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Sleep disturbances as an adverse effect of propranolol use in children with infantile hemangioma

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World Journal of Pediatrics 2020年第5期16卷 537-538页

作者： Ellen M.S.Xerfan monica l.andersen Anamaria S.Facina Sergio Tufik Jane Tomimori Programa de Pós-Gradua(c)(a)o em Medicina Translacional Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Dermatologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Psicobiologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil

Infantile hemangiomas(IHs)are the most prevalent benign vascular tumor in children,with an estimated rate of 5-10%.Most IHs resolve spontaneously after the proliferation stage,but about 12-24%develop with sequelae and complications which require pharmacological interventions[1].The beta blocker propranolol is considered as the first-line treatment for complicated cases of IHs[2].

关键词： propranolol children effect

Cellular stress responses regulated by two ubiquitin-conjugating enzyme variants

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Cellular stress responses regulated by two ubiquitin-conjuga...

Mindfulness interventions during pregnancy:A narrative review

中国细胞生物学学会2005年学术大会、青年学术研讨会

作者： Parker l.andersen Department of Microbiology and Immunology University of Saskatchewan Saskatoon SK Canada

When cells face environmental stresses such as bacterial and viral infections, they activate pro-survival and anti-apoptotic pathways to enhance proliferation of defending cells. On the other hand, stresses that cause DNA damage activate cell-cycle checkpoints and induce apoptosis when the damage cannot be repaired. A central question is how cells detect different types of environmental stresses and make correct response.

关键词： Cellular stress responses regulated by two ubiquitin-conjugating enzyme variants

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Journal of Integrative Medicine 2020年第6期18卷 470-477页

作者： leandro lucena Cristina Frange Ana Claudia Amorim Pinto monica levy andersen Sergio Tufik Helena Hachul Department of Psychobiology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04023062Brazil Department of Neurology and Neurosurgery Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04039002Brazil Department of Gynecology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04024002Brazil

Pregnancy is a period of major transformations in a woman’s life;increased stress,and mood and sleep disorders are *** review evaluates mindfulness interventions during pregnancy and their ability to help manage stress,anxiety,depression,emotional regulation,level of mindfulness and sleep quality.A search of English language scientific literature relevant to mindfulness interventions for pregnant women was conducted using PubMed,Scopus and Web of Science,without restriction on publication *** criteria were randomized clinical trials with pregnant women,using mindfulness as an intervention for at least three weeks,in one of our main areas of interest,and using only validated scales to measure *** hundred and thirty studies were identified in our searches of research databases,and thirteen were included in our *** found a large diversity of mindfulness programs,heterogeneity among the instruments used to evaluate outcomes,and inconsistency in the gestational periods used in the *** interventions were beneficial for stress,anxiety and *** was also effective when applied in pregnant women with a history of depression or experiencing *** emotional regulation and the level of mindfulness,there were signs of improvement,but more studies are *** of the studies evaluated sleep *** review provides information about current mindfulness programs,an overview of the effects of mindfulness interventions,a description of the measurements used so far,and recommendations for developing highquality mindfulness protocols for pregnant women.

关键词： Mindfulness Pregnancy Anxiety Stress Depression Sleep

Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： Therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper l.andersen lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 ml/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 ml/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p l treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p ll-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词： Bone mineral density (BMD) Intensity Intermittent Motivation Muscle mass Physical performance Recreational handball Well-being

Functions of lysosomes in Mammalian Female Reproductive System

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Reproductive and Developmental Medicine 2020年第2期4卷 109-122页

作者： Yuehuan li Zidao Wang Christian l.andersen Xiaoqin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA

The lysosome is the most acidic membrane-bound intracellular *** acidity is primarily maintained by vacuolar H+-ATPase(V-ATPase)and counter ion *** are>60 hydrolytic enzymes in the lysosome for its fundamental digestive *** also play important roles in endocytosis,exocytosis,autophagy,and cell *** that have implicated roles of lysosomes in the female reproductive system are reviewed *** the ovary,lysosomes are implicated in the preparation of free cholesterol for steroidogenesis and degradation of regulators of steroidogenesis,regulation of follicular atresia,follicle rupture during ovulation,luteal cell survival,and luteal *** the oviduct,lysosomes are involved in endocytosis of both serum and oviductal luminal *** the uterus during the menstrual/estrous cycle,lysosomes are associated with endometrial secretion,apoptosis,and *** the uterus during early pregnancy,lysosomes are involved in the temporal and directional changes of endocytosis,uterine epithelial acidification upon embryo implantation initiation,and embryo-maternal mutual communications via extracellular *** the placenta,lysosomes are implicated in nutrient transport and placental separation from the uterus for *** the mammary gland,lysosomes are important for mammary gland development and *** findings suggest/demonstrate functions of lysosomes in multiple processes of female reproduction,from ovulation to ovarian steroidogenesis for pregnancy maintenance,and from essential in utero nurturing of developing embryos/fetuses via embryo/fetal-maternal communications,to optional postpartum nurturing of newborns via *** studies using genetically or modified animal models and pharmacological approaches will provide novel insights into the functions and mechanisms of lysosomes in the mammalian female reproductive system.

关键词： Autophagy Endocytosis lysosome Ovary Steroidogenesis Uterus

Comparison of optimizers for model predictive thermal control of buildings

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Energy and AI 2024年第1期15卷 279-287页

作者： Torben andersen Department of physics Lund UniversityProfessorsgatan 1Lund22663Sweden

Considering recent developments in the energy sector,further reduction of electricity cost and flattening of the electric power demand curve are *** have focused on an autonomous electric heater control system that can easily be implemented in existing buildings without strict comfort *** are winter heating of warehouses and vacation homes,and heat drying of buildings under *** have set up a system that typically reduces electricity cost by about 40%on the basis of automatic weather and real time pricing *** system uses the building as an energy reservoir over periods with high electricity *** a model predictive control system,we compare use of a genetic algorithm,a particle swarm optimization,and a neural network for heater control,all working in a closed loop to reduce the influence of modeling *** have simulated the performance of the systems using realistic data and found that all three optimizers give about the same performance,varying only a few percent in ***,the computational and memory requirements of the neural network are much lower than for the other optimizers,so it is preferable for use with inexpensive *** carried out a full-scale experiment at a residential house and found agreement with simulation results.

关键词： Home energy management system Demand response Genetic algorithm Particle swarm optimization Neural network Model predictive control

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美国核工业对辐射防护进行有益改进的观点

辐射防护通讯 2005年第2期25卷 33-35页

作者： Ralph l.andersen 郝建中核能研究所

当前的辐射防护框架为保护工作人员,保护公众和保护环境提供了足够的基础,然而国际的和国家的辐射防护组织目前正致力于改进、澄清和强化辐射防护的原则,这也正是我们在辐射安全护领域不断改进,追求卓越的文化。因此,核能工业界感谢有... 详细信息

当前的辐射防护框架为保护工作人员,保护公众和保护环境提供了足够的基础,然而国际的和国家的辐射防护组织目前正致力于改进、澄清和强化辐射防护的原则,这也正是我们在辐射安全护领域不断改进,追求卓越的文化。因此,核能工业界感谢有机会对这一努力提出自己的观点。核能工业界从三个方面提出自己的观点:作为运营者,承担着保护人的健康与安全和保护环境的主要职责;作为许可证持有者,负责遵守政府的法规;作为能源生产者,负责为消费者提供安全、可靠和经济的电力生产。对于如何改进辐射防护原则,目标是帮助促成在科学上有明确表述依据的成果;这些成果在当前和未来的被审管的广泛活动中的应用是灵活的;它的实施和维持是可行的,有成本效益的。

关键词：辐射防护明确表述劳动保护核能工业原子能工业能源工业剂量限值辐射防护标准集体剂量年剂量剂量约束放射性物质 ICRP 职业照射

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泻下法检查犬体内细粒棘球绦虫

疾病预防控制通报 1987年第1期 65-69页

作者： Ferron l.andersen,PhD,杨晓东美国犹他州杨伯翰大学动物系美国犹他州杨伯翰大学动物系

细粒棘球绦虫的体积非常小(虫体长4～6 mm)。成虫寄生在狗和少数几种食肉类动物(如山狗和狼)的小肠内。完全成熟的成虫可在这些食肉类动物体内产卵,卵随粪便排出体外。绵羊(包括其它食草类动物,如山羊、牛、骆驼、猪、马等)可食入被感... 详细信息

细粒棘球绦虫的体积非常小(虫体长4～6 mm)。成虫寄生在狗和少数几种食肉类动物(如山狗和狼)的小肠内。完全成熟的成虫可在这些食肉类动物体内产卵,卵随粪便排出体外。绵羊(包括其它食草类动物,如山羊、牛、骆驼、猪、马等)可食入被感染动物的粪便污染的草而感染。一旦虫卵被这些动物摄入(中间宿主),虫卵在十二指肠孵化,穿过肠粘膜表层,随血流被运到肝、肺这样的血液滤过器官,在这些器官里虫卵发育成为幼虫,称为细粒棘球绦虫包囊,这些包囊内充满着液体(包囊液)。

关键词：细粒棘球绦虫垃圾桶包囊废料坑泻下法食肉类动物

Novel immune modulatory vaccines targeting TGFβ

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Cellular & Molecular Immunology 2023年第5期20卷 551-553页

作者： Mads Hald andersen National Center for Cancer Immune Therapy(CCIT-DK) Department of OncologyCopenhagen University Hospital HerlevHerlevDenmark Department of Immunology and Microbiology University of CopenhagenCopenhagenDenmark

Immune modulatory vaccines (IMVs) are novel therapies designed to activate anti-regulatory T cells (anti-Tregs) [1]. Anti-Tregs recognize HlA-restricted antigens on the surface of regulatory immune cells derived from tumor microenvironment antigens (TMAs) [2], such as IDO [3], PD-l1 [4], and TGFβ [5, 6]. Having established that specific T cells recognize target cells in a TGFβ-dependent manner, we reported that such TGFβ-specific T cells are associated with clinical benefit and improved survival after combined treatment with radiotherapy (RT) and immune checkpoint inhibitors (ICIs) in patients with pancreatic cancer (PC) [7]. Additionally, we found that a TGFβ-based IMV impacted tumor growth in murine models of PC via immune modulation of the tumor microenvironment (TME) [8]. These data suggest that combining a TGFβ-based IMV with RT/ICI therapy will be beneficial for patients with PC.

关键词： TGFβ vaccines immune