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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： Seon-Yeong Lee Su-Jin moon Young-Mee moon Hyeon-Beom Seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som Kim Yang-Mi Her Jeong Won choi Seung-Ki Kwok Sung-Hwan Park Mi-La cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:Seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

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Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 785-789页

作者： Tae-Il Jeon Chang-Hwa Jung Jeong-Yong cho Dong Ki Park Jae-Hak moon Department of Animal Science.College of Agriculture & Life Science Chonnam National UniversityKorea Food Function Research Center Korea Food Research InstituteSeoungnamKorea Division of Food Biotechnology University of Science and TechnologyDaejeonKorea Department of Food Science & Technology and Functional Food Research Center.Chonnam National UniversityKorea Department of Bioscience and Biotechnology Konkuk UniversityKorea

Objective:To isolate and identify the anticancer compound against proliferation of human colon cancer cells from ethyl acetate(EtOAc)extract ol Phellinus linteus grown on germinated brown rice(PB).Methods:EtOAc extract of PB was partitioned with n-hexane,EtOAc,and water-saturated *** compound of n-hexane layer was isolated and identified by HPLC and NMR,*** against HT-29 cells was tested by SRB ***:The n-hexane layer obtained after solvent fractionation of PB EtOAc extracts showed a potent anticancer activity against the HT-29 cell *** I,a eudesmane-type sesquiterpene lactone,a major anticancer substance of PB,was isolated from the n-hexane layer by silica gel column chromatography and *** structure was elucidated by one-and two-dimensional NMR spectroscopic *** I has not been reported in mushrooms or rice as of *** isolated compound dose-dependently inhibited the growth of HT-29 human colon cancer ***:Atractylenolide I might contribute to the anticancer effect of PB.

关键词： Atractylenolide I Human colon cancer cells NMR Phellinus linteus Germinated brown rice

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Fuzzy Based Assignment Method of Filtering Nodes in Wireless Sensor Networks

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Wireless Sensor Network 2012年第2期4卷 40-44页

作者： Soo Young moon Tae Ho cho School of Information and Communication Engineering Sungkyunkwan University School of Information and Communication Engineering Sungkyunkwan University Suwon South Korea

Wireless sensor networks (WSNs) are networked systems that are able to sense various events and report the events to a user to enable appropriate responses. One of security threats to a WSN is false data injection attacks in which an attacker steals some sensor nodes in the network and injects forged event messages into the network through the captured nodes. As a result, the intermediate nodes on the forwarding paths of the false event messages waste their limited energy. Additionally, the network cannot provide the user with correct information. There have been many studies on en-route detection of false event messages for WSNs. Yang et al. proposed the commutative cipher-based en-route filtering scheme (CCEF) which establishes a secure session between a sink node and a cluster head (CH) based on the commutative cipher. In CCEF, each intermediate node on the path between the sink node and the CH receives an event message and verifies the authenticity of the session based on a probability. Due to the probabilistic approach, it is hard to adapt to the change of false traffic ratio in the network and energy inefficiency may occur. We propose a filtering scheme which applies a deterministic approach to assign filtering nodes to a given session. The proposed method consumes less energy than that of CCEF without sacrificing security.

关键词： Wireless Sensor Network WSN False Data Filtering Scheme

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Pancreatic tuberculosis masquerading as pancreatic serous cystadenoma

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World Journal of Gastroenterology 2009年第8期15卷 1010-1013页

作者： Seung Goun Hong Jae Seon Kim moon Kyung Joo Kwang Gyun Lee Key Hyeon Kim cho Rong Oh Jong-Jae Park Young-Tae Bak Department of Internal Medicine Korea University College of Medicine Seoul South Korea

Solitary pancreatic involvement of tuberculosis is rare, especially in an immunocompetent individual, and it may be misdiagnosed as pancreatic cystic neoplasms. Pancreatic cystic neoplasms are being identified in increasing numbers, probably because of the frequent use of radiology and advances in endoscopic techniques. However, they are composed of a variety of neoplasms with a wide range of malignant potential, and it is often difficult to differentiate pancreatic tuberculosis mimicking cystic neoplasms from benign or malignant pancreatic cystic neoplasms. Non-surgical diagnosis of pancreatic tuberculosis is inconclusive and continues to be a challenge in many cases. If so, then laparotomy should be employed to establish the diagnosis. Therefore, pancreatic tuberculosis should be kept in mind during the differential diagnosis of solitary cystic masses in the pancreas. We report a patient who had solitary pancreatic tuberculosis masquerading as pancreatic serous cystadenoma.

关键词： Tuberculosis Pancreas Cystadenoma Serous neoplasm

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Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

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World Journal of Gastroenterology 2005年第14期11卷 2072-2079页

作者： Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-taek Jang Jae Won cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park School of Biological Sciences Seoul National University SeoulKorea Hepatology Center and Laboratory of Hepatocarcinogenesis Bundang Jesaeng General Hospital KyungkidoKorea School of Chemistry Seoul National University SeoulKorea Department of Pathology Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea General Surgery Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea Internal Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea

AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related ***: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically ***: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic ***: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.

关键词： Heat shock protein Hepatocellular carcinoma Dysplastic nodule Hepatocarcinogenesis Immunohisto-chemistry Dot immunoblot analysis

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Tacrolimus for children with refractory nephrotic syndrome:a one-year prospective,multicenter,and open-label study of Tacrobell®,a generic formula

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World Journal of Pediatrics 2016年第1期12卷 60-65页

作者： Eun Mi Yang Sang taek Lee Hyun Jin choi Hee Yeon cho Joo Hoon Lee Hee Gyung Kang Young Seo Park Hae Il Cheong Il-Soo Ha Department of Pediatrics Chonnam National University HospitalGawngjuKorea Department of Pediatrics Seoul National University Children's HospitalSeoulKorea Department of Pediatrics Samsung Medical CenterSungkynkwan University School of MedicineSeoulKorea Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoulKorea Research Coordination Center for Rare Diseases Seoul National University HospitalSeoulKorea Kidney Research Institute Medical Research CenterSeoul National University College of MedicineSeoulKorea

Background:Cyclosporine A and tacrolimus(TAC)are often used as a second-line treatment for children with refractory nephrotic syndrome(NS).This study was undertaken to investigate the efficacy and safety of Tacrobell®,a locally produced generic form of ***:This study was a one-year prospective,open-label,single-arm,multicenter ***-four children with steroid-dependent NS(SDNS)and 33 children with steroid-resistant NS(SRNS)were *** primary endpoints were defined as the remission rates,whereas the secondary endpoints were recognized as the duration of remission and adverse effects of ***:After one-year treatment,34(77.3%)of the 44 patients with SDNS were in complete remission,and 6(13.6%)were in partial ***(43.2%)patients did not relapse during the study;for those who did relapse,the mean duration of remission was 4.6±2.9 *** number of relapse episodes during the study period(0.90 per patient-year)was significantly lower than that in the preceding year(2.8 per patientyear).After treatment for 3 and 6 months,12(36.4%)of the 33 patients with SRNS were in remission,and after treatment for 12 months,the number of patients had increased to 13(39.4%).The mean time to achieve remission was 4.0±3.2 *** remission(duration,3.7±2.7 months),12(54.5%)of 22 patients *** fasting blood glucose and blood pressure levels during the therapy were similar to those at the time of study ***:Treatment with Tacrobell®was effective and safe for children with refractory *** efficacy of this generic form of TAC was better than that of the original TAC formula.

关键词： generic drugs nephrotic syndrome tacrolimus

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An Anionic Covalent Organic Framework as an Electrostatic Molecular Rectifier for Stabilizing Mg Metal Electrodes

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CCS Chemistry 2023年第11期5卷 2567-2575页

作者： Zhongping Li Hyunseok moon Seok-Kyu cho Changqing Li Jeong-Min Seo Jong-Beom Baek Hong Xu Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03772 School of Energy and Chemical Engineering Ulsan National Institute of Science and TechnologyUlsan 44919 UBATT Inc. Daejeon 34036 Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084

Despite its potential as a high-capacity battery electrode,magnesium(Mg)metals are highly susceptible to electrolytes,resulting in the formation of unwanted passivation layers,which hinder charge transfer ***,we first report an anionic covalent organic framework(a-COF)as an electrostatic molecular rectifier(that can preferentially trap solvent molecules)to stabilize Mg metal *** to a neutral COF(n-COF)as a control sample,the a-COF enhances Mg^(2+)transport by facilitating the desolvation of Mg^(2+)-solvent complexes and cationic mobility through its negatively charged one-dimensional columns,thereby achieving an ionic conductivity eight times higher than that of the *** addition,the anionic porous frameworks in contact with Mg metal electrodes enable a uniform Mg^(2+)flux and interfacial stability with Mg metal ***,the a-COF exhibited reversible Mg plating/stripping cyclability on Mg metal electrodes compared to the n-COF,demonstrating the electrochemical viability of the anionic frameworks for Mg metal electrode stabilization.

关键词： anionic covalent organic framework Mg metal electrodes ion transport interfacial stability Mg plating/stripping

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Unconventional assemblies of bisacylhydrazones:The role of water for circularly polarized luminescence

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Aggregate 2022年第5期3卷 185-193页

作者： Hye Jin cho Dong Yeun Jeong Hwihyun moon Taewoo Kim You Kyoung Chung Yeongdong Lee Zonghoon Lee Joonsuk Huh Youngmin You Changsik Song Department of Chemistry Sungkyunkwan UniversitySuwonGyeonggi 16419Republic of Korea Division of Chemical Engineering and Materials Science Graduate Program in System Health Science and EngineeringEwha Womans UniversitySeoul 03760Republic of Korea Center for Multidimensional Carbon Materials Institute for Basic Science(IBS)Department of Materials Science and EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Understanding the precise molecular arrangement of chiral supramolecular polymers is essential not only to comprehend complex superstructures like proteins and DNA but also for the development of next-generation optoelectronic materials,including materials displaying high-performance circularly polarized luminescence(CPL).Herein,we report the first chiral supramolecular polymer systems based on hydrazone–pyridinium conjugates comprising alkyl chains of different lengths,which afforded control of the apparent supramolecular *** supramolecular chirality is governed basically by the remote chiral centers of alkyl chains,helicity inversion was achieved by controlling the conditions under which the hydrazone building blocks underwent aggregation(i.e.,solvent compositions or temperature).More importantly,the addition of water to the system led to aggregationinduced hydrazone deprotonation,which resulted in a completely different selfassembly *** water molecules played an essential role,forming the assembly’s channel-like backbone,around which hydrazone molecules gathered as a result of hydrogen bonding *** co-assembly of an achiral hydrazone luminophore with the given supramolecular polymer system allowed the fabrication of a novel CPL-active hydrazone-based material exhibiting a high maximum value for the photoluminescence dissymmetry factor of -2.6×10^(-2).

关键词： circularly polarized luminescence(CPL) helicity control hydrazone self-assembly structural water supramolecular polymerization

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Neuroprotective Effect of Chunghyuldan(Qing Xue Dan)on Hypoxia-Reoxygenation Induced Damage of Neuroblastoma 2a Cell Lines

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Chinese Journal of Integrative Medicine 2013年第12期19卷 940-944页

作者： Chang-Nam Ko In-Seo Park Seong-Uk Park Woo-Sang Jung Sang-Kwan moon Jung-Mi Park Chulhun Kang Ki-Ho cho Department of Cardiology and Neurology Diseases College of Korean MedicineKyung Hee University Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University

Objectives： Chunghyuldan （CHD）, a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of CHD＇s neuroprotective effect, we examined whether CHD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 （Bcl-2） expression in mouse neuroblastoma 2a （N2a） cells subjected to hypoxia-reoxygenation （H/R）. Methods： In order to evaluate the effects of CHD on the cytotoxicity induced from hypoxia or H/R condition, lactate dehydrogenase （LDH） assay was performed. To explore whether the suppression of neural damage when pre-treated with CHD is associated with its anti-apoptotic effect, the CHD effect on the expression of Bcl-2 and Bax was analyzed by Western blotting analysis. Results： Cytotoxicity of N2a cell line was slightly increased in 42 h hypoxia condition and dramatically increased under the H/R condition. CHD treatment markedly decreased the cytotoxicity in both conditions （P〈0.01, P〈0.05）. H/R markedly increased the expression of the pro-apoptotic protein, Bax, but slightly increased the expression of the anti-apoptotic protein, Bcl-2, compared with the normoxia or hypoxia group. CHD significantly decreased Bax expression （P〈0.01） and slightly decreased Bcl-2 expression （P〉0.05）, resulted in a reduction of Bax/Bcl-2 ratio in N2a cells subjected to H/R. Conclusion： CHD has neuroprotective effect in N2a cells subjected to H/R, which might be derived at least in part from its ability to decrease the expression of the pro-apoptotic protein, Bax.

关键词： apoptosis stroke Chunghyuldan herbal

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Effect of ischemic preconditioning on antioxidant status in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第7期11卷 1081-1089页

作者： Seung Min Park Chan Woo Park Tae-Kyeong Lee Jeong Hwi cho Joon Ha Park Jae-Chul Lee Bai Hui Chen Bich-Na Shin Ji Hyeon Ahn Hyun-Jin Tae Myoung Cheol Shin taek Geun Ohk Jun Hwi cho Moo-Ho Won Soo Young choi In Hye Kim Department of Emergency Medicine Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University Department of Neurobiology School of MedicineKangwon National University Department of Physiology College of MedicineHallym University Department of Biomedical Science Research Institute of Bioscience and BiotechnologyHallym University

Ischemic preconditioning（IPC） is a condition of sublethal transient global ischemia and exhibits neuroprotective effects against subsequent lethal ischemic ***,in this study,examined the neuroprotective effects of IPC and its effects on immunoreactive changes of antioxidant enzymes including superoxide dismutase（SOD） 1 and SOD2,catalase（CAT） and glutathione peroxidase（GPX） in the gerbil hippocampal CA1 region after transient forebrain *** neurons of the stratum pyramidale（SP） in the hippocampal CA1 region of animals died 5 days after lethal transient ischemia without IPC（8.6%（ratio of remanent neurons） of the sham-operated group）;however,IPC prevented the pyramidal neurons from subsequent lethal ischemic injury（92.3%（ratio of remanent neurons） of the sham-operated group）.SOD1,SOD2,CAT and GPX immunoreactivities in the sham-operated animals were easily detected in pyramidal neurons in the stratum pyramidale（SP） of the hippocampal CA1 region,while all of these immunoreactivities were rarely detected in the stratum pyramidale at 5 days after lethal transient ischemia without ***,their immunoreactivities in the sham-operated animals with IPC were similar to（SOD1,SOD2 and CAT） or higher（GPX） than those in the sham-operated animals without ***,their immunoreactivities in the stratum pyramidale of the ischemia-operated animals with IPC were steadily maintained after lethal ischemia/*** of western blot analysis for SOD1,SOD2,CAT and GPX were similar to immunohistochemical *** conclusion,IPC maintained or increased the expression of antioxidant enzymes in the stratum pyramidale of the hippocampal CA1 region after subsequent lethal transient forebrain ischemia and IPC exhibited neuroprotective effects in the hippocampal CA1 region against transient forebrain ischemia.

关键词： hippocampal operated antioxidant stratum subsequent superoxide glutathione neuronal hippocampus peroxidase

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