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Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury

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Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 609-620页

作者： Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala monika Bhadauria Toxicology and Pharmacology Laboratory Department of Zoology Guru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social development Guru Ghasidas University

To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury.

关键词： Antituberculosis drugs Propolis Biochemical Hepatic injury

Implant biomaterials: A comprehensive review

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World Journal of Clinical Cases 2015年第1期3卷 52-57页

作者： monika Saini Yashpal Singh Pooja Arora Vipin Arora Krati Jain Department of Oral and Maxillofacial Rehabiliatation Al Qaseem Pvt.CollegesBuraydahQassim 51431Saudi Arabia Department of Prosthodontics Subharati Dental College Meerut 250003India Department of Operative Dentistry and Endodontics Subharati Dental College Meerut 250003 India

Appropriate selection of the implant biomaterial is a key factor for long term success of implants. The biologic environment does not accept completely any material so to optimize biologic performance, implants should be selected to reduce the negative biologic response while maintaining adequate function. Every clinician should always gain a thorough knowledge about thedifferent biomaterials used for the dental implants. This article makes an effort to summarize various dental biomaterials which were used in the past and as well as the latest material used now.

关键词： Biomaterials Zirconium Surface roughness Ceramic Corrosion

Dominance of transposable element‑related satDNAs results in great complexity of“satDNA library”and invokes the extension towards“repetitive DNA library”

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Marine Life Science & Technology 2024年第2期6卷 236-251页

作者： monika Tunjić‑Cvitanić Daniel García‑Souto Juan J.Pasantes EvaŠatović‑Vukšić Division of Molecular Biology Ruđer BoškovićInstitute10000 ZagrebCroatia Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain Department of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Centro de Investigación Mariña Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Research on bivalves is fast-growing,including genome-wide analyses and genome *** characteristics qualify oysters as a valuable model to explore repetitive DNA sequences and their genome *** we char-acterize the satellitomes of five species in the family Ostreidae(Crassostrea angulata,***,***,***,Ostrea edulis),revealing a substantial number of satellite DNAs(satDNAs)per genome(ranging between 33 and 61)and peculiarities in the composition of their *** satDNAs were either associated to or derived from transposable elements,displaying a scarcity of transposable element-unrelated satDNAs in these *** to the non-conventional satellitome constitution and dominance of Helitron-associated satDNAs,comparative satellitomics demanded more in-depth analyses than standardly *** analyses(including ***,the first bivalve species with a defined satellitome)revealed that 13 satDNAs occur in all six oyster genomes,with Cg170/HindIII satDNA being the most abundant in all of *** the“satDNA library model”highlighted the necessity to adjust this term when studying tandem repeat evolution in organisms with such *** repetitive sequences with potential variation in the organizational form and repeat-type affiliation are examined across related species,the introduction of the terms“TE library”and“repetitive DNA library”becomes essential.

关键词： Satellitome Comparative satellitomics Helitron Bivalves “Dark matter of the genome”

Rational design of carbon shell-encapsulated cobalt nanospheres to enhance microwave absorption performance

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Progress in Natural Science:Materials International 2019年第1期29卷 88-93页

作者： Rambabu Kuchi monika Sharma Sung Woo Lee Dongsoo Kim Namgee Jung Jong-Ryul Jeong Department of Materials Science and Engineering Graduate School of Energy Science and Technology Chungnam National University Department of Engineering Chemistry SRKR Engineering College Convergence Research Center for Development of Mineral Resources Korea Institute of Geoscience and Mineral Resources Powder and Ceramics Division Korea Institute of Materials Science Graduate School of Energy Science and Technology Chungnam National University

Co@C core–shell nanospheres highly dispersed on carbon supports were rationally designed to improve the microwave absorbing property of the composite material, and fabricated by one pot thermal decomposition and simple annealing process. The Co nanospheres were completely encapsulated with thin carbon shells, which can effectively prevent the oxidation of the Co surface. Additionally, the particle size of Co nanospheres were properly controlled to optimize the electromagnetic property of the composite material. As a result, the lightweight Co@C/C composites with the particle size of 20 nm exhibited much enhanced microwave absorption properties. The improved microwave absorption performance is attributed mainly to the enhanced isotropic ratio and impedance matching of magnetic composites via tuning the Co particle size. Therefore, the welldesigned core-shell Co@C composite structure will provide a new insight for the development of high performance microwave absorbers.

关键词： Co@C/C composites Thermal decomposition Nanoscale size Impedance matching Microwave absorption

Role of discs large homolog 5

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World Journal of Gastroenterology 2006年第23期12卷 3651-3656页

作者： Frauke Friedrichs monika Stoll Genetic Epidemiology Leibniz-Institute for Arteriosclerosis ResearchMuensterGermany

In 2004, an association of genetic variation in the discs large homolog 5 （DLG5＇） gene with inflammatory bowel disease （IBD） was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions.

关键词： DLG5 Association Gender Genetic heterogeneity Inflammatory bowel disease Crohndisease

Intravascular lithotripsy for coronary calcium:A case report and review of the literature

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World Journal of Cardiology 2022年第9期14卷 496-507页

作者： Akshyaya Pradhan Pravesh Vishwakarma monika Bhandari Rishi Sethi Department of Cardiology King George Medical UniversityLucknow 226006Uttar PradeshIndia

BACKGROUND Coronary calcium poses a challenge for the interventional cardiologist often leading to stent under-expansion and subsequent ischemic *** balloon post-dilatation though helpful is usually *** plaque ablation techniques are in vogue,but they are technically demanding and are not without *** intravascular lithotripsy(S-IVL)has emerged as a user-friendly and effective mechanism for calcium management with a high safety margin.A series of trials(DISRUPT CAD I-IV)have demonstrated both short-term and long-term safety and efficacy of the *** experience with the technique grows more and more,therapy areas like stent restenosis are being covered by the *** SUMMARY We report a series of 2 cases successfully managed with S-IVL therapy at our *** first case is of a 57-year-old smoker who presented with acute coronary *** left anterior descending coronary artery revealed calcified 90%stenosis on angiogram and a combination of superficial-deep calcium on intracoronary *** calcium was treated with 20 pulses of S-IVL to create discontinuity and a sirolimus eluting drug-eluting stent was successfully *** second case is that of an elderly lady who presented with stable angina and demonstrated diffuse calcified lesions in the left anterior descending artery on *** also demonstrated a mixture of superficial and deep seated calcium zones on imaging.S-IVL therapy was applied to generate fractures in calcium,and two overlapping drug-eluting stents were implanted successfully without any *** S-IVL is an emerging,efficient,user-friendly and safe therapy for managing intracoronary calcium in routine interventional practice.

关键词： Coronary artery calcification Acute coronary syndromes DISRUPT-CAD Shock wave Premature ventricular contraction Case report

Postpartum pubic symphysis diastasis-conservative and surgical treatment methods, incidence of complications: Two case reports and a review of the literature

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World Journal of Clinical Cases 2020年第1期8卷 110-119页

作者： Kristina Norvilaite monika Kezeviciute Diana Ramasauskaite Audrone Arlauskiene Daiva Bartkeviciene Valentinas Uvarovas Clinic of Obstetrics and Gynaecology Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius LT-08661Lithuania Vilnius University Institute of Clinical MedicineFaculty of MedicineVilnius LT-08661Lithuania Department of Orthopedics and Traumatology Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius LT-08661Lithuania

BACKGROUND Widening of the pubic joint of more than 10 mm is diagnostic and defined as pubic symphysis diastasis and is considered a complication of vaginal childbirth or *** it is a rare pathology(ranging from 1 in 300 to 1 in 30000 pregnancies),no gold standard treatment has been *** SUMMARY This study examines two cases,a 27-year-old woman(gravida 1,para 1)and a 32-year-old woman(gravida 2,para 2),who presented to the clinic after uneventful vaginal deliveries.A normal pregnancy with no complications was observed in both *** pain in the pubic region occurred after labour and was accompanied by complicated *** symphysis diastasis was confirmed radiologically and bed rest with lateral decubitus positioning was *** non-steroidal antiinflammatory drugs were administered to relieve pain *** symptoms decreased after *** magnetic resonance imaging(MRI)in the first case showed a reduction in symphyseal separation with no signs of *** years later the symptoms recurred;MRI examination showed no further symphyseal widening or signs of osteitis.A relapse of symphyseal separation was diagnosed and conservative treatment was re-administered resulting in successful *** the second case,pain recurred when the patient conceived for the second *** time no benefit following conservative treatment was *** pain and complicated locomotion led to scoliotic deformation of the lumbar part of the spine and leg length discrepancy,thus surgical treatment was chosen and internal pubic synthesis was *** Overall,surgical treatment resulting from insufficient conservative treatment showed a high risk of postoperative complications following the treatment of postpartum pubic symphysis diastasis.

关键词： Pubic symphysis diastasis Conservative treatment Internal pubic synthesis Pregnancy Vaginal delivery Case report

Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 518-525页

作者： Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala monika Bhadauria Toxicology and Pharmacology Laboratory Department of ZoologyGuru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social DevelopmentGuru Ghasidas University

Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(***) against anti-tuberculosis drugs(ATDs) induced liver ***:Wistar albino rats were divided into seven groups of six animal in *** ATDs and *** extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were ***:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin *** lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs *** of *** extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent *** and ultra-structural observations substantiated biochemical ***:*** has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies.

关键词： Antituberculosis drugs Hepatic injury Pergularia daemia Antioxidant activity

Immune checkpoint therapy for pancreatic cancer

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World Journal of Gastroenterology 2016年第43期22卷 9457-9476页

作者： Henrik Johansson Roland Andersson monika Bauden Sarah Hammes Stefan Holdenrieder Daniel Ansari Department of Surgery Clinical Sciences Lund Lund University and Sk?ne University Hospital Institute of Laboratory Medicine German Heart Center at the Technical University Munich

Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. Pub Med, Clinical *** and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.

关键词： Pancreatic cancer Immune checkpoint inhibitors Clinical trials