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Monitoring of Heart Ischemia in Blood Serum

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Spectral Analysis Review 2016年第2期4卷 11-22页

作者： Vladimíra Tomečková Vladimír Komanický Mohammad Kakoush Kristína Krajčíková Gabriela Glinská monika Široká Lýdia Pundová Tomáš Samuely Dominika Hložná Dmytro Lotnyk Department of Medical and Clinical Biochemistry Faculty of Medicine Pavol Jozef Safárik University in Kosice Slovak Republic Institute of Physics Faculty of Science Pavol Jozef Safárik University in Kosice Slovak Republic 1st Department of Internal Medicine Faculty of Medicine Pavol Jozef Safárik University in Kosice Slovak Republic

Our aim was to study the selected cases of the patients with ischemic heart disease and to analyze the structure of blood serum of patients in comparison with control serum of healthy subjects by methods: synchronous fluorescence fingerprint and atomic force microscopy that are still not used in clinical practice. Our results of fluorescence analysis showed that blood serum of all patients with ischemic heart disease decreased intensity of fluorescence in comparison with control blood serum. Endogenous fluorescence of synchronous fluorescence fingerprint of blood serum of patients with unstable angina pectoris state after non ST elevation myocardial infarction;angina pectoris and arterial hypertension 3 was similar, but atomic force microscopy revealed differences in the structure of blood serum of patients with the angina pectoris. Blood serum of patients with angina pectoris exhibited disappearance of fluorescence peak with maximum fluorescence and showed lower fluorescence intensity than control blood serum and blood serum of patients with arterial hypertension 2. Profiles of synchronous fluorescence fingerprint of blood serum of patients with arterial hypertension stage 2 showed formation of the new fluorescent peak with maximum fluorescence, similar shape of synchronous fluorescence fingerprint and higher fluorescence intensity than blood serum of healthy subjects. Blood serum sensitively revealed changes in the body by using untraditional novel techniques which enable the analysis of the mixture of blood serum and might be a new possibility in study of heart ischemia diseases.

关键词： Blood Serum Fluorescence Analysis Atomic Force Microscopy Ischemic Heart Disease

Twenty Five Years’ Friendship with CPAFFC

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Voice of Friendship 2014年第2期 21-21页

作者： Countess monika von Borries Association for Germany-China Friendship Donnersberg

The year 2014 marks the 60th anniversary of the founding of the Chinese People’s Association for Friendship with Foreign Countries(C PA F F C).O n b e h a l f o f t h e Association for Germany-China Friendship Donnersberg(AGCFDonnersberg),I wish to extend my sincere *** September 2013,our own association celebrated its 25th *** back,we have cooperated with the CPAFFC for a quarter of a century.

关键词： celebrated birthday quarter founding anniversary m

Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 74-87页

作者： Kimberly A.Webster Mary L.O’Connor Aaron R.Hansen Sheetal Kircher Heather S.L.Jim Adam P.Dicker monika Janda Kari Ala-leppilampi Clifton O.Bingham III Josephine Feliciano Norah Lynn Henry Laurie E.Steffen McLouth David Cella Department of Medical Social Sciences Northwestern University Feinberg School of MedicineChicagoIL 60611USA Princess Margaret Cancer Center University Health NetworkToronto M5G 1Z5Canada Robert H Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Health Outcomes and Behavior Moffitt Cancer CenterTampaFL 33612USA Department of Radiation Oncology Sidney Kimmel Medical College and Cancer Center at Thomas Jefferson UniversityPhiladelphiaPA 19107USA Centre for Health Services Research The University of QueenslandQLD 4102Australia Applied Health Research Centre Li Ka Shing Knowledge InstituteSt Michael’s HospitalToronto M5B 1W8Canada Divisions of Rheumatology and Allergy and Clinical Immunology Johns Hopkins UniversityBaltimoreMD 21224USA Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center BaltimoreMD 21231USA University of Michigan Rogel Cancer Center Ann ArborMI 48109USA Department of Behavioral Science Center for Health Equity Transformation and Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY 40536USA

Aim:To develop a comprehensive item library of patient-reported,immunotherapy-related adverse events(irAEs)that draws from and expands on the Functional Assessment of Chronic Illness Therapy(FACIT)Measurement ***:Literature review and iterative expert *** on a literature review of irAEs,we developed a framework of immunotherapy classes and their associated *** experts then reviewed iterations of symptom summaries and item maps linked to the immunotherapy *** provided content review and feedback was shared across experts until consensus was *** iterative process facilitated creation of a Primary Symptom List associated with immune checkpoint modulators(ICMs),drawn from the larger set of *** FACIT items were mapped to the symptom list,and new items were written as needed to create the item ***:The full item library of irAEs is comprised of 239 items,covering 142 unique symptoms across 75 inflammatory reactions/immune conditions.A subset of 66 items comprises a Primary Symptom List considered most common/relevant to ICM *** includes gastrointestinal,skin,pulmonary,neurologic,musculoskeletal,and multiple miscellaneous and constitutional ***:The FACIT Immunotherapy Item Library is a compilation of 239 self-report items that capture the wide range of AEs experienced by people receiving immune treatments.A subset of 66 items comprises a Primary Symptom List meant for ICM *** of items selected from this library is encouraged in clinical research and clinical practice evaluation.

关键词： Immunotherapy immune checkpoint modulators quality of life immune-related adverse events patient reported outcomes cancer oncology

What Is the Personal Experience of IBD Patients about Their Anti-TNF-Alpha Therapy?

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Health 2017年第7期9卷 1007-1018页

作者： Agnes Milassin Mariann Rutka Agnes Anna Csontos Pal Miheller Karoly Palatka monika Szucs Zoltan Szepes Anita Balint Renata Bor Anna Fabian Klaudia Farkas Ferenc Nagy Tamas Molnar First Department of Medicine University of SzegedSzegedHungary 2^(nd) Department of Medicine Semmelweis UniversityBudapestHungary 2^(nd) Department of Internal Medicine University of DebrecenDebrecenHungary Department of Medical Physics and Informatics University of SzegedSzegedHungary

AIM: To evaluate and compare the patients opinion on the two types of anti- TNF-α therapies in a Hungarian cohort of IBD patients. METHODS: This was a prospective, multicentre, questionnaire-based observational study carried out in three Hungarian tertiary centres. From April to September 2014, an anonymous questionnaire was distributed to patients diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD), who have received infliximab (IFX) and/or adalimumab (ADA). The survey focused on the preferences of the two anti-TNF-α therapies on the basis of the efficacy, the administration routes and the side effects. RESULTS: 292 IBD patients, 216 CD, 75 UC and 1 indeterminate colitis patient completed the questionnaire. The mean duration of biological therapy was 1.7 (1 - 7) years. IFX treated patients noticed improvement of symptoms at 4 - 5 weeks while ADA treated patients noticed at 5 - 6 weeks. There was no difference between the patients’ satisfaction regarding the types of anti-TNF-α therapy if they received both. However, subcutaneous administration was preferred by ADA-treated patients previously receiving IFX (p = 0.007) compared to intravenous route and they did not intend to change the mode of therapy (p = 0.040). 90% of the patients, receiving only IFX or ADA were satisfied with their present therapy. The majority of patients (186/292, 63.7%) would not switch therapy. 63 of 291, 22% of the patients reported to have some concern with biological therapy—the majority (32/63, 50.8%) due to fear from side effects. CONCLUSION: Generally, patients preferred and would not change the present anti-TNF-α therapy, however, subcutaneous administration was preferred among those patients who had have experience with both.

关键词： Patient’s Satisfaction Personal Experience Questionnaire Anti-TNF-Alpha Therapy Patient’s Preference

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国有企业:贸易影响和政策隐喻(下)

中国政府采购 2014年第9期 46-54页

作者： Przemyslaw Kowalski Max Buge monika Sztajerowska Matias Egeland 董立阳郭成龙不详工信部国际经济技术合作中心

为了整理出对于在国际贸易和投资中的国有企业的作用进行在方法上一致的评估，本文采用了作为大多数的国有企业所使用的国有企业的定义，同时对于其他形式的国有产权和政府创设的竞争优势进行了观察。

关键词：国有企业贸易影响隐喻政策国际贸易竞争优势国有产权投资

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国有企业:贸易影响和政策隐喻(上)

中国政府采购 2014年第8期 51-56页

作者： Przemyslaw Kowalski Max Buge monika Sztajerowska Matias Egeland 董立阳郭成龙工信部国际经济技术合作中心

随着贸易和投资的结合日趋紧密，传统上主要侧重国内市场的国有企业开始在国际市场上同私营企业竞逐。从国际贸易的角度考量，该论文显示出在许多国际以及经济领域中国有企业有重要影响。如果这些国有企业中的一部分受益于政府赋予的非... 详细信息

随着贸易和投资的结合日趋紧密，传统上主要侧重国内市场的国有企业开始在国际市场上同私营企业竞逐。从国际贸易的角度考量，该论文显示出在许多国际以及经济领域中国有企业有重要影响。如果这些国有企业中的一部分受益于政府赋予的非公平优势，对于经济扭曲的潜在可能性很大，该文讨论了国有企业潜在的优势如何能够产生跨境影响。文中对于现存的国家、双边以及多边层面的现存规则的调查被认为是决定是否需要填补法律空白以及找到开展这一工作的最有建设性方式的第一步。

关键词：国有企业贸易影响隐喻政策国际市场私营企业国内市场国际贸易

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胶片摄影的艺术

Image Noise Analysis of a Large Ring PET Scanner

作者： (德)莫妮卡·安德烈(monika Andrae) (德)克里斯·马夸特(Chris Marquardt)

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第2期6卷 208-215页

作者： M. M. Ahasan S. Akter R. Khatun M. F. Uddin A. N. monika M. A. Rahman M. N. Khanam Institute of Nuclear Medical Physics AERE Savar Bangladesh Medical Physics Division Atomic Energy Centre Dhaka Bangladesh Infertility Unit Department of Gynae & Obs BSMMU Dhaka Bangladesh

Image noise analysis of a large ring PET scanner “macro PET” performed using two different phantoms, namely a Jaszczak SPECT phantom and a uniform cylindrical phantom. In the present work, simple 2D filtered back projection was used to reconstruct all the images, and in almost all the cases a Hamming filter of cutoff frequency 0.4 and a 256 by 256 matrix with zoom factors from 1 to 4 were used in order to investigate the imaging capabilities of the new scanner and the influence of filter and cut-off frequency on the filtered back projected images. Results indicate that 11.1 mm cold rod in the Jaszczak phantom images can consistently be seen. The Coefficient of variation (CV) results for Hann and Hamming filters are very similar and increase approximately in linear fashion with higher cutoff frequency. The value of CV for the Parsen filter is lower than the value for Hann and Hamming filters. It concludes that all filters with low cut off-frequency (0.6) would suppress image noise but decrease contrast.

关键词： PET Sinogram Filter & CV

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瘤胃的吸收及其机理研究进展

瘤胃的吸收及其机理研究进展