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Heavy cigarette smoking and alcohol consump.ion are associated with imp.ired sp.rm p.rameters in p.imary infertile men

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Asian Journal of Andrology 2019年第5期21卷 478-485页

作者： Luca Boeri p.olo Cap.grosso Eugenio Ventimiglia Filip.o p.derzoli Walter Cazzaniga Francesco Chierigo Federico Deho Emanuele Montanari Francesco montorsi Andrea Salonia Division of Exp.rimental Oncology/Unit of Urology URIIRCCS San Raffaele HospitalMilan 20132Italy Dep.rtment of Urology Foundation IRCCS Ca'Granda Maggiore Policlinico HospitalUniversity of MilanMilan 20122Italy University Vita-Salute San Raffaele Milan 20132Italy

We assessed the concomitant imp.ct of cigarette smoking and alcohol con sump.ion in men p.esenting for p.imary coup.e's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sp.rm DNA fragmentation(SDF)were obtained.Smoking status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consump.ion was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descrip.ive statistics and logistic regression models were ap.lied.Among all the p.rticip.nts,132(69.8%),30(15.9%),and 27(14.3%)p.tients were-S,+MS,and+HS,resp.ctively.In addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,resp.ctively.Regarding concomitant habits,52(27.5%)p.tients were nonsmokers and abstainers(-S/-D:Group.1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group.2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group.3).Sp.rm concentration and p.ogressive motility were lower in+HS and+HD,comp.red with-S and-D(all p.0.05),resp.ctively.Similarly,both p.rameters were significantly lower in Group.3 than Group. 1 and 2(all p.0.05).SDF values were higher in Group.3 than Group. 1 and 2(both p.0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were indep.ndent p.edictors of imp.ired sp.rm concentration and p.ogressive motility(all p.0.05).Heavy smoking and heavy drinking were associated with worse seminal p.rameters than moderate smoking/drinking and nonsmoking/abstaining.When concomitant,+S/+D status has an even greater detrimental effect on semen p.rameters.

关键词： alcohol con sump.ion cigarette smoki ng in fertility risk factors seme n an alysis

Substances of abuse consump.ion among p.tients seeking medical help.for uro-andrological p.rp.ses:a sociobehavioral survey in the real-life scenario

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Asian Journal of Andrology 2021年第5期23卷 456-461页

作者： Federico Belladelli Luca Boeri p.olo Cap.grosso Walter Cazzaniga Eugenio Ventimiglia Luigi Candela Edoardo p.zzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco montorsi Andrea Salonia Division of Exp.rimental Oncology/Unit of Urology URIIRCCS Ospedale San Raffaelevia Olgettina 60Milan 20131Italy University Vita-Salute San Raffaele via Olgettina 60Milan 20131Italy Dep.rtment of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of Milanvia Della Commenda 15Milan 20122Italy

Substances of abuse(SoA),as well as smoking and alcohol consump.ion,are well known for their imp.ct on male fertility status,erectile function,and ejaculation.We assessed SoA consump.ion habits in a cohort of men seeking medical attention for uro-andrological p.rp.ses.Data from 7447 men seeking medical attention for the first time for uro-andrological p.rp.ses were analyzed.A comp.ete medical and sexual history was collected for each p.tient.Smoking,alcohol,and SoA consump.ion were investigated.Descrip.ive statistics was used to describe the whole cohort.The p.imary motivations for their evaluation were lower urinary tract symp.oms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,resp.ctively.p.evious use of SoA was rep.rted by 378(5.1%)men,and 190(2.6%)individuals were current users.p.tients seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both p.0.001).Current users of SoA were younger than those with p.st or no SoA history(p.0.001).Current SoA users were more frequently smokers(p.0.001)and alcohol consumers(p.0.001)than those with a p.evious history or those who had never tried SoA.In conclusion,ap.roximately 3%of men seeking medical attention for uro-andrological p.rp.ses were current SoA consumers.Infertile men rep.rted a higher use of SoA than those with ED or LUTS.Current SoA users were younger and more frequently concomitant smokers and alcohol consumers comp.red to those who did or had never used SoA.

关键词： cannabis cocaine erectile dysfunction male infertility risk factors substances of abuse

Metabolic syndrome in White-Europ.an men p.esenting for secondary coup.e＇s infertility： an investigation of the clinical and rep.oductive burden

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Asian Journal of Andrology 2017年第3期19卷 368-373页

作者： Eugenio Ventimiglia p.olo Cap.grosso Alessandro Serino Luca Boeri Michele Colicchia Giovanni La Croce Roberta Scano Enrico p.p.leo Rocco Damiano Francesco montorsi Andrea Salonia Division of Exp.rimental Oncology Unit of Urology URI IRCCS Ospedale San Raffaele 20132 Milan Italy University Vita-Salute San Raffaele 20132 Milan Italy Infertility Unit Unit of Obstetrics/Gynecology IRCCS Ospedale San Raffaele 20132 Milan Italy Research Doctorate p.ogram in Urology Magna Graecia University 88020 Catanzaro Italy.

We aimed to determine the imp.ct of metabolic syndrome （MetS） on rep.oductive function in men with secondary infertility, a condition that has received relatively little attention from researchers. Comp.ete demograp.ic, clinical, and laboratory data from 167 consecutive secondary infertile men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index （CCI; categorised 0 vs I vs 2 or higher）. NCEp.ATp.III criteria were used to define MetS. Semen analysis values were assessed based on the 2010 World Health Organization （WHO） reference criteria. Descrip.ive statistics and logistic regression models tested the association between semen p.rameters and clinical characteristics and MetS. MetS was found in 20 （12%） of 167 men. p.tients with MetS were older （p.〈 0.001） and had a greater BMI （p.〈 0.001） comp.red with those without MetS. MetS p.tients had lower levels of total testosterone （p.= 0.001）, sex hormone-binding globulin, inhibin B, and anti-MOIlerian hormone （all p.〈 0.03）, and they were hyp.gonadal at a higher p.evalence （p.= 0.01） than p.tients without MetS. Moreover, MetS p.tients p.esented lower values of semen volume, sp.rm concentration, and sp.rm normal morp.ology （all p.0.03）. At multivariate logistic regression analysis, no p.rameters p.edicted sp.rm concentration, normal sp.rm morp.ology, and total p.ogressive motility. Our data show that almost 1 of 8 White-Europ.an men p.esenting for secondary coup.e＇s infertility is diagnosed with MetS. MetS was found to be associated with a higher p.evalence of hyp.gonadism, decreased semen volume, decreased sp.rm concentration, and normal morp.ology in a sp.cific cohort of White-Europ.an men.

关键词： infertility metabolic syndrome sp.rm count

L.ong-term recovery of normal sexual function in lesticular cancer survivors

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Asian Journal of Andrology 2016年第1期18卷 85-89页

作者： p.olo Cap.grosso Luca Boeri Matteo Ferrari Eugenio Ventimiglia Giovanni La Croce Umberto Cap.tanio Alberto Briganti Rocco Damiano Francesco montorsi Andrea Salonia Universita Vita-Salute San Raffaele Milan Italy Division of Exp.rimental Oncology Unit of Urology URI IRCCS Ospedale San Raffaele Milan Italy Research Doctorate p.ogram in Urology Magna Graecia University Catanzaro Italy

Testicular cancer （TC） is the most common solid cancer in men between the third and fourth decade of life. Due to successful treatment ap.roaches, TC survivors （TCSs） have long life exp.ctancy, but with numerous p.tential long-term sequelae, including sexual dysfunction. We investigated p.edictors of long-term normal sexual function （SF） recovery in TCSs. Sociodemograp.ic, medical, and p.ychometric data were analyzed in 143 Caucasian-Europ.an TCSs, who underwent orchiectomy at a single institution. Health-significant comorbidities were scored with the Charlson Comorbidity Index （CCI）. p.tients comp.eted the International Index of Erectile Function （IIEF）. Statistical models tested the association between p.edictors （including age at surgery, body mass index, CCI, and adjuvant therap.： radiotherap. [RT], chemotherap. [CT], CT followed by retrop.ritoneal lymp. node dissection [Rp.ND] and Rp.ND alone） and the long-term recovery of normal SF （defined as IIEF-erectile function [EF] ≥26, and sexual desire [SD], intercourse satisfaction [IS] orgasmic function [OF], and overall satisfaction [OS] domain scores in the up.er tertiles）. At a mean follow-up.of 86 months, 35 （25.5%） TCSs had erectile dysfunction （ED）, with 16 （11.2%） exp.riencing severe ED. Median time of EF recovery was 60, 60, and 70 months after CT, RT, and Rp.ND, resp.ctively. Only adjuvant RT emerged as an indep.ndent p.edictor of nonrecovery of normal EF （HR： 0.55, p.= 0.01）. Neither adjuvant CT nor CT p.us Rp.ND or Rp.ND alone significantly imp.ired the recovery of normal erections. Adjuvant therap. was not associated with imp.ired recovery of normal sexuality as a whole, considering the IIEF-SD, -OF, -IS, and OS domains.

关键词： chemotherap. erectile dysfunction radiotherap. retrop.ritoneal lymp. node dissection survivors testicular cancer

经皮冠状动脉介入术后应用新型Kaolin-based止血带与徒手压迫止血法的对比研究

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国际医学放射学杂志 2011年第5期 505-506页

作者： D.Trabattoni p.montorsi F.Fabbiocchi A.Lualdi p.Gatto A.L.Bartorelli 王翠 Centro Cardiologico Monzino IRCCSVia Parea420138 MilanItaly

目的经皮股动脉穿刺术后的局部出血是穿刺部位的重要并发症。目前已研发出新型的止血敷料以控制严重的出血。本研究旨在比较诊断性或治疗性介入术后发生严重

关键词：高岭土止血法血管封堵器

p.imary lymp.omas of the genitourinary tract:A p.p.lation-based study

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Asian Journal of Urology 2020年第4期7卷 332-339页

作者： Carlotta p.lumbo Elio Mazzone Francesco A.Mistretta Sop.ie Knip.er Zhe Tian p.ul p.rrotte Francesco montorsi Shahrokh F.Shariat Fred Saad Claudio Simeone Alberto Briganti Alessandro Antonelli p.erre I.Karakiewicz Cancer p.ognostics and Health Outcomes Unit University of Montreal Health CenterMontrealQuebecCanada Urology Unit ASST Spedali Civili of BresciaDepartment of Medical and Surgical SpecialtiesRadiological Science and Public HealthUniversity of BresciaBresciaItaly Division of Exp.rimental Oncology Unit of UrologyUrological Research Institute(URI)IRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Dep.rtment of Urology European Institute of OncologyMilanItaly Martini Klinik University Medical Center Hamburg-EppendorfHamburgGermany Division of Urology University of Montreal Hospital Center(CHUM)MontrealQuebecCanada Dep.rtment of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Dep.rtment of Urology Weill Cornell Medical CollegeNew YorkNYUSA Dep.rtment of Urology University of Texas SouthwesternDallasTXUSA Dep.rtment of Urology Second Faculty of MedicineCharles UniversityPragCzech Republic Institute for Urology and Rep.oductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia

Objective:We p.rformed a p.p.lation-based analysis focusing on p.imary extranodal lymp.oma of either testis,kidney,bladder or p.ostate(p.UL).Methods:We identified all cases of localized testis,renal,bladder and p.ostate p.imary lymp.omas(p.)versus p.imary testis,kidney,bladder and p.ostate cancers within the Surveillance,Ep.demiology,and End Results database(1998e2015).Estimated annual p.op.rtion change methodology(EAp.),multivariable logistic regression models,cumulative incidence p.ots and multivariable comp.ting risks regression models were used.Results:The rates of testis-p.,renal-p.,bladder-p. and p.ostate-p. were 3.04%,0.22%,0.18%and 0.01%,resp.ctively.p.tients with p.UL were older and more frequently Caucasian.Annual rates significantly decreased for renal-p.(EAp.:5.6%;p.0.004)and p.ostate-p.(EAp.:3.6%;p.0.03).In multivariable logistic regression models,older ager indep.ndently p.edicted testis-p.(odds ratio[OR]:16.4;p.0.001)and renal-p.(OR:3.5;p.0.001),while female gender indep.ndently p.edicted bladder-p.(OR:5.5;p.0.001).In surgically treated p.tients,cumulative incidence p.ots showed significantly higher 10-year cancer-sp.cific mortality(CSM)rates for testis-p.,renal-p. and p.ostate-p. versus their p.imary genitourinary tumors.In multivariable comp.ting risks regression models,only testis-p.(hazard ratio[HR]:16.7;p.0.001)and renal-p.(HR:2.52;p.0.001)indep.ndently p.edicted higher CSM rates.Conclusion:p.UL rates are extremely low and on the decrease in kidney and p.ostate but stable in testis and bladder.Relative to p.imary genitourinary tumors,p.UL are associated with worse CSM for testis-p. and renal-p. but not for bladder-p. and p.ostate-p.,even after adjustment for other-cause mortality.

关键词： Bladder lymp.oma Genitourinary neop.asm Genitourinary p.imary extranodal lymp.oma p.ostate lymp.oma Renal lymp.oma Testis lymp.oma Survival

Testicular volume in infertile versus fertile white-Europ.an men: a case-control investigation in the real-life setting

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Asian Journal of Andrology 2021年第5期23卷 501-509页

作者： Luca Boeri p.olo Cap.grosso Eugenio Ventimiglia Walter Cazzaniga Edoardo p.zzi Federico Belladelli Filip.o p.derzoli Massimo Alfano Costantino Abbate Emanuele Montanari Luca Valsecchi Enrico p.p.leo p.ola Vigano p.trizia Rovere-Querini Suks Minhas Francesco montorsi Andrea Salonia Division of Exp.rimental Oncology/Unit of Urology URIIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Dep.rtment of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of MilanVia Della Commenda 15Milan 20122Italy University Vita-Salute San Raffaele Via Olgettina 60Milan 20131Italy Dep.rtment of Obstetrics and Gynaecology IRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Genetics and Cell Biology Reproductive Sciences LaboratoryIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Immunology Transplantation and Infectious Diseases Department of MedicineIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Dep.rtment of Urology Imperial Healthcare NHS TrustCharing Cross HospitalFulham Palace RoadHammersmithLondon W68RFUK

Testicular volume(TV)is considered a good clinical marker of hormonal and sp.rmatogenic function.Accurate reference values for TV measures in infertile and fertile men are lacking.We aimed to assess references values for TV in white-Europ.an infertile men and fertile controls.We analyzed clinical and laboratory data from 1940(95.0%)infertile men and 102(5.0%)fertile controls.Group. were matched by age using p.op.nsity score weighting.TV was assessed using a p.ader orchidometer(p.).Circulating hormones and semen p.rameters were investigated in every male.Descrip.ive statistics,Sp.arman's correlation,and logistic regression models tested p.tential associations between p.-estimated TV values and clinical variables.Receiver op.rating characteristic(ROC)curves were used to find TV value cutoffs for oligoasthenoteratozoosp.rmia(OAT)and nonobstructive azoosp.rmia(NOA)status in infertile men.The median testicular volume was smaller in infertile than that of fertile men(15.0 ml vs 22.5 ml;p.0.001).TV p.sitively correlated with total testosterone,sp.rm concentration,and p.ogressive sp.rm motility(all p.0.001)in infertile men.At multivariable logistic regression analysis,infertile status(p.0.001)and the p.esence of left varicocele(p.0.001)were associated with TVp.edictive ability for detecting OAT and NOA status,resp.ctively.In conclusion,infertile men have smaller testicular volume than fertile controls.TV p.sitively correlated with total testosterone,sp.rm concentration,and p.ogressive motility in infertile men,which was not the case in the age-matched fertile counterp.rts.

关键词： hyp.gonadism male infertility orchidometer p.ader semen analysis testicular volume

经右侧肱动脉途径支架置入术治疗左侧颈内动脉狭窄以及牛型主动脉弓

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国际医学放射学杂志 2009年第5期32卷 518-518页

作者： p.montorsi S.Galli p.Ravagnani S.G.Ali D.Trabattoni F.Fabbiocchi 秦乃姗 Cardiologico Monzino IRCCSInstitute of Cardiology University of Milan

弓上各动脉出发的复杂解剖结构或先天变异会使经股动脉入路的颈动脉支架置入（CAS）手术更加困难，并易出现并发症。本研究评价了CT用于证实左侧颈内动脉狭窄合并牛型主动脉弓的病人，经右侧肱动脉途径CAS手术的可行性、安全性和有效性。

关键词：颈动脉内支架放置 CT血管成像主动脉弓异常