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The Immune System and the Role of Inflammation in Perinatal Depression

Neuroscience Bulletin 2016年第4期32卷 398-420页

作者： Philippe Leff-Gelman Ismael Mancilla-Herrera monica flores-ramos Carlos Cruz-Fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio National Institute of Perinatology Mexico City Mexico National Institute of Psychiatry Mexico City Mexico National Institute of Genomic Medicine Mexico CityMexico Faculty of Psychology Anahuac University HuixquilucanMexico National Council of Science and Technology Mexico CityMexico

Major depression during pregnancy is a common psychiatric disorder that arises from a complex and mul- tifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. Dysregulation of this intricate neu- roimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neu- ropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during preg- nancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Thl/Th2 bias towards a predominant Thl/Thl7 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy.

关键词： Depression Pregnancy Immune systemInflammation Cytokine Serotonin Indoleamine dioxygenase Glucocorticoid Brain Placenta

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解压指南

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健与美 2025年第1期 169-173页

作者： monica

不摧毁压力，就会被压力摧毁。如果你总是感觉充满压力——无论是内在的还是外在的，就不可能长期保持健康和健美。本文将帮助你从压力的奴隶，变成压力的老板。要怪就怪那些不断发送短信、提醒音和电子邮件给我们的智能手机，要怪就怪...

不摧毁压力，就会被压力摧毁。如果你总是感觉充满压力——无论是内在的还是外在的，就不可能长期保持健康和健美。本文将帮助你从压力的奴隶，变成压力的老板。要怪就怪那些不断发送短信、提醒音和电子邮件给我们的智能手机，要怪就怪拥挤的地铁、高速公路和大卖场吧，要怪就怪大萧条、全球变暖、网络泡沫，或者你手上那杯不便宜的拿铁咖啡吧。

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减量增效中级水平选手的最佳训练模式

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健与美 2025年第1期 160-163页

作者： monica

本文是受到奥赛冠军多里安·耶茨在1983～1986年期间的训练计划的启发而产生的。对于自然健美运动员来说，最大的错误就是训练量太大。如果你目前的训练效果不尽人意，不妨试试下面的增肌策略，效果很可能比你以前采用的方法更好。

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Risk assessment of chemical substances of safety concern generated in processed meats

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Food Science and Human Wellness 2019年第3期8卷 244-251页

作者： monica flores Leticia Mora Milagro Reig Fidel Toldra Instituto de Agroquímica y Tecnología de Alimentos(CSIC) Avenue Agustín Escardino 746980PaternaValenciaSpain Instituto de Ingeniería de Alimentos para el Desarrollo Universitat Politècnica de ValenciaCamino de vera s/n46022ValenciaSpain

This manuscript is reviewing the presence of substances of safety concern that may be generated in different types of meat *** substances include N-nitrosamines that can be generated under certain conditions when using nitrite as preservative,the polycyclic aromatic hydrocarbons generated as a consequence of particular smoking processes,heterocyclic aromatic amines generated under particular cooking conditions,compounds released from the oxidation of lipids and proteins,Maillard reaction products like acrylamide and carboxymethyl lysine,and amines that can be generated and accumulated in fermented *** hazardous compounds,their mechanisms of generation,risks for health and ways of preventing its presence in meat products are briefly described in this review.

关键词： Polycyclic aromatic hydrocarbons Heterocyclic amines Nitrosamines Amino acids oxidation Lipids oxidation Maillard reaction products Biogenic amines

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Non-perturbative multiphoton excitation studies in an excitonic coupled quantum well system using high-intensity THz laser fields

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Chinese Physics B 2019年第8期28卷 355-363页

作者： monica Gambhir Vinod Prasad Department of Physics Swami Shraddhanand CollegeUniversity of DelhiDelhi 110036India Departmento de Quimica Universidad Autonoma MetropolitansSan Rafael Atlixco No186IztapalapaMexico DF 09340Mexico

Multiphoton excitations and nonlinear optical properties of exciton states in GaAs/AlxGa1-xAs coupled quantum well structure have been theoretically investigated under the influence of a time-varying high-intensity terahertz(THz)laser ***-perturbative Floquet theory is employed to solve the time-dependent equation of motion for the laser-driven excitonic quantum well *** response to the field parameters,such as intensity and frequency of the laser electric field on the state populations,can be used in various optical semiconductor device applications,such as photodetectors,sensors,all-optical switches,and terahertz emitters.

关键词： quantum well excitons terahertz non-perturbative multiphoton laser Floquet

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Estimation of the behavior factor of existing RC-MRF buildings

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Earthquake Engineering and Engineering Vibration 2018年第1期17卷 191-204页

作者： Marco Vona monica Mastroberti School of Engineering University of Basilicata

In recent years, several research groups have studied a new generation of analysis methods for seismic response assessment of existing buildings. Nevertheless, many important developments are still needed in order to define more reliable and effective assessment procedures. Moreover, regarding existing buildings, it should be highlighted that due to the low knowledge level, the linear elastic analysis is the only analysis method allowed. The same codes（such as NTC2008, EC8） consider the linear dynamic analysis with behavior factor as the reference method for the evaluation of seismic demand. This type of analysis is based on a linear-elastic structural model subject to a design spectrum, obtained by reducing the elastic spectrum through a behavior factor. The behavior factor（reduction factor or q factor in some codes） is used to reduce the elastic spectrum ordinate or the forces obtained from a linear analysis in order to take into account the non-linear structural capacities. The behavior factors should be defined based on several parameters that influence the seismic nonlinear capacity, such as mechanical materials characteristics, structural system, irregularity and design procedures. In practical applications, there is still an evident lack of detailed rules and accurate behavior factor values adequate for existing buildings. In this work, some investigations of the seismic capacity of the main existing RC-MRF building types have been carried out. In order to make a correct evaluation of the seismic force demand, actual behavior factor values coherent with force based seismic safety assessment procedure have been proposed and compared with the values reported in the Italian seismic code, NTC08.

关键词： seismic behavior existing buildings seismic safety assessment behavior factor

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Bioactive Compounds Recovery from Larrea tridentata by Green Ultrasound- Assisted Extraction

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Phyton-International Journal of Experimental Botany 2024年第11期93卷 3091-3107页

作者： Muyideen Olaitan Bamidele Jose Sandoval-Cortes Maria Liliana flores-Lopez Olga Berenice Alvarez Perez monica Lizeth Chavez Gonzalez Cristobal Noe Aguilar Bioprocesses and Bioproducts Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de CoahuilaSaltillo25070Mexico Centro de Investigacion e Innovacion Cientifica y Tecnologica Universidad Autonoma de CoahuilaSaltillo25070Mexico

Postharvest losses remain a signiﬁcant challenge,particularly in developing countries that have inadequate *** plants offer an eco-friendly and sustainable solution for managing diseases and pests in agri-cultural *** plants are rich in bioactive compounds,such as alkaloids,ﬂavonoids,terpenoids,phenolics,and essential oils,many of which have proven antimicrobial,antifungal,insecticidal,and antioxidant *** characteristics make medicinal plants viable candidates for postharvest disease and pest *** these,Larrea tridentata(creosote bush)is particularly notable for its bioactive compounds with strong antifungal *** potential applications include agriculture,food preservation,and *** study aimed to evaluate how different solvent mixtures affect the efﬁciency of ultrasound-assisted extraction,total polyphenol content,antioxidant capacity,and antifungal activity of *** leaves and ***ﬁndings revealed that the 60%ethanol ultrasound-assisted extract of *** leaves(ULL 60%)contained the highest concentration of bioactive compounds,including hydrolysable tannins(690.2 mg GAE/100 g)and condensed tan-nins(329.9 mg CE/100 g).All extracts demonstrated notable antioxidant activity in ABTS,DPPH,and FRAP assays,with ethanol-based extracts showing greater antioxidant potential than their aqueous *** terms of antifungal efﬁcacy,100%ethanol leaf extract exhibited the strongest inhibition against Fusarium oxyspor-um(60.03%),whereas 50%ethanol extract effectively inhibited Alternaria alternata(53.61%).Six major polyphe-nolic compounds were identiﬁed using reverse-phase high-performance liquid chromatography coupled with electrospray ionization mass spectrometry(RP-HPLC-ESI-MS).These include quercetin,luteolin,3,4-dihydrox-yphenylethanol,elenolic acid,nordihydroguaiaretic acid(NDGA),and *** compounds are known to have antibacterial,antifungal and antioxidant propert

关键词： Phytopathogens bioactive compounds desert plants Fusarium oxysporum Alternaria alternata

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On Standard Invariants of Bi-polymatroidal Ideals

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Algebra Colloquium 2014年第2期21卷 267-274页

作者： monica La Barbiera University of Messina Department of'Mathematics Viale Ferdinando Stagno d'Aleontres 31 98166 Messina Italy

The standard invariants of the bi-polymatroidal ideals of Veronese type are computed.

关键词： bi-polymatroidal ideals linear quotients

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Gallstones in patients with liver cirrhosis:Incidence,etiology,clinical and therapeutical aspects

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World Journal of Gastroenterology 2014年第23期20卷 7277-7285页

作者： monica Acalovschi 3~(rd) Medical Clinic University of Medicine and Pharmacy400162 Cluj-NapocaRomania

Gallstones occur in about one third of the patients having liver *** gallstones are the most frequent type,while cholesterol stones represent about15%of all stones in *** secretion of unconjugated bilirubin,increased hydrolysis of conjugated bilirubin in the bile,reduced secretion of bile acids and phospholipds in bile favor pigment lithogenesis in *** hypomotility also contributes to *** most recent data regarding risk factors for gallstones are *** prevalence increases with age,with a ratio male/female higher than in the general *** alcoholism,viral C cirrhosis,and non-alcoholic fatty liver disease are the underlying liver diseases most often associated with *** are often asymptomatic,and discovered *** asymptomatic,expectant management is recommended,as for asymptomatic gallstones in the general ***,a closer follow-up of these patients is necessary in order to earlier treat symptoms or *** symptomatic stones,laparoscopic cholecystectomy has become the therapy of ***-Pugh class and MELD score are the best predictors of outcome after *** with severe liver disease are at highest surgical risk,therefore gallstone complications should be treated using noninvasive or minimally invasive procedures,until stabilization of the patient condition.

关键词： Liver cirrhosis Pigment gallstones Cholesterol gallstones Lithogenesis Risk factors Asymptomatic gallstones Laparoscopic cholecystectomy

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Insulin:A connection between pancreaticβcells and the hypothalamus

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World Journal of Diabetes 2023年第2期14卷 76-91页

作者： Brenda De la Cruz Concepción Yaccil Adilene flores Cortez Martha Isela Barragán Bonilla Juan Miguel Mendoza Bello monica Espinoza Rojo Molecular and Genomic Biology Laboratory Faculty of Chemical-Biological SciencesAutonomous University of GuerreroChilpancingo 39070GuerreroMexico

Insulin is a hormone secreted by pancreaticβ*** concentration of glucose in circulation is proportional to the secretion of insulin by these *** target cells,insulin binds to its receptors and activates phosphatidylinositol-3-kinase/protein kinase B,inducing different mechanisms depending on the cell *** the liver it activates the synthesis of glycogen,in adipose tissue and muscle it allows the capture of glucose,and in the hypothalamus,it regulates thermogenesis and *** in insulin function[insulin resistance(IR)]are related to the development of neurodegenerative diseases in obese ***,in obesity and diabetes,its role as an anorexigenic hormone in the hypothalamus is diminished during ***,hyperphagia prevails,which aggravates hyperglycemia and IR further,becoming a vicious circle in which the patient cannot regulate their need to *** calorie intake induces an increase in reactive oxygen species,overcoming cellular antioxidant defenses(oxidative stress).Reactive oxygen species activate stress-sensitive kinases,such as c-Jun Nterminal kinase and p38 mitogen-activated protein kinase,that induce phosphorylation in serine residues in the insulin receptor,which blocks the insulin signaling pathway,continuing the mechanism of *** brain and pancreas are organs mainly affected by oxidative *** use of drugs that regulate food intake and improve glucose metabolism is the conventional therapy to improve the quality of life of these ***,the use of antioxidants that regulate oxidative stress has given good results because they reduce oxidative stress and inflammatory processes,and they also have fewer side effects than synthetic drugs.

关键词： Insulin Pancreas Hypothalamus Hyperphagia Hyperglycemia Stress

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