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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Nanomaterials for Fighting multidrug-Resistant Biofilm Infections

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Biomedical Engineering Frontiers 2023年第1期4卷 133-143页

作者： vincent m.Rotello Department of Chemistry University of Massachusetts Amherst710 North Pleasant StreetAmherstMA 01003USA

multidrug-resistant bacterial infections represent a dire threat to global *** development of antibiotic resistance in bacteria coupled with the lack of development of new antibiotics is creating infections requiring antibiotics of last resort,and even some infections for which we have no available ***-based infections present some of the most challenging targets for *** biofilm matrix provides a physical barrier that can impede access of antibiotics and antimicrobials to resident *** phenotypic diversity found in biofilms further exacerbates the difficulty of eliminating infections,with quiescent“persister”cells evading therapeutics and re-initiating infections after *** provide a tool for combatting these refractory biofilm *** distinctive size regime and physical properties of nanomaterials provide them with the capability to penetrate and disrupt *** can also access antimicrobial pathways inaccessible to conventional antimicrobials,providing a synergistic strategy for treating biofilm *** review will summarize key challenges presented by antibiotic resistance and biofilms when treating infection and provide selected examples of how nanomaterials are being used to address these challenges.

关键词： resort initiating eliminating

Toward a Deeper Appreciation of Inherited Conventions

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Language and Semiotic Studies 2021年第3期7卷 32-54页

作者： vincent m.Colapietro The Pennsylvania State University(University Park)and University of Rhode Island USA

Conventionalism makes far too much of conventions,alleging that not only matters of fact,but also the adoption of a framework,are merely matters of ***,experiential,and other forms of compulsion are,tout court,*** Buchler,however,crafts a general theory of human judgment in which both conventionality and compulsion are given their due.1 moreover,he does so in a manner attuned to the axiological dimensions of human communication(whatever its modes or media).These conventions are hardly an ultimately dispensable *** are rather intrinsically constitutive *** also are in countless instances *** nature and authority of the normative constraints inherent in many shared conventions(more often than not,enabling constraints)are,however,neither appreciated nor ***’s account facilitates us in appreciating and understanding such constraints and much else.

关键词： arbitrariness Buchler Cavell compulsion contingency judgment justification

Engineering carbon quantum dots for photomediated theranostics

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Nano Research 2018年第1期11卷 1-41页

作者： mahbub Hassan vincent G. Gomes Alireza Dehghani Sara m. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQDs） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （QDs） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQDs elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQDs can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQDs to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of QD probes with a range of metal-free and emer^in~ 2D materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

Small fishes crossed a large mountain range:Quaternary stream capture events and freshwater fishes on both sides of the Taebaek mountains

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Integrative Zoology 2017年第4期12卷 292-302页

作者： Daemin KIm m.vincent HIRT Yong-Jin WON Andrew m.SImONS Division of EcoScience Ewha Womans UniversitySeoulKorea Department of Fisheries Wildlife and Conservation BiologySaint PaulMinnesotaUSA Bell museum of Natural History University of Minnesota100 Ecology BuildingSaint PaulMinnesotaUSA

The Taebaek mountains in Korea serve as the most apparent biogeographic barrier for Korean freshwater fishes,resulting in 2 distinct ichthyofaunal assemblages on the eastern(East/Japan Sea slope)and western(Yellow Sea and Korea Strait slopes)sides of the mountain *** nearly 100 species of native primary freshwater fishes in Korea,only 18 species occur naturally on both sides of the mountain ***,there are 5 rheophilic species(Phoxinus phoxinus,Coreoleuciscus splendidus,Ladislavia taczanowskii,Iksookimia koreensis and Koreocobitis rotundicaudata)found on both sides of the Taebaek mountains that are geographically restricted to the Osip River(and several neighboring rivers,for *** and ***)on the eastern side of the mountain *** Osip River and its neighboring rivers also shared a rheophilic freshwater fish,Liobagrus mediadiposalis,with the Nakdong River on the western side of the mountain *** assessed historical biogeographic hypotheses on the presence of these rheophilic fishes,utilizing DNA sequence data from the mitochondrial cytochrome b *** of our divergence time estimation indicate that ichthyofaunal transfers into the Osip River(and several neighboring rivers in East Sea slope)have occurred from the Han(Yellow Sea slope)and Nakdong(Korea Strait slope)Rivers since the Late *** inferred divergence times for the ichthyofaunal transfer across the Taebaek mountains were consistent with the timing of hypothesized multiple reactivations of the Osip River Fault(Late Pleistocene),suggesting that the Osip River Fault reactivations may have caused stream capture events,followed by ichthyofaunal transfer,not only between the Osip and Nakdong Rivers,but also between the Osip and Han Rivers.

关键词： biogeographic barrier comparative phylogeography divergence time Korean fishes Osipcheon fault

Implementation of distortion symmetry for the nudged elastic band method with DiSPy

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npj Computational materials 2019年第1期5卷 685-693页

作者： Jason m.munro vincent S.Liu Venkatraman Gopalan Ismaila Dabo Department of materials Science and Engineering and materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Penn State Institutes of Energy and the Environment The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Engineering Science and mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA

The nudged elastic band(NEB)method is a commonly used approach for the calculation of minimum energy pathways of kinetic ***,the final paths obtained rely heavily on the nature of the initially chosen *** often necessitates running multiple calculations with differing starting points in order to obtain accurate ***,it has been shown that the NEB algorithm can only conserve or raise the distortion symmetry exhibited by an initial *** this knowledge,symmetryadapted perturbations can be generated and used as a tool to systematically lower the initial path symmetry,enabling the exploration of other low-energy pathways that may ***,the group and representation theory details behind this process are presented and implemented in a standalone piece of software(DiSPy).The method is then demonstrated by applying it to the calculation of ferroelectric switching pathways in LiNbO_(3).Previously reported pathways are more easily obtained,with new paths also being found which involve a higher degree of atomic coordination.

关键词： symmetry distortion details

Optimal transport maps on infinite dimensional spaces

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Frontiers of mathematics in China 2015年第4期10卷 715-732页

作者： Shizan FANG vincent NOLOT I.m.B. BP 47870 Universite de Bourgogne Dijon France

We will give a survey on results concerning Girsanov transforma- tions, transportation cost inequalities, convexity of entropy, and optimal transport maps on some infinite dimensional spaces. Some open Problems will b... 详细信息

关键词： Girsanov theorem entropy optimal transport map Wiener space,Lebesgue point

Post-analysis simulation of the collapse of an open sabo dam of steel pipes subjected to boulder laden debris flow

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International Journal of Sediment Research 2020年第6期35卷 621-635页

作者： Toshiyuki Horiguchi vincent Richefeu Department of Civil Engineering National Defense Academy Universite Grenoble Alpes Laboratoire 3SR (solsSolidesStructuresRisques)

The objective of the proposed method is to utilize a site investigation of a debris flow disaster and verify a real scale analysis to evaluate the impulsive load on an open sabo *** Nagiso debris flow disaster which occurred in Nagano in 2014,where damage caused by Typhoon Neogri was *** verification result of the site investigation demonstrated the weak components of the open Sabo dam experienced damage owing to the debris flow.A discrete element method is normally applied to a solid body to calculate an interaction function force with respect to the contact point between boulders and the *** numerical method initially concatenates elements that model the open Sabo ***,the stiffness coefficient of flanges and coupling joints between pipes was expressed to utilize the sectional partition method to determine the structural *** method was improved to separate from the connecting elements beyond the boundary *** debris flow model uses a water flow distribution model,and the debris flow flowed from 200m upstream of the open sabo ***,the proposed method was examined to verify the primary cause of damage to the open sabo dam and used to reproduce the circumstances that evaluated the impulsive load occurrence mechanism in the case of a real *** addition,the coupling joints between the hollow steel pipes utilized a’reproduction analysis’ for a real sabo dam and a‘reinforced analysis’ for a reinforced sabo dam were applied to assess the weak point of the dam.

关键词： Open sabo dam Site investigation Damage verification Discrete element method

Soil carbon stock and emission: estimates from three land-use systems in Ghana

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Ecological Processes 2021年第1期10卷 157-169页

作者： Joseph Anokye vincent Logah Andrews Opoku Department of Crop and Soil Sciences Kwame Nkrumah University of Science and Technology(KNUST)KumasiGhana

Background:Land-use systems that sequester carbon and reduce CO_(2) emissions are key in the global mitigation strategies of climate *** gas emission from agro-ecosystems in sub-Saharan Africa is little ***,we quantified soil carbon stock(SCS)and CO_(2) emissions from three land-use systems *** land,oil palm plantation and forestland in the semi-deciduous forest zone of ***:Soil organic carbon concentration at the 0–15 cm layer in the forestland was 62 and 23%greater than that in the arable land and palm plantation,*** SCS along the 1.0-m profile was 108.2,99.0 and 73.5 mg ha^(−1) in the forestland,palm plantation and arable land,*** land emitted 30–46%more CO_(2) than palm plantation and *** the dry season,CO_(2) emissions were respectively 0.93,0.63 and 0.5 kg ha^(−1) h−1 from the arable land,palm plantation and *** relationships were observed between CO_(2) emissions and SCS,soil temperature,and *** SCS greatly influenced CO_(2) emission in the dry season more than in the wet season in the relatively higher carbon-input systems(forestland and palm plantation).Soil temperature accounted for more than 55%of CO_(2) emissions in both seasons,which has implications in the era of rising global ***:The study provides relevant information on carbon storage abilities of the three land-use types in tropical climate and calls for drastic climate change actions to reduce degradation of forest cover and soil disturbance in agro-ecosystems in sub-Saharan Africa.

关键词： Arable land Carbon dioxide emission Climate change Soil moisture Soil temperature Sub-Saharan Africa