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Levels of neutrophil gelatinase-assosciated lipocalin in patients with head and neck squamous cell carcinoma in Indian population from Haryana state

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World Journal of Clinical Oncology 2017年第3期8卷 261-265页

作者： monica verma Kiran Dahiya Abhishek Soni Rakesh Dhankhar Veena S Ghalaut Aastha Bansal Vivek Kaushal Department of Biochemistry Pt.B.D.SharmaUniversity of Health Sciences Department of Radiotherapy Pt.B.D.SharmaUniversity of Health Sciences

AIM To study the levels of neutrophil gelatinase associated lipocalin(NGAL) in head and neck squamous cell carcinoma(HNSCC).METHODS This was a non randomized case control study conducted at Department of Biochemistry,in collaboration with Regional Cancer Center over a period of one *** study population included 50 adult newly diagnosed HNSCC patients reporting in outpatient department at Regional Cancer Center and compared with 50 healthy *** was estimated by ELISA *** t test and χ~2 test were applied for comparison of means of study *** between groups were analyzed using Pearson correlation coefficient(r) *** Patients with HNSCC exhibited significantly increased levels of NGAL(P < 0.05) as compared to healthy controls(978.88 ± 261.39 ng/mL vs 34.83 ± 7.59 ng/mL).Out of 50,26 patients(52%) were in stage Ⅳ,21(42%) in stage Ⅲ,1(2%) patient in stage Ⅱ and 2(4%) patients were in stage Ⅰ.Metastasis was absent in 98% patients and mean NGAL levels were highest in these patients but P value was not *** NGAL levels were highest in stage Ⅳ [1041.54 ± 222.15 ng/mL(stage Ⅳ) vs 1040 ± 0.00 ng/mL(stage Ⅰ);900 ± 0.00 ng/mL(stage Ⅱ) and 1031.90 ± 202.55 ng/mL(stage Ⅲ)] and χ~2 test was highly significant(P < 0.001).Thirty-six patients(72%) were having moderately differentiated HNSCC and mean NGAL levels were maximum in patients with well differentiated HNSCC(1164 ± 315.64 ng/mL vs 1013.33 ± 161.19 ng/mL in moderately differentiated and 890 ± 11.55 ng/mL in poorly differentiated) and the results were also highly significant(P < 0.001,χ~2 test).CONCLUSION The present work demonstrates a potential role of NGAL as cancer biomarker and its use in monitoring the HNSCC progression.

关键词： Neutrophil gelatinase associated lipocalin Head and neck squamous cell carcinoma Metastasis Biomarker Lipocalin 2

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Assessment of quality control system by sigma metrics and quality goal index ratio: A roadmap towards preparation for NABL

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World Journal of Methodology 2018年第3期8卷 44-50页

作者： monica verma Kiran Dahiya Veena Singh Ghalaut Vasudha Dhupper Department of Biochemistry Pt. B.D. Sharma University of Health Sciences

AIM To study sigma metrics and quality goal index ratio(QGI). METHODS The retrospective study was conducted at the Clinical Biochemistry Laboratory, PGIMS, Rohtak, which recently became a National Accreditation Board for Testing and Calibration of Laboratories accredited lab as per the International Organization for Standardization 15189:2012 and provides service to a > 1700-bed tertiary care hospital. Data of 16 analytes was extracted over a period of one year from January 2017 to December 2017 for calculation of precision, accuracy, sigma metrics, total error, and QGI. RESULTS The average coefficient of variation ranged from 2.12%(albumin) to 5.42%(creatinine) for level 2 internal quality control and 2%(albumin) to 3.62%(high density lipoprotein-cholesterol) for level 3 internal quality control. Average coefficient of variation of all the parameters was below 5%, reflecting very good precision. The sigma metrics for level 2 indicated that 11(68.5%) of the 16 parameters fall short of meeting Six Sigma quality performance. Of these, five failed to meet minimum sigma quality performance with metrics less than 3, and another six just met minimal acceptable performance with sigma metrics between 3 and 6. For level 3, the data collected indicated eight(50%) of the parameters did not achieve Six Sigma quality performance, out of which three had metrics less than 3, and five had metrics between 3 and 6. QGI ratio indicated that the main problem was inaccuracy in the case of total cholesterol, aspartate transaminase, and alanine transaminase(QGI > 1.2), imprecision in the case of urea(QGI < 0.8), and both imprecision and inaccuracy for *** On the basis of sigma metrics and QGI, it may be concluded that the Clinical Biochemistry Laboratory, PGIMS, Rohtak was able to achieve satisfactory results with world class performance for many analytes one year preceding the accreditation by the National Accreditation Board for Testing and Calibration of Laboratories. As

关键词： Sigma Quality goal index Bias Imprecision Inaccuracy Coefficient of variation

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白蚁生物防治方法橛述（下）

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城市害虫防治 2010年第1期 32-44页

作者： monica verma Satyawati Sharma Rajendra Prasad 王余霞童康琼李阳艳阮健伟（译）印度理工学院农村发展与技术中心新德里110016印度湖北武汉市白蚁防治研究所

5白蚁防治尽管白蚁是枯木和其它纤维素源的出色分解者，但它们侵入住宅和农作物已成为一个非常严重的问题。所以，有效的防治白蚁的方法已被发现。到目前为之，不同的防治方法（图1）已被运用，其中重要的防治方法将在以下讨论。

关键词：防治方法白蚁防治生物分解者纤维素农作物住宅

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白蚁生物防治方法概述（上）

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城市害虫防治 2009年第4期 45-47页

作者： monica verma Satyawati Sharma Rajendra Prasad 王余霞（译）童康琼（译）李阳艳（译）阮健伟（译）印度理工学院农村发展与技术中心新德里110016印度湖北武汉市白蚁防治研究所

白蚁严重危害了植物和建筑物，是危害农业和城市环境最严重的害虫。白蚁导致一年生和多年生作物重大的经济损失，且破坏建筑物中的木质构件，尤其在半干旱和半湿润的热带地区。化学防治虽然已经是一种预防白蚁侵害的成功的方法，但化学... 详细信息

白蚁严重危害了植物和建筑物，是危害农业和城市环境最严重的害虫。白蚁导致一年生和多年生作物重大的经济损失，且破坏建筑物中的木质构件，尤其在半干旱和半湿润的热带地区。化学防治虽然已经是一种预防白蚁侵害的成功的方法，但化学药品对我们的健康和自然环境的影响问题也是不容忽视的。在这方面生物防治是一种适用的可选择的方法。本篇文献综述了白蚁防治的各种方法（物理、化学和生物），概述了白蚁防治最新研究进展和过去的研究工作中强调的生物防治方法。生物防治方法包括植物源（香精油、种子、茎皮、叶片、果实、根部、木材、树脂），以及真菌、细菌和线虫方法，讨论了白蚁防治中有效的活性成分的化学结构和杀白蚁剂活性的关系。在防治白蚁方面，植物有很好的杀虫特性。这些植物源经常单独一种或者几种混合使用来防治白蚁，从这些生物活性成分中可以提取出制备有效的杀虫剂配方。

关键词：台湾土栖白蚁植物源生物控制剂毒饵技术土壤杀白蚁剂化学熏蒸法拒食驱避

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