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胶质瘤的基因治疗(英文)

中华神经外科疾病研究杂志 2013年第4期12卷 326-326页

作者： Tobias A Ahmed A moon ks Lesniak MS. Brain Tumour Center The University of Chicago5841 South Maryland AveMC 3026ChicagoIL 60637USA.

Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and *** treatment options such as gene therapy provide an intriguing option for curbing glioma related *** date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical *** most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal *** this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM.

关键词：摘要编辑部编辑工作读者

EFFECT OF VINYL ACETATE CONTENT ON THE MECHANICAL PROPERTIES AND MORPHOLOGICAL STRUCTURES OF POLYPROPYLENE

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Chinese Journal of Polymer Science 2006年第1期24卷 29-34页

作者： Mustafa ksüz Technical Education Faculty Marmara University 34722 GztepeIstanbulTurkey

The effect of vinyl acetate （VA） content in ethylene vinyl acetate （EVA） copolyrner on the mechanical properties of polypropylene was investigated. Three different EVA copolymers with concentrations of 3 wt%, 6 wt%, 9 wt%, 12 wt% and 15 wt%, were blended to polypropylene. The mechanical properties such as yield and tensile strengths, elastic modulus, Izod impact strength, hardness and melt flow index of the blends were investigated. Relationship between type of vinyl acetate and concentrations, mechanical, MFI and morphological properties were explored.

关键词： Compound Mechanical properties Morphology.

Preparation and Properties of Foam Glass-ceramic from Diatomite

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Journal of Wuhan University of Technology(Materials Science) 2018年第2期33卷 273-277页

作者： Ivanov ks Institute of the Earth Cryosphere Siberian Branch of Russian Academy of Sciences Tyumen 625026 Russia Tyumen Industrial University Tyumen 625000 Russia

The results of the study of raw mix preparation and foam glass-ceramics production using diatomite as a raw material were presented in the following article. A mixture of diatomite and 40% NaOH solution was subjected to heating at a constant temperature of 775 ℃. Samples of foam glass-ceramic from diatomite with an average density of 290-580 kg/m^3, compressive strength of 1.7-7.8 MPa and thermal conductivity of 0.08-0.14 W/（m·K） were obtained. The investigations have shown that the hydrothermal pretreatment of mixture at the temperature of 90 ℃ may lead to the acceleration of the leaching of amorphous SiO_2 from diatomite. It was discovered that the resulting soluble alkali silicates promote the process of foaming during heating and reduce the average density of the obtained samples. The optimal duration of the leaching process was estimated to be 30 minutes, which corresponds to the yield of SiO_2 equal to 42.5% by the weight of dry diatomite.

关键词： diatomite liquid glass foam glass-ceramics

Delaying clozapine: how long is too long?

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General Psychiatry 2020年第2期33卷 88-93页

作者： Tom Varghese M ks Jyothi ks Shaji Lekshmi Rita Venugopal Department of Psychiatry Government Medical College ThrissurThrissurKeralaIndia Department of Psychiatry General Hospital KozhikodeKozhikodeKeralaIndia School of public health University of CaliforniaBerkeleyCaliforniaUSA

Background Although clozapine is the most effective drug for treatment-resistant schizophrenia,its use remains restricted in clinical practice in *** delay in initiating treatment with clozapine and its impact on disease outcome needs *** To identify the implications of delaying clozapine initiation in clinical outcomes among people with treatment-resistant *** Subjects with treatment-resistant schizophrenia,stabilised on clozapine monotherapy,were recruited from the outpatient clinic of a general hospital psychiatry unit offering tertiary care services in Thrissur district,Kerala,India.A retrospective cohort design was employed,and information on duration of illness,total duration of treatment and duration of treatment with clozapine was *** symptom status was measured using the Positive and Negative Syndrome *** associated with higher symptom scores were analysed using an independent sample f test,Spearman correlation and multiple linear *** Forty subjects stabilised on long-term clozapine therapy formed the study *** mean dose of clozapine used in the study population was 200 *** mean duration of antipsychotic treatment before starting clozapine was 89.3 months(7.4 years).The duration of treatment before starting clozapine was found to have a significant positive association with the total Positive and Negative Syndrome Scale score(correlation coefficient 0.40;p=0.01)and negative symptom score(correlation coefficient 0.33;p=0.04).The multiple regression analysis adjusting for covariates showed that the duration of treatment before starting clozapine was an independent factor associated with a higher negative symptom score in the Positive and Negative Syndrome Scale(slope p=0.05;p=0.02;R2=0.27).Conclusion Poor treatment outcomes in treatmentresistant schizophrenia could be secondary to a delay in initiating clozapine therapy.

关键词： clozapine starting treatment

Studies on the flow and distribution of leukocytes in mesentery microcirculation of rats

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World Journal of Gastroenterology 1999年第3期5卷 231-234页

作者： Jiang Y Liu AH Zhao ks Mil Med Univ 1st Chinese PLA Lab Shock & Microcirculat Guangzhou 510515 Peoples R China

AIM To study the effect of leukocyteendothelium interaction (LEI) on the flow anddistribution of leukocytes in microcirculationunder physiological *** A microcirculation image multipleparameter computer analysis system (MIMPCAS)was used to study the flow and distribution ofleukocytes in mesentery microcirculation of ratsIn *** The difference of visible leukocyteflux (VLF) was as high as 131 times in thearterioles and venules with similar diameter andblood velocity. The visible leukocytes rolledalong the blood vessel wall as a" jerky"movement. The frequency distribution of thevisible leukocyte velocity (VLV) showed a "twopeak" Curve. The low peak value was at 10 pm/ s-- 15 pm/ s while the high peak fell between25 pm/ s-- 30 pm/ s. With the increase of diameterof venules, VLF increased while the VLVremained at the same level. With the increase ofRBC velocity, VLV trends to elevate and VLF tofal I *** The results herein might providea basic theory for the study on the mechanism ofLEI under physiological condition and novelmethods for the prevention and treatment of highLEI in many pathological

关键词： Studies on the flow and distribution of leukocytes in mesentery microcirculation of rats flow

Microstructure and Deformation Behavior of Ti-10V-2Fe-3Al Alloy during Hot Forming Process

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Journal of Wuhan University of Technology(Materials Science) 2015年第6期30卷 1332-1337页

作者：管仁国 ZHAO Zhanyong Choi ks Lee CS Key Laboratory of Electromagnetic Processing of Materials of Ministry of Education Northeastern University College of Materials Science and Engineering Northeastern University Materials and Metallurgical School Pohang University of Science and Technology

The microstructure evolution and formability of Ti-10V-2Fe-3Al alloy related to the initial microstructures and processing variables were investigated during hot forming process. The experimental results show that the α-phase growth is controlled by solute diffusion during the heat treatment processes. Four different microstructures were established by combinations of several heat treatments, and Ti-10V-2Fe-3Al alloy shows excellent formability both above and below the β transus temperature. The alloy possesses low deformation resistance and active restoration mechanism during the deformation. A constitutive equation describing the hot deformation behavior of Ti-10V-2Fe-3Al alloy was obtained. Higher fl ow stress was observed for the acicular morphology of α phase in microstructures with large aspect ratios as compared with that of small aspect ratios. Due to the dynamic recovery in soft β phase, and the dynamic recrystallization and breakage of acicular α-phase, fl ow softening occurred signifi cantly during deformation. Dynamic recrystallization also occurred especially in the severely deformed regions of forged parts.

关键词： Ti-10V-2Fe-3Al alloy microstructure evolution hot forging constitutive equation recovery dynamic recrystallization

Dielectric Behavior of Middle Phase Microemulsion

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Chinese Chemical Letters 2000年第8期11卷 739-742页

作者： Lei, JP Li, Y Zhao, ks S China Normal Univ Dept Chem Guangzhou 510631 Peoples R China

Dielectric measurements were performed on middle phase microemulsions composed of sodium dodecylsulfate(SDS), cetyltrimethylammonium bromide(CTAB), n-butanol, n-heptane and brine. Distinct and unique dielectric behavior, with characteristic frequency dependence regularity on the salinity of the microemulsions, was observed in the low-frequency range from 10-10(3)Hz. It can be considered to be an interfacial polarization mechanism.

关键词： middle phase microemulsions dielectric spectroscopy relaxation time

Characterization of Microstructural and Morphological Properties in As-deposited Ta/NiFe/IrMn/CoFe/Ta Multilayer System

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Journal of Materials Science & Technology 2014年第4期30卷 359-364页

作者： Ramis Mustafa ksoglu Umut Sarac Mustafa Yildirm Hakan inar Department of Materials Sciences and Engineering University of Anadolu Department of Elementary Education University of Bartin

Surface morphology and its relationship with microstructure in Ta/NiFe/IrMn/CoFe/Ta multilayer system deposited by pulsed DC magnetron sputtering have been investigated in dependence of Ta buffer and NiFe seed layer thicknesses using atomic force microscopy. The structural parameters such as grain size, dislocation density, texture and strain were calculated. For each surface, a self-affinity behavior with mean fractal dimensions in the range of 2.03-2.18 was found. Additionally, it was also observed that the surface of all samples has locally smooth textured surface structure in the short range. The texture aspect parameter and texture direction index have been obtained for isotropy/anisotropy surface texture. A significant relationship between the surface texture and the strength of the 〈111〉 texture in IrMn layer has been found. The analysis indicated that the surface roughness is strongly affected by the thicknesses of the NiFe seed and Ta buffer layers.

关键词： Pulsed DC magnetron sputtering Surface roughness Strain and texture