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NecAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NecAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NecAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NecAB2 interacts with predominantly striatal G-protein-coupled receptors, while NecAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NecAB proteins exhibit distinct subcellular localizations: NecAB1 is found in the nucleus and cytosol, NecAB2 resides in endosomes and the plasma membrane, and NecAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NecAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. however, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NecAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Luminescence properties of dysprosium doped YVO_4 phosphor

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journal of Rare earths 2018年第12期36卷 1245-1249页

作者： h.j.Rajendra c.PANDurangappa D.L.monika Department of Physics RNS Institute of TechnologyChannasandra Department of Physics SJB Institute of Technology

Trivalent dysprosium(Dy) activated nanocrystalline yttrium vanadate(YVO) phosphor was synthesized via co-precipitation method. The prepared samples were characterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SeM), optical absorption and photo luminescence(PL) techniques. The XRD patterns reveal the tetragonal crystalline phase. SeM images reveal that Dy doped YVOnanocrystals are agglomerated. eDAX confirms the formation of YVO:Dy. FTIR spectrum shows two strong absorption bands at 459 and 761 cm. Optical absorption spectrum showed the surface defects in the as-prepared samples. The PL emission spectrum shows two characteristic emission bands at 485 and 575 nm. The strong yellow emission peak at 575 nm is assigned to ~4 F→~6 hhyper sensitive transition of Dyions, Study of cIe chromaticity diagram indicates the suitability of the phosphor for the development of yellow-green LeDs.

关键词： Precipitation Yttrium vanadate Dysprosium X-ray diffraction Photoluminescence Rare earths

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Quality assessment between calibrated highway safety manual safety performance functions and calibration functions for predicting crashes on freeway facilities

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journal of Traffic and Transportation engineering(english edition) 2020年第1期7卷 76-87页

作者： Imalka c.Matarage Sunanda dissanayake Department of civil engineering Kansas State UniuersityManhattanKS 66502USA

crash prediction models are commonly used for network screening in highway safety management process,where potential impacts of highway safety treatments are *** highway Safety Manual(hSM)provides crash prediction models for various types of highway facilities that are often referred to as safety performance functions(SPFs).Freeway facility SPFs in the hSM were developed using data gathered from the states of california,Maine,and *** applying these hSM-default SPFs to a local jurisdiction,the hSM recommends calibration of hSM-default SPFs or development of jurisdiction-specific SPFs to improve the accuracy of crash *** study first calibrated the hSM-default freeway SPFs and for further accuracy and comparison purposes calibration functions were developed using Kansas freeway *** performance of calibrated hSM-default SPFs was then compared with developed calibration functions concerning the accuracy in crash *** facility calibration dataset included521 freeway segments,351 entrance-related speed-change lanes,and 366 exit-related speed-change *** residual plots and several other goodness-of-fit measures were used to assess the quality of calibrated hSM-default SPFs and calibration *** functions fitted better compared to calibrated hSM-default SPFs for Kansas freeway *** methodology used in this study could be beneficial and practiced to any *** functions could be used as an alternative to jurisdiction-specific SPFs or a replacement for hSM-default SPFs,which are frequently used in comparing alternatives,in calculating economic benefits of project improvements,and in estimating economic effectiveness of crash reduction in highway safety-related decision making.

关键词： Transportation Freeway segments Speed-change lanes crash prediction models Goodness-of-fit measures calibration factor

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Microfungi on Tectona grandis(teak)in Northern Thailand

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Fungal Diversity 2017年第1期82卷 107-182页

作者： Mingkwan Doilom asha j.dissanayake Dhanushka N.Wanasinghe Saranyaphat Boonmee jian-Kui Liu D.jayarama Bhat joanne e.Taylor Ali.h.Bahkali eric h.c.McKenzie Kevin D.hyde Key Laboratory for Plant Diversity and Biogeography of east Asia Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650201China center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute of Plant and environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Formerly Department of Botany Goa UniversityTaleigãoGoaIndia No.128/1-j Azad Housing SocietyCurcaGoa VelhaIndia Royal Botanic Garden edinburgh 20A Inverleith RowEdinburgh EH35LRUK Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 1145Saudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand

To date there is virtually no information available concerning the fungi associated with Tectona grandis(teak)(Lamiaceae)in *** this study,samples of microfungi were collected from both asymptomatic stems and dead wood,and symptomatic branches,stem and leaves of *** 27 sites in six provinces(chiang Mai,chiang Rai,Phayao,Phitsanulok,Phrae and Uttaradit Provinces).Morphology and combined multi-gene phylogeny(cAL,GAPDh,ITS,LSU,RPB2,SSU,TeF1 and TUB)were used to identify taxa.A total of 270 collections,representing 28 fungal species residing in 12 families,7 orders and 21 genera,with three species of uncertain taxonomic placement were *** these,one family,three genera and 14 species are new to *** new family,Pseudocoleodictyosporaceae is introduced based on its distinct lineage in the Dothideomycetes and its unique morphology as compared to Roussoellaceae and *** new genera are Neooccultibambusa,Pseudocoleodictyospora and *** newly described species are Diaporthe neoraonikayaporum,***,***,***,hermatomyces tectonae,***,Manoharachariella tectonae,Neooccultibambusa chiangraiensis,Pseudocoleodictyospora sukhothaiensis,***,***,Rhytidhysteron tectonae,Subglobosporium tectonae and Tubeufia *** species are known published taxa including Alternaria tillandsiae,Berkleasmium talaumae,Boerlagiomyces macrospora,ceratocladium purpureogriseum,Fusarium solani,helicoma siamense,Lasiodiplodia theobromae,Macrovalsaria megalospora,Paradictyoarthrinium diffractum,Phaeoacremonium italicum,Sphaeropsis eucalypticola,Stachybotrys levispora,*** and Thaxteriellopsis *** or reference specimens are designated for Boerlagiomyces macrospora and Macrovalsaria *** megalospora is transferred from Botryosphaeriaceae to Dothideomycetes genus,incertae sedis based on taxonomy and phylogenetic analysis,which indicate i

关键词： Ascomycota Basidiomycota Dothideomycetes Sordariomycetes Taxonomy Multi-gene phylogenetics

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Status and prospects for symmetric organic redox flow batteries

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journal of energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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One stop shopⅢ:taxonomic update with molecular phylogeny for important phytopathogenic genera:51–75(2019)

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Fungal Diversity 2019年第5期98卷 77-160页

作者： Ruvishika S.jayawardena Kevin D.hyde eric h.c.McKenzie Rajesh jeewon Alan j.L.Phillips Rekhani h.Perera Nimali I.de Silva Sajeewa S.N.Maharachchikumburua Milan c.Samarakoon anusha h.ekanayake Danushka S.Tennakoon asha j.dissanayake chada Norphanphoun chuangen Lin Ishara S.Manawasinghe Qian Tian Rashika Brahmanage Putarak chomnunti Sinang hongsanan Subashini c.jayasiri F.halleen chitrabhanu S.Bhunjun Anuruddha Karunarathna Yong Wang Department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025GuizhouChina center of excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Key Laboratory for Plant Diversity and Biogeography of east Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Landcare Research-Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Faculdade de ciéncias Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Institute of Plant and environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of ShuguanghuayuanzhongluHaidian DistrictBeijing 100097People’s Republic of China college of Life Science and Oceanography Shenzhen University1068Nanhai AvenueNanshanShenzhen 518055China Plant Protection Division ARC Infruitec-NietvoorbijPrivate Bag X5026Stellenbosch 7599South Africa Department of Plant Pathology University of StellenboschPrivate Bag X1Matieland 7602South Africa

This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and *** paper focuses on 25 phytopathogenic genera:Alternaria,capnodium,chaetothyrina,cytospora,cyphellophora,cyttaria,Dactylonectria,Diplodia,Dothiorella,entoleuca,eutiarosporella,Fusarium,Ilyonectria,Lasiodiplodia,Macrophomina,Medeolaria,Neonectria,Neopestalotiopsis,Pestalotiopsis,Plasmopara,Pseudopestalotiopsis,Rosellinia,Sphaeropsis,Stagonosporopsis and *** genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.A new database(Onestopshopfungi)is established to enhance the current understanding of plant pathogenic genera among plant pathologists.

关键词： classification Database Plant pathology Phylogeny Taxonomy Symptoms Systematics

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cytogenetic analysis of chromosomal abnormalities in Sri Lankan children

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World journal of Pediatrics 2015年第4期11卷 374-379页

作者： Sharmila Thillainathan Nirmala D.Sirisena Kariyawasam W.j.c.Kariyawasam Rohan W.jayasekara Vajira h.W.dissanayake human Genetics Unit Faculty of MedicineUniversity of ColomboSri Lanka Asiri center for Genomic and Regenerative Medicine Asiri Surgical HospitalColomboSri Lanka

Background: cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspected chromosomal disorders. The objective of this study was to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis. Methods: cytogenetic reports of 1554 consecutive children with suspected chromosomal disorders who underwent karyotyping in two genetic centers in Sri Lanka from january 2006 to December 2011 were reviewed retrospectively. Results: A total of 1548 children were successfully karyotyped. Abnormal karyotypes were found in 783 (50.6%) children. Numerical and structural abnormalities accounted for 90.8% and 9.2%, respectively. Down syndrome was the commonest aneuploidy identifi ed. Other various autosomal and sex chromosomal aneuploidies as well as micro-deletion syndromes were also detected. conclusions: The prevalence of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis for suspected chromosomal disorders was relatively higher than that in caucasian and other Asian populations.

关键词： aneuploidy chromosome aberrations cytogenetic analysis karyotypes

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A re-evaluation of Diaporthe:refining the boundaries of species and species complexes

A re-evaluation of Diaporthe:refining the boundaries of spec...

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中国菌物学会2024年学术年会

作者： asha j.dissanayake jian-Kui Liu School of Life Science and Technology Center for Informational BiologyUniversity of Electronic Science and Technology of China

A significant genus of plant pathogens,Diaporthe also includes endophytes and *** morphologically similar Diaporthe species turned out to be genetically *** taxonomy of Diaporthe as currently understood by applying morphological characters,host associations,and multi-gene phylogeny is problematic and can cause an overestimation or underestimation of the number of species in this important genus of fungal *** of right now,the recognized species has no set ***,the current study aims to restructure the genus Diaporthe using single gene phylogenies(ITS,tef,tub,cal,and his),multi-gene phylogeny and coalescence-based models(PTP – Poisson Tree Processes and mPTP – multi-rate Poisson Tree Processes).Multi-gene phylogenies are justified by applying GcPSR(Genealogical concordance Phylogenetic Species Recognition) *** genus Diaporthe is split into seven sections based on all available type isolates,and boundaries for 13 species and 15 species-complexes are ***-two Diaporthe isolates from woody hosts in Guizhou Province,china,were examined to support this reevaluation of the *** results showed the presence of two new species and 17previously recognized ***-one species have their synonyms determined by morphological studies and molecular *** future taxonomic studies,it may be possible to avoid creating lengthy phylogenetic trees of the entire genus by dividing Diaporthe into several distinct sections based on phylogenetic *** another way,only species from the relevant section should be chosen for phylogenetic analysis when conducting Diaporthe related research.

关键词： coalescence-based models GcPSR PTP/mPTP Species/species-complexes species boundaries Taxonomy

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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