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Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury

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Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 609-620页

作者： Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala monika Bhadauria Toxicology and Pharmacology Laboratory Department of Zoology Guru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social development Guru Ghasidas University

To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury.

关键词： Antituberculosis drugs Propolis Biochemical Hepatic injury

Stress Ameliorative Effects of Indole Acetic Acid on Hordeum vulgare L. Seedlings Subjected to Zinc Toxicity

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Phyton-International Journal of Experimental Botany 2020年第1期89卷 71-86页

作者： monika Sood Shanti S.Sharma Joginder Singh Ram Prasad Dhriti Kapoor School of Bioengineering and Biosciences Lovely Professional University PhagwaraPunjab144411India School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou510006China Department of Botany Mahatma Gandhi Central UniversityMotihariBihar845401India

The heavy metals present in the environment accumulate in the plants and affect their productivity and *** entering the food chain,metals cause several serious health problems in human beings as well as in other *** acetic acid(IAA)is known to act as a signaling molecule between symbiotic association of metal accumulating plants and plant growth promoting rhizobacteria(PGPR).Present study demonstrated a protective role of IAA against surplus Zinc(Zn)-induced toxicity to Hordeum vulgare *** Zn concentrations suppressed the plant growth,caused a reduction in leaf relative water contents(RWC)and elevated free proline and non-protein thiols(NPT)*** treatment also led to enhanced lipid peroxidation(MDA contents)as well as the activity of ascorbate peroxidase(APX),showing the involvement of antioxidative defense mechanism to reduce Zn induced *** oxidase activity was also observed to increase due to Zn *** pretreatment of *** caryopsis could partly revert the Zn-induced toxicity in seedlings.

关键词： Heavy metals phytohormone lipid peroxidation non-protein thiols(NPT) relative water contents(RWC) free proline ascorbate peroxidase(APX) IAA oxidase

Rational design of carbon shell-encapsulated cobalt nanospheres to enhance microwave absorption performance

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Progress in Natural Science:Materials International 2019年第1期29卷 88-93页

作者： Rambabu Kuchi monika Sharma Sung Woo Lee Dongsoo Kim Namgee Jung Jong-Ryul Jeong Department of Materials Science and Engineering Graduate School of Energy Science and Technology Chungnam National University Department of Engineering Chemistry SRKR Engineering College Convergence Research Center for Development of Mineral Resources Korea Institute of Geoscience and Mineral Resources Powder and Ceramics Division Korea Institute of Materials Science Graduate School of Energy Science and Technology Chungnam National University

Co@C core–shell nanospheres highly dispersed on carbon supports were rationally designed to improve the microwave absorbing property of the composite material, and fabricated by one pot thermal decomposition and simple annealing process. The Co nanospheres were completely encapsulated with thin carbon shells, which can effectively prevent the oxidation of the Co surface. Additionally, the particle size of Co nanospheres were properly controlled to optimize the electromagnetic property of the composite material. As a result, the lightweight Co@C/C composites with the particle size of 20 nm exhibited much enhanced microwave absorption properties. The improved microwave absorption performance is attributed mainly to the enhanced isotropic ratio and impedance matching of magnetic composites via tuning the Co particle size. Therefore, the welldesigned core-shell Co@C composite structure will provide a new insight for the development of high performance microwave absorbers.

关键词： Co@C/C composites Thermal decomposition Nanoscale size Impedance matching Microwave absorption

Postpartum pubic symphysis diastasis-conservative and surgical treatment methods, incidence of complications: Two case reports and a review of the literature

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World Journal of Clinical Cases 2020年第1期8卷 110-119页

作者： Kristina Norvilaite monika Kezeviciute Diana Ramasauskaite Audrone Arlauskiene Daiva Bartkeviciene Valentinas Uvarovas Clinic of Obstetrics and Gynaecology Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius LT-08661Lithuania Vilnius University Institute of Clinical MedicineFaculty of MedicineVilnius LT-08661Lithuania Department of Orthopedics and Traumatology Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius LT-08661Lithuania

BACKGROUND Widening of the pubic joint of more than 10 mm is diagnostic and defined as pubic symphysis diastasis and is considered a complication of vaginal childbirth or *** it is a rare pathology(ranging from 1 in 300 to 1 in 30000 pregnancies),no gold standard treatment has been *** SUMMARY This study examines two cases,a 27-year-old woman(gravida 1,para 1)and a 32-year-old woman(gravida 2,para 2),who presented to the clinic after uneventful vaginal deliveries.A normal pregnancy with no complications was observed in both *** pain in the pubic region occurred after labour and was accompanied by complicated *** symphysis diastasis was confirmed radiologically and bed rest with lateral decubitus positioning was *** non-steroidal antiinflammatory drugs were administered to relieve pain *** symptoms decreased after *** magnetic resonance imaging(MRI)in the first case showed a reduction in symphyseal separation with no signs of *** years later the symptoms recurred;MRI examination showed no further symphyseal widening or signs of osteitis.A relapse of symphyseal separation was diagnosed and conservative treatment was re-administered resulting in successful *** the second case,pain recurred when the patient conceived for the second *** time no benefit following conservative treatment was *** pain and complicated locomotion led to scoliotic deformation of the lumbar part of the spine and leg length discrepancy,thus surgical treatment was chosen and internal pubic synthesis was *** Overall,surgical treatment resulting from insufficient conservative treatment showed a high risk of postoperative complications following the treatment of postpartum pubic symphysis diastasis.

关键词： Pubic symphysis diastasis Conservative treatment Internal pubic synthesis Pregnancy Vaginal delivery Case report

Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 518-525页

作者： Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala monika Bhadauria Toxicology and Pharmacology Laboratory Department of ZoologyGuru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social DevelopmentGuru Ghasidas University

Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(***) against anti-tuberculosis drugs(ATDs) induced liver ***:Wistar albino rats were divided into seven groups of six animal in *** ATDs and *** extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were ***:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin *** lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs *** of *** extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent *** and ultra-structural observations substantiated biochemical ***:*** has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies.

关键词： Antituberculosis drugs Hepatic injury Pergularia daemia Antioxidant activity

Immune checkpoint therapy for pancreatic cancer

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World Journal of Gastroenterology 2016年第43期22卷 9457-9476页

作者： Henrik Johansson Roland Andersson monika Bauden Sarah Hammes Stefan Holdenrieder Daniel Ansari Department of Surgery Clinical Sciences Lund Lund University and Sk?ne University Hospital Institute of Laboratory Medicine German Heart Center at the Technical University Munich

Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. Pub Med, Clinical *** and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.

关键词： Pancreatic cancer Immune checkpoint inhibitors Clinical trials

Intravascular lithotripsy for coronary calcium:A case report and review of the literature

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World Journal of Cardiology 2022年第9期14卷 496-507页

作者： Akshyaya Pradhan Pravesh Vishwakarma monika Bhandari Rishi Sethi Department of Cardiology King George Medical UniversityLucknow 226006Uttar PradeshIndia

BACKGROUND Coronary calcium poses a challenge for the interventional cardiologist often leading to stent under-expansion and subsequent ischemic *** balloon post-dilatation though helpful is usually *** plaque ablation techniques are in vogue,but they are technically demanding and are not without *** intravascular lithotripsy(S-IVL)has emerged as a user-friendly and effective mechanism for calcium management with a high safety margin.A series of trials(DISRUPT CAD I-IV)have demonstrated both short-term and long-term safety and efficacy of the *** experience with the technique grows more and more,therapy areas like stent restenosis are being covered by the *** SUMMARY We report a series of 2 cases successfully managed with S-IVL therapy at our *** first case is of a 57-year-old smoker who presented with acute coronary *** left anterior descending coronary artery revealed calcified 90%stenosis on angiogram and a combination of superficial-deep calcium on intracoronary *** calcium was treated with 20 pulses of S-IVL to create discontinuity and a sirolimus eluting drug-eluting stent was successfully *** second case is that of an elderly lady who presented with stable angina and demonstrated diffuse calcified lesions in the left anterior descending artery on *** also demonstrated a mixture of superficial and deep seated calcium zones on imaging.S-IVL therapy was applied to generate fractures in calcium,and two overlapping drug-eluting stents were implanted successfully without any *** S-IVL is an emerging,efficient,user-friendly and safe therapy for managing intracoronary calcium in routine interventional practice.

关键词： Coronary artery calcification Acute coronary syndromes DISRUPT-CAD Shock wave Premature ventricular contraction Case report

Physico-chemical and biological evaluation of doxycycline loaded into hybrid oxide-polymer layer on Ti-Mo alloy

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Bioactive Materials 2020年第3期5卷 553-563页

作者： Alicja Kazek-Kęsik Agnieszka Nosol Joanna Płonka monikaŚmiga-Matuszowicz Sebastian Student monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Biotechnology Centre Silesian University of TechnologyKrzywoustego 8 Street44-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

Oxide-polymer coatings were formed on the surface of the vanadium-free Ti–15Mo titanium *** Ti alloy surface was modified by the plasma electrolytic oxidation process,and then,the polymer layer of a poly(D,Llactide-co-glycolide)with doxycycline was *** polymer evenly covered the porous oxide layer and filled some of the ***,the microstructure of the polymer surface was completely different from that of the PEO *** surface morphology,roughness and microstructure of the polymer layer were examined by scanning electron microscopy(SEM)and a confocal *** results confirmed the effectiveness of polymer and doxycycline deposition in their stable chemical *** drug analysis was performed by highperformance liquid *** 1H NMR technique was used to monitor the course of hydrolytic degradation of *** was shown that the PLGA layer is hydrolysed within a few weeks,and the polyglycolidyl part of the copolymer is hydrolysed to glycolic acid as first and much faster than the polylactide one to lactic *** paper presents influence of different microstructures on the biological properties of modified titanium *** and bacterial adhesion tests were evaluated using osteoblast-like MG-63 cells and using the reference *** and *** *** results showed that the optimum concentration of doxycycline was found to inhibit the growth of the bacteria and that the layer is still cytocompatible.

关键词： Biomaterials Titanium alloy Plasma electrolytic oxidation Oxide-polymer hybrid coatings Doxycycline

Fat,oil,and grease as new feedstock towards bioelectrogenesis in microbial fuel cells:Microbial diversity,metabolic pathways,and key enzymes

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Journal of Energy Chemistry 2023年第10期85卷 418-429,I0011页

作者： monika Sharma Mohammed Jalalah Saeed AAlsareii Farid AHarraz Abdulrhman AAlmadiy Nandini Thakur El-Sayed Salama Xiangkai Li MOE Key Laboratory of Cell Activities and Stress AdaptationsSchool of Life SciencesLanzhou UniversityLanzhou 730000GansuChina Promising Centre for Sensors and Electronic Devices(PCSED) Advanced Materials and Nano-Research CentreNajran UniversityP.O.Box:1988Najran 11001Saudi Arabia Department of Electrical Engineering College of EngineeringNajran UniversityNajran 11001Saudi Arabia Department of Surgery College of MedicineNajran UniversityNajran 11001Saudi Arabia Department of Chemistry Faculty of Science and Arts at SharurahNajran UniversitySharurah 68342Saudi Arabia Department of Biology Faculty of Arts and SciencesNajran University1988 NajranSaudi Arabia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

Microbial fuel cells(MFCs)are a well-known technology used for bioelectricity production from the decomposition of organic waste via electroactive ***,oil,and grease(FOG)as a new substrate in the anode and microalgae in the cathode were added to accelerate the *** effect of FOG concentrations(0.1%,0.5%,1%,and 1.5%)on the anode chamber was *** FOG degradation,volatile fatty acid(VFAs)production,and soluble chemical oxygen demand along with voltage output kinetics were ***,the microbial community analysis and active functional enzymes were also *** maximum power and current density were observed at 0.5%FOG which accounts for 96 mW m^(-2)(8-folds enhancement)and 560 mA m^(-2)(3.7-folds enhancement),*** daily voltage output enhanced upto 2.3-folds with 77.08%coulombic efficiency under 0.5%FOG,which was the highest among all the *** 0.5%FOG was degraded>85%,followed by a 1%FOG-loaded *** chief enzymes inβ-oxidation and electrogenesis were acetyl-CoA C-acetyltransferase,riboflavin synthase,and riboflavin *** identified enzymes symbolize the presence of Clostridium sp.(>15%)and Pseudomonas(>10%)which served as electrochemical active bacteria(EAB).The major metabolic pathways involved in electrogenesis and FOG degradation were fatty acid biosynthesis and glycerophospholipid *** of lipidic-waste(such as FOG)in MFCs could be a potential approach for simultaneous biowaste utilization and bioenergy generation.

关键词： Lipidic-waste Microalgae Electrogenesis Microbial community Functional enzymes