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A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández montserrat ortega-juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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Premature losses of leaf area in response to drought and insect herbivory through a leaf lifespan gradient

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Journal of Forestry Research 2022年第1期33卷 39-50页

作者： Sonia Mediavilla montserrat Martínez-ortega Santiago Andrés Javier Bobo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain Departamento de Botánica y Fisiología Vegetal Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain

Implications of the differences in leaf life span are still subject to debate in the field of *** leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate *** study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic *** of leaf area may be an important determinant of total leaf carbon *** Mediterranean tree species,distributed on four sites with different climates were *** species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit *** leaf area losses were estimated in response to insect herbivory and summer drought over two *** results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer *** respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.

关键词： Accelerated senescence Insect herbivory Leaf life span Leaf structural reinforcement Summer drought

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高血压患者从难治性到顽固性变化的相关因素:一项实用纵向研究

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中华高血压杂志 2019年第12期27卷 1214-1214页

作者：刘青(译) 叶鹏(摘/审校) Navarro-Soriano C Martínez-García MA Torres G Barbé F Caballero-Eraso C Lloberes P Cambriles TD Somoza M Masa JF González M Ma as E de la Pe a M García-Río F montserrat JM Muriel A Oscullo G Olmos LF García-ortega A Calhoun D Campos-Rodriguez F 无不详 Spanish Sleep Network

顽固性高血压(refractory hypertension,RfH)被定义为尽管服用了至少5种抗高血压药物,但血压仍未达到控制。与其自然病史相关的因素尚不清楚。该研究旨在评估难治性高血压(resistant hypertension,RH)患者的RfH发生率及其进展相关因素... 详细信息

顽固性高血压(refractory hypertension,RfH)被定义为尽管服用了至少5种抗高血压药物,但血压仍未达到控制。与其自然病史相关的因素尚不清楚。该研究旨在评估难治性高血压(resistant hypertension,RH)患者的RfH发生率及其进展相关因素。这是一项观察性前瞻性多中心研究(24个中心).

关键词：纵向研究高血压患者阻塞性睡眠呼吸暂停顽固性难治性

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