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Repeated inoculations of Mycobacterium bovis Bacille Calmette-Guérin (BCG) are needed to induce a strong humoral immune response against antigens expressed by the bacteria

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Open Journal of Immunology 2013年第3期3卷 71-81页

作者： monique C. da Silva Elena B. Lasunskaia Wilmar Dias da Silva Laboratory of Biology of Recognition Universidade Estadual do Norte Fluminense Campos Rio de Janeiro Brazil Laboratory of Immunochemistry Institute Butantan S&atilde o Paulo Brazil

The cellular immune response elicited by Mycobacterium bovis Bacille Calmette-Guérin (BCG) has been carefully investigated, but the humoral immune response has been partially neglected. BALB/c mice were immunized with BCG strain used to immunize humans. Anti-BCG antibodies, as assayed by ELISA, began to appear in the sera after the third week of immunization and plateaued three weeks after the 8th immunization. The total immunoglobulins (Igs) were purified by caprylic acid method from pooled serum collected after the 8th immunization. Anti-BCG antigen antibodies were detected in the total Igs preparation as well as in IgG, IgM, IgA, IgG1, IgG2a, and IgG2b, but not in the IgG3. Distinct BCG proteins were recognized the IgGs in Western blot analysis. Opsonization of BCG bacilli by the purified Igs potentiated internalization of the bacteria by murine Raw 264.7 macrophages. The intracellular BCG elimination coincided with the induction of NO production, which was more pronounced in cells infected with opsonized BCG compared to those infected with the non-opsonized bacteria. Coincidently, the production of NO was also higher in macrophages infected with opsonized BCG (maximal NO production at 48 h of incubation). The obtained results demonstrate that repeated inoculations of BCG effectively activate the humoral immune response, justifying the use of BCG as a live recombinant vaccine vector to insert genes encoding virulence factors controlled by antibodies.

关键词： Mycobacterium bovis Bacille Calmette-Guérin BCG Antibodies Opsonization Bacterial Killing

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巴黎地下空间计划

北京规划建设 2004年第1期 22-23页

作者： monique Labbe 法国D.P.L.G地下空间

现在有的城市规划忽视了地下空间,这让人感到很遗憾.但是,城市规划应包括城市的各种层面,无论是它的功能还是它的基础,无论是地上还是地下,只有综合合理地利用自然资源,才能够实现城市的持续发展.从1850年计划改造巴黎时一直到今天,综... 详细信息

现在有的城市规划忽视了地下空间,这让人感到很遗憾.但是,城市规划应包括城市的各种层面,无论是它的功能还是它的基础,无论是地上还是地下,只有综合合理地利用自然资源,才能够实现城市的持续发展.从1850年计划改造巴黎时一直到今天,综合开展利用地下空间,建设多重地下空间网络,我们已经经历了很多发展的模型.虽然私有权对地下空间的发展也存在相当的影响.但地下空间必须统一地开发治理以形成系统.

关键词：巴黎地下空间城市规划地下建筑地铁

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Reactivity of Recycled Glass Powder in a Cementitious Medium

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New Journal of Glass and Ceramics 2020年第3期10卷 29-44页

作者： monique Tohoue Tognonvi Arezki Tagnit-Hamou Léon Koffi Konan Ablam Zidol Wilfried Cyrille N’Cho Department of Biological Sciences University of Peleforo-Gbon-Coulibaly Korhogo C&#244 te d’Ivoire Department of Civil Engineering University of Sherbrooke Quebec Canada Laboratory of Chemistry of Inorganic Materials University of Felix Houphouet-Boigny Abidjan C&#244 te d’Ivoire

The reactivity of the recycled glass powder (GP) in a cementitious medium has been studied over time by means of X-ray diffraction and thermal gravimetric analysis. Two different mixtures based on cement/glass powder (0 or 20 wt% GP) and lime/glass powder (70 wt% GP) were considered. Analysis revealed the coexistence of both hydration and pozzolanic reaction during the hardening of the mortars. At young age, the cement hydration would prevail over the pozzolanic one resulting in a decrease of physico-chemical and mechanical properties of the material due to the dilution effect. The pozzolanic reaction that predominates from 91 days, would induce the formation of supplementary C-S-H leading to improve the material properties.

关键词： Glass Powder Pozzolanic Reaction Calcium Silicate Hydrate Thermal Analysis X-Ray Diffraction

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Bvlgari钥匙包行云流水

汽车生活 2007年第8期 86-89页

作者： monique 张灏

作为工业社会标志之一的汽车,自诞生之日起,注定加速了世界的节奏。往后电子时代的来临,人们开始用键盘代替纸笔。快的同时却丧失了慢的乐趣,比如书写,从心流淌,经由手指笔尖跃然纸上,此时的文字、符号、图画都有着独一无二的灵光。正... 详细信息

作为工业社会标志之一的汽车,自诞生之日起,注定加速了世界的节奏。往后电子时代的来临,人们开始用键盘代替纸笔。快的同时却丧失了慢的乐趣,比如书写,从心流淌,经由手指笔尖跃然纸上,此时的文字、符号、图画都有着独一无二的灵光。正因为每一次书写不可能完全相同,它才显得如此珍贵。"偏执"的人会精雕细琢每一个步骤,笔、纸、气、神,想必由此带来的乐趣与敲打键盘相较,不可同日而语。当你开着爱车时,也不妨降慢速度,看一下沿途风景,别有一番滋味。

关键词：书写工具键盘笔记本金属色墨水电子时代设计音乐家工业社会表达

E-Cigarette: A New Tobacco Product for Schoolchildren in Paris

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Open Journal of Respiratory Diseases 2013年第1期3卷 21-24页

作者： Bertrand Dautzenberg Pierre Birkui Maryvonne Noel Johanna Dorsett monique Osman Marie-Dominique Dautzenberg Paris Sans Tabac(PST) ParisFrance Office Francais de Prevention du Tabagisme(OFT) ParisFrance Groupe Hospitalier Pitie-Salpetriere(APHP) ParisFrance UniversitePierre et Marie Curie ParisFrance Rectorat de l’Academie de Paris ParisFrance Hopital Necker Enfants-Malades ParisFrance UniversiteReneDescartes ParisFrance

Objectives: To explore if the dramatic decrease in price of e-cigarette has transformed this new product into a product used for tobacco initiation among a teenage population. Methods: The authors added a question in 2012 on e-cigarette in the yearly survey on tobacco consumption in Paris schoolchildren. The study is conducted on a randomly selected sample from 2% of classes since 1991. Results: 277 (8.1%) of the 3409 schoolchildren studied (including 575 non responders to this question) reported having had an experience with e-cigarette. Experimentation rate is 6.4% among the 12 - 14-year-old, 11.8% among the 15 - 16-year-old and 9% among the 17-year-old schoolchildren. Among the 12 - 14- year-old schoolchildren, 64.4% of e-cigarette experimentation was by non-smokers. Of the 17-year-old teenagers who had used e-cigarettes, 12.4% were non-smokers. For the whole population, 33.2% of those having tried e-cigarette are non-smoker, 22.7% occasional smoker, 3.6% ex-smoker and 40.4% daily smoker. Those who experiment cannabis, shisha or binge-drinking are more frequently users of e-cigarette. In the smoker group, there is an inverse trend of rela- tionship between the readiness to quit tobacco and the rate of use of e-cigarette. Conclusion: For teenager’s, e-cigare- ttes have become not a product to aid quit tobacco but a product for experimentation and initiation of cigarette use. Regulation is urgently needed to control the emergent use of this new tobacco product by children.

关键词： E-Cigarettes Teenagers Tobacco Initiation Epidemiologic Study

Uncertainty following an inconclusive result from the BRCA1/2 genetic test:A review about psychological outcomes

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World Journal of Psychiatry 2021年第5期11卷 189-200页

作者： Sonia monique Bramanti Carmen Trumello Lucia Lombardi Alessandra Cavallo Liborio Stuppia IvanaAntonucci Alessandra Babore Department of Psychological Health and Territorial SciencesSchool of Medicine and Health SciencesUniversity“G.d’Annunzio”Chieti 66100Italy

BACKGROUND An inconclusive result from BRCA1/2 genetic testing indicates that a genetic variant of uncertain significance is *** case constitutes the majority of genetic test results,but studies specifically addressing the psychological adjustment of people with inconclusive results are *** To examine psychological outcomes of receiving an uninformative BRCA1/2 test *** PubMed,PsychInfo,and Cochrane Central Register of Controlled Trials were screened for studies focusing on distress,anxiety,and depression levels in individuals with inconclusive genetic test *** review is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** Studies on psychological outcomes of inconclusive BRCA1/2 focused on general and specific distress,anxiety,and ***,they produced mixed *** inconsistent findings are probably due to the uncertainty caused by this type of result,that may also influence the decisions of individuals about surveillance and prophylactic options,reducing their *** addition,this review highlights specific risk and protective factors that affect psychological adjustment in individuals with an inconclusive genetic testing *** Individuals with inconclusive genetic test results need specific educational programs and support to better understand the meaning of their results in order to be able to make decisions about surveillance and prophylactic options.

关键词： Genetic testing BRCA1/2 mutation Inconclusive result Psychological distress Depression Anxiety Review

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镜相学

汽车生活 2007年第6期 98-101页

作者： monique 张灏朱骞

翻开最新的时尚杂志,不难发现今季的重点——眼镜!墨镜,毋庸置疑是明星外出的必备品,赶潮流的人们也喜欢有事没事戴着一副无镜片的黑框眼镜示人,眼镜的装饰性逐渐超越了功能性,成为鼻梁上的艺术品。那么,你是不是该考虑在驾车时戴上一... 详细信息

翻开最新的时尚杂志,不难发现今季的重点——眼镜!墨镜,毋庸置疑是明星外出的必备品,赶潮流的人们也喜欢有事没事戴着一副无镜片的黑框眼镜示人,眼镜的装饰性逐渐超越了功能性,成为鼻梁上的艺术品。那么,你是不是该考虑在驾车时戴上一副眼镜,别有性格地上路?

关键词：眼镜板材镜片广告创意时尚杂志气质混合金属潮流装饰性功能性

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合作更迭:冲绳军事基地重整策略

景观设计学（中英文） 2020年第6期8卷 146-157页

作者：黄晓昕 Snohetta建筑事务所

自冲绳岛战役和二战结束以来,作为日本五大岛屿之一的冲绳本岛一直是美国武装部队的战略要地。驻日美军基地中约有70%位于冲绳本岛,占据整个岛屿面积的五分之一,并使其暴露于各种社会–生态的威胁之中。这种高度军事化带来的社会–生态... 详细信息

自冲绳岛战役和二战结束以来,作为日本五大岛屿之一的冲绳本岛一直是美国武装部队的战略要地。驻日美军基地中约有70%位于冲绳本岛,占据整个岛屿面积的五分之一,并使其暴露于各种社会–生态的威胁之中。这种高度军事化带来的社会–生态影响遍布整个岛屿,并未受限于军事基地边界,污染和破坏了当地居民和野生动植物赖以生存的生态系统。鉴于目前关于冲绳本岛军事基地重整问题依然争论不休,本研究提出以景观为媒介的替代重整策略来应对上述挑战,并针对即将到来的2022年(冲绳回归日本50周年)概述了4项策略,以期在自然、冲绳原住民和美军基地之间建立起生态共生关系,并加强军事化岛屿景观的自持续性。

关键词：冲绳本岛意愿土著社区军事基地重整景观策略

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LANGMUIR BLODGETT多分子层

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食品与生物技术学报 1984年第4期 56-64页

作者： monique Dupeyrat,华西苑巴黎第六大学物理化学实验室无锡轻工业学院化工系法国

一、LANGMUIR BLODGETT多分子层Langmuir Blodgett多分子层是由不溶物(两亲分子)的单分子层按一定规律组成的集合体。此类实验一般是在Langmuir槽上进行的。图1是其示意图。图中A表示飘浮于液体表面的一个栅栏,可以通过与之相连接的天... 详细信息

一、LANGMUIR BLODGETT多分子层Langmuir Blodgett多分子层是由不溶物(两亲分子)的单分子层按一定规律组成的集合体。此类实验一般是在Langmuir槽上进行的。图1是其示意图。图中A表示飘浮于液体表面的一个栅栏,可以通过与之相连接的天平记录膜中表面压的变化,B表示可移动的活塞,可用之改变膜的表面积。实验方法如下:在Langmuir槽中放满液体,于其表面上铺展

关键词：单分子层液面板面单分子膜物面 LANGMUIR BLODGETT 表面压多分子层吸附两亲分子润湿角接触角