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Different kinds of stem cells in the development of SARS-CoV-2 treatments

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World Journal of Stem Cells 2021年第5期13卷 439-451页

作者： monica maribel mata-miranda Miguel Sanchez-Brito Gustavo Jesus Vazquez-Zapien Cell and Tissue Biology Laboratory Escuela Militar de MedicinaMexico 11200Mexico Computational Sciences TecNM/Technological Institute of AguascalientesAguascalientes 20256Mexico Embryology Laboratory Escuela Militar de MedicinaMexico 11200Mexico

On February 11,2020,the World Health Organization officially announced the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),as an emerging recent pandemic illness,which currently has approximately taken the life of two million persons in more than 200 ***,clinical,and scientific efforts have focused on searching for new prevention and treatment *** medicine and tissue engineering focused on using stem cells(SCs)have become a promising tool,and the regenerative and immunoregulatory capabilities of mesenchymal SCs(MSCs)and their exosomes have been ***,it has been essential to establishing models to reproduce the viral life cycle and mimic the pathology of COVID-19 to understand the virus's *** fields of pluripotent SCs(PSCs),induced PSCs(iPSCs),and artificial iPSCs have been used for this purpose in the development of infection models or ***,some inconveniences have been declared in SC use;for example,it has been reported that SARS-CoV-2 enters human cells through the angiotensin-converting enzyme 2 receptor,which is highly expressed in MSCs,so it is important to continue investigating the employment of SCs in COVID-19,taking into consideration their advantages and *** this review,we expose the use of different kinds of SCs and their derivatives for studying the SARS-CoV-2 behavior and develop treatments to counter COVID-19.

关键词： COVID-19 SARS-CoV-2 Stem cells Exosomes Pluripotent stem cells Mesenchymal stem cells Artificial stem cells

Classification of the Juturnaíba Dam: Potential Risk and Damage

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Journal of Water Resource and Protection 2018年第1期10卷 1-19页

作者： monica de Aquino Galeano da Hora Rocha Manoel Isidro de miranda Neto Master’s Program in Civil Defense and Security Fluminense Federal University Niteroi Rio de Janeiro Brazil

A Dam Safety Program aims to reduce the risks to human life, property, and the environment from dam related hazards. In Brazil, despite of the contemporary law about dam safety, there is still no cadastral information nor the classification of risk and associated potential damage to all dams. Besides that, the recent disaster caused by the failure of the Fund?o dam, located in Mariana city, Minas Gerais State, is an issue that aggravates the urgency of preventive measures and plans for disaster action. The present study proposes to classify the Juturnaíba dam, which maintains the largest reservoir for water supply in the state of Rio de Janeiro, Southeast region of Brazil. It was sought to analyze the risks and potential damage associated with the dam, in accordance with two classifications: one from the Brazilian Dams Committee and the other from the National Water Resources Council. It was possible to conclude that the Juturnaíba dam potentially presents high risk and associated high rates of damage, both regarding losses of human lives and regarding environmental and socioeconomic impacts. This is mainly due to the poor state of conservation that it currently presents. It is recommended that future studies should assess the slope stability of the earth dam, and that repair work should be implemented on the degraded concrete structures, with recuperation or installation of instruments that would enable monitoring of possible movement of the earth dam.

关键词： Dam Safety Disaster Hydrology

Endoscopic ultrasonography guided drainage:Summary of consortium meeting,May 21,2012,San Diego,California

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World Journal of Gastroenterology 2015年第3期21卷 726-741页

作者： Michel Kahaleh Everson LA Artifon Manuel Perez-miranda monica Gaidhane Carlos Rondon Takao Itoi Marc Giovannini Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medical CenterNew YorkNY 10021United States Department of Surgery University of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil Endoscopy Unit Hospital Universitario Rio Hortega47012 ValladolidSpain Department of Gastroenterology and Hematology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology PaoliCalmettes Institute13273 MarseilleFrance

Endoscopic retrograde cholangiopancreatography(ERCP) is the preferred procedure for biliary and pancreatic *** ERCP is successful in about 95% of cases,a small subset of cases are unsuccessful due to altered anatomy,peri-ampullary pathology,or malignant *** ultrasound-guided drainage is a promising technique for biliary,pancreatic and recently gallbladder decompression,which provides multiple advantages over percutaneous or surgical biliary *** retrospective and some prospective studies have shown endoscopic ultrasoundguided drainage to be safe and *** on the currently reported literature,regardless of the approach,the cumulative success rate is 84%-93% with an overall complication rate of 16%-35%.endoscopic ultrasoundguided drainage seems a viable therapeutic modality for failed conventional drainage when performed by highly skilled advanced endoscopists at tertiary centers with expertise in both echo-endoscopy and therapeutic

关键词： Endoscopic ultrasound Endoscopic ultrasoundguided

Pattern of Development in Foals from Four Different Breeds between Birth and Weaning

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Open Journal of Veterinary Medicine 2014年第5期4卷 72-77页

作者： Helio Cordeiro Manso Filho monica miranda Hunka Erika Korinfsky Wanderley Stephania Katurchi Mendes Melo Maria do Rosario Beltrao Jose Mario Girao Abreu Helena Emília Costa Cordeiro Manso Núcleo de Pesquisa Equina Departamento de ZootecniaUniversidade Federal Rural de PernambucoRecifeBrazil Faculdade de Medicina Veterinaria Universidade Estadual do CearaFortalezaBrazil

Several studies have shown a major development in height and cannon bone circumference in foals from birth to weaning and from different breeds. However, in Brazil, there is little information about foal development. For this reason, this study has used data on foals from seven different farms in Pernambuco, Northeast Brazil, where horses have a major economic importance. The aim of this study was to compare foal’s development from four breeds and to develop a regression formula in order to estimate such development. It was used data from 210 suckling foals (Arabians n = 18, Campolina n = 86, Mangalarga Marchador n = 42 and Quarter Horses n = 64), raised in similar management practices. Their height at withers, heart girth, and cannon bone girth were measured monthly from birth to weaning. Data we reanalyzed by ANOVA and Tukey Test, with P established in 5%. The highest mean of height at withers was observed in the Arabian foals, and it was similar to Campolina and Mangalarga Marchador foals. The last breed presented a higher percentage of gain in height (~36%) and higher heart girth. On the other hand, Campolina foals had the highest mean of cannon bone girth. There was a significant interaction between breed and development phase in heart and cannon bone girths. All regression for mulas obtained from this data was very significant, and it was showed that they can predict height at withers in the four breeds studied. Heart and cannon bone girths showed medium value of R2 and large significance. It is important to highlight that fetal programing produces significant impact on foal development, even after weaning. So, this study would have observed some more changes if its scope had been extended beyond this phase.

关键词： Equine Body Measurement Horse Breeds New Born Foals

Development and Body Composition of Quarter Horse Foals during Nursing

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Open Journal of Veterinary Medicine 2014年第11期4卷 276-280页

作者： monica miranda Hunka Helena Emília Cavalcanti da Costa Cordeiro Manso Ramona Bastos Bernardo Elizabeth Regina Rodrigues da Silva Lúcia Maia Cavalcante Ferreira Hélio Cordeiro Manso Filho Núcleo de Pesquisa Equina Departamento de Zootecnia Universidade Federal Rural de Pernambuco Recife Brazil

The monitoring and development of foals, based on biometric indices, and the determination of body composition could be important for genetic improvement and the elaboration of nutritional plans for horses. Considering that little information was available, the aim of the present study was to assess the growth and determine the body composition of suckling Quarter Horse foals. Animals (n = 46) of both sexes were monitored monthly from birth until the fifth month of age, using an ultrasound device and the following measurements: Wither Height (WH);Chest Perimeter (CP);Cannon Bone Circumference (CBC) Cannon Bone Girth (CG);Body Mass (BM);and Rump Fat Thickness (RFT). These tests determined the Fat-Free Mass (FFM), BM, Fat Percentage (FP) and Fat Thickness (FT). The data were analyzed using ANOVA and Tukey’s test, with differences considered statistically significant when P ≤ 0.05. The results demonstrated that the parameters analyzed changed significantly during the study period. The BM was ~41 at birth and ~177 kg at the point of weaning. Conversely, the FM was ~3.8 at birth and 18.1 kg at the point of weaning. The FFM was ~37 and ~160 kg at the time of birth and weaning, respectively. The FP varied from 9.3 at birth to 9.54 at weaning. The mean FT was ~1.39 and ~1.91 cm at birth and weaning, respectively. The WH measured ~91 at birth and 116 cm at weaning. In conclusion, suckling foals gain BM quickly from the time of birth to the time of weaning. The main cause of this gain is FFM. Therefore, due to the significant changes in the parameters studied herein, it is important to monitor these values in order to prevent nutritional imbalances.

关键词： Body Mass Fat-Free Mass Fat Percentage Horse Ultrasound

Feeding Behavior, Body Weight and Growth Rate during Post-Deprivation Period in Rats

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Food and Nutrition Sciences 2015年第14期6卷 1307-1315页

作者： Antonio López-Espinoza Alma Gabriela Martínez Moreno Virginia Gabriela Aguilera Cervantes Elia Valdé s Miramontes Luis Alfonso Mojica Contreras monica Navarro-Meza Claudia Patricia Beltrán-miranda Ana Cristina Espinoza-Gallardo Behavioral Feeding and Nutrition Research Center (CICAN) CUSur University of Guadalajara Guadalajara M&eacute xico

Deprivation is an environmental experience that organisms are continually exposed to. However, few studies analyze deprivation effects on the consumption pattern during the post-deprivation period systematically. The aim of this study was to evaluate the deprivation effect on feeding pattern, growth rate and body weight during post-deprivation. Sixteen albino rats (3 months old at the beginning of the experiment) were exposed to 72-hour total food deprivation every 15 days. Food and water were freely available during non-deprivation periods. Rats completed three cycles comprised by a free access period followed by food deprivation. Once deprivation was removed, food and water consumption increased and then decreased, while body weight was recovered. Growth rate increased after every deprivation period and reached similar levels to those presented by the control group. Depriving rats from one commodity (i.e., food) cause them to restrain their consumption of the other freely available commodity (i.e., water). Results confirm that food deprivation modifies growth rate, water and food consumption. Additionally, during post-deprivation period, differences between males and females were not registered.

关键词： Body Weight Food Intake Water Intake Post-Deprivation Period Growth Rate