检索结果-南通市图书馆

Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients

World Journal of Gastroenterology 2021年第42期27卷 7340-7349页

作者： Min-Woo Chung moon-ju kim Eun Jeong Won Yu Jeong Lee Yong-Woon Yun Sung Bum Cho Young-Eun Joo jun-Eul Hwang Woo Kyun Bae Ik-Joo Chung Myung Geun Shin Jong Hee Shin Department of Internal Medicine Chonnam National University Hospital and College of MedicineHwasun 58128Jeollanam-doSouth Korea Department of Parasitology and Tropical Medicine Chonnam National University Medical SchoolHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Preventive Medicine Chonnam National University Medical SchoolHwasun-eupHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Immunotherapy has revolutionized the clinical outcomes of intractable cancer *** is known about the intestinal nonpathogenic bacterial composition of hepatocellular carcinoma(HCC)patients treated by *** To determine whether there is a correlation between gut bacterial composition and prognosis in HCC *** From September 2019 to March 2020,we prospectively collected fecal samples and examined the gut microbiome of 8 advanced HCC patients treated with nivolumab as a second-or third-line systemic *** samples were collected before the start of *** samples of patients with progression during treatment were collected at the time of progression,and fecal samples of patients who showed good response to nivolumab were collected after 5-7 mo as *** data from 16S ribosomal RNA sequencing were analyzed using CLC Genomics *** data were analyzed according to therapeutic *** All 8 patients were male,of which 6 had underlying chronic hepatitis B.A higher Shannon index was found in the responders than in the non-responders after nivolumab therapy(P=0.036).The unweighted beta diversity analysis also showed that the overall bacterial community structure and phylogenetic diversity were clearly distinguished according to therapeutic *** was no significant difference in the diversity or composition of the patient gut microbiome according to the immunotherapy *** taxa specific to therapeutic response were designated as follows:Dialister pneumosintes,Escherichia coli,Lactobacillus reteri,Streptococcus mutans,Enterococcus faecium,Streptococcus gordonii,Veillonella atypica,Granulicatella sp.,and Trchuris trichiura for the nonresponders;Citrobacter freundii,Azospirillum *** Enterococcus durans for the *** note,a skewed Firmicutes/Bacteroidetes ratio and a low Prevotella/Bacteroides ratio can serve as predictive markers of non-response,wh

关键词： Microbiome Nivolumab Firmicutes/Bacteroidetes ratio Prevotella/Bacteroides ratio Hepatocellular carcinoma Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

引用

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

引用

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extremely rare case of necrotizing gastritis in a patient with autoimmune hepatitis: A case report

引用

World Journal of Clinical Cases 2021年第14期9卷 3472-3477页

作者： Seung Ki moon Jeong-ju Yoo Sang Gyune kim Young Seok kim Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Gastroenterology and Hepatology Soonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Autoimmune hepatitis can cause liver fibrosis,liver cirrhosis,and hepatocellular *** treatment option include the use of steroids and/or immunesuppressive agents such as ***,these drugs have some side ***,close follow-up is needed during ***,we present an extremely rare case of a patient with an autoimmune hepatitis who died from necrotizing gastritis during immunosuppressive *** SUMMARY A 52-year-old female patient was diagnosed with autoimmune *** treated this patient with immunosuppressive ***-dose steroid treatment was initially *** azathioprine treatment was added while steroid was *** weeks after the start of treatment,she visited the emergency room due to generalized abdominal pain and *** computed tomography scan,the patient was diagnosed with necrotizing gastritis and the patient progressed to septic *** for sepsis was continued in the intensive care ***,the patient died at 6 h after admission to the emergency *** In patients with autoimmune infections undergoing immunosuppressant therapy,rare complications such as necrotizing gastritis may occur,thus requiring clinical attention.

关键词： Autoimmune hepatitis Azathioprine Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare case of hepatocellular carcinoma metastasis to urinary bladder:A case report

引用

World Journal of Clinical Cases 2022年第16期10卷 5470-5478页

作者： Yohan kim Young Seok kim Jeong-ju Yoo Sang Gyune kim Susie Chin Ahrim moon Department of Gastroenterology Soonchunhyang University Hospital BucheonBucheon B14200202Gyeonggi-doSouth Korea Division of Gastroenterology and Hepatology Department of Internal MedicineSoonchunhyang University Bucheon HospitalBucheon B14200202Gyeonggi-doSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalBucheon B14200202Gyeonggi-doSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon B14200202Gyeonggi-doSouth Korea

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver cancer with high prevalence and *** are many cases of advanced HCC at the time of *** methods and prognosis are different depends on whether metastasis is ***,it is necessary to make an accurate evaluation at the time of *** metastases of HCC usually occur through hematogenous spread or through adjacent organs such as the *** to the urinary bladder alone is ***,we report a rare case of biopsy-proven solitary metastasis of HCC to the bladder in a 60-year-old *** SUMMARY A 60-year-old female patient was found to be positive for hepatitis B surface antigen by chance after abdominal ultrasonography showed abnormal ***,liver dynamic computed tomography(CT)was *** patient visited the hospital for further *** and CT showed 3.6 cm sized arterial enhancing mass in segment 5 and an infiltrative mass in segment *** patient was diagnosed with HCC through liver dynamic magnetic resonance imaging and liver ***,she underwent two transcatheter arterial chemoembolizations within five months for *** follow-up,a newly appeared bladder tumor was found on liver dynamic *** underwent transurethral resection of the bladder tumor for diagnosis and *** tissue was confirmed as metastatic *** Although rare,metastasis to urinary bladder from HCC can occur without evidence of other distant ***,regular follow-up imaging examination and clinical attention are required.

关键词： Hepatocellular carcinoma Metastasis Urinary bladder Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two climate factors in May that affect Korean rainfall in September

引用

Acta Oceanologica Sinica 2013年第1期32卷 32-47页

作者： CHOI Ki-Seon moon Il-ju National Typhoon Center Korea Meteorological Administration College of Ocean Science/Ocean and Environment Research Institute Jeju National University

This study revealed a high positive correlation between rainfall in Korea during September and the trade wind （TW）/Arctic Oscillation （AO） index in May that combines two climate factors, low-level TWs and the AO. This correlation was identified on the basis of the difference in the 850 hPa streamline analysis between the positive and negative phases selected using the combined TW/AO index. In May, the spatial pattern of the anomalous pressure systems is similar to that in the positive AO phase. These anomalous pressure sys- tems continue in june to August （JJA） and September, but the overall spatial distribution shifts a little to the south. Particularly in September, a huge anomalous anticyclone centered over the southeast seas of Japan strengthens in most of the western north Pacific region and supplies a large volume of warm and humid air to the region near Korea. This characteristic is confirmed by the facts that during the positive TW/AO phase, the subtropical western north Pacific high （SWNPH） is more developed to the north and that the continu- ous positioning of the upper troposphere jet over Korea from May to September strengthens the anomalous upward flow, bringing warm and humid air to all layers. These factors contribute to increasing September rainfall in Korea during the positive TW/AO phase. Because the SWNPH develops more to the north in the positive phase, tropical cyclones tend to make landfall in Korea frequently, which also plays a positive role in increasing September rainfall in *** above features are also reflected by the differences in average rainfall between the six years that had the highest May Nifio 3.4 indices （El Niflo phase） and the six years that had the lowest May Niflo 3.4 indices （La Nifia phase）.

关键词： anomalous pressure Arctic Oscillation Korea low-level trade wind rainfall tropical cyclone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine Learning-Assisted Fabrication of PCBM-Perovskite Solar Cells with Nanopatterned TiO_(2)Layer

引用

Energy & Environmental Materials 2024年第4期7卷 223-230页

作者： Siti Norhasanah Sanimu Hwa-Young Yang Jeevan Kandel Ye-Chong moon Gangasagar Sharma Gaudel Seung-ju Yu Yong ju kim Sejung kim Bong-Hyun jun Won-Yeop Rho Graduate School of Integrated Energy-AI Jeonbuk National University567 Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Korea Department of Herbal Medicine Resources College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Korea School of Chemical Engineering Jeonbuk National University567 BaekjedaeroDeokjin-guJeonju-siJeollabuk-do 54896Korea Department of Bioscience and Biotechnology Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Korea School of International Engineering and Science Jeonbuk National University567 Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Korea

To unlock the full potential of PSCs,machine learning(ML)was implemented in this research to predict the optimal combination of mesoporous-titanium dioxide(mp-TiO_(2))and weight percentage(wt%)of phenyl-C_(61)-butyric acid methyl ester(PCBM),along with the current density(J_(sc)),open-circuit voltage(V_(oc)),fill factor(ff),and energy conversion efficiency(ECE).Then,the combination that yielded the highest predicted ECE was selected as a reference to fabricate PCBM-PSCs with nanopatterned TiO_(2)***,the PCBM-PSCs with nanopatterned TiO_(2)layers were fabricated and characterized to further understand the effects of nanopatterning depth and wt%of PCBM on ***,the highest ECE of 17.338%is achieved at 127 nm nanopatterning depth and 0.10 wt%of PCBM,where the J_(sc),V_(oc),and ff are 22.877 mA cm^(-2),0.963 V,and 0.787,*** measured J_(sc),V_(oc),ff,and ECE values show consistencies with the ML ***,these findings not only revealed the potential of ML to be used as a preliminary investigation to navigate the research of PSCs but also highlighted that nanopatterning depth has a significant impact on J_(sc),and the incorporation of PCBM on perovskite layer influenced the V_(oc)and ff,which further boosted the performance of PSCs.

关键词： machine learning nanopatterning PCBM perovskite solar cells prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

引用

Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In Yoon Sung-Gyu Lee Deok-Bog moon Shin Hwang Ki-Hun kim Hui-ju kim Ki-Hoon Choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between june 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Silicon nanowire CMOS NOR logic gates featuring onevolt operation on bendable substrates

引用

Nano Research 2018年第5期11卷 2625-2631页

作者： Jeongje moon Yoonjoong kim Doohyeok Lim Sangsig kim Department of Electrical Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 02841 Republic of Korea LED PKG Development Group Samsung Electronics Co. Ltd. 1 Samsung-ro Yongin-si Gyeonggi-do 17113 Republic of Korea

In this study, we propose complementary metal-oxide-semiconductor （CMOS） NOR logic gates consisting of silicon nanowire （NW） arrays on bendable substrates. A circuit consisting of two p-channel NW field-effect transistors （NWFETs） in series and two n-channel NWFETs in parallel is constructed to operate a two- input CMOS NOR logic gate. The NOR logic gates operate at a low supply voltage of 1 V with a rail-to-rail logic swing and a high voltage gain of approximately -3.0. The exact NOR logic functionality is achieved owing to the superior electrical characteristics of the well-aligned p- and n-NWFETs, which are obtained using conventional Si-based CMOS technology. Moreover, the NOR logic gates exhibit stable characteristics and have good mechanical properties. The proposed bendable NW CMOS NOR logic gates are promising building blocks for future bendable integrated electronics.

关键词： field-effect transistor silicon nanowire NOR logic gate bendable substrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fruits extracts of Hovenia dulcis *** lipopolysaccharide—stimulated inflammatory responses through nuclear factor—kappaB pathway in Raw 264.7 cells

引用

Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 349-355页

作者： ju-Yeon Park Jin-Young moon Sun-Dong Park Won-Hwan Park Hyuck kim Jai-Eun kim Department of Acupoint College of Korean Medicine.Dongguk University Department of Prescription College of Korean MedicineDongguk University Department of Diagnostics College of Korean Medicine.Dongguk University Department of Pathology College of Korean Medicine.Dongguk University

Objective:To investigate the anti-inflammatory effects and the action mechanism of the fruits of Horenia dulcis(***) in lipopolysaccharide(LPS)-induced mouse macrophage Raw ***:The extract of *** fruits(EHDF) were extracted with 70%*** macrophages were treated with different concentrations of EHDF in the presence and absence of LPS(1 μg/mL).To demonstrate the inflammatory mediators including nitric oxide,inducible nitric oxide synthase and cyclooxygenase(COX)-2 expression levels were analyzed by usingin vitro assay ***-derived pro-inflammatory cytokines including interleukin-1 β.tumor necrosis factor- α and prostaglandin F_2 were determined using ELISA *** viability,heme oxygenase-1 expression,nuclear factor-kappaB and nuclear factor F.2-related factors 2 translocation were also ***:EHDF potently inhibited the LPS-stimulated nitric oxide,inducible nitric oxide ***-2,interleukin-1 β and tumor necrosis factor- α expression in a dose-dependent *** suppressed the phosphorylation of inhibited kappaB-alpha and p65 nuclear *** of macrophage cells with EHDF alone induced the heme oxygenase-1 and nuclear translocation of nuclear factor E2-reIated factor ***:These results suggest that the ethanol extract of *** fruit exerts its anti-inflammatory effects by inhibiting inhibited kappaBalpha phorylation and nuclear translocation of nuclear factor-kappaB.

关键词： Fruits of Hovenia dulcis Inflammation Macrophage Nuclear factor-kappaB Heme oxygenase-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：