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Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network

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Journal of Animal Science and Biotechnology 2018年第3期9卷 574-584页

作者： Jae Yong Han Hyo Gun Lee Young Hyun Park Young Sun Hwang Sang kyung Kim Deivendran Rengaraj Byung Wook cho Jeong Mook Lim Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University Department of Animal Science and Technology Chung-Ang University Department of Animal Science College of Natural Resources and Life Sciences Pusan National University

Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well ***: We found that chicken NANOG(c NANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I(EGK.I) to X. However, c POUV was not expressed during fol iculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, c SOX2 could not be detected during fol iculogenesis and intrauterine embryonic development. Instead of c SOX2, c SOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as c ENS-1, c KIT, c LIN28 A, c MYC, c PRDM14, and c SALL4 began to be dramatical y upregulated between *** and ***: These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and c SOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around *** to VI I.

关键词： Avian Embryonic development NANOG Pluripotency Transcriptional factor

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Chronic gastrointestinal symptoms and quality of life in the Korean population

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World Journal of Gastroenterology 2008年第41期14卷 6388-6394页

作者： Jeong-Jo Jeong Myung-Gyu choi Young-Seok cho Seung-Geun Lee Jung-Hwan Oh Jae-Myung Park Yu-kyung cho In-Seok Lee Sang-Woo Kim Sok-Won Han Kyu-Yong choi In-Sik Chung Department of Internal Medicine the Catholic University of Korea Department of Biostatistics University of North Carolina at Chapel Hill NC

AIM： To evaluate the prevalence of chronic gastroin- testinal symptoms and their impact on health-related quality of life （HRQOL） in the Korean population. METHODS： A cross-sectional survey, using a reliable and valid Rome I] based questionnaire, was per- formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey （SF-36）. RESULTS： Of the 1807 eligible subjects, 1417 （78.4%： male 762; female 655） were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro- esophageal reflux disease （GERD）, defined as heart- burn and/or acid regurgitation experienced at least weekly, was 3.5% （95% CI, 2.6-4.5）. The prevalence of uninvestigated dyspepsia, irritable bowel syndrome （IBS） and chronic constipation based on Rome Ⅱ criteria were 11.7% （95% CI, 10.1-13.5）, 2.2% （95% CI, 1.5-3.1）, and 2.6% （95% CI, 1.8-3.5） respectively. Compared with subjects without chronic gastrointesti- nal symptoms （n = 1153）, those with GERD （n = 50）, uninvestigated dyspepsia （n = 166） and IBS （n = 31） had significantly worse scores on most domains of the SF-36 scales. CONCLUSION： The prevalence of GERD, uninvesti- gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health- related quality of life was significantly impaired in subjects with GERD, uninvestigated dyspepsia and IBS in this community.

关键词： Chronic gastrointestinal symptom Gastroesophageal reflux disease Dyspepsia Irritable bowel syndrome Qaulibl of life

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Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer

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World Journal of Gastroenterology 2011年第48期17卷 5310-5316页

作者： Chan Ho Park Hee Cheol Kim Yong Beom cho Seong Hyeon Yun Woo Yong Lee Young Suk Park Doo Ho choi Ho-kyung Chun Departmentof Surgery Samsung Medical Center Sungkyunkwan Univer-sity School of Medicine Irwon-dong 50 Gangnam-gu Seoul135-710 South Korea Division of Hematology-Oncology Depart-ment of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Irwon-dong 50 Gangnam-guSeoul 135-710 South Korea Department of Radiation Oncology SamsungMedical Center Sungkyunkwan University School of MedicineIrwon-dong 50 Gangnam-gu Seoul 135-710 South Korea

AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete ***: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information.

关键词： Rectal cancer Preoperative chemoradiotherapy Downstaging Tumor regression Validation

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Spontaneous resolution of multiple lymphangiomas of the colon:A case report

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World Journal of Gastroenterology 2011年第11期17卷 1515-1518页

作者： Ji Min Lee Woo Chul Chung Kang-moon Lee Chang Nyol Paik Yeon-Ji Kim Bo-In Lee Young Seok cho Hyun Joo choi Department of Internal Medicine College of Medicine the Catholic University of KoreaSt.Vincent's Hospital 93-6Ji dongPaldal-guSuwonGyeonggi-do442-723South Korea

Lymphangioma of the colon is a relatively rare nonepithelial tumor and usually presents as a submucosal polypoid *** cases incidentally discovered are usually ***,they may present as abdominal pain or bleeding,and their resection is normally *** itself is generally recognized as a benign tumor and no cases of malignant transformation have yet been reported,although its natural history is currently *** the best of our knowledge,this study is the first to describe a case of spontaneous resolution in multiple colonic lymphangiomas without any specific treatment.

关键词： Lymphangioma Colon Natural history

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Transient Hypertensive Response to CO<sub>2</sub>Aortography in a Patient with Pheochromocytoma

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Open Journal of Radiology 2015年第1期5卷 1-7页

作者： Nimesh Patel kyung J. cho University of Michigan Medical School Ann Arbor MI USA Department of Radiology Division of Vascular & Interventional Radiology University of Michigan Health System Ann Arbor MI USA

We report on a 15-year-old male with 4-year history of hypertension and retroperitoneal masses referred to Interventional Radiology to evaluate the nature of the persistent masses and renal artery stenosis. Angiographic evaluation began with CO2aortogram during which the patient had a hypertensive response with bradycardia and arrhythmia to the intra-aortic injection of CO2. His hypertension, bradycardia, and arrhythmia responded to an intravenous nitroglycerin drip without administration of alpha or beta blockers. Due to this response and neovascularity of the mass, selective venous sampling of catecholamines and renin was performed which confirmed functioning paragangliomas and hemodynamically significant stenosis of left accessory renal artery, respectively. This is the first known case of hypertensive response to CO2 aortography in a patient with unsuspected functioning paragangliomas. We propose that patients with known or suspected diagnosis of catecholamine-secreting tumors undergoing CO2 angiography should be considered for pre-procedural treatment with alpha and beta blockage or have the appropriate medication on hand with close monitoring in the event of hypertensive response.

关键词： CO2 Aortography Paraganglioma Caval Venous Sampling Renal Artery Stenosis

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： Seon-Yeong Lee Su-Jin moon Young-Mee moon Hyeon-Beom Seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som Kim Yang-Mi Her Jeong Won choi Seung-Ki Kwok Sung-Hwan Park Mi-La cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:Seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

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Dynamic Channel Allocation by Using Allocation Function in PCS

Dynamic Channel Allocation by Using Allocation Function in P...

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亚太地区通信会议暨光电子通信会议

作者： Kwang moon cho AIN(Advanced Intelligent Network)Software Lab. SAMSUNG Electronics Co. Ltd.Samsung Plaza 18E.263 SeoHyun-Dong BunDang-Gu SeongNam kyungKi Korea 463-050

In this paper a dynamic channel allocation method applicable tothe microcell system like as PCS is *** factors for the quality of channels are *** function that consists of these factors has *** channel allocation for a call is processed by usingthe function *** a channel is being allocated to a call,the adequate quality channel is used instead of the best *** probability of call blocking is decreased even inthe cells having the high traffic load.

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Role of dietary gamma-aminobutyric acid in broiler chickens raised under high stocking density

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Animal Nutrition 2020年第3期6卷 293-304页

作者： Su-Been Jeong Yoo Bhin Kim Jeong-Woo Lee Da-Hye Kim Byung-Hern moon Hong-Hee Chang Yang-Ho choi kyung-Woo Lee Department of Animal Science and Technology Konkuk UniversitySeoul05029Republic of korea CellTech Co. Ltd.Chungbuk27622Republic of Korea Department of Animal Science Gyeongsang National Universityjinju52828Republic of Korea

The present study was conducted to evaluate the effects of dietary gamma-aminobutyric acid(GABA)in broiler chickens raised in high stocking density(HSD)on performance and physiological responses.A total of 900 male broiler chicks(Ross 308)at 1 d old were assigned in a 2×2 factorial arrangement to 4 treatments(10 replicates per treatment)with stocking density,7.5 birds/m^2(low stocking density;LSD)or 15 birds/m^2(HSD),and dietary GABA,0 or 100 mg/*** raised in HSD exhibited a decrease in body weight gain in all phases(P<0.05)and feed intake in starter and whole phases(P<0.01),and an increase in feed conversion ratio in the finisher phase(P<0.01)compared with LSD-raised ***,dietary GABA did not affect growth performance nor interacted with stocking density on production *** HSD *** increased relative liver weight on d 35 whereas dietary GABA increased relative liver weight and decreased relative bursa weight on d *** stocking density and dietary GABA affected yield and quality of breast and leg *** GABA increased(P<0.05)width of tibia on d 35 and interacted(P=0.054)with stocking density on breaking stocking density on d *** HSD *** group lowered(P<0.05)feather coverage *** interaction between stocking density and GABA on surface temperature of shank on d 21 was noted(P=0.024).Dietary GABA exhibited an opposite effect on the concentrations of cecal short-chain fatty acids depending on stocking density leading to a moderate to significant *** density decreased alpha-1-acid glycoprotein whereas dietary GABA decreased heterophil-to-lymphocyte ratio and corticosterone in blood or serum *** biochemical parameters were altered by stocking density or dietary *** is concluded that dietary GABA alleviated stress indices including corticosterone and heterophilto-lymphocyte ratio,but failed to reverse stocking density-induced growth depression.

关键词： Gamma-aminobutyric acid Stocking density Growth performance Stress indicator Broiler chicken

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THE EFFECTIVNE SSS AND LIMITATION OF MOBILE CT

THE EFFECTIVNE SSS AND LIMITATION OF MOBILE CT

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： kyung Gi cho Department of Neurosurgery Bundang CHA Hospital CHA University

＜正＞INTRODUCTION: We report our preliminary experience in a prospective series of patients with regard to feasibility, work flow, image quality and its limitation using a a portable CT scanner （CereTom? Dimensions...

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Ischemic colitis after mesotherapy combined with anti-obesity medications

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World Journal of Gastroenterology 2010年第12期16卷 1537-1540页

作者： Jong Bin Kim Won moon Seun Ja Park Moo In Park Kyu-Jong Kim Jae Nam Lee Seong Joo Kang Lee La Jang Hee kyung Chang Department of Internal Medicine Kosin University College of Medicine Department of Pathology Kosin University College of Medicine

Mesotherapy and anti-obesity medications are gradually gaining worldwide popularity for purposes of body contouring and weight *** adverse effects are various,but there is a tendency to disregard *** colitis is one of the most common diseases associated with non-obstructive blood vessel ***,there have been no case reports about the adverse effects resulting from mesotherapy only or in combination with anti-obesity *** report on an interesting case of ischemic colitis after mesotherapy combined with anti-obesity medications in a 39-year-old female who had no risk factors.

关键词： Mesotherapy Anti-obesity medications Adverse effects Ischemic colitis

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