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Galectin-3 mediated risk of inflammation in stable schizophrenia,with only possible secondary consequences for cognition

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World Journal of Psychiatry 2022年第9期12卷 1183-1193页

作者： Slavica Minic Janicijevic Ivan P Jovanovic Nevena M Gajovic Milena M Jurisevic monojit debnath Nebojsa N Arsenijevic Milica M Borovcanin University of Kragujevac Faculty of Medical SciencesKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Human Genetics National Institute of Mental Health and NeurosciencesBangalore 560029India Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Evidence suggests that cytokines cause immune disturbances,shape immunological sequelae later in life,and modulate the risk of schizophrenia(SC).Galectin-3(Gal-3),a multifaceted molecule of the glycan family,is involved in the formation of the immunological synapse and modulates the signalling pathway and effector functions of T lymphocytes,which are major producers of *** have previously reported elevated serum Gal-3 levels in stable SC ***,Gal-3 as a link between cognitive functioning and inflammation has not yet been investigated in *** To investigate the relationship between serum Gal-3 levels and cognitive performance,serum cytokines,and white blood cell count in three-month stably treated SC *** Twenty-seven patients with SC in remission and 18 healthy volunteers participated in this casecontrol and correlational *** assessment was performed using the Positive and Negative Syndrome Scale and the Montreal-Cognitive *** results of previously measured serum levels of Gal-3,interleukin(IL)-33,soluble suppression of tumorigenicity 2(sST2),tumor necrosis factor-alpha(TNF-α),IL-6 and IL-17 were used for further statistical analyses,and IL-4,IL-23,IL-1βand transforming growth factor-beta(TGF-β)were now additionally measured with a sensitive enzyme-linked immunosorbent *** number of leukocytes in the blood and the percentage of neutrophils,lymphocytes,and monocytes were determined with a standardized routine measurement procedure(Sysmex Technology).Statistical analyses were performed using SPSS 20.0 *** We found no correlation between serum Gal-3 levels and cognitive functioning in SC patients.A positive correlation was found between the levels of Gal-3 and TNF-α(r=0.476;P=0.012),Gal-3and IL-23(r=0.417;P=0.031),and Gal-3 and sST2(r=0.402;P=0.038).The binary logistic model,which included all nine cytokines measured in this patient sample,indicated the particular role of Gal-3 and T

关键词： Schizophrenia Galectin-3 Cytokines Leukocytes Antipsychotics

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