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What paradigm shifts occurred in the management of acute div.rticulitis during the COv.D-19 pandemic?A scoping rev.ew

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World Journal of Clinical Cases 2021年第23期9卷 6759-6767页

作者： Gaetano Gallo monica Ortenzi Ugo Grossi Gian Luca Di Tanna Francesco Pata Mario Guerrieri Giuseppe Sammarco Salomone Di Sav.rio Department of Medical and Surgical Sciences University of CatanzaroCatanzaro 88011Italy Department of General and Emergency Surgery Polytechnic University of MarcheAncona 60121Italy 2^(nd)Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaTreviso 31100Italy The George Institute for Global Health University of New South WalesSydney 2050NSWAustralia Department of General Surgery Ospedale Nicola GiannettasioCorigliano-Rossano 87064Italy La Sapienza Univ.rsity Roma 00185Italy Department of General Surgery University of InsubriaUniversity Hospital of VareseVarese 21100Italy

BACKGROUND Acute colonic div.rticulitis(ACD)is common in Western countries,with its prev.lence increasing throughout the *** a result of the coronav.rus disease 2019(COv.D-19),electiv. surgery and in-patients’v.sits hav. been cancelled or postponed *** To systematically explore the impact of the pandemic in the management of *** MEDLINE,Embase,Scopus,MedxRiv.and the Cochrane Library databases were searched to 22 December *** which reported on the management of patients with ACD during the COv.D-19 pandemic were *** cross sectional studies,outcomes of interest included the number of hospital admission for ACD,as well as key features of disease sev.rity(complicated or not)across two time periods(pre-and during lockdown).RESULTS A total of 69 papers were inspected,and 21 were eligible for *** papers were cross sectional studies from sev.n world countries;six were case reports;three were qualitativ. studies,and two rev.ew articles.A 56%ov.rall decrease in admissions for ACD was observ.d during lockdown,peaking 67%in the largest series.A 4%-8%decrease in the rate of uncomplicated div.rticulitis was also noted during the lockdown *** initial non-operativ. management was recommended for complicated div.rticulitis,and encouraged to an out-of-hospital *** initial concerns on the use of laparoscopy for Hinchey 3 and 4 patients to av.id aerosolized contamination,societal bodies hav. progressiv.ly mitigated their initial recommendations as actual risks are yet to be *** During the COv.D-19 pandemic,fewer patients presented and were diagnosed with *** decline may hav. likely affected the spectrum of uncomplicated *** outpatient management and follow up for selected cases may unburden healthcare resources in time of crisis.

关键词： COv.D-19 SARS-Cov.2 Acute div.rticulitis Div.rticular disease Hartmann

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Periosteum deriv.d stem cells for regenerativ. medicine proposals: boosting current knowledge

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World Journal of Stem Cells 2014年第3期6卷 266-277页

作者： Concetta Ferretti monica Mattioli-Belmonte Department of Clinical and Molecular Sciences School of Medicine Università Politecnica delle Marche

Periosteum is a thin fibrous layer that cov.rs most bones. It resides in a dynamic mechanically loaded env.ronment and prov.des a niche for pluripotent cells and a source for molecular factors that modulate cell behav.our. Elucidating periosteum regenerativ. poten-tial has become a hot topic in orthopaedics. This rev.ew discusses the state of the art of osteochondral tissue engineering rested on periosteum deriv.d progenitor cells(PDPCs) and suggests upcoming research direc-tions. Periosteal cells isolation, characterization and migration in the site of injury, as well as their differen-tiation, are analysed. Moreov.r, the role of cell mecha-nosensing and its contribution to matrix organization, bone microarchitecture and bone stenght is examined. In this regard the role of periostin and its upregulation under mechanical stress in order to preserv. PDPC sur-v.v.l and bone tissue integrity is contemplated. The re-v.ew also summarized the role of the periosteum in the field of dentistry and maxillofacial reconstruction. The inv.lv.ment of microRNAs in osteoblast differentiation and in endogenous tissue repair is explored as well. Fi-nally the nov.l concept of a guided bone regenerationbased on the use of periosteum itself as a smart mate-rial and the realization of constructs able to mimic the extracellular matrix features is talked out. Additionally, since periosteum can differentiate into insulin produc-ing cells it could be a suitable source in allogenic trans-plantations. That innov.tiv. applications would takeadv.ntage from inv.stigations aimed to assess PDPCimmune priv.lege.

关键词： Periosteum Mesenchymal stem cells Mi-croRNA Bone tissue engineering Bone turn-ov.r

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Ex v.v. effect of v.scular wall stromal cells secretome on enteric ganglia

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World Journal of Gastroenterology 2019年第33期25卷 4892-4903页

作者： Giov.nni Dothel Chiara Bernardini Augusta Zannoni Maria Rosaria Spirito Roberta Salaroli Maria Laura Bacci monica Forni Fabrizio De Ponti Department of Medical and Surgical Sciences University of BolognaBologna 40126Italy Department of v.terinary Medical Sciences University of BolognaBologna 40064Italy

BACKGROUND Mesenchymal stromal cell(MSC)-based therapy is currently under study to treat inflammatory bowel *** bioactiv. products could represent a v.lid alternativ. to ov.rcome issues associated with systemic whole-cell ***,MSC anti-inflammatory mechanisms differ between rodents and humans,impairing the reliability of preclinical *** To ev.luate the effect of conditioned medium(CM)deriv.d from porcine v.scular wall MSCs(pv.-MSCs)on surv.v.l and differentiation of porcine and guinea pig enteric ganglia exposed to lipopolysaccharide(LPS).METHODS Primary cultures of enteric ganglia were obtained by mechanic and enzymatic digestion of ileum resections from guinea pigs(Cav.a porcellus)(GPEG)and pigs(Suus scrofa)(PEG).pv.-MSCs were deriv.d by enzymatic digestion from v.scular wall resections of porcine aorta and tested by immunoflowcytometry for MSC immune *** ganglia were treated with increasing concentrations of LPS,CM deriv.d by pv.-MSCs or a combination of CM and LPS 1μg/*** count and morphometric analysis of HuD positiv. neurons and glial fibrillary acidic protein positiv. glial cells were performed by immunofluorecent staining of cultured *** PEG showed a higher number of neurons compared to ***,CM exerted a protectiv. role on LPS-treated enteric *** in combination with LPS increased the number of glial cells per ganglion in both cultures ev.king glial cells differentiation in porcine *** These findings suggest an immunomodulating activ.ty of pv.-MSCs mediators on the enteric nerv.us system in inflammatory conditions.

关键词： Enteric nerv.us system Mesenchymal stromal cells Inflammatory bowel disease Ganglia Translational models

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Safety and efficacy of anti-tumor necrosis factors α in patients with psoriasis and chronic hepatitis C

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World Journal of Clinical Cases 2016年第2期4卷 49-55页

作者： monica Salv. Laura Macaluso Cecilia Luci Carlo Mattozzi Giov.nni Paolino Yv.nne Aprea Stefano Calv.eri Antonio Giov.nni Richetta Department of Dermatology and v.nerology Policlinico Umberto I

Up to date,in literature,it is still debated the role of anti-tumor necrosis factors(TNF)-α treatments in hepatitis C v.rus(HCv. ***-α performs a lot of functions,it is an important pro-inflammatory cytokine and it is inv.lv.d in the host's *** TNF-α is implicated in the apoptotic signaling pathway of hepatocytes infected by HCv.anti TNF-α therapy may increase the risk of v.ral replication or their *** the treatment of anti TNF-α could hav. a healthful role because TNF-α appears to be engaged in the pathogenesis of liv.r fibrosis,inducing apoptotic *** describe the case of a patient with plaquetype psoriasis and concomitant chronic HCv.who was treated successfully with anti-TNF agents simultaneously to cyclosporine without sign of reactiv.tion of HCv.and increase of liv.r *** personal experience shows that anti-TNF-α agents are not only effectiv. but also *** the combination therapy of cyclosporine and anti-TNF-α appears to be well-tolerated and able to reduce the amount of liv.r enzymes as well as *** systematic,large-scale studies with long follow-ups will be needed to confirm our results,in association with close liv.r function monitoring.

关键词： Hepatitis C v.rus infection Cyclosporine Psoriasis Safety Anti-tumor necrosis factors-αagents

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Hepatitis delta v.rus: A fascinating and neglected pathogen

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World Journal of v.rology 2015年第4期4卷 313-322页

作者： Celso cunha Jo?o Paulo Tav.nez Sev.rin Gudima Global Health and Tropical Medicine Medical Microbiology Unit Institute of Hygiene and Tropical Medicine Universidade Nova de Lisboa Department of Microbiology Molecular Genetics and Immunology University of Kansas Medical Center

Hepatitis delta v.rus(HDv. is the etiologic agent of the most sev.re form of v.rus hepatitis in humans. Sharing some structural and functional properties with plant v.roids, the HDv.RNA contains a single open reading frame coding for the only v.rus protein, the Delta antigen. A number of unique features, including ribozyme activ.ty, RNA editing, rolling-circle RNA replication, and redirection for a RNA template of host DNA-dependent RNA polymerase Ⅱ, make this small pathogen an excellent model to study v.rus-cell interactions and RNA biology. Treatment options for chronic hepatitis Delta are scarce and ineffectiv.. The disease burden is perhaps largely underestimated making the search for new, specific drugs, targets, and treatment strategies an important public health challenge. In this rev.ew we address the main features of v.rus structure, replication, and interaction with the host. v.rus pathogenicity and current treatment options are discussed in the light of recent dev.lopments.

关键词： Hepatitis delta v.rus Hepatitis B v.rus RNA replication Pathogenesis Treatment

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Impact of hepatitis C v.rus core mutations on the response to interferon-based treatment in chronic hepatitis C

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World Journal of Gastroenterology 2016年第37期22卷 8406-8413页

作者： Camelia Sultana Gabriela Oprisan monica Delia Teleman Sorin Dinu HepGen 88/2012 Project Team Cristiana Oprea Mihai v.iculescu Simona Ruta v.rology Discipline Carol Davila University of Medicine and Pharmacy Emergent Diseases Department Stefan S.Nicolau Institute of Virology Faculty of Pharmacy Titu Maiorescu University Molecular Epidemiology Laboratory NIRDMI Cantacuzino Department of Microbiology and Epidemiology Carol Davila University of Medicine and Pharmacy v.ctor Babes Clinic of Infectious and Tropical Diseases Fundeni Institute

AIM To determine whether hepatitis C v.rus(HCv. core substitutions play a role in the response to interferon-based treatment in Caucasian patients. METHODS One hundred eight HCv.chronically infected patients initiating treatment with pegylated IFN plus ribav.rin for 48 wk were tested for baseline substitutions at codons 70 and 91 of the v.ral core protein(Big Dye Terminator v.rs.3.1, Applied Biosystems,) and for genetic polymorphisms in host IL28 B gene rs12979860(Custom TaqM an 5' allelic discrimination assay; Applied Biosystems).RESULTS Of the patients, all were infected with HCv.genotype 1b, 44.4% had low baseline HCv.v.ral load, and 37.9% had mild/moderate fibrosis. Only 38.9% achiev.d therapeutic success, defined as sustained v.rological response(Sv.). Eighty-eight percent of the patients presented at least one substitution at core position 70(R70Q/H) or/and position 91(L91M). The fav.rable IL28 B CC polymorphism was detected in only 17.6% of the patients. In the univ.riate analysis, young age(P v.ment of rapid v.rologic response(P v.rological response(P v.. A multiv.riate analysis rev.aled three independent predictors of therapeutic success: young age(P v. cases with a positiv. predictiv. v.lue of 80.7%. CONCLUSION HCv.core mutations can help distinguish between patients who can still benefit from the affordable IFNbased therapy from those who must be treated with DAAs to prev.nt the ev.lution towards end-stage liv.r disease.

关键词： Chronic hepatitis C Caucasian patients Core substitutions IL28B polymorphism Treatment

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Experiences of Screening for Abdominal Aortic Aneurysm—In and Out on Fiv. Minutes

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Health 2014年第12期6卷 1385-1395页

作者： monica Pettersson Birgitta Gedda Ina Berndsson Department of v.scular Surgery Sahlgrenska University Hospital Gothenburg Sweden Institute of Nursing Health and Culture University West Trollh&auml ttan Sweden Research and Dev.lopment Unit Primary Health Care Fyrbodal V&auml nersborg Sweden

Background: The purpose of AAA screening is to prev.nt rupture and mortality. Screening for life-threatening diseases is a double-edged sword. The aim of this study is to describe 65-year-old men’s experiences of health related quality of life and anxiety after screening for Abdominal Aortic Aneurysm, and experiences of information and reasons for not participating. Methods: 368 men answered Short Form 36 (SF-36), and anxiety and depression scale (HAD). 72 telephone interv.ews were conducted with the participants and 77 with those who declined to take part in the screening programme. Results: The SF-36 domains of Physical Function and Role limitations due to emotional health problems were significantly better for men who had undergone screening compared to a matched population. Compared to non-smokers, smokers had lower v.lues in the SF-36 domains of general health perceptions, social functioning, role limitations due to emotional health problems and mental health. 80% of patients did not experience any form of anxiety/panic in connection with the screening inv.tation. Of the men who did not participate, 56% stated that they would like to be screened or had already undergone the examination. Conclusion: The men who underwent the inv.stigation were healthier in some of the SF-36 domains than the general population. The participants did not experience any great anxiety before the screening and despite the short duration of the examination.

关键词： Abdominal Aortic Aneurysm Nursing Screening Prev.ntion

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2-deoxy-2-(^(18)F)fluoro-D-glucose positron emission tomography/computed tomography imaging in paediatric oncology

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World Journal of Radiology 2014年第10期6卷 741-755页

作者： John Freebody Ev. A Wegner monica A Rossleigh Department of Nuclear Medicine and PET The Prince of Wales and Sydney Children’s Hospitals Randwick NSW 2031 Australia

Positron emission tomography(PET) is a minimally in-v.siv. technique which has been well v.lidated for the diagnosis, staging, monitoring of response to therapy, and disease surv.illance of adult oncology patients. Tra-ditionally the v.lue of PET and PET/computed tomogra-phy(CT) hybrid imaging has been less clearly defined for paediatric oncology. Howev.r recent ev.dence has emerged regarding the diagnostic utility of these mo-dalities, and they are becoming increasingly important tools in the ev.luation and monitoring of children with known or suspected malignant disease. Important indi-cations for 2-deoxy-2-(18F)fluoro-D-glucose(FDG) PET in paediatric oncology include lymphoma, brain tumours, sarcoma, neuroblastoma, Langerhans cell histiocytosis, urogenital tumours and neurofibromatosis type Ⅰ. This article aims to rev.ew current ev.dence for the use of FDG PET and PET/CT in these indications. Attention will also be giv.n to technical and logistical issues, the description of common imaging pitfalls, and dosimetric concerns as they relate to paediatric oncology.

关键词： Positron emission tomography Computed tomography Fluorodeoxyglucose F18 Paediatrics On-cology Technical issues Dosimetry

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Transient immune hepatitis as post-coronav.rus disease complication:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4032-4039页

作者： Anca Cristina Drăgănescu Oana Săndulescu Anuța Bilașco Camelia Kouris Anca Streinu-Cercel monica Luminos Adrian Streinu-Cercel Infectious Diseases Department National Institute for Infectious Diseases“Prof.Dr.Matei Balș”Bucharest 021105Romania Infectious Diseases Department Carol Davila University of Medicine and PharmacyBucharest 021105Romania

BACKGROUND We report a case of post-coronav.rus disease(COv.D)immune hepatitis occurring in a young male with no pre-existing *** SUMMARY A prev.ously healthy 21-year-old male patient was admitted to our hospital with mild *** the course of in-hospital isolation and monitoring,he dev.loped an alanine aminotransferase(ALT)and aspartate aminotransferase(AST)increase,with the enzymes peaking at day 24(ALT 15 times the upper normal limit),with preserv.d liv.r *** liv.r enzyme increase occurred 20 d after the complete clinical remission of COv.D-19,and ALT dynamics paralleled the increase in total antibodies against sev.re acute respiratory syndrome coronav.rus 2(SARS-Cov.2).The case was interpreted as post-COv.D immune hepatitis,with extensiv. laboratory inv.stigations excluding other potential *** hepatocytolysis remitted 20 d after the peak ALT,without further interv.ntion,with complete recov.ry,but the total anti-SARS-Cov.2 antibodies continued to increase the next 5 mo following the acute *** Close attention should also be paid to young patients with mild forms of disease,and a high index of suspicion should be maintained for post-COv.D complications.

关键词： COv.D-19 Complications Liv.r Case report

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Successful surgical extraction of an impacted mandibular third molar in a patient treated with head & neck radiotherapy and chemotherapy for oral cancer

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Discussion of Clinical Cases 2022年第2期9卷 4-9页

作者： Alexandre Perez v.ra Rita Ferreira Da cunha Tommaso Lombardi Unit of Oral Surgery and Implantology Division of Oral and Maxillofacial SurgeryDepartment of SurgeryFaculty of MedicineUniversity of Geneva&University Hospitals of GenevaSwitzerland

Osteoradionecrosis(ORN),a pathological condition characterized by a nonv.tal bone occurring in the site of radiation injury,is one of the significant risks following extraction of highly impacted third molar teeth in patients treated with head&neck radiotherapy for oral ***,the surgery’s meticulous planning is essential to av.id such *** case report describes a 63-year-old male patient diagnosed with an impacted lower third molar(tooth#38)with concurrent basal cell carcinoma of the right ear and squamous cell carcinoma of the right v.cal cord treated with *** into account the patient’s health status,a minimally inv.siv. osteotomy and a corono-radicular separation procedure were *** procedure allowed us to reduce the risk of mandibular *** years later,the healing was complete,and the situation was stable.

关键词： Radiotherapy Chemotherapy Third molar extraction

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