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An Integrated Systems Biology Approach Identifies ZIKV and DENV Replication

Genomics, Proteomics & Bioinformatics 2021年第1期19卷 108-122页

作者： Guang Song Emily M.Lee Jianbo Pan Miao Xu Hee-Sool Rho Yichen Cheng Nadia Whitt Shu Yang Jennifer Kouznetsova Carleen Klumpp-Thomas Samuel G.Michael cedric moore Ki-Jun Yoon Kimberly M.Christian Anton Simeonov Wenwei Huang Menghang Xia Ruili Huang Madhu Lal-Nag Hengli Tang Wei Zheng Jiang Qian Hongjun Song Guo-li Ming Heng Zhu Department of Pharmacology&Molecular Sciences Johns Hopkins School of MedicineBaltimoreMD 21205USA Department of Biological Science Florida State UniversityTallahasseeFL 32306USA Department of Ophthalmology Johns Hopkins School of MedicineBaltimoreMD 21205USA National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Cell and Developmental Biology Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Regenerative Medicine Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA The Epigenetics Institute Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

The Zika virus(ZIKV)and dengue virus(DENV)flaviviruses exhibit similar replicative processes but have distinct clinical outcomes.A systematic understanding of virus–host protein–protein interaction networks can reveal cellular pathways critical to viral replication and disease *** we employed three independent systems biology approaches toward this ***,protein array analysis of direct interactions between individual ZIKV/DENV viral proteins and20,240 human proteins revealed multiple conserved cellular pathways and protein complexes,including proteasome ***,an RNAi screen of 10,415 druggable genes identified the host proteins required for ZIKV infection and uncovered that proteasome proteins were crucial in this ***,high-throughput screening of 6016 bioactive compounds for ZIKV inhibition yielded 134 effective compounds,including six proteasome inhibitors that suppress both ZIKV and DENV *** analyses of these orthogonal datasets pinpoint proteasomes as critical host machinery for ZIKV/DENV *** study provides multi-omics datasets for further studies of flavivirus–host interactions,disease pathogenesis,and new drug targets.

关键词： Protein–protein interaction RNAi screening Chemical genetics screening Multi-omics

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Corrigendum to“An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication"[Genomics Proteomics Bioinformatics 19(1)(2021)108-122]

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 808-809页

作者： Song, Guang Lee, Emily M. Pan, Jianbo Xu, Miao Rho, Hee-Sool Cheng, Yichen Whitt, Nadia Yang, Shu Kouznetsova, Jennifer Klumpp-Thomas, Carleen Michael, Samuel G. moore, cedric Yoon, Ki-Jun Christian, Kimberly M. Simeonov, Anton Huang, Wenwei Xia, Menghang Huang, Ruili Lal-Nag, Madhu Tang, Hengli Zheng, Wei Qian, Jiang Song, Hongjun Ming, Guo-li Zhu, Heng Department of Pharmacology & Molecular Sciences Johns Hopkins School of Medicine Baltimore MD 21205 USA Department of Biological Science Florida State University Tallahassee FL 32306 USA Department of Ophthalmology Johns Hopkins School of Medicine Baltimore MD 21205 USA National Center for Advancing Translational Sciences National Institutes of Health Bethesda MD 20892 USA Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 China Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Cell and Developmental Biology Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Institute for Regenerative Medicine Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA The Epigenetics Institute Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Assessment of Linear and Non-Linear Two-Equation Turbulence Models for Aerothermal Turbomachinery Flows

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Journal of Thermal Science 2006年第1期15卷 14-26页

作者： Pascale KULISA cedric DANO Laboratoire de Mecanique des Fluides et d'Acoustique UMR5509 Ecole Centrale de Lyon 69134 ECULLY Cedex France

Three linear two-equation turbulence models k- ε, k- ω and k- 1 and a non-linear k- 1 model are used for aerodynamic and thermal turbine flow prediction. The pressure profile in the wake and the heat transfer coefficient on the blade are compared with experimental data. Good agreement is obtained with the linear k-1 model. No significant modifications are observed with the non-linear model. The balance of transport equation terms in the blade wake is also presented. Linear and non-linear k - 1 models are evaluated to predict the threedimensional vortices characterising the turbine flows. The simulations show that the passage vortex is the main origin of the losses.

关键词： turbulence model numerical simulation turbomachinery.

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A New Guiding Framework for Engaging Diverse Populations in Disaster Risk Reduction: Reach, Relevance, Receptiveness,and Relationships

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International Journal of Disaster Risk Science 2018年第4期9卷 507-518页

作者： Jay Marlowe ANDreas Neef cedric Tevaga cedric Tevaga Counselling Human Services and Social WorkUniversity of AucklandAuckland 1023New Zealand Development Studies School of Social SciencesUniversity of AucklandAuckland 1023New Zealand The Southern Initiative Auckland CouncilAuckland 1010New Zealand

In urban environments characterized by rich diversity across language, migration status, demographic profiles, and usage of different forms of media, there can be significant challenges to ensuring that particular disaster risk reduction(DRR) communications reach those potentially affected. This article presents a study with 20 Pacific Island community leaders and connectors about their communities' perspectives and anticipated responses to natural hazards in Auckland, New Zealand. Home to the largest population of Pacific people in the world, Auckland provides the basis for understanding the complexities of delivering disaster information across numerous community groups. The rich cultural and linguistic backgrounds of multiple Pacific communities living in this city highlight the need to consider the complexities of disaster messaging related to natural hazards. In particular, the article forwards the importance of incorporating the guiding concepts of reach, relevance, receptiveness, and relationships into a DRR approach with culturally and linguistically diverse groups. These concepts are presented as an embedded guiding framework that can helpfully inform disaster communication.

关键词： Auckland Community resilience Disaster communication Disaster risk reduction New Zealand Pacific Island groups Social capital

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What controls the critical temperature of high temperature copper oxide superconductors:insights from scanneling tunnelling microscopy

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Science Bulletin 2017年第2期62卷 102-104页

作者： cedric Weber King's College London Theory and Simulation of Condensed Matter The Strand London WC2R 2LS UK

Since their discovery,the electronic structure of the high temperature superconductors has been a subject of intensive theoretical attention as well as controversy,a situation that continues even today.

关键词：高温超导体铜氧化物超导体隧道显微镜临界温度控制电子结构

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Review： Tip-based vibrational spectroscopy for nanoscale analysis of emerging energy materials

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Frontiers in Energy 2018年第1期12卷 43-71页

作者： Amun JARZEMBSKI cedric SHASKEY Keunhan PARK Department of Mechanical Engineering University of Utah Salt LakeCity UT 84112 USA

Vibrational spectroscopy is one of the key instrumentations that provide non-invasive investigation of structural and chemical composition for both organic and inorganic materials. However, diffraction of light funda- mentally limits the spatial resolution of far-field vibrational spectroscopy to roughly half the wavelength. In this article, we thoroughly review the integration of atomic force microscopy （AFM） with vibrational spectroscopy to enable the nanoscale characterization of emerging energy materials, which has not been possible with far-field optical techniques. The discussed methods utilize the AFM tip as a nanoscopic tool to extract spatially resolved electronic or molecular vibrational resonance spectra of a sample illuminated by a visible or infrared （IR） light source. The absorption of light by electrons or individual functional groups within molecules leads to changes in the sample＇s thermal response, optical scattering, and atomic force interactions, all of which can be readily probed by an AFM tip. For example, photothermal induced resonance （PTIR） spectroscopy methods measure a sample＇s local thermal expansion or temperature rise. Therefore, they use the AFM tip as a thermal detector to directly relate absorbed IR light to the thermal response of a sample. Optical scattering methods based on scanning near-field optical microscopy （SNOM） correlate the spectrum of scattered near-field light with molecular vibrational modes. More recently, photo-induced force microscopy （PiFM） has been developed to measure the change of the optical force gradient due to the light absorption by molecular vibrational resonances using AFM＇s superb sensitivity in detecting tip-sample force interactions. Such recent efforts successfully breech the diffraction limit of light to provide nanoscale spatial resolution of vibrational spectroscopy,which will become a critical technique for characterizing novel energy materials.

关键词： vibrational spectroscopy atomic force micro-scopy photo-thermal induced resonance scanning near-field optical microscopy tip-enhanced Raman spectro-scopy photo-induced force microscopy molecular reso-nances surface phonon polaritons energy materials

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A co-evolving memetic wrapper for prediction of patient outcomes in TCM informatics

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Frontiers of Computer Science 2012年第5期6卷 621-629页

作者： Dion DETTERER Paul KWAN cedric GONDRO School of Science and Technology University of New England Armidale NSW 2351 Australia The Centre for Genetic Analysis and Applications University of New England Armidale NSW 2351 Australia

Traditional Chinese medicine （TCM） relies on the combined effects of herbs within prescribed formulae. However, given the combinatorial explosion due to the vast number of herbs available for treatment, the study of these combined effects can become computationally intractable. Thus feature selection has become increasingly crucial as a pre-processing step prior to the study of combined effects in TCM informatics. In accord with this goal, a new feature se- lection algorithm known as a co-evolving memetic wrapper （COW） is proposed in this paper. COW takes advantage of recent research in genetic algorithms （GAs） and memetic al- gorithms （MAs） by evolving appropriate feature subsets for a given domain. Our empirical experiments have demonstrated that COW is capable of selecting subsets of herbs from a TCM insomnia dataset that shows signs of combined effects on the prediction of patient outcomes measured in terms of classification accuracy. We compare the proposed algorithm with results from statistical analysis including main effects and up to three way interaction terms and show that COW is capable of correctly identifying the herbs and herb by herb effects that are significantly associated to patient outcome prediction.

关键词： genetic algorithm memetic algorithm wrapper,feature selection traditional Chinese medicine (TCM) informatics

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Drag reduction of compressible wall turbulence with active dimples

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Science China(Physics,Mechanics & Astronomy) 2011年第2期54卷 329-337页

作者： SUN ZhenSheng REN YuXin LARRICQ cedric Department of Engineering Mechanics.Tsinghua University Beijing 100084 China Xi'an Research Institute of High-tech Xi'an 710025China

Direct numerical simulations are carried out to assess the potential drag reduction of compressible turbulent flow between isothermal *** the sake of achieving drag reduction,the flow is actively controlled by deformable dimples lying on the bottom wall of the *** first stage of the procedure consists in assessing the optimum geometry of the *** this regard,the lower wall is allowed to freely deform itself according to the loop of *** method is called the smart wall approach in this *** an analysis of the typical shape of the wall deformation thus obtained,it is found that dimples should be thinner than or comparable to the width of streaky structures in the spanwise direction and elongated in the streamwise *** active dimples as the wall-deformation actuators,a 15% drag reduction is obtained for the flow at Mam = 0.35 while the drag reduction rate is about 12% for the flow at Mam = *** fundamental mechanism of the drag reduction is then discussed in this *** drag reduction is believed to result from two aspects:the reduction of the mean streamwise velocity gradient near the deformable wall and the suppression of the turbulent fluctuations.

关键词： compressible wall turbulence direct numerical simulation active dimples drag reduction

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Biolinguistics:Future Prospects and Current Challenges

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语言科学 2013年第1期12卷 3-6页

作者： cedric Boeckx 西班牙加泰罗尼亚语高等研究院巴塞罗那大学

I am delighted to contribute in a small way to the celebration of the 10th anniversary of the Journal of Linguistic Sciences(although sadly,I cannot be physically among you).It is interesting to note that the annivers... 详细信息

关键词：英文摘要编辑工作学术论文语言科学

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