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systematic mechanism-orientated approach to chronic pancreatitis pain

World Journal of Gastroenterology 2015年第1期21卷 47-59页

作者： stefan AW Bouwense Marjan de Vries Luuk TW schreuder soren s Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor oliver HG Wilder-smith Pain and Nociception Neuroscience Research Group Department of SurgeryRadboud University Medical Center6500HB GelderlandThe Netherlands Department of Gastroenterology and Hepatology and Clinical Medicine Aalborg University Hospital9100 AalborgDenmark Center for sensory-Motor Interaction Department of Health Science and TechnologyAalborg University9100 AalborgDenmark Department of Anaesthesiology Pain and Palliative MedicineRadboud University Medical Center6500HB GelderlandThe Netherlands

Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar *** causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic ***,CP pain continues to be a major clinical *** is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain *** this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically *** central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance *** techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain *** present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms *** research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and *** we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders.

关键词： Chronic pancreatitis Pain Pain treatment Central sensitization Quantitative sensory testing Electroencephalograpy Magnetic resonance imaging

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IFRs adoption in China and foreign institutional investments

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China Journal of Accounting Research 2019年第1期12卷 1-32页

作者： Mark DeFond Xinzi Gao oliver Zhen Li Lijun Xia University of southern California sun Yat-sen University shanghai Lixin University of Accounting and Finance shanghai Jiao Tong University

We examine the effectiveness of China’s IFRs adoption from the perspective of an important set of financial report users, foreign institutional investors. We find that foreign institutional investment does not increase after China’s IFRs adoption, and some evidence that it actually declines, particularly among firms with weaker incentives to credibly implement IFRs, or with greater ability to manipulate IFRs’s fair value provisions. We also find that the association between earnings and returns generally declines after IFRs adoption, consistent with reduced earnings quality. In addition, we find that foreign institutional investors’ returns decrease after China’s IFRs adoption. Finally, the decline in foreign institutional investment is greater among investors from countries with weak institutions that have also adopted IFRs. Taken together, our evidence suggests that the weak institutional infrastructure in China’s transitional economy impairs IFRs’s intended goal of attracting institutional investment through improved financial reporting quality. Further, financial information users’ home country institutions and IFRs adoption experience affect the effectiveness of IFRs adoption.

关键词： IFRs Foreign institutional investment Institutions China

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学习能力与学习障碍的遗传学：英国的近期发展和中国的研究的可能方向

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心理学报 2008年第10期40卷 1051-1061页

作者： Robert Plomin Claire M.A. Haworth oliver.s.P. Davis social Genetic and Developmental Psychiatry Centre Institute of Psychiatry King＇s College London United Kingdom.

中国的行为遗传学诞生在遗传学突飞猛进的时代，令人振奋。作为一个新兴学科，中国的行为遗传学研究可以避免走前人的弯路，而成为领先而不是滞后的领域。以学习能力的研究为例，计量行为遗传学可以避免“性与养”（***）的争论而直接... 详细信息

中国的行为遗传学诞生在遗传学突飞猛进的时代，令人振奋。作为一个新兴学科，中国的行为遗传学研究可以避免走前人的弯路，而成为领先而不是滞后的领域。以学习能力的研究为例，计量行为遗传学可以避免“性与养”（***）的争论而直接研究一些遗传学与心理学里有意义的问题，包括正常与异常、稳定与变动、同质与异质的关系等问题。尤为重要的是超越“性与养”的争论而直接研究遗传对行为的影响。本文也扼要介绍了英国“双生子早期发展”项目的计量行为遗传学和“全基因组关联”对学习能力研究的结果。可以预计，飞速发展的遗传学发现将会持续一些时日，其发展将会对中国和世界的心理学产生更大的影响。

关键词：计量行为遗传学分子行为遗传学中国今后的学科发展

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Constrained crystals deep convolutional generative adversarial network for the inverse design of crystal structures

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npj Computational Materials 2021年第1期7卷 588-594页

作者： Teng Long Nuno M.Fortunato Ingo Opahle Yixuan Zhang Ilias samathrakis Chen shen oliver Gutfleisch Hongbin Zhang Institute of Materials science Technische Universität DarmstadtDarmstadtGermany

Autonomous materials discovery with desired properties is one of the ultimate goals for materials science,and the current studies have been focusing mostly on high-throughput screening based on density functional theory calculations and forward modeling of physical properties using machine *** the deep learning techniques,we have developed a generative model,which can predict distinct stable crystal structures by optimizing the formation energy in the latent *** is demonstrated that the optimization of physical properties can be integrated into the generative model as on-top screening or backward propagator,both with their own *** the generative models on the binary Bi-se system reveals that distinct crystal structures can be obtained covering the whole composition range,and the phases on the convex hull can be reproduced after the generated structures are fully relaxed to the *** method can be extended to multicomponent systems for multi-objective optimization,which paves the way to achieve the inverse design of materials with optimal properties.

关键词： properties crystal inverse

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Risk of second primary cancers after testicular cancer in East and West Germany： a focus on contralateral testicular cancers

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte streller Christa stegmaier Pietro Trocchi oliver Kuss Katherine A McGlynn Britton Traberts Andreas stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Common Cancer Registry of Berlin Berlin saarland Cancer Registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （sIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual sIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （sIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （sIR： 1.7; 95% Ch 1.4-2.0）. The sIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in saarland to 13.9 in East Germany. The sIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based sIRs for contralateral testicular cancers. The majority of reported sIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms

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认知与情绪过程的脑诱发电位研究——情绪的适应性假说

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心理学报 1992年第4期24卷 406-414页

作者：王晓田 Victor s.Johnston Juan C.oliver 美国新墨西哥州立大学心理系

本研究观测了30名女性被试在月经周期中的不同激素时相对图像刺激的情绪价值的主观评估和脑诱发电位反应。调节刺激的情绪价值的五类幻灯片分别为普通人像、婴儿像、皮肤病人像、男模特儿像和女模特儿像。实验发现只有脑诱发电位的P3成... 详细信息

本研究观测了30名女性被试在月经周期中的不同激素时相对图像刺激的情绪价值的主观评估和脑诱发电位反应。调节刺激的情绪价值的五类幻灯片分别为普通人像、婴儿像、皮肤病人像、男模特儿像和女模特儿像。实验发现只有脑诱发电位的P3成份随刺激的情绪价值和激素的时相而变化。被评为喜爱与不喜爱的图像(婴儿像和皮肤病人像)所诱发的P3波在幅度上均明显高于中性图像(普通人像)所致的P3反应。在高孕激素时相,对婴儿像和男模特儿像的P3反应高于在低孕激素时相对同类刺激的P3反应。高孕激素时相还伴有对各类图像性感程度评估值的降低。对各类图像喜爱程度的评估则随雌激素水平的上升而增高。上述实验结果表明,P3波敏感于刺激的情绪价值并反映了认知与情绪过程中受生理状态调节的适应性变化。

关键词：认知情绪月经周期脑诱发电位

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Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study

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World Journal of Gastroenterology 2007年第15期13卷 2193-2197页

作者： Elena Ricart Maria Esteve montserrat Andreu Francesc Casellas David Monfort Miquel sans Natalia Oudovenko Raúl Lafuente Julián Panés Hospital de sant Pau Barcelona Spain Hospital Mútua de Terrassa Terrassa Spain Hospital del Mar Barcelona Spain Hospital de la Vall d'Hebró Barcelona Spain Hospital Clínic CIBER-EHD BarcelonaSpain Otsuka Pharmaceutical spain

AIM： To evaluate the efficacy of 5 compared to ：tO granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis. METHODs： In this pilot, prospective, multicenter randomized trial, 20 patients with moderately active steroid-dependent ulcerative colitis were randomized to 5 or 10 granulocyteaphaeresis sessions. The primary objective was clinical remission at wk 17. secondary measures included endoscopic remission and steroid consumption.REsULTs： Nine patients were randomized to 5 granulocyteaphaeresis sessions （group 1） and 11 patients to 10 granulocyteaphaeresis sessions （group 2）. At wk 17, 37.5% of patients in group 1 and 45.45% of patients in group 2 were in clinical remission. Clinical remission was accompanied by endoscopic remission in all cases. Eighty-six percent of patients achieving remission were steroid-free at wk 17. Daily steroid requirements were significantly lower in group 2. Eighty-nine per cent of patients remained in remission during a one year follow-up. One serious adverse event, not related to the study therapy, was reported. CONCLUsION： Granulocyteaphaeresis is safe and effective for the treatment of steroid-dependent ulcerative colitis. In this population, increasing the number of aphaeresis sessions is not associated with higher remission rates, but affords a significant steroid-sparing effect.

关键词： Ulcerative colitis Granulocyteaphaeresis steroid-dependence Inflammatory bowel diease treatment

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A prognostic nomogram for patients with resected fibrolamellar hepatocellular carcinoma

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Hepatobiliary surgery and Nutrition 2019年第4期8卷 338-344页

作者： Kelly J. Lafaro oliver.s. Eng Mustafa Raoof Philip Ituarte susanne G. Warner Gagandeep singh Yuman Fong Laleh G. Melstrom Department of surgery City of Hope National Medical Center Duarte CA USA

Background: Fibrolamellar hepatocellular carcinoma (FLHC) is a unique entity compared to conventional hepatocellular carcinoma. The aim of this study was to examine post-resection outcomes and prognostic indicators for survival in this group of FLHC patients. Methods: A retrospective analysis of the National Cancer Database (NCDB) for patients with FLHC who underwent resection from 2004 to 2014 was performed. Univariate and multivariate Cox proportional hazard models were used to identify factors associated with overall survival, and a prognostic nomogram was generated. Results: There were 197 patients identified, 171 (86.8%) of whom had long-term follow-up data. Univariate and multivariate analyses were performed using patient and tumor demographics with the outcome variable of overall survival. On multivariate analysis, age [hazard ratio (HR) 1.03, P=0.003], vascular invasion (HR 1.75, P=0.05), tumor size >7 cm (HR 2.18, P=0.044), multifocal disease (HR 3.34, P=0.002), and node positive (pN+) disease (HR 2.75, P=0.003) were all negative predictors of overall survival. A prognostic nomogram was generated using these factors with a c-statistic superior to that of American Joint Committee on Cancer (AJCC) staging (0.710 vs. 0.654). Conclusions: Independent predictors of decreased overall survival in patients with FLHC include age, vascular invasion, tumor size >7 cm, multifocal disease, and pN+ disease. This is the first study to develop a nomogram exclusively for FLHC that may predict survival in future studies.

关键词： Fibrolamellar hepatocellular carcinoma (FLHC) liver resection overall survival

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scCloudMine:A cloud-based app for visualization,comparison,and exploration of single-cell transcriptomic data

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Plant Communications 2022年第4期3卷 14-24页

作者： Mathew G.Lewsey Changyu Yi oliver Berkowitz Felipe Ayora Maurice Bernado James Whelan La Trobe Institute for Agriculture and Food La Trobe UniversityAgriBio BuildingBundooraVIC 3086Australia Australian Research Council Research Hub for Medicinal Agriculture La Trobe UniversityAgriBio BuildingBundooraVIC 3086Australia BizData Level 9/278Collins StreetMelbourneVIC 3000Australia Department of Animal Plant and Soil SciencesSchool of Life ScienceLa Trobe UniversityBundooraVIC 3086Australia Research and Advanced Computing BizDataLevel 312-6Gilmer TerraceWellington6011New Zealand

scCloudMine is a cloud-based application for visualization,comparison,and exploration of single-cell transcriptome *** does not require an on-site,high-power computing server,installation,or associated expertise and *** upload their own or publicly available scRNA-seq datasets after preprocessing for visualization using a web *** data can be viewed in two color modes—Cluster,representing cell identity,and Values,showing levels of expression—and data can be queried using keywords or gene identification number(s).Using the app to compare studies,we determined that some genes frequently used as cell-type markers are in fact study *** apparent cell-specific expression of PHO1;H3 differed between GFP-tagging and scRNA-seq *** phosphate transporter genes were induced by protoplasting,but they retained cell specificity,suggesting that cell-specific responses to stress(i.e.,protoplasting)can *** of the cell specificity of hormone response genes revealed that 132 hormone-responsive genes display restricted expression and that the jasmonate response gene TIFY8 is expressed in endodermal cells,in contrast to previous *** also appears that JAZ repressors have cell-type-specific *** features identified using scCloudMine highlight the need for resources to enable biological researchers to compare their datasets of interest under a variety of *** enables researchers to form new hypotheses and perform comparative studies and allows for the easy re-use of data from this emerging technology by a wide variety of users who may not have access or funding for high-performance on-site computing and support.

关键词： single cell RNA sequencing visualization discovery comparison

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RDA：21世纪的元数据(英文)

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图书馆杂志 2016年第3期35卷 4-11页

作者： Christine oliver 加拿大渥太华大学图书馆

在详细解读RDA基础上着重谈了两大问题。第一,RDA如何在数字化环境中应运而生,如何更好地适应大数据时代的到来;第二,RDA的初衷和发展目标是为了更好地实现数据揭示的国际化和互通性,不局限于英语系国家和图书馆性质的文化机构。

关键词： RDA 数字化发展国际化数据互通性

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