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Arabidopsis Squalene Epoxidase 3 （SQE3） Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity

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Molecular Plant 2015年第7期8卷 1090-1102页

作者： Sara Laranjeira Vitor Amorim-Silva Alicia Esteban monserrat arro Albert Ferrer Rui Manuel Tavares Miguel Angel Botella Abel Rosado Herlander Azevedo Center for Biodiversity Functional & Integrative Genomics (BioFIG) Plant Functional Biology Center University of Minho Campus de Gualtar 4710-057 BragaPortugal Instituto de Hortofruticultura Subtropical y Mediterranea 'La Mayora' Universidad de Malaga-Consejo Superior de Investigaciones Cientificas (IHSM-UMA-CSIC)Departmento de Biologia Molecular y Bioquimica Universidad de Malaga Campus Teatinos 29071 Malaga Spain Department of Molecular Genetics Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB) Bellaterra-Cerdanyola del Valles 08193 Spain Department of Biochemistry and Molecular Biology Faculty of Pharmacy University of Barcelona 08028 Barcelona Spain Canada Research Chair in Plant Physiology and Cellular Dynamics Department of Botany Faculty of Sciences University of British Columbia VancouverBC V6T 1Z4 Canada CIBIO InBIO - Research Network in Biodiversity and Evolutionary Biology Universidade do Porto Campus Agrario de Vairao 4485-661 Vairao Portugal

The existence of multigenic families in the mevalonate pathway suggests divergent functional roles for pathway components involved in the biosynthesis of plant sterols. Squalene epoxidases （SQEs） are key components of this pathway, and Squalene Epoxidase 1 （SQE1） has been identified as a fundamental enzyme in this biosynthetic step. In the present work, we extended the characterization of the remaining SQE family members, phylogenetically resolving between true SQEs and a subfamily of SQE-like proteins that is exclusive to Brassicaceae. Functional characterization of true SQE family members, Squalene Epox- idase 2 （SQE2） and Squalene Epoxidase 3 （SQE3）, indicates that SQE3, but not SQE2, contributes to the bulk SQE activity in Arabidopsis, with sqe3-1 mutants accumulating squalene and displaying sensitivity to ter- binafine. We genetically demonstrated that SQE3 seems to play a particularly significant role in embryo development. Also, SQE1 and SQE3 both localize in the endoplasmic reticulum, and SQE3 can functionally complement SQEI. Thus, SQE1 and SQE3 seem to be two functionally unequal redundant genes in the pro- motion of plant SQE activity in Arabidopsis.

关键词： Arabidopsis embryo development MVA pathway squalene epoxidase sterol biosynthesis

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Distinct vibrational signatures and complex phase behavior in metallic oxygen

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Matter and Radiation at Extremes 2024年第2期9卷 4-11页

作者： Philip Dalladay-Simpson Bartomeu monserrat Li Zhang Federico Gorelli Center for High Pressure Science Technology Advanced Research 1690 Cailun RoadShanghai 201203China Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB3 OFSUnited Kingdom Cavendish Laboratory University of CambridgeJ.J.Thomson AvenueCambridge CB3 OHEUnited Kingdom Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)50125 FlorenceItaly Shanghai Advanced Research in Physical Sciences(SHARPS) ShanghaiChina

Evidence for metallization in dense oxygen has been reported for over 30 years[Desgreniers et al.,***.94,1117(1990)]at a now routinely accessible 95 GPa[Shimizu et al.,Nature 393,767(1998)].However,despite the longevity of this result and the technological advances since,the nature of the metallic phase remains poorly constrained[Akahama et al.,***.74,4690(1995);Goncharov et al.,***.B 68,224108(2003);Ma,***.B 76,064101(2007);and Weck et al.,***.102,255503(2009)].In this work,through Raman spectroscopy,we report the distinct vibrational characteristics of metallicζ-O_(2) from 85 to 225 *** comparison with numerical simulations,weﬁnd reasonable agreement with the candidate structure up to about 150 *** higher pressures,the C2/mstructure is found to be unstable and incompatible with experimental *** candidate structures,and Ci,with C2/m C2/conly two molecules in the primitive unit cell,are found to be stable and more compatible with measurements above 175 GPa,indicative of the dissociation of(O_(2))4 ***,we report and discuss a strong hysteresis and metastability with the precursory phaseϵ-O_(2).Theseﬁndings will reinvigorate experimental and theoretical work into the dense oxygen system,which will have importance for oxygen-bearing chemistry,prevalent in the deep Earth,as well as fundamental physics.

关键词： metallic phase vibrational

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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico Department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUND Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst Dental root end cyst Case report

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Periodontal disease:A silent factor in the development and progression of diabetic retinopathy

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World Journal of Diabetes 2024年第8期15卷 1672-1676页

作者： Sarah monserrat LomelíMartínez Irán Cortés Trujillo Melissa Martínez Nieto Ana Esther Mercado González Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Guadalajara 44280Mexico

The global increase in the prevalence of type 2 diabetes mellitus(T2DM)and its complications presents significant challenges to public ***,periodontal disease(PD)was recognized as a factor that is likely to influence the progression of T2DM and its complications due to its potential to exacerbate systemic inflammation and oxidative *** this editorial,we comment on the article published by Thazhe Poyil et al in the very recent issue of the World Journal of Diabetes in 2024,which investigated the correlation between PD and diabetic retinopathy(DR)in T2DM patients,with emphasis on the association between periodontal swollen surface area,glycated hemoglobin(HbA1c),interleukin-6(IL-6),and lipoprotein(a).The findings by Thazhe Poyil et al are significant as they demonstrate a strong link between PD and DR in T2DM *** correlation highlights the importance of addressing periodontal health in diabetes management to potentially reduce the risk and severity of DR,a complication of *** integration of periodontal evaluation and treatment into diabetes care protocols may lead to improved glycemic control and better overall outcomes for T2DM patients.A few studies have established an interconnection between PD and diabetic complication,specifically DR,in T2DM patients,which we aim to highlight in this *** was placed on the different mechanisms that suggest a bidirectional relationship between PD and T2DM,where the presence of periodontal inflammation negatively influenced glycemic control and contributed to the development and progression of DR through shared inflammatory and vascular *** article highlights the importance of collaboration amongst diabetes specialists,ophthalmologists,periodontists,and public health professionals to advance the prevention,early detection,and treatment of PD and *** will improve the health and quality of life of T2DM ***,the editorial highlights the need for further re

关键词： Type 2 diabetes mellitus Periodontal disease Periodontitis Diabetic retinopathy Editorial

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Bofedal response to climate variability, local management, and water extraction: A case study of Chucuyo, Northern Chile

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Journal of Mountain Science 2022年第1期19卷 241-252页

作者： URIBE-ÁLVAREZ monserrat C PRIETO Manuel MESEGUER-RUIZ Oliver Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáArica 1010069Chile Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáIquique 1101783Chile

Andean high-altitude wetlands are important ecosystems that serve a range of socialecological functions. In the Andes, bofedales, a specific type of peat-producing wetland, are essential for the sustainability of mountain ecosystems and indigenous pastoralist communities. The Chucuyo bofedal in northern Chile is affected by climatic variability and water extraction for agricultural uses via the Lauca canal. Herders in the local community also actively manage this wetland according to their traditional ecological knowledge to ensure permanent fodder for their animals. In this article, we analyze the annual behavior of the Chucuyo bofedal after the wet season. Based on precipitation data, extracted water flows, vegetation vigor from satellite images, and an ethnographic approach, we determined that the bofedal’s productivity was negatively correlated with the amount of precipitation and positively correlated with the surface area of the wetland. However, water extraction via the Lauca channel had no significant relationship with either surface area or vegetation vigor. We identify community practices and traditional ecological knowledge as key elements in the maintenance of these ecosystems. This situation is critical in the context of an aging population and the current pattern of migration out of the region to urban areas. The results provide substantial empirical evidence for future decision-making regarding the conservation of these ecosystems.

关键词： Atacama Bofedales Indigenous people Lauca canal Normalized Difference Vegetation Index

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Gingival enlargement induced by cyclosporine in Medullary aplasia:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12750-12760页

作者： Giovanna Victory Rodríguez Alondra del Carmen Ruiz Gutiérrez Juan Ramón Gómez Sandoval Sarah monserrat LomelíMartínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Research Institute of Dentistry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico

BACKGROUND Cyclosporine is an immunosuppressive agent used effectively for treatment of a rare haematological disorder known as medullary *** drug prevents several side effects,including gingival enlargement(GE)which compromises aesthetics,phonetics and chewing,and also predisposes patients to *** SUMMARY This clinical case reports a 41-year-old woman who presented with cyclosporineinduced GE with underlying periodontitis and medullary *** management of the disease was approached through multidisciplinary strategy which allowed for accurate diagnosis and a strategic treatment based on the systemic condition and severity of oral *** diagnosis was confirmed through histopathological *** treatment was carried out in phases:Initial(oral hygiene motivation,mechanical supragingival plaque control,and non-surgical therapy);systemic treatment,corrective treatment,and *** Multidisciplinary management of cyclosporine-induced GE and medullary aplasia allows for correct diagnosis and effective treatment of this pathological expression through a phased therapeutic approach.

关键词： Cyclosporine Gingival enlargement Medullary aplasia Periodontal surgery Case report

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Degenerate topological line surface phonons in quasi-1D double helix crystal SnIP

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npj Computational Materials 2021年第1期7卷 1792-1799页

作者： Bo Peng Shuichi Murakami Bartomeu monserrat Tiantian Zhang TCM Group Cavendish LaboratoryUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUnited Kingdom Department of Physics Tokyo Institute of TechnologyOokayamaMeguro-kuTokyo 152-8551Japan Tokodai Institute for Element Strategy Tokyo Institute of TechnologyNagatsutaMidori-kuYokohamaKanagawa 226-8503Japan Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUnited Kingdom

Degenerate points/lines in the band structures of crystals have become a staple of the growing number of topological *** bulk-boundary correspondence provides a relation between bulk topology and surface *** line degeneracies of bulk excitations have been extensively characterised,line degeneracies of surface states are not well *** show that SnIP,a quasi-one-dimensional van der Waals material with a double helix crystal structure,exhibits topological nodal rings/lines in both the bulk phonon modes and their corresponding surface *** a combination of first-principles calculations,symmetrybased indicator theories and Zak phase analysis,we find that two neighbouring bulk nodal rings form doubly degenerate lines in their drumhead-like surface states,which are protected by the combination of time-reversal symmetry T and glide mirror symmetry *** results indicate that surface degeneracies can be generically protected by symmetries such as T My,and phonons provide an ideal platform to explore such degeneracies.

关键词： topological symmetry quasi

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Unusual clinical presentation of oral pyogenic granuloma with severe alveolar bone loss:A case report and review of literature

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World Journal of Clinical Cases 2023年第16期11卷 3907-3914页

作者： Sarah monserrat LomelíMartínez Dennisse Bocanegra Morando Ana Esther Mercado González Juan Ramón Gómez Sandoval Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Guadalajara 44280Mexico Research Institute of Dentistry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico

BACKGROUND Pyogenic granuloma(PG)is a localized,reddish and vascularized hyperplastic lesion of the connective tissue which occurs in the oral *** most cases,the presence of this lesion does not show alveolar bone *** pathology is diagnosed clinically with some ***,the diagnosis and treatment are usually corroborated with histopathological *** SUMMARY Three clinical cases of PG associated with bone loss were described in this *** three patients presented tumor-like growth which bled on touch,and were associated with local irritant *** showed bone *** cases were treated with conservative surgical *** scarring was satisfactory,and there was no case of *** diagnoses were based on clinical findings,and were confirmed *** The occurrence of oral PG with bone loss is ***,clinical and radiographic evaluations are important for the diagnosis.

关键词： Hyperplastic lesion Pyogenic granuloma Alveolar bone loss Case report

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Direct electrification of silicon microfluidics for electric field applications

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微系统与纳米工程(英文) 2023年第3期9卷 145-157页

作者： Diego monserrat Lopez Philipp Rottmann Gabriel Puebla-Hellmann Ute Drechsler Marcel Mayor Sven Panke Martin Fussenegger Emanuel Lörtscher IBM Research Europe-Zurich Säumerstrasse 4CH-8803 RüschlikonSwitzerland ETH Zürich Department of Biosystems Science and EngineeringMattenstrasse 264058 BaselSwitzerland University of Basel Department of ChemistrySt.Johanns-Ring 19CH-4056 BaselSwitzerland Institute for Nanotechnology(INT) Karlsruhe Institute of Technology(KIT)P.O.Box 364076021 KarlsruheGermany University of Basel Faculty of Life ScienceBaselSwitzerland

Microfluidic systems are widely used in fundamental research and industrial applications due to their unique behavior, enhanced control, and manipulation opportunities of liquids in constrained geometries. In micrometer-sized channels, electric fields are efficient mechanisms for manipulating liquids, leading to deflection, injection, poration or electrochemical modification of cells and droplets. While PDMS-based microfluidic devices are used due to their inexpensive fabrication, they are limited in terms of electrode integration. Using silicon as the channel material, microfabrication techniques can be used to create nearby electrodes. Despite the advantages that silicon provides, its opacity has prevented its usage in most important microfluidic applications that need optical access. To overcome this barrier, silicon-on-insulator technology in microfluidics is introduced to create optical viewports and channel-interfacing electrodes. More specifically, the microfluidic channel walls are directly electrified via selective, nanoscale etching to introduce insulation segments inside the silicon device layer, thereby achieving the most homogeneous electric field distributions and lowest operation voltages feasible across microfluidic channels. These ideal electrostatic conditions enable a drastic energy reduction, as effectively shown via picoinjection and fluorescence-activated droplet sorting applications at voltages below 6 and 15 V, respectively, facilitating low-voltage electric field applications in next-generation microfluidics.

关键词： injection walls overcome

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