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Olfactory response of Anastrepha striata （Diptera： Tephritidae） to guava and sweet orange volatiles

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Insect Science 2016年第5期23卷 720-727页

作者： Edvin Diaz-Santiz, Julio C. rojas Leopoldo Cruz-Lopez Emilio Hernandez Edi A. Malo Grupo de Ecologia de Artr6podos y Manejo de plagas El Colegio de la Frontera Sur (ECOSUR) Carretera Antiguo Aeropuerto km 2.5 Tapachula Chiapas CP 30700 programa Moscafrut SAGARPA-IICA Subdirecci6n de Desarrollo de M6todos Camino a los Cacahotales SIN Metapa de Dominguez Chiapas CP 30860 Mexico

The behavioral responses of virgin and mated female Anastrepha striata Schiner （Diptera： Tephritidae） to guava （Psidium guajava L.） or sweet orange （Citrus sinensis L.） were evaluated separately using multilure traps in two-choice tests in field cages. The results showed that flies were more attracted to guava and sweet orange volatiles than to control （unbaited trap）. The physiological state （virgin or mated） of females did not affect their attraction to the fruit volatiles. Combined analysis of gas chromatography coupled with electroantennography （GC-EAD） of volatile extracts of both fruits showed that 1 and 6 compounds from orange and guava, respectively elicited repeatable antennal responses from mated females. The EAD active compounds in guava volatile extracts were identified by gas chromatography-mass spectrometry （GC-MS） as ethyl butyrate, （Z）-3-hexenol, hexanol, ethyl hexanoate, hexyl acetate, and ethyl octanoate. Linalool was identified as the only antennal active compound in sweet orange extracts. In field cage tests, there were no significant differences between the number of mated flies captured by the traps baited with guava extracts and the number caught by traps baited with the 6-component blend that was formulated according to the relative proportions in the guava extracts. Similar results occurred when synthetic linalool was evaluated against orange extracts. From a practical point of view, the compounds identified in this study could be used for monitoring A. striata populations.

关键词： Anastrepha striata attraction GC-EAD GC-MS guava and sweet orangevolatiles multilure traps

Technological trajectory based on micro level technological capability:Evidence from the Brazilian rice industry

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International Journal of Innovation Studies 2022年第3期6卷 196-215页

作者： monica Fitz-Oliveira Jorge Tello-Gamarra Institute of Economic Administrative and Accounting SciencesFederal University of Rio GrandeRio Grande96203-900Brazil School of Chemistry and Food Federal University of Rio GrandeSanto.Antonio da Patrulha95500-000Brazil School of Administration Federal University of Rio Grande do SulPorto Alegre90010-460Brazil

This study examines technological capability accumulation and the Brazilian rice industry's technological *** case design was chosen,with an analysis of seven firms involved in the Brazilian rice *** results indicate three factors:The first was the identification of technological landmarks for firms in this sector(peeling and polishing,electronic grain selection,electronic packaging,use of forklifts and palletizers,and Industry 4.0).The second is related to the fact that different firms implemented innovative activities and technologies at different speeds,originating from the sector's different technological *** third is associated with identifying activities within the Brazilian rice industry that can be generalized to other food *** results have implications for formulating public policies in the sector,such as creating producer support mechanisms(research and technology transfer institutions),qualification of professionals,and encouragement for economic efficiency and competition.

关键词： Technological capability Technological trajectory Firm Industry Innovation Rice

Applications of stem cells and bioprinting for potential treatment of diabetes

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World Journal of Stem Cells 2019年第1期11卷 13-32页

作者： Shweta Anil Kumar monica Delgado Victor E Mendez Binata Joddar Inspired Materials and Stem-Cell Based Tissue Engineering Laboratory Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso Border Biomedical Research Center University of Texas at El Paso

Currently, there does not exist a strategy that can reduce diabetes and scientists are working towards a cure and innovative approaches by employing stem cellbased therapies. On the other hand, bioprinting technology is a novel therapeutic approach that aims to replace the diseased or lost β-cells, insulin-secreting cells in the pancreas, which can potentially regenerate damaged organs such as the pancreas. Stem cells have the ability to differentiate into various cell lines including insulinproducing cells. However, there are still barriers that hamper the successful differentiation of stem cells into β-cells. In this review, we focus on the potential applications of stem cell research and bioprinting that may be targeted towards replacing the β-cells in the pancreas and may offer approaches towards treatment of diabetes. This review emphasizes on the applicability of employing both stem cells and other cells in 3 D bioprinting to generate substitutes for diseased β-cells and recover lost pancreatic functions. The article then proceeds to discuss the overall research done in the field of stem cell-based bioprinting and provides future directions for improving the same for potential applications in diabetic research.

关键词： Bioprinting Tissue engineering Pluripotent stem cells Mesenchymal stem cells Human embryonic stem Adult human liver cells β-cells Islet cells Biomaterials Bioink Stem cell Diabetes

Peptide aptamers:The versatile role of specific protein function inhibitors in plant biotechnology

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Journal of Integrative Plant Biology 2015年第11期57卷 892-901页

作者： monica Colombo Chiara Mizzotti Simona Masiero Martin M.Kater Paolo Pesaresi Research and Innovation Centre Fondazione Edmund MachSan Michele all'Adige(Trento) Department of Biosciences University of Milan

In recent years, peptide aptamers have emerged as novel molecular tools that have attracted the attention of researchers in various fields of basic and applied science, ranging from medicine to analytical chemistry. These artificial short peptides are able to specifically bind, track, and inhibit a given target molecule with high affinity, even molecules with poor immunogenicity or high toxicity, and represent a remarkable alternative to antibodies in many different applications. Their use is on the rise, driven mainly by the medical and pharmaceutical sector. Here we discuss the enormous potential of peptide aptamers in both basic and applied aspects of plant biotechnology and food safety. The different peptide aptamer selection methods available both in vivo and in vitro are introduced, and the most important possible applications in plant biotechnology are illustrated. In particular, we discuss the generation of broad- based virus resistance in crops, ＂reverse genetics＂ and aptasensors in bioassays for detecting contaminations in food and feed. Furthermore, we suggest an alternative to the transfer of peptide aptamers into plant cells via genetic transformation, based on the use of cell-penetrating peptides that overcome the limits imposed by both crop transformation and Genetically Modified Organism commercialization.

关键词： Biosensors functional genomics peptide aptamers resistance

Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis

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World Journal of Gastroenterology 2014年第44期20卷 16535-16543页

作者： Natasha Irrera Alessandra Bitto monica Interdonato Francesco Squadrito Domenica Altavilla Department of Clinical and Experimental Medicine University of Messina Department of Paediatric Gynaecological Microbiological and Biomedical Sciences University of Messina

Acute pancreatitis(AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of acute pancreatitis. Pancreatitis is initiated by activation of digestive enzymes within the acinar cells that are involved in autodigestion of the gland, followed by a massive infiltration of neutrophils and macrophages and release of inflammatory mediators, responsible for the local and systemic inflammatory response. The hallmark of AP is parenchymal cell necrosis that represents the cause of the high morbidity and mortality, so that new potential therapeutic approaches are indispensable for the treatment of patients at high risk of complications. However, not all factors that determine the onset and course of the disease have been explained. Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis.

关键词： Experimental acute pancreatitis Mitogen-activated protein kinases Mitogen-activated protein kinases inhibitors Cytokines Cholecystokinin Cerulein

Exercise-induced hypoalgesia in chronic neck pain: A narrative review

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Sports Medicine and Health Science 2024年第1期6卷 37-47页

作者： Fernando rojas-Galleguillos Cecilia Clark-Hormazabal Eduardo Mendez-Fuentes Francisco Guede-rojas Cristhian Mendoza Andres Riveros Valdes Claudio Carvajal-Parodi Universidad San Sebastian Programa Magíster en Kinesiología MusculoesqueleticaLientur#1457ConcepcionChile Exercise and Rehabilitation Sciences Laboratory School of Physical TherapyFaculty of Rehabilitation SciencesUniversidad Andres BelloSantiago7591538Chile Universidad San Sebastian Laboratoriode NeurobiologíFacultad de Odontologíay Ciencias dela RehabilitacionLientur#1457ConcepcionChile Universidad San Sebastian Departamento de Ciencias MorfologicasFacultad de MedicinaCienciaLientur#1457ConcepcionChile Universidad San Sebastian Escuelade KinesiologíaFacultad de OdontologíaCiencias dela RehabilitacionLientur#1457ConcepcionChile

Chronic neck pain(CNP)is a worldwide health problem with several risk *** of the most widely used treatments for managing this condition is therapeutic exercise,which could generate a response called exerciseinduced hypoalgesia(EIH).There is no consensus on the best exercise modality to induce ***,this review aims to analyze and synthesize the state-of-the-art about the hypoalgesic effect of exercise in subjects with *** included articles on EIH and CNP in patients older than 18 years,with pain for more than three months,where the EIH response was *** that studied CNP associated with comorbidities or measured the response to treatments other than exercise were *** studies reviewed reported variable *** in healthy subjects has been shown to reduce indicators of pain sensitivity;however,in people with chronic pain,the response is *** investigations reported adverse effects with increased pain intensity and decreased pain sensitivity,others found no clinical response,and some even reported EIH with decreased pain and increased *** is an identifiable,stimulable,and helpful therapeutic response in people with *** research is still needed on subjects with CNP to clarify the protocols and therapeutic variables that facilitate the EIH *** addition,it is necessary to deepen the knowledge of the intrinsic and extrinsic factors that influence EIH in people with CNP.

关键词： Exercise-induced hypoalgesia Neck pain Chronic pain Neck exercise therapy

Variations in the medical treatment of inflammatory bowel disease among gastroenterologists

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Gastroenterology Report 2018年第1期6卷 61-64,I0002,I0003页

作者： Shailendra Singh monica Chowdhry Shifa Umar Mohammad Bilal Kofi Clarke Division of Gastroenterology Allegheny Health NetworkAllegheny General HospitalPittsburghPAUSA Department of Internal Medicine Charleston Area Medical CenterWest Virginia UniversityCharlestonWVUSA

Background and aims:With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease(IBD),there is the possibility of significant variations in treatment and *** is known about the variation in treatment between IBD specialists and other gastroenterology(GI)*** possible variations is an important first step to help address standardized care and optimize *** studied the differences in use of biologics and immunomodulators in the management of IBD patients at a tertiary care hospital between IBD-trained physicians and other ***:A total of 325 IBD patients were included in the *** these,216 patients received care with an IBD physician and 109 had other GI/non-IBD physicians as their main ***:The unadjusted use of immunomodulators(35.6%vs 16.5%,p¼0.001),biologics(45.8%vs 22.9%,p¼0.001)and dual therapy(biologics and immunomodulator)(14.4%vs 3.7%,p¼0.001)was significantly higher in the IBD-physician *** differences in therapy between the two groups remained after adjusting for patient and disease ***:There are significant variations in the treatment of patients with IBD by GI *** use of biologics and immunomodulators is higher in GI physicians with dedicated IBD interest and training.

关键词： variation in treatment inflammatory bowel disease Crohn’s disease,ulcerative colitis biologics immunomodulator

Development of an inflatable solar dryer for improved postharvest handling of paddy rice in humid climates

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 269-282页

作者： Ana Salvatierra-rojas Marcus Nagle Martin Gummert Tom de Bruin Joachim Müller Institute of Agricultural Engineering Tropics and Subtropics GroupUniversität HohenheimGarbenstrasse 9Stuttgart 70599Germany Postharvest Development Program International Rice Research Institute(IRRI)Los Baños 4031Philippines GrainPro Philippines Inc. Subic Bay 2222Philippines

Rice is the staple food for more than three billion people *** considerable progress has been made with respect to improved breeds and production practices,losses during postharvest handling remain *** and storage of paddy are two key stages where management can be *** rice,grain moisture content of 14%prevents microbiological activity,while a level of about 12%minimizes quality losses over prolonged storage *** to the need for simple and economical technologies,an inflatable solar dryer(ISD)was developed based on adaptations of the Hohenheim-type solar tunnel *** form a drying tunnel,transparent polyethylene(PE)film attaches by zipper to a reinforced black polyvinyl chloride(PVC)*** reduce heat loss,a flexible multilayer floor was used along the drying *** tunnel does not need a substructure as it is stabilized adequately from pressure created by two axial flow *** experiments,paddy was spread on the floor and mixed with a special roller *** ISD has been evaluated for paddy in the Philippines during both rainy and dry seasons and was subsequently *** drying and shade drying were carried out in parallel for comparison and product was evaluated for moisture content and quality in terms of milling recovery and head rice *** content was reduced from 23%to 14%within 26-52 h of continuous operation during the rainy season and 16%to 14%within 4-26 h of drying during the dry *** both seasons,the final moisture content of 12%was reached after prolonged drying *** was not found to be affected with respect to drying *** ISD showed advantages over sun drying,despite longer drying periods.

关键词： paddy rice postharvest handling solar dryer mobile dryer collapsible dryer Philippines

Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

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World Journal of Gastroenterology 2023年第6期29卷 997-1010页

作者： Armando rojas Cristian Lindner Iván Schneider Ileana González Miguel Angel Morales Biomedical Research Laboratories Medicine FacultyCatholic University of MauleTalca 34600000Chile Medicine Faculty Catholic University of MauleTalca 34600000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori *** the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and ***,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关键词： Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products Alarmins Helicobacter pylori Chronic inflammation