检索结果-南通市图书馆

Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2019年第2期17卷 115-124页

作者： Asmae Assaidi Ikram Dib monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer Mohammed Aziz Hassane Mekhfi Mohammed Bnouham Michel Frederich Abderrahim Ziyyat Laboratory of Physiology Genetics and Ethnopharmacology Department of Biology Faculty of Sciences Mohammed I University Laboratory of Pharmacognosy Center for Interdisciplinary Research on the Medicines (CIRM) University of Liège

Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of ***: The vasorelaxant effect and the mode of action of various extracts from the leaves of C. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic ***: The various active extracts of C. ambrosioides at four concentrations(10^(-3), 10^(-2), 10^(-1) and 1 mg/mL) relaxed the contraction elicited by phenylephrine, in a concentration-dependent *** effect seems to be endothelium-dependent, since the vasodilatory effect was entirely absent in denuded aortic rings. The vasorelaxant effect of the methanol fraction(MF) of C. ambrosioides at 1 mg/mL was also inhibited by atropine and tetraethylammonium. This effect remained unchanged by Nx-nitro-L-arginine methyl ester hydrochloride and glibenclamide. The preliminary phytochemical analysis showed that the leaves of C. ambrosioides are rich in phenolic and flavonoid ***: These results suggest that the MF of C. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of Ca^(2+)-activated potassium channels.

关键词： Chenopodium ambrosioides Chenopodiaceae Vasorelaxation Ca^2+-activated potassium channels Thin-layer chromatography High-performance liquid chromatography Plant Complementary and alternative medicine

Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第20期12卷 3275-3282页

作者： Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten Department of Gastroenterology Hepatology and Endocrinology Hannover Medical SchoolGermany Departments of Visceral and Transplantation Surgery Hannover Medical School Germany

AIM： To analyze the phenotype and function of dendritic cells （DC） from patients with hepatocellular carcinoma （HCC） in order to understand their role in this disease. METHODS： Myeloid dendritic cells were enumerated in peripheral blood of HCC patients. CD80, CD83, CD86 and HLA-DR expression on naive and stimulated myeloid dendritic cells from peripheral blood were analyzed. Myeloid dendritic cells were isolated from peripheral blood and their function was tested. Phagocytosis was analyzed using FITC-dextran beads, peptide specific stimulation, the capacity to stimulate allogeneic T cells and secretion of cytokines upon poly dZ：dC was tested. RESULTS： Myeloid dendritic cells were reduced in patients with HCC. No differences in CD80, CD83, CD86 and HLA-DR expression were found on naive and stimulated myeloid dendritic cells from HCC patients and healthy controls. Normal phagocytosis or stimulation of peptide specific T cells was observed in contrast to an impaired allo-stimulatory capacity and a reduced IL-12 secretion. CONCLUSION： Impaired IL-12 production of mDCs in patients could lead to an impaired stimulatory capacity of naive T cells suggesting that IL-12 directed therapies may enhance tumor specific immune responses in HCC patients.

关键词： Myeloid DC Hepatocellular carcinoma CD80 CD83 CD86

Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2015年第8期8卷 1237-1252页

作者： Lars Dietzel Christine Glaeer monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt Department of Plant Physiology Institute of General Botany and Plant Physiology Friedrich-Schiller-University of Jena Domburger Strasse 159 07743 JenaGermany MIPS/IBI Helmholtz Zentrum MGnchen German Research Center for Environmental Health (GmbH) Ingolst~dter Landstrasse 1 85764 Neuherberg Germany Institute of Biology/Plant Physiology Humboldt-University Berlin Philippstrasse 13 Building 12 10115 Berlin Germany Institute of Biology Genetics Humboldt-University Berlin Chausseestrasse 117 10115 Berlin Germany present address: Institut fer Molekulare Biowissenschaften Pflanzliche Zellphysiologie Max-von-Laue-Strasse 9 Biozentrum Goethe-Universit~t Frankfurt 60438Frankfurt am Main Germany Present address: Zentrum fur Molekulare Biologie an der Universitat zu Heidelberg (ZMBH) Im Neuenheimer Feld 282 69120 Heidelberg Germany present address: Universite Grenoble-Alpes F-38000 Grenoble France Present address: CNRS UMR5168 F-38054 Grenoble France present address: CEA iRTSV Laboratoire de Physiologie Cellulaire & Vgetale F-38054 Grenoble France Present address: INRA USC1359 F-38054 Grenoble France Present address: Plant Reproductive Biology Group Department of Physiology and Ceil-Biology Leibniz Institute of Rant Genetics and Crop Plant Research (IPK)OT Gatersleben Corrensstrasse 3 D-06466 Stadt Seeland Germany present address: KWS Saat AG Grimsehlstrasse 31 37555 Einbeck Germany present address: Dartmouth College Department of Biological Sciences Ufe Sciences Center 78 College Street Hanover NH 03755 USA

Natural illumination conditions are highly variable and because of their sessile life style, plants are forced to acclimate to them at the cellular and molecular level. Changes in light intensity or quality induce changes in the reduction/oxidation （redox） state of the photosynthetic electron chain that acts as a trigger for compen- satory acclimation responses comprising functional and structural adjustments of photosynthesis and metabolism. Such responses include redox-controlled changes in plant gene expression in the nucleus and organelles. Here we describe a strategy for the identification of early redox-regulated genes （ERGs） in the nucleus of the model organism Arabidopsis thaliana that respond significantly 30 or 60 min after the generation of a reduction signal in the photosynthetic electron transport chain. By comparing the response of wild-type plants with that of the acclimation mutant stn7, we could specifically identify ERGs. The results reveal a significant impact of chloroplast redox signals on distinct nuclear gene groups including genes for the mitochondrial electron transport chain, tetrapyrrole biosynthesis, carbohydrate metabolism, and signaling lipid synthesis. These expression profiles are clearly different from those observed in response to the reduction of photosynthetic electron transport by high light treatments. Thus, the ERGs identified are unique to redox imbalances in photosynthetic electron transport and were then used for analyzing potential redox-responsive cis-elements, trans-factors, and chromosomal regulatory hot spots. The data identify a novel redox-responsive element and indicate extensive redox control at transcriptional and chromosomal levels that point to an unprecedented impact of redox signals on epigenetic processes.

关键词： plastidial redox signaling,early redox-regulated gene Arabidopsis thaliana Molecular Plant

The Role of Harmattan in the Edaphic Processes in the Extreme-North-Cameroon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering(B) 2012年第5期1卷 699-708页

作者： Anselme Wakponou monique Mainguet Frederic Dumay Department of Geography University of Ngaoundere Ngaoundere 454 Cameroon Laboratory of Zonal Geography for the Development University of Reims Champagne-Ardenne Reims 51100 France

In the Cameroonian sudano-sahelian and sahelian zone, karal soils i.e., vertisoils and soils with vertic similarities largely spread on tropical black clay in depressions and fiat sectors. Those black cotton soils are out of season＇s sorghum loft, locally called as muskwari. As the staple diet in the Cameroonian dry areas, this crop becomes more and more an alternative to drying or better to climate changes. Till now, those soils are considered to be lacustrine or they are resulting just from weathering, according to pedologic researchs. The purpose of this communication, therefore, is to show the effects of Harmattan on the basis of our field＇s observations, investigations and superficial deposits＇ analysis： granulometry and diffractometry in the laboratory. Harmattan is a dry and stable air mass which originates from the saharian anticyclone. Its participation in edaphics process is very relevant. Indeed, dust storms take place throughout the dry season and vertisoil spreads out on various topographic locations bringing about homogeneity of texture and similarity of mineralogic spectrum. Their high kaolinite content, thin granulometric component （fine sand, silt and clay） are indicative of Aeolian loessial dust deposits. It could not be something else in this area of the most southern saharian blow of the great Saharo-Sahelian GWAS （global wind action system） in sub-equatorial latitudes, in line with the venturi formed by Ennedi and Tibesti mountains.

关键词： Society-environment-climate interaction Cameroon Harmattan loess muskwari vertisoils.

Pilot study:Nursing students'perceptions of the environment in two different clinical models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2016年第3期3卷 285-290页

作者： Robert D.Perry Madeline M.Press Noelle Rohatinsky Roslyn M.Compton monique Sedgwick Department of Educational Administration University of SaskatchewanSaskatoonSaskatchewanCanada School of Nursing Saskatchewan PolytechnicSaskatoonSaskatchewanCanada College of Nursing University of SaskatchewanSaskatoonSaskatchewanCanada Nursing Program University of LethbridgeLethbridgeAlbertaCanada

Purpose:This pilot study aimed to assess the reliability and validity of a modified Dundee Ready Educational Environment Measure(m-DREEM)tool used to evaluate the effects of different pedagogical approaches in a clinical learning environment on nursing students'learning ***:A sample consisting of 130 nursing students in two different models of clinical education was ***:This pilot study demonstrated that m-DREEM yields a high internal *** tool can be used to evaluate nursing students'perceptions of their clinical learning environment on the basis of five sub-scales:students'learning perceptions,facilitators,academic self-perception,atmosphere,social self-perception,and ***:A definitive and inferential relationship between sub-scales and clinical models,namely,block and non-block dispersed models,could not be determined because of the small sample size of the block clinical ***,further research should be performed.

关键词： Clincial environments Nursing education Student nurse Perceptions of learning Quantitative m-DREEM

Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath monique Ryan Elaine Holmes Jeremy K.Nicholson Mark W.Fear Fiona M.Wood Luke Whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

论美国在国际法和国际规范的影响下保护少数族群权利法律框架的形成

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论美国在国际法和国际规范的影响下保护少数族群权利法律框架的形...

作者： Jessica monique Rampone 厦门大学

学位级别：硕士

该论文研究的是美国在国际法和国际规范的影响下保护少数族群权利的法律框架的形成。美国的少数群体包括少数民族群体、宗教群体、语言或文化群体等等,相对于主题民族,他们在数量上较少,他们一般希望保留他们自己的认同。这些群体在政... 详细信息

该论文研究的是美国在国际法和国际规范的影响下保护少数族群权利的法律框架的形成。美国的少数群体包括少数民族群体、宗教群体、语言或文化群体等等,相对于主题民族,他们在数量上较少,他们一般希望保留他们自己的认同。这些群体在政治、社会和语言等方面都处于弱势地位。这些人因为他们的差异性无法参与社会生活。随着18世纪和19世纪民族国家的创建和世界民族主义浪潮的兴起,这些弱势群体开始努力争取保护他们的文化、宗教和民族个性。美国队这些群体权利的承认和保护始于国联所签署的几个保护少数族群的条约。在1945年联合国建立并取代国联后,一系列保护少数群体权利的规范、程序和机制逐渐形成和发展起来。国际法要求在国际关系中以及在国家内部对待不同个体国家有责任保护他们的权利。美国历史上三大主要事件促成美国保护少数群体权利法律框架的形成。本文主要讨论着三个主要事件以及它们是如何促使美国保护少数群体权利法律框架的形成。为此,本文从国际法对美国国内相关法律和地方法规等的影响来研究相关法律框架的形成过程,也触及那些确保相关法律和规范的实施的机构。本文研究的目的是要厘清美国当今促进保护少数族群权利的法律框架结构,分析这些法律框架的优点和不足之处以作为本文的结论。

关键词：美国少数群体公民权法律框架国际法和国际规范

Encyclopedia of Autographa californica Nucleopolyhedrovirus Genes

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Virologica Sinica 2009年第5期24卷 359-414页

作者： David P. A. Cohen Martin Marek Bryn G. Davies Just M. Vlak monique M. van Oers Wageningen University Laboratory of Virolo Box 629 6700AP wageningen The Netherlands Généthon Department of Bioprocess Development Evry France University of York YCR Cancer Research Dept. of Biology Heslington York United Kingdom

The Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) was the first baculovirus for which the complete nucleotide sequence became known. Since then 15 years lapsed and much research has been performed to elucidate putative functions of the annotated open reading frames of this virus and this endeavour is still ongoing. AcMNPV is the most well-known and well-studied baculovirus species, not in the least for its application as a vector for the high-level expression of foreign genes in insect cells. This article is the first monograph of a single baculovirus and gives a current overview of what is known about the 151 AcMNPV ORFs, including (putative) function and temporal and spatial presence of transcripts and protein. To date 60 ORFs have a proven function, another 19 ORFs have homologs for which functions are known in other baculoviruses and 72 ORFs are still enigmatic. This paper should assist the reader in quickly finding the essentials of AcMNPV.

关键词： Baculovirus Autographa californica multiple capsid nucleopolyhedrovirus(AcMNPV) Functional genomics Review

卢旺达女子足球发展体系的现状与发展对策研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

卢旺达女子足球发展体系的现状与发展对策研究

作者： IMANIZABAYO monique（莫尼克）首都体育学院

学位级别：硕士

2001年以来,卢旺达一直致力于推动女子足球项目,并提高女子足球的竞赛水平。但是,到目前为止,这些努力并没有得到良好的回报。本研究的目的是分析卢旺达女子足球发展体系,并找到造成目前情况的原因;本文的结果阐明了卢旺达女子足球发展... 详细信息

2001年以来,卢旺达一直致力于推动女子足球项目,并提高女子足球的竞赛水平。但是,到目前为止,这些努力并没有得到良好的回报。本研究的目的是分析卢旺达女子足球发展体系,并找到造成目前情况的原因;本文的结果阐明了卢旺达女子足球发展体系的实际情况,并提出了解决方案,从而来改善卢旺达女子足球发展体系未来的状况。研究结果分析了卢旺达女子足球发展计划,研究了参与该计划的不同组织及其贡献。但是,整体来看,大众对目前的状况并不满意。原因是有关的机构数量不足(培训中心,健康中心等)。61%的卢旺达政府体育管理人员认为卢旺达女子足球发展计划缺乏配套措施,67%的被调查者认为该计划缺乏问责制度。99%的被调查者认为缺乏基础设施,70%的被调查者认为,由于文化观念的问题,卢旺达妇女缺乏从事足球运动的热情。根据卢旺达女子足球发展以及本研究的调查结果,就完善卢旺达女子足球发展提出以下建议:1.构建卢旺达女子足球运动员从童年到退役的生涯发展路径。2.增强卢旺达社会文化意识。在提升女子足球方面而言,应给予女子与男子相同的竞赛能力和机会,并在每个月设置社区服务日,强制进行宣传和呈现。3.政府应确保卢旺达女子足球运动员获得相应权力、受到政府保护。在政治体系上确保一代又一代女子运动员的可持续发展。4.在资金支持上,政府应当鼓励私营部门对女足发展体系进行投资。5.为保障女子足球体系的成功运转,在基础设施和人力资源方面,卢旺达女子足球发展体系需要合格的雇员来维持。6.注重运动员的营养与健康,在训练恢复、运动损伤恢复等方面提供全面的健康保险。7.制定保护卢旺达女子足球运动员发展的战略和政策,通过建立卢旺达女子联赛和发展评价体系,帮助她们参与国际层面的竞赛。卢旺达女子发展体系应当保证连贯、健全的体系,每个运动员在成长中的每一个环节都要有相应负责的人。

关键词：女子足球发展计划卢旺达