoma patients with poor visual acuity, but not necessarily advanced visual field loss, are likely to have difficultly identifying the color of their bottle caps. Physicians should be cognizant of this potential issue when reviewing medications with patients.

关键词： glaucoma color vision compliance medication patient communication

NMR double resonance study of azide binding to cytochrome c

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1992年第1期10卷 40-44页

作者： CONCAR D. moore G.R. WILLIAMS R.J.P. Inorganic Chemistry Laboratory University of OxfordUK

Equilibrium constants for the binding of azide to ferri-cytochrome c at temperature range of 305—325 K were determined at pH=7 by using ~1H double resonance *** values(⊿H^o=-34.5 kJ/mol,⊿S^o=-100 J/mol)were obtained from van't Hoff's relation and were compared with those for azide binding to other ferric *** reason of lower affinity of cytochrome c for azide was discussed.

关键词： NMR double resonance study of azide binding to cytochrome c

Poly(ethylene glycol)hydrogel elasticity influences human mesenchymal stem cell behavior

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2018年第3期5卷 167-175页

作者： Anna K.Whitehead Haley H.Barnett Mary E.Caldorera-moore Jamie J.Newman School of Biological Sciences Department of Biomedical Engineering Louisiana Tech UniversityRustonLA 71272USA

Coordinated investigations into the interactions between biologically mimicking(biomimetic)material constructs and stem cells advance the potential for the regeneration and possible direct replacement of diseased cells and *** clinically relevant therapies will require the development and optimization of methods that mass produce fully functional cells and *** advances in the design and synthesis of biomaterial scaffolds,one of the biggest obstacles facing tissue engineering is understanding how specific extracellular cues produced by biomaterial scaffolds influence the proliferation and differentiation of various cell *** elasticity is one such tailorable property of synthetic scaffolds that is known to differ between ***,we investigate the interactions between an elastically tailorable polyethylene glycol(PEG)-based hydrogel platform and human bone marrow-derived mesenchymal stem cells(hMSCs).For these studies,two different hydrogel compositions with elastic moduli in the ranges of 50-60 kPa and 8-10 kPa were *** findings demonstrate that the different elasticities in this platform can produce changes in hMSC morphology and proliferation,indicating that the platform can be implemented to produce changes in hMSC behavior and cell state for a broad range of tissue engineering and regenerative ***,we show that the platform’s different elasticities influence stem cell differentiation potential,particularly when promoting stem cell differentiation toward cell types from tissues with stiffer *** findings add to the evolving and expanding library of information on stem cell-biomaterial interactions and opens the door for continued exploration into PEG-based hydrogel scaffolds for tissue engineering and regenerative medicine applications.

关键词： biomaterial-cell interaction scaffolds stem cells

The temporal fluctuations and development of faecal microbiota in commercial layer flocks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2023年第4期15卷 197-209页

作者： Nitish Joat Yadav S.Bajagai Thi Thu Hao Van Dragana Stanley Kapil Chousalkar Robert J.moore School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia5371Australia Institute for Future Farming Systems Central Queensland UniversityRockhamptonQueensland4701Australia School of Science RMIT UniversityBundooraVictoria3083Australia

The microbiota of the gastrointestinal tract influences gut health,which in turn strongly impacts the general health and productivity of laying *** is essential to characterise the composition and temporal development of the gut microbiota in healthy layers raised under different management systems,to understand the variations in typical healthy microbiota structure,so that deviations from this might be recognised and correlated with production and health issues when they *** present investigation aimed to study the temporal development and phylogenetic composition of the gut microbiota of four commercially raised layer flocks from hatch to end of the production ***-intrusive faecal sampling was undertaken as a proxy to represent the gut *** of 16S rRNA gene amplicons was used to characterise the *** diversity analysis indicated that each faecal microbiota was different across the four flocks and had subtly different temporal development *** these inter-flock differences,common patterns of microbiota development were *** and Proteobacteria were dominant at an early age in all *** microbiota developed gradually during the rearing phase;richness and diversity increased after 42 d of age and then underwent significant changes in composition after the shift to the production farms,with Bacteroidota becoming more dominant in older *** developing a more profound knowledge of normal microbiota development in layers,opportunities to harness the microbiota to aid in the management of layer gut health and productivity may be more clearly seen and realised.

关键词： Chicken microbiota Faecal microbiota Firmicutes Housing condition Proteobacteria

Dredging effects on selected nutrient concentrations and ecoenzymatic activity in two drainage ditch sediments in the lower Mississippi River Valley

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2017年第3期5卷 190-195页

作者： Matt moore Martin A.Locke Michael Jenkins Robert W.Steinriede Daniel S.McChesney USDA-Agricultural Research Service National Sedimentation Laboratory598 McElroy DriveOxfordMS 38655USA

Agricultural drainage ditches are conduits between production acreage and receiving aquatic *** overlooked for their mitigation capabilities,agricultural drainage ditches provide an important role for nutrient transformation via microbial *** in ecoenzyme activities have been used to elucidate microbial metabolism and resource demand of microbial communities to better understand the relationship between altered nutrient ratios and microbial activity in aquatic *** agricultural drainage ditches,one in the northeast portion of the Arkansas Delta and the other in the lower Mississippi Delta,were monitored for a *** samples were collected prior to each ditch being dredged(cleaned),and subsequent post-dredging samples occurred as soon as access was *** samples were then collected throughout a year to examine effects of dredging on selected nutrient concentrations and ecoenzymatic activity recovery in drainage ditch *** concentrations in sediments after dredging decreased 33–66%,depending on ditch and phosphorus extraction ***,ecoenzymatic activity was significantly decreased in most sediment samples after *** diacetate hydrolysis activity,an estimate of total microbial activity,decreased 56–67%after dredging in one of the two *** sample sites also had significant phosphorus and ecoenzymatic activity differences between the post-dredge samples and the year-long follow-up *** indicate microbial metabolism in dredged drainage ditches may take up to a year or more to recover to pre-dredged ***,while sediment nutrient concentrations may be decreased through dredging and removal,runoff and erosion events over time tend to quickly replenish nutrient concentrations in replaced *** nutrient dynamics and microbial metabolism within agricultural drainage ditches is a crucial step toward addressing issues of nutri

关键词： Phosphorus FDA Denitrification Mehlich III Microbial Metabolism

Microscale tissue-engineered models:overcoming barriers to adoption for neural regeneration research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第3期11卷 386-387页

作者： Michael J.moore Department of Biomedical Engineering Tulane University

The last decade has seen a steady proliferation in the use of tissue-engineered cell culture systems（Deforest and Anseth,2012）,and these have been put to good use for studying neural axon growth and guidance（Li and Hoffman-Kim,2008;Roy et al.,2013）.These systems have been designed to more closely mimic the natural microenvironment of the developing or repairing nervous system and to enable spatiotemporal control over certain aspects of the microenvironment.

关键词： engineered regeneration adoption barriers mimic enable guidance projection friendly overcome