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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Antoni oliver-Gelabert JoséMaría Vallejo-Gil Javier Fañanás-Mastral Manuel Vázquez-sancho Javier AndréBellido-Morales Alexánder sebastián Vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical signal Interpretation and Computational simulation group(BsICos) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BsICos Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Photometric and spectroscopic study of Ten Low Mass Ratio Contact Binary systems:Orbital stability,O'Connell Effect and Infrared Calcium Line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： surjit s.Wadhwa Adam Popowicz Raúl Michel Petar Kostić oliver Vince Nick F.H.Tothill Ain Y.De Horta Miroslav D.Filipović school of science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available Large sky Area Multi-Object Fiber spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

Catatonia:A deep dive into its unfathomable depths

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World Journal of Psychiatry 2024年第2期14卷 210-214页

作者： Peter Phiri Gayathri Delanerolle oliver Hope Tharangini Murugaiyan Geoffrey Dimba shanaya Rathod Zukiswa Zingela Research&Innovation Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom school of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJHampshireUnited Kingdom Acute Inpatients services Southern Health NHS Foundation TrustBasingstoke RG249RHUnited Kingdom Home Treatment Team South WestSurrey and Borders Partnerships NHS Foundation TrustGuildford GU27XLSurreyUnited Kingdom Faculty of Health sciences Nelson Mandela UniversitySummerstrand 6001GqeberhaSouth Africa

This editorial addresses catatonia,a complex neuropsychiatric syndrome characterised by a spectrum of psychomotor *** editorial seeks to clarify the ambiguous aspects of catatonia,integrating recent research findings,including global studies and diagnostic *** discusses catatonia’s clinical manifestations,prevalence,and associated psychiatric and medical conditions,with particular emphasis on its frequent co-occurrence with schizophrenia and mood *** prevalence of catatonia,which varies across psychiatric populations,is illustrated by a significant study conducted in Nelson Mandela Bay,south *** study provides valuable insights into the effectiveness of the Bush-Francis screening Instrument compared to the Diagnostic and statistical Manual 5 criteria in diagnosing *** editorial evaluates treatment approaches,primarily focusing on benzodiazepines and electroconvulsive therapy,and discusses emerging therapeutic *** underscores the importance of robust diagnostic frameworks and early intervention in managing catatonia,as recommended by the latest evidence-based consensus ***,it suggests future research directions,particularly in exploring the neurobiological and genetic factors of catatonia,to enhance our understanding and improve treatment *** editorial succinctly aims to demystify catatonia and provide valuable insights for clinicians and researchers in mental health care.

关键词： Catatonia schizophrenia Neuropsychiatry Benzodiazepines Electroconvulsive therapy Bush-Francis screening instrument Diagnosis

Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma:A case report

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1933-1938页

作者： Miao-Miao Zhang Jie Tao Huan-Chen sha Yun Li Xiao-Gang song oliver J Muensterer Fang-Fang Dong Li Zhang Yi Lyu Xiao-Peng Yan Department of Hepatobiliary surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Pediatric surgery Dr.von Hauner Children’s HospitalLudwig-Maximilians-University Medical CenterMunich 80337Germany

BACKGROUND The combination of magnetic compression anastomosis(MCA)and endoscopy has been used to treat biliary stricture after liver ***,its use for the treatment of complex biliary obstruction after major abdominal trauma has not been *** case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.A 23-year-old man underwent major abdominal surgery(repair of liver rupture,right half colon resection,and ileostomy)following a car accident one year *** abdominal drainage tube,positioned at the Winslow foramen,was draining approximately 600-800 mL of bile per *** the two endoscopic retrograde cholangiopancreatography procedures,the guide wire was unable to enter the common bile duct,which prevented placement of a biliary *** combined with endoscopy was used to successfully achieve magnetic anastomosis of the peritoneal sinus tract and duodenum,and then a choledochoduodenal stent was ***,the external biliary drainage tube was *** patient achieved internal biliary drainage leading to the removal of the external biliary drainage tube,which improved the quality of *** Magnetic compression technique can be used for the treatment of complex biliary obstruction with minimal operative trauma.

关键词： Magnetic compression anastomosis Magnetosurgery Endoscopy Magnetic surgery Clinic Biliary obstruction Case report

Premature losses of leaf area in response to drought and insect herbivory through a leaf lifespan gradient

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Journal of Forestry Research 2022年第1期33卷 39-50页

作者： sonia Mediavilla montserrat Martínez-Ortega santiago Andrés Javier Bobo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain Departamento de Botánica y Fisiología Vegetal Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain

Implications of the differences in leaf life span are still subject to debate in the field of *** leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate *** study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic *** of leaf area may be an important determinant of total leaf carbon *** Mediterranean tree species,distributed on four sites with different climates were *** species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit *** leaf area losses were estimated in response to insect herbivory and summer drought over two *** results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer *** respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.

关键词： Accelerated senescence Insect herbivory Leaf life span Leaf structural reinforcement summer drought

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

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Advanced Photonics 2024年第2期6卷 50-60页

作者： shiqi Xu Xi Yang Paul Ritter Xiang Dai Kyung Chul Lee Lucas Kreiss Kevin C.Zhou Kanghyun Kim Amey Chaware Jadee Neff Carolyn Glass seung Ah Lee oliver Friedrich Roarke Horstmeyer Duke University DurhamNorth CarolinaUnited States Friedrich-Alexander University ErlangenGermany UC san Diego La JollaCaliforniaUnited States Yonsei University SeoulRepublic of Korea UC Berkeley BerkeleyCaliforniaUnited States Duke University Medical Center DurhamNorth CarolinaUnited States

We report tensorial tomographic Fourier ptychography(T^(2)oFu),a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in *** upon Fourier ptychography,a quantitative phase imaging technique,T^(2)oFu additionally highlights the vectorial nature of *** imaging setup consists of a standard microscope equipped with an LED matrix,a polarization generator,and a polarization-sensitive *** tensors of anisotropic samples are computationally recovered from polarized intensity measurements across three *** demonstrate T^(2)oFu’s efficiency through volumetric reconstructions of refractive index,birefringence,and orientation for various validation samples,as well as tissue samples from muscle fibers and diseased heart *** reconstructions of healthy muscle fibers reveal their 3D fine-filament structures with consistent ***,we demonstrate reconstructions of a heart tissue sample that carries important polarization information for detecting cardiac amyloidosis.

关键词： computational imaging three-dimensional imaging phase retrieval microscopy polarization-sensitive imaging labelfree imaging

Lightweight and secure Mutual Authentication scheme for IoT Devices Using CoAP Protocol

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Computer systems science & Engineering 2022年第5期41卷 767-780页

作者： s.Gladson oliver T.Purusothaman Department of Information Technology Government College of TechnologyCoimbatore641013India Department of Electronics and Communication Engineering Government College of TechnologyCoimbatore641013India

Internet of things enables every real world objects to be seamlessly integrated with traditional *** objects of real world are enhanced with capability to communicate,computing capabilities and standards to interoperate with existing network and these entities are resource constrained and vulnerable to various security *** number of research works are being carried out to analyze various possible attacks and to propose standards for securing communication between devices in internet of things(IoT).In this article,a robust and lightweight authentication scheme for mutual authentication between client and server using constrained application protocol is *** of things enables devices with different characteristics and capabilities to be integrated with *** heterogeneous devices should interoperate with each other to accumulate,process and transmit data for facilitating smart *** growth of IoT applications leads to the rapid growth of IoT devices incorporated to the global network and network traffic over the traditional *** scheme greatly reduces the authentication overhead between the devices by reducing the packet size of messages,number of messages transmitted and processing overhead on communicating *** of this authentication scheme against attacks such as Dos(denial of service),replay attacks and attacks to exhaust the resources are also *** transmission time reduced upto 50%of using proposed techniques.

关键词： IoT CoAP AEs encryption message transmisssion

Maturation of sperm volume regulation in the rat epididymis

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Asian Journal of Andrology 2010年第4期12卷 578-590页

作者： oliver.s. Damm Trevor G. Cooper Centre of Reproductive Medicine and Andrology of the University Miinster D-48149 Miinster Germany

sperm maturation in the epididymis may involve differences between mature and immature spermatozoa in their volume regulatory osmolyte response. spermatozoa obtained from the rat caput and cauda epididymidis were examined for their ability to regulate volume after transfer from in situ epididymal osmolality （measured to be 343 ± 13 and 365 ± 19 mmol kg^-1, respectively） to that of the female tract in single- and multiple-step protocols. Cells withstood the single-step treatment better than the multistep protocol. sperm volume estimates by flow cytometric measure- ments of forward scatter of cells with intact head membranes was more sensitive than those by assessing cell coiling microscopically. At osmolalites below 210 mmol kg l both caput and cauda cells ruptured, limiting the use of flow cytometry. Above this critical value, the use of quinine showed that both caput and cauda cells could regulate volume, but cauda cells were the more effective. Of several organic osmolytes studied, myo-inositol, glutamate and KCl caused only temporary and slight swelling of spermatozoa cells in hypotonic medium. spermatozoa of both maturities seemed to use potassium as the preferred osmolyte for regulating volume.

关键词： rat sperm sperm maturation volume regulation

Fluids in abdominal surgery: what is the goal?

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Hepatobiliary surgery and Nutrition 2018年第3期7卷 227-228页

作者： oliver.s. Eng Division of surgical Oncology Department of SurgeryCity of Hope National Medical CenterDuarteCAUSA

In the early 2000s, the approach to perioperative fluid management in major abdominal surgery underwent a paradigm change in favor of restrictive, rather than standard or liberal, fluid regimens. The basis for this shift in philosophy was a result of randomized controlled trials such as one by Brandstrup et al., which demonstrated improved morbidity and outcomes with perioperative fluid restriction (1). With similar results reported across a variety of other prospective trials, the practice of perioperative fluid restriction garnered more support and acceptance (2,3).

关键词： fluid surgery s.