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NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

Journal of materials Science & Technology 2022年第19期114卷 120-130页

作者： m.m.Costa A.miranda F.Bartolomeu O.Carvalho S.matos G.miranda F.S.Silva Center for microElectromechanical Systems(CmEmS-Uminho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for *** work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based *** performance was evaluated in vivo through implantation in Sprague Dawley rats’femur,being then analyzed after 4 and 12 weeks of ***-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured *** showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had ***-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212%when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

关键词： NiTi Laser surface texturing In vivo studies Osseointegration Implants

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Interplay between genome organization and epigenomic alterations of pericentromeric DNA in cancer

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Journal of Genetics and Genomics 2021年第3期48卷 184-197页

作者： Subhadip Kundu m.D.Ray Ashok Sharma Laboratory of Chromatin and Cancer Epigenetics Department of BiochemistryAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Surgical Oncology IRCHAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

In eukaryotic genome biology,the genomic organization inside the three-dimensional(3D)nucleus is highly complex,and whether this organization governs gene expression is poorly *** lamina(NL)is a filamentous meshwork of proteins present at the lining of inner nuclear membrane that serves as an anchoring platform for genome *** chromatin domains termed as lamina-associated domains(LADs),play a major role in silencing genes at the nuclear *** interaction of the NL and genome is dynamic and ***,many genes change their positions during developmental processes or under disease conditions such as cancer,to activate certain sorts of genes and/or silence *** heterochromatin(PCH)is mostly in the silenced region within the genome,which localizes at the nuclear *** show that several genes located at the PCH are aberrantly expressed in *** interesting question is that despite being localized in the pericentromeric region,how these genes still manage to overcome pericentromeric *** epigenetic mechanisms control the expression of the pericentromeric region,recent studies about genome organization and genome-nuclear lamina interaction have shed light on a new aspect of pericentromeric gene regulation through a complex and coordinated interplay between epigenomic remodeling and genomic organization in Cancer.

关键词： LADs Pericentromere Heterochromatin Gene regulation Epigenetics Cancer Genome organization

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Radial variations in xylem sap flux in a temperate red pine plantation forest

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Ecological Processes 2021年第1期10卷 328-336页

作者： Alanna V.Bodo m.Altaf Arain School of Earth Environment and SocietyMcMaster UniversityHamiltonONCanada mcmaster Centre for Climate Change HamiltonONCanada

Background:Scaling sap flux measurements to whole-tree water use or stand-level transpiration is often done using measurements conducted at a single point in the sapwood of the tree and has the potential to cause significant *** studies have shown that much of this uncertainty is related to(i)measurement of sapwood area and(ii)variations in sap flow at different depths within the tree ***:This study measured sap flux density at three depth intervals in the sapwood of 88-year-old red pine(Pinus resinosa)trees to more accurately estimate water-use at the tree-and stand-level in a plantation forest near Lake Erie in Southern Ontario,*** showed that most of the water transport(65%)occurred in the outermost sapwood,while only 26%and 9%of water was transported in the middle and innermost depths of sapwood,***:These results suggest that failing to consider radial variations in sap flux density within trees can lead to an overestimation of transpiration by as much as 81%,which may cause large uncertainties in water budgets at the ecosystem and catchment *** study will help to improve our understanding of water use dynamics and reduce uncertainties in sap flow measurements in the temperate pine forest ecosystems in the Great Lakes region and help in protecting these forests in the face of climate change.

关键词： Sap flow Transpiration Water use Red pine Temperate forest Great Lakes region

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Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage

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National Science Review 2020年第4期7卷 815-822页

作者： Alida m.Bailleul Wenxia Zheng John R.Horner Brian K.Hall Casey m.Holliday mary H.Schweitzer Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment Department of Biological Sciences North Carolina State University Department of Geology University of Lund Honors Program Chapman University Department of Pathology and Anatomical Sciences University of Missouri North Carolina museum of Natural Sciences Department of Biology Dalhousie University

A histological ground-section from a duck-billed dinosaur nestling(Hypacrosaurus stebingeri) revealed microstructures morphologically consistent with nuclei and chromosomes in cells within calcified *** hypothesized that this exceptional cellular preservation extended to the molecular level and had molecular features in common with extant avian cartilage. Histochemical and immunological evidence supports in situ preservation of extracellular matrix components found in extant cartilage, including glycosaminoglycans and collagen type II. Furthermore, isolated Hypacrosaurus chondrocytes react positively with two DNA intercalating stains. Specific DNA staining is only observed inside the isolated cells, suggesting endogenous nuclear material survived fossilization. Our data support the hypothesis that calcified cartilage is preserved at the molecular level in this mesozoic material, and suggest that remnants of once-living chondrocytes, including their DNA, may preserve for millions of years.

关键词： cartilage dinosaur nuclei chromosomes collagen Ⅱ DNA markers

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Expert perspectives on GIS use in Spanish geographic education

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International Journal of Digital Earth 2022年第1期15卷 1204-1218页

作者： I.J.Buzo-Sánchez C.mínguez m.L.De Lázaro-Torres IES San Roque BadajozSpain Geography Department Universidad Complutense de MadridMadridSpain Geography Department UNEDMadridSpain

The emergence of new technological tools for territorial analysis,such as cloud-based GIS,or GIS viewers,compels us to closely examine its usefulness in geographic education. Specifically,it raises the professors and teachers’ questions: what to teach? how to teach? and what will students learn? This research responds to these three questions by interviewing Spanish experts who know how to use these tools to teach geography at university and secondary school levels. The Delphi technique was applied to achieve this,which established consensus and led to the following results from experts’ own experience: (1) that GIS help to understand territory in an experiential and non-memoristic way and (2) they enable the development of spatial thinking. This paper concludes that changes in methodologies and integrate technical knowledge into teacher training are needed.

关键词： Geography Delphi GIS competencies spatial thinking

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The extended cubic B-spline algorithm for a modified regularized long wave equation

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Chinese Physics B 2013年第4期22卷 75-80页

作者： I.Dag D.Irk m.SarI Faculty of Science and Arts Department of Mathematics and Computer Sciences Eskis ehir Osmangazi niversitesi Eskis ehir Turkey Faculty of Science and Arts Department of Mathematics Pamukkale niversitesi Denizli Turkey

A collocation method based on an extended cubic B-spline function is introduced for the numerical solution of the modified regularized long wave equation. The accuracy of the method is illustrated by studying the single solitary wave propagation and the interaction of two solitary waves of the modified regularized long wave equation.

关键词： collocation methods solitary waves

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A Template matching Based Feature Extraction for Activity Recognition

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Computers, materials & Continua 2022年第7期72卷 611-634页

作者： muhammad Hameed Siddiqi Helal Alshammari Amjad Ali madallah Alruwaili Yousef Alhwaiti Saad Alanazi m.m.Kamruzzaman College of Computer and Information Sciences Jouf UniversitySakakaAljouf2014Kingdom of Saudi Arabia Department of Computer Science COMSATS University IslamabadLahore CampusPakistan

Human activity recognition(HAR)can play a vital role in the monitoring of human activities,particularly for healthcare conscious *** accuracy of HAR systems is completely reliant on the extraction of prominent *** methods find it very challenging to extract optimal features due to the dynamic nature of activities,thereby reducing recognition *** this paper,we propose a robust feature extraction method for HAR systems based on template ***,in this method,we want to associate a template of an activity frame or sub-frame comprising the corresponding *** this regard,the template is placed on the frame pixels to calculate the equivalent number of pixels in the template correspondent those in the *** process is replicated for the whole frame,and the pixel is directed to the optimum *** best count is estimated to be the pixel where the silhouette(provided via the template)presented inside the *** this way,the feature vector is *** feature vector generation,the hiddenmarkovmodel(Hmm)has been utilized to label the incoming *** utilized different publicly available standard datasets for *** proposed method achieved the best accuracy against existing state-of-the-art systems.

关键词： Activity recognition feature extraction template matching video surveillance

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Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation

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Asian Journal of Andrology 2020年第3期22卷 302-308页

作者： Giorgia Spaggiari Antonio R m Granata Daniele Santi Unit of Endocrinology Department of BiomedicalMetabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModena 41126Italy Unit of Endocrinology Department of Medical SpecialtiesAzienda Ospedaliero-Universitaria of ModenaOspedale Civile of BaggiovaraModena 41126Italy.

Testicular volume(TV)is proposed to be a positive predictor of male fertility status,because of the relation known between the TV and the seminiferous tubule *** of the measurement methodology,the role of TV and testicular ultrasound(US)assessments is still debated in andrological clinical *** this retrospective cohort study,we evaluated TV and testis US role in the diagnostic workup of andrological *** consecutive outpatients undergoing single-operator testis US(modena,Italy)from march 2012 to march 2018 were enrolled,matching sonographic,hormonal,and seminal data.A total of 302 men were referred and evaluated for gynecomastia,suspected hypogonadism,couple infertility(Cl),or sexual *** the hypogonadal group,TV was lower compared to that in other groups(Pmozoospermic patients showed higher TV compared to men with impaired semen quality(P=0.003)and azoospermia(P=0.003).However,TV was not able to discriminate between patients presenting normal and altered semen *** the contrary,testis US inhomogeneity was more frequent in patients with impaired sperm quality(55.0%;P=0.007)and azoospermia(40.0%;P=0.012),compared to patients with normozoospermia(5%),identifying thereby the sonographic pattern as an informative parameter of the fertility ***,in the Cl workup,US evaluation seems to be more informative than the TV assessment alone.

关键词： male hypogonadism male infertility testicular diseases testis

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Current and near-term advances in Earth observation for ecological applications

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Ecological Processes 2021年第1期10卷 1-57页

作者： Susan L.Ustin Elizabeth m.middleton John muir Institute of the Environment University of CaliforniaDavisCA 95616USA NASA/Goddard Space Flight Center(Emerita) GreenbeltMD 20771USA.

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole *** identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s,were recently launched,or are planned for launch in this *** have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data *** focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal *** suite of instruments we describe measure land surface characteristics,including land cover,but provide a more detailed monitoring of ecosystems,plant communities,and even some species then possible from historic *** newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area(LmA),total nitrogen content,and leaf area index(LAI).They provide new information on physiological processes related to photosynthesis,transpiration and respiration,and stress detection,including capabilities to measure key plant and soil biophysical *** include canopy and soil temperature and emissivity,chlorophyll fluorescence,and biogeochemical contents like photosynthetic pigments(e.g.,chlorophylls,carotenoids,and phycobiliproteins from cyanobacteria),water,cellulose,lignin,and nitrogen in foliar *** data will enable us to quantify and characterize various soil properties such as iron content,several types of soil clays,organic matter,and other *** of these satellites are in low Earth orbit(LEO),but we include a few in geostationary orbit(GEO)because of their potential to measure plant physiological traits over diurnal periods,impro

关键词： Terrestrial ecosystems Earth Observing Satellites Ecosystem processes Physiological functions multispectral Hyperspectral Thermal LiDAR Radar imagers Biochemistry Soil properties Species mapping Change detection 3D canopy structure Topography

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Waste materials to Replace Natural Resources

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武汉理工大学学报 2010年第17期32卷 35-42页

作者： VAN DE VEN m F C mOLENAAR A A A POOT m R Delft University of Technology

A number of waste materials were studied on their application into asphalt mixtures. materials tested were plastic waste as (soft) granular material,ceramic waste from electrical insulators,foundry sand and sintered granulate from burned household waste. Both plastic waste,crushed ceramics and large fractions of sintered household waste could be used as partial replacement for coarse aggregates. Foundry sand could partially replace natural sand in asphalt mixtures. The first step of the study was to find out if the waste materials could satisfy basic requirements and for some if their leaching behavior was acceptable. In the next phase mixtures were designed and mechanical tests were done on several mixtures with waste components to determine indirect tensile strength,stiffness,fatigue. In order to estimate the water sensitivity of some mixtures,retained indirect tension tests were done. The properties are reported and compared with each other and reference mixtures. From the research it becomes clear that it takes a lot of work to replace virgin materials in asphalt mixtures with waste materials.

关键词： waste materials plastic ceramic sintered household waste leaching,mechanical properties

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