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作者： James mooney 上海交通大学

学位级别：硕士

The relationship between The People’s Republic of China and Australia is one that in a modern context is viewed as the result of an economic co-dependence;The growth of the Chinese economy has complemented Australia's reliance on the export of its vast mineral *** linkages between the two go much further than just economics,though it is undeniable the role that this has played in acting as the catalyst for the *** prevailing thought that emerges from the existing literature on the topic has a heavy focus on the economic relationship and the role of the United States,mainly in the context of China's geopolitical *** purpose though of this research is to explore the contemporary factors which contribute to,and dictate the health of,the China-Australia relationship through the lens of Gideon roses neo-classical realism *** the research,it should become evident that the role that the United States plays in Australian decision making in a geopolitical context directs its security arrangements in the ***'s reliance on the United States is pronounced,and the *** will continue to impact Australia's engagement with Beijing on a range of *** of this proverbial triangle,is the role of the Australian Liberal Party in setting the governments tone toward *** conservatism in Australia's politicians reflects the opinions of the broader electorate,with the LNP more assertive in their dealings with ***,the most compounding factor currently affecting Chinese Australian relations,is allegations of espionage and attempts by China to undermine critical institutions *** attempts to subvert and influence democratic institutions has cultivated a culture of suspicion and mistrust of Chinese and the *** analysis of these three factors challenges the idea that the ChinaAustralia relationship is business as *** highlighting the role of Australian actors in t

关键词： Australia,Australian,party,political,Minister,officials,conservative,alliance,politics,affairs,

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Phenotypic plasticity in prostate cancer： role of ntrinsically disordered proteins

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Asian Journal of Andrology 2016年第5期18卷 704-710页

作者： Steven M mooney Mohit Kumar Jolly Herbert Levine Prakash Kulkarni Department of Biology University of Waterloo Waterloo ON N2L 3G1 Canada Center for Theoretical Biological Physics Rice University Houston TX 77005 USA Department of Bioengineering Rice University Houston TX 77005 USA Department of Physics and Astronomy Rice University Houston TX 77005 USA institute for Bioscience and Biotechnology Research University of Maryland Rockville Maryland 20850 USA

A striking characteristic of cancer ceLls is their remarkable phenotypic plasticity, which is the ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic changes such as a partial or complete epithelial to mesenchymal transition （EMT） that play important roles in their survival and proliferation, and development of resistance to therapeutic treatments, are widely believed to arise due to somatic mutations in the genome. However, there is a growing concern that such a deterministic view is not entirely consistent with multiple lines of evidence, which indicate that stochasticity may also play an important role in driving phenotypic plasticity. Here, we discuss how stochasticity in protein interaction networks （PINs） may play a key role in determining phenotypic plasticity in prostate cancer （PCa）. Specifically, we point out that the key players driving transitions among different phenotypes （epithelial, mesenchymal, and hybrid epithelial/mesenchymal）, including ZEB1, SNAIl, OVOL1, and OVOL2, are intrinsically disordered proteins （IDPs） and discuss how plasticity at the molecular level may contribute to stochasticity in phenotypic switching by rewiring PINs. We conclude by suggesting that targeting iDPs implicated in EMT in PCa may be a new strategy to gain additional insights and develop novel treatments for this disease, which is the most common form of cancer in adult men.

关键词： epithelial to mesenchymal transition intrinsically disordered proteins prostate cancer state-switching

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Identification of the Early Jurassic mylonitic granitic pluton and tectonic implications in Namling area,southern Tibet

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Geoscience Frontiers 2021年第1期12卷 13-28页

作者： Yuanku Meng Walter D.mooney Runlong Fan Jinqing Liu Youqing Wei College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China U.S.Geological Survey Menlo ParkCA 94025USA SHRIMP Center Institute of GeologyChinese Academy of Geological SciencesBeijing 102206China

A number of studies revealed that the Gangdese magmatic belt of southern Tibet was closely related to the northward subduction of the Neo-Tethys oceanic lithosphere and Indo-Asian ***,pre-Cretaceous magmatism is still poorly constrained in the Gangdese magmatic belt,southern ***,we conducted systematically geochronology and geochemistry studies on a newly-identified granitic pluton in the middle Gangdese magmatic belt(Namling area),southern *** SHRIMPⅡU-Pb dating for one representative sample gives a weighted age of 184.2±1.8 Ma(MSWD=±1.11),corresponding to emplacement and crystallization age of the granitic pluton in the Early Jurassic(Pliensbachian).High SiO2(68.9-72.1 wt.%)contents and intermediate Mg#values(35-38)together suggest that the newly-identified granitic pluton was probably formed by partial melting of crustal material with minor injection of mantle-derived magma,precluding an origin from melting of metasedimentary rocks that are characterized by low Mg#and high zirconδ^18O values(>8‰).Geochemically,the newly-identified granitic pluton belongs to typical I-type granitic affinity,whereas this is inconsistent with aluminium saturation index(ASI=A/CNK ratios)and geochemical *** suggests that zircon oxygen isotopes(4.30‰-5.28‰)and mineral features(lacking Al-rich minerals)are reliable indicators for discriminating granitic *** depleted whole-rock Sr-Nd-Hf isotopic compositions and zirconεHf(t)values indicate that the granitic pluton was derived from partial melting of depleted arc-type *** addition,the granitic pluton shows zirconδ^18O values ranging from 4.30‰to 5.28‰(with a mean value of 4.77‰)that are consistent with mantle-derived zircon values(5.3‰±0.6‰)within the uncertainties,indicating that the granitic pluton might have experienced weak short-living high-temperature hydrous fluid-rock *** with the Sr-Nd-Hf-O isotopes and geochemical signatures,we propose that the newl

关键词： Sr-Nd-Hf-O isotopes SHRIMP U-Pb dating Early Jurassic Mylonitic granitic pluton Gangdese belt

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Cancer/testis antigens and obligate participation in multiple hallmarks of cancer： an update

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Asian Journal of Andrology 2016年第5期18卷 711-712页

作者： Steven M mooney Krithika Rajagopalan Govindan Rangarajan Prakash Kulkarni Department of Biology University of Waterloo Waterloo ON N2L 3G1 Canada Department of Biological Sciences Columbia University NY 10027 USA Department of Mathematics and Centre for Neuroscience Indian Institute of Science Bengaluru Karnataka India Institute for Bioscience and Bietechnology Research University of Maryland Rockville. Marvland 20850. USA.

The Cancer/Testis Antigens （CTAs） are a group of so-called tumor antigens that exhibit provocative expression patterns in most types of cancer. However, because most CTAs appear to be intrinsically disordered, they ... 详细信息

关键词： INTRINSICALLY DISORDERED PROTEINS C-JUN TRANSACTIVATION PHOSPHORYLATION NOISE

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Treatment and survival in a population-based sample of patients diagnosed with gastroesophageal adenocarcinoma

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World Journal of Gastroenterology 2008年第20期14卷 3165-3173页

作者： Deirdre P Cronin-Fenton Margaret M mooney Limin X Clegg Linda C Harlan Surveillance Research Program DCCPS National Cancer Institute CTEP DCTD National Cancer Institute Applied Research Program DCCPS National Cancer Institute

AIM： TO examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS： The US National Cancer Institutes＇ Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroesophageal adenocarcinoma （/7 = 1356）. The study re-abstracted data and verified therapy with treating physicians for a population-based stratified random sample. RESULTS： Approximately 62% of patients had stomach adenocarcinoma （SAC）, while 22% had gastric-cardia adenocarcinoma （GCA）, and 16% lower esophageal adenocarcinoma （EAC）. Stage 1V/ unstaged esophageal cancer patients were most likely and stage Ⅰ -Ⅲ stomach cancer patients least likely to receive chemotherapy as all or part of their therapy; gastric-cardia patients received chemotherapy at a rate between these two. In multivariable analysis by anatomic site, patients 70 years and older were significantly less likely than younger patients to receive chemotherapy alone or chemoradiation for all three anatomic sites. Among esophageal and stomach cancer patients, receipt of chemotherapy was associated with lower mortality; but no association was found among gastric-cardia patients. CONCLUSION： This study highlights the relatively low use of clinical trials-validated anti-cancer therapies in community practice. Use of chemotherapy-based treatment was associated with lower mortality, dependent on anatomic site. Findings suggest that physicians treat lower esophageal and SAC as two distinct entities, while gastric-cardia patients receive a mix of the treatment strategies employed for the two other sites.

关键词： Adenocarcinoma Esophageal adeno-carcinoma Gastroesophageal Gastric adenocarcinoma Survival Chemotherapy Radiotherapy

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西北太平洋俯冲带大地幔楔及地幔过渡带各向异性证据和特征

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地球物理学报 2021年第2期64卷 455-470页

作者：郭广瑞李娟陈思丹 Walter D.mooney 中国科学院地质与地球物理研究所北京100029 中国科学院大学北京100049 漠河地球物理国家野外科学观测研究站北京100029 美国地质调查局 CA 94025

地震层析成像研究清晰给出了地球深部俯冲板片的大尺度形态,但与俯冲过程相关的地幔流动特征仍不明确.在俯冲地幔楔系统中,前人观测到了与海沟平行和垂直的快波偏振方向.本文研究了西北太平洋俯冲板片在地幔过渡带中停滞形成的"大地幔楔... 详细信息

地震层析成像研究清晰给出了地球深部俯冲板片的大尺度形态,但与俯冲过程相关的地幔流动特征仍不明确.在俯冲地幔楔系统中,前人观测到了与海沟平行和垂直的快波偏振方向.本文研究了西北太平洋俯冲板片在地幔过渡带中停滞形成的"大地幔楔"中的各向异性特征.对具有长期稳定观测数据的MDJ台站SKS震相和区域深源地震的直达S波震相进行了详细的剪切波分裂研究.采用多波形同时反演方法在保证数据后方位角覆盖范围的基础上得到了更加精确的SKS震相各向异性结果.剪切波分裂参数具有明显的频率依赖性和随初始极化方向变化的特征,表明台站下方存在多个可能的各向异性源区.对不同频段各向异性观测结果的双层各向异性模型拟合表明,上层各向异性参数为φ=32°±12°,δt=1.4±0.4 s,表现出受郯庐断裂带影响的岩石圈中"固化"各向异性特征;下层各向异性参数为φ=-71°±6°,δt=2.4±0.4 s,与海沟近乎垂直.下层较大的各向异性延时表明研究区域的地幔楔和地幔过渡带中存在明显各向异性,推测是由地幔中软流圈流动引起的橄榄石晶格优势取向和停滞的西北太平洋板片引起的地幔水平流动产生的瓦兹利石晶格优势取向共同作用所导致.

关键词：各向异性剪切波分裂大地幔楔地幔过渡带频率依赖性双层各向异性模型多波形同时反演

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A study on 3-D velocity structure of crust and upper mantle in Sichuan -Yunnan region, China

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Acta Seismologica Sinica(English Edition) 2002年第1期15卷 1-17页

作者：王椿镛 mooney W.D 王溪莉吴建平楼海王飞 Institute of Geophysics China Seismological Bureau Beijing 100081 China U. S. Geological Survey Menlo Park CA94025 USA

Based on the first arrival P and S data of 4 625 regional earthquakes recorded at 174 stations dispersed in the Yunnan and Sichuan Provinces, the 3-D velocity structure of crust and upper mantle in the region is determined, incorporating with previous deep geophysical data. In the upper crust, a positive anomaly velocity zone exists in the Sichuan basin, whereas a negative anomaly velocity zone exists in the western Sichuan plateau. The boundary between the positive and negative anomaly zones is the Longmenshan fault zone. The images of lower crust and upper mantle in the Longmenshan fault, Xianshuihe fault, Honghe fault and others show the characteristic of tectonic boundary, indicating that the faults likely penetrate the Moho discontinuity. The negative velocity anomalies at the depth of 50 km in the Tengchong volcanic area and the Panxi tectonic zone appear to be associated with the temperature and composition variations in the upper mantle. The overall features of the crustal and the upper mantle structures in the SichuanYunnan region are the lower average velocity in both crust and uppermost mantle, the large crustal thickness variations, and the existence of high conductivity layer in the crust or/and upper mantle, and higher geothermal value. All these features are closely related to the collision between the India and the Asia plates. The crustal velocity in the SichuanYunnan rhombic block generally shows normal value or positive anomaly, while the negative anomaly exists in the area along the large strike-slip faults as the block boundary. It is conducive to the crustal block side-pressing out along the faults. In the major seismic zones, the seismicity is relative to the negative anomaly velocity. Most strong earthquakes occurred in the upper-mid crust with positive anomaly or normal velocity, where the negative anomaly zone generally exists below.

关键词： regional earthquake Moho discontinuity 3-D velocity structure network method plate collision seismicity

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Recent developments in topoisomerase-targeted cancer chemotherapy

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Acta Pharmaceutica Sinica B 2018年第6期8卷 844-861页

作者： Kirk E.Hevener Tatsiana A.Verstak Katie E.Lutat Daniel L.Riggsbee Jeremiah W.mooney Department of Pharmaceutical Sciences University of Tennessee Health Science Center

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously in all domains of life. The various topoisomerase enzymes perform a wide range of functions related to the maintenance of DNA topology during DNA replication, and transcription are the targets of a wide range of antimicrobial and cancer chemotherapeutic agents. Natural product-derived agents, such as the camptothecin, anthracycline, and podophyllotoxin drugs, have seen broad use in the treatment of many types of cancer. Selective targeting of the topoisomerase enzymes for cancer treatment continues to be a highly active area of basic and clinical research. The focus of this review will be to summarize the current state of the art with respect to clinically used topoisomerase inhibitors for targeted cancer treatment and to discuss the pharmacology and chemistry of promising new topoisomerase inhibitors in clinical and preclinical development.

关键词： Topoisomerase Inhibition Cancer Oncology Clinical Pre-clinical

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Analysis of a ten step protocol to decrease postoperative spinal wound infections

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World Journal of Orthopedics 2018年第11期9卷 271-284页

作者： Hossein Elgafy Craig J Raberding Megan L mooney Kyle A Andrews Joan M Duggan Department of Orthopedics and Infectious Diseases University of Toledo Medical Center

AIM To define a ten-step protocol that reduced the incidence of surgical site infection in the spine surgery practice of the senior author and evaluate the support for each step based on current *** In response to unexplained increased infection rates at our institution following spine surgery,a ten-step protocol was implemented:(1) preoperative glycemic management based on hemoglobin A1 c(HbA1 c);(2) skin site preoperative preparation with 2% chlorhexidine gluconate disposable cloths;(3) limit operating room traffic;(4) cut the number of personnel in the room to the minimum required;(5) absolutely no flash sterilization of equipment;(6) double-gloving with frequent changing of outer gloves;(7) local application of vancomycin powder;(8) re-dosing antibiotic every 4 h for prolonged procedures and extending postoperative coverage to 72 h for high-risk patients;(9) irrigation of subcutaneous tissue with diluted povidone-iodine solution after deep fascial closure; and(10) use of Dura Prep skin preparation at the end of a case before skin closure. Through an extensive literature review,the current data available for each of the ten steps was *** Use of vancomycin powder in surgical wounds,routine irrigation of surgical site,and frequent changing of surgical gloves are strongly supported by the literature. Preoperative skin preparation with chlorhexidine wipes is similarly supported. The majority of current literature supports control of HbA1 c preoperatively to reduce risk of infection. Limiting the use of flash sterilization is supported,but has not been evaluated in spine-specific surgery. Limiting OR traffic and number of personnel in the OR are supported although without level 1 evidence. Prolonged use of antibiotics postoperativelyis not supported by the literature. Intraoperative use of Dura Prep prior to skin closure is not yet *** The ten-step protocol defined herein has significantly helped in decreasing surgical site

关键词： Wound infections Spine Ten step protocol Surgical site infections

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台湾—阿尔泰地学断面阿尔金—龙门山剖面的地壳纵波速度结构

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地球物理学报 2005年第1期48卷 98-106页

作者：王有学 W D mooney 韩果花袁学诚姜枚桂林工学院资源与环境工程系广西桂林541004 美国地质调查局中国地质调查局发展研究中心北京100081 中国地质科学院地质研究所北京100037

通过分析阿尔金—龙门山地学断面的地震资料 ,建立了该剖面的地壳纵波速度结构 .研究结果表明 ,阿尔金北侧的塔里木盆地地区莫霍面为 5 0km ,而在其南侧的祁连地块莫霍面突然加深至 73km ,在柴达木盆地莫霍面又抬升至 5 8km左右 ,然后 ... 详细信息

通过分析阿尔金—龙门山地学断面的地震资料 ,建立了该剖面的地壳纵波速度结构 .研究结果表明 ,阿尔金北侧的塔里木盆地地区莫霍面为 5 0km ,而在其南侧的祁连地块莫霍面突然加深至 73km ,在柴达木盆地莫霍面又抬升至 5 8km左右 ,然后 ,在松潘甘孜地块莫霍面降至 70km ,并呈现为台阶状向龙门山方向抬升到 6 0km左右 ,最后在四川盆地 ,莫霍面的埋深仅为 5 2km .以昆仑断裂为界 ,在其北部地区的中地壳底部存在一速度为 5 80km s的低速层 ,而在其南部地区则没有低速层出现 ,推测低速层为地壳中部的局部熔融物质 .阿尔金—龙门山剖面上的两个莫霍面坳陷区分别与祁连地块和松潘—甘孜地块上的两个莫霍面坳陷区相对应 ,指示出这两个地块具有较深的山根 ,青藏高原北部的巨厚地壳很可能是由于中生代以来发生的印度板块与亚洲板块碰撞时受到来自东西及南北方向的挤压 ,使地壳缩短所致 .

关键词：阿尔金-龙门山地学断面地壳纵波结构

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