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Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li young Soo Kim Buyun Kim Hwan-Suck Chung younghoon Go Hyun-Jeong Ko Jae-Hyoung Song young Ho Kim Chun Whan choi Jang-Gi choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

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Plant-derived nanovesicles: Current understanding and applications for cancer therapy

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Bioactive Materials 2023年第4期22卷 365-383页

作者： Ngoc Phung Ly Hwa Seung Han Myungsuk Kim Jae Hyung Park Ki young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea School of Chemical Engineering College of EngineeringSungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Biomedical Institute for Convergence at SKKU Sungkyunkwan UniversitySuwon16419Republic of Korea

Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological *** the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer ***,much remains unknown about these vesicles,and current research remains *** review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.

关键词： Plant-derived vesicles Extracellular vesicles Cancer therapy Anti-cancer Drug delivery

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Docurity: A New Cryptographic Primitive for Collaborative Cloud Systems

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Intelligent Automation & Soft Computing 2023年第6期36卷 3725-3742页

作者： Byeori Kim Minseong choi Taek-young Youn Jeong Hyun Yi Haehyun Cho Soongsil University Seoul06978Korea Dankook University Yongin16890Korea

Recently,there has been a sudden shift from using traditional office applications to the collaborative cloud-based office suite such as Microsoft Office *** cloud-based systems allow users to work together on the same docu-ment stored in a cloud server at once,by which users can effectively collaborate with each ***,there are security concerns unsolved in using cloud *** of the major concerns is the security of data stored in cloud ser-vers,which comes from the fact that data that multiple users are working together cannot be stored in encrypted form because of the dynamic characteristic of cloud *** this paper,we propose a novel mode of operation,DL-ECB,for AES by which we can modify,insert,and delete the ciphertext based on changes in ***,we can use encrypted data in collaborative cloud-based *** demonstrate that the DL-ECB mode can preserve the confidential-ity,integrity,and auditability of data used in collaborative cloud systems from adversaries,we implement and evaluate the prototype of the DL-ECB mode.

关键词： Cloud collaboration mode of operation auditability of ciphertext

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Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

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Congenital Heart Disease 2022年第5期17卷 569-578页

作者： Jae Hee Seol Se Yong Jung Jae young choi Han Ki Park young Hwan Park Nam Kyun Kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

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High-responsivity InAs quantum well photo-FET integrated on Si substrates for extended-range short-wave infrared photodetector applications

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光子学研究:英文版 2023年第8期11卷 1465-1473页

作者： DAEHWAN AHN SUNGHAN JEON †HOyoung SUH SEUNGWAN WOO RAFAEL JUMAR CHU DAEHWAN JUNG WON JUN choi DONGHEE PARK JIN-DONG SONG WOO-young choi JAE-HOON HAN Center for Opto-Electronic Materials and Devices Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Electrical and Electronic Engineering Yonsei UniversitySeoul 03722Republic of Korea

Low-intensity light detection necessitates high-responsivity *** achieve this,we report In_(0.53)Ga_(0.47)As∕In As∕In_(0.53)Ga_(0.47)As quantum well(InAs QW)photo-field-effect-transistors(photo-FETs)integrated on a Si substrate using direct wafer *** of the In As QW channel was carefully designed to achieve higher effective mobility and a narrower bandgap compared with a bulk In_(0.53)Ga_(0.47)As,while suppressing the generation of defects due to lattice ***-performance 2.6 nm In As QW photo-FETs were successfully demonstrated with a high on/off ratio of 10~5 and a high effective mobility of 2370 cm^(2)∕(V·s).The outstanding transport characteristics in the InAs QW channel result in an optical responsivity 1.8 times greater than InGaAs photo-FETs and the fast rising/falling ***,we experimentally confirmed that the InAs QW photo-FET can detect light in the short-wavelength infrared(SWIR;1.0–2.5μm)near 2μm thanks to bandgap engineering through In As QW *** result suggests that the InAs QW photo-FET is promising for high-responsivity and extended-range SWIR photodetector applications.

关键词： responsivity quantum wave

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Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis

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Nano-Micro Letters 2022年第3期14卷 308-321页

作者： Huiyan Piao Goeun choi Xiaoyan Jin Seong‑Ju Hwang young Jae Song Sung‑Pyo Cho Jin‑Ho Choy Intelligent Nanohybrid Materials Laboratory(INML) Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan 31116Republic of Korea College of Science and Technology Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Materials Science and Engineering College of EngineeringYonsei UniversitySeoul 03722Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea National Center for Inter‑University Research Facilities(NCIRF) Seoul National UniversitySeoul 08826Republic of Korea Graphene Research Center Advanced Institute of Convergence TechnologySuwon 16229Republic of Korea Department of Pre‑Medical Course College of MedicineDankook UniversityCheonan 31116Republic of Korea Tokyo Tech World Research Hub Initiative(WRHI) Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226‑8503Japan

The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic *** has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics *** this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step *** atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic *** addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine *** to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction *** addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).

关键词： Graphitic carbon nitride Monolayer Atomic image Electro-and photo-catalysis

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Massive hemothorax following internal jugular vein catheterization under ultrasound guidance:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5776-5782页

作者： Hyun Kang Soo young Cho Eun Ha Suk Wan Ju Joon Yong choi Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Hemothorax is a rare but life-threatening complication of central venous *** reports suggest that ultrasound guidance may reduce complications however,it does not guarantee safety CASE SUMMARY A 75-year-old male patient was admitted for laparoscopic radical *** ultrasound guidance,right internal jugular vein catheterization was successfully achieved after failure to aspirate blood from the catheter in the first *** hypotension developed after surgical positioning and persisted until the end of the operation,lasting for about 4 *** the recovery room,a massive hemothorax was identified on chest radiography and computed *** patient recovered following chest tube drainage of 1.6 L *** Hemothorax must be suspected when unexplained hemodynamic instability develops after central venous catheterization despite ultrasound *** the proper use of ultrasound is important.

关键词： Central venous catheterization Hemothorax Ultrasound guidance Internal jugular vein Case report

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Modulating the synergy of Pd@Pt core-shell nanodendrites for boosting methanol electrooxidation kinetics

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Journal of Materials Science & Technology 2023年第34期165卷 153-160页

作者： Hyeon Jeong Kim Cheol Joo Moon Seokhee Lee Jayaraman Theerthagiri Jong Wook Hong Myong Yong choi young Wook Lee Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National UniversityJinju 52828Republic of Korea Core-Facility Center for Photochemistry&Nanomaterials Gyeongsang National UniversityJinju 52828Republic of Korea Energy&Environment Division Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Chemistry University of UlsanUlsan 44610Republic of Korea Department of Education Chemistry and Research Institute of Natural Sciences Gyeongsang National UniversityJinju 52828Republic of Korea

The single-pot production of Pd@Pt core-shell structures is a promising approach as it offers large surface area,catalytic capability,and *** this work,we established a single-pot process to produce Pd@Pt core-shell nanodendrites with tunable composition,shape and size for optimal electrochemical ***@Pt nanodendrites with diverse compositions were synthesized by tuning the ratios of Pd and Pt sources in an aqueous environment using cetyltrimethylammonium chloride,which functioned as both the surfactant and the reducing agent at an elevated temperature(90°C).The synthesized Pd5@Pt5 nanodendrites showed exceptional electrochemical action toward the methanol oxidation reaction related with another compositional Pd@Pt nanodendrites and conventional Pt/C *** addition,Pd5@Pt5 nanodendrites exhibited good CO tolerance owing to their surface features and the synergistic effect among Pt and ***,nanodendrites with a Pt-rich surface provided exceptional catalytic active *** with the conventional Pt/C electrocatalyst,the anodic peak current obtained by Pd5@Pt5 nanodendrites was 3.74 and 2.18 times higher in relations of mass and electrochemical active surface area-normalized current density,*** approach offers an attractive strategy to design electrocatalysts with unique structures and outstanding catalytic performance and stability for electrochemical energy conversion.

关键词： Core-shell nanostructure Pd@Pt electrocatalysis One-pot synthesis Formation mechanism of nanodendrites Methanol oxidation reaction

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Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

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International Journal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun choi Ji-Eun Kim Si-On Park Eun-young Kim Soyoon Oh Hyuksu choi Dohee Yoon Hyo-Jin Min Hyung-Ryong Kim Eun-Ju Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

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A conformal titanyl phosphate amorphous overlayer for enhancing photoelectrochemical hydrogen peroxide production

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Journal of Energy Chemistry 2023年第11期86卷 399-408,I0009页

作者： Jaekyum Kim young Eun Kim Minyeong Je Won Tae Hong Chang-Lyoul Lee Tae-Hoon Kim Sung Min Cho Chang Hyuck choi Heechae choi Woo-Seok Choe Jung Kyu Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Theoretical Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939CologneGermany Advanced Photonics Research Institute(APRI) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology(I-CREATE) Yonsei UniversitySeoul 03722Republic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Photoelectrochemical(PEC)H_(2)O_(2)production through water oxidation reaction(WOR)is a promising strategy,however,designing highly efficient and selective photoanode materials remains challenging due to competitive reaction ***,for highly enhanced PEC H_(2)O_(2)production,we present a conformal amorphous titanyl phosphate(a-TP)overlayer on nanoparticulate TiO_(2)surfaces,achieved via lysozyme-molded in-situ surface *** a-TP overlayer modulates surface adsorption energies for reaction intermediates,favoring WOR for H_(2)O_(2)production over the competing O_(2)evolution *** density functional theory calculations reveal that a-TP/TiO_(2)exhibits a substantial energy uphill for the O·*formation pathway,which disfavors O_(2)evolution but promotes H_(2)O_(2)***,the a-TP overlayer strengthens the built-in electric field,resulting in favorable ***,a-TP/TiO_(2)exhibits 3.7-fold higher Faraday efficiency(FE)of 63%at 1.76 V *** hydrogen electrode(RHE)under 1 sun illumination,compared to bare TiO_(2)(17%),representing the highest FE among TiO_(2)-based WOR H_(2)O_(2)production *** the a-TP overlayer constitutes a promising strategy for controlling reaction pathways and achieving efficient solar-to-chemical energy conversion.

关键词： Solar H_(2)O_(2) production In-situ surface reforming Titanyl phosphate Amorphous overlayer Reaction pathway control

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